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WO2005007665A3 - Lincomycin derivatives possessing antibacterial activity - Google Patents

Lincomycin derivatives possessing antibacterial activity Download PDF

Info

Publication number
WO2005007665A3
WO2005007665A3 PCT/US2004/019497 US2004019497W WO2005007665A3 WO 2005007665 A3 WO2005007665 A3 WO 2005007665A3 US 2004019497 W US2004019497 W US 2004019497W WO 2005007665 A3 WO2005007665 A3 WO 2005007665A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial activity
lincomycin derivatives
derivatives possessing
possessing antibacterial
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/019497
Other languages
French (fr)
Other versions
WO2005007665A8 (en
WO2005007665A2 (en
Inventor
Jason G Lewis
Dinesh V Patel
Sampath K Anandan
Mikhail F Gordeev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vicuron Pharmaceuticals LLC
Original Assignee
Vicuron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2003/025820 external-priority patent/WO2004016632A2/en
Priority claimed from US10/777,455 external-priority patent/US7199105B2/en
Application filed by Vicuron Pharmaceuticals LLC filed Critical Vicuron Pharmaceuticals LLC
Priority to BRPI0411537-6A priority Critical patent/BRPI0411537A/en
Priority to EP04785949A priority patent/EP1654268A2/en
Priority to JP2006517386A priority patent/JP2007528360A/en
Priority to CA002528596A priority patent/CA2528596A1/en
Publication of WO2005007665A2 publication Critical patent/WO2005007665A2/en
Publication of WO2005007665A8 publication Critical patent/WO2005007665A8/en
Publication of WO2005007665A3 publication Critical patent/WO2005007665A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
PCT/US2004/019497 2003-06-17 2004-06-17 Lincomycin derivatives possessing antibacterial activity Ceased WO2005007665A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BRPI0411537-6A BRPI0411537A (en) 2003-06-17 2004-06-17 lincomycin derivatives that have antibacterial activity
EP04785949A EP1654268A2 (en) 2003-06-17 2004-06-17 Lincomycin derivatives possessing antibacterial activity
JP2006517386A JP2007528360A (en) 2003-06-17 2004-06-17 Lincomycin derivatives with antibacterial activity
CA002528596A CA2528596A1 (en) 2003-06-17 2004-06-17 Lincomycin derivatives possessing antibacterial activity

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US47950203P 2003-06-17 2003-06-17
US60/479,502 2003-06-17
USPCT/US03/25820 2003-08-15
US10/642,807 2003-08-15
PCT/US2003/025820 WO2004016632A2 (en) 2002-08-15 2003-08-15 Lincomycin derivatives possessing antibacterial activity
US10/642,807 US7164011B2 (en) 2002-08-15 2003-08-15 Lincomycin derivatives possessing antibacterial activity
US10/777,455 2004-02-11
US10/777,455 US7199105B2 (en) 2002-08-15 2004-02-11 Lincomycin derivatives possessing antibacterial activity

Publications (3)

Publication Number Publication Date
WO2005007665A2 WO2005007665A2 (en) 2005-01-27
WO2005007665A8 WO2005007665A8 (en) 2005-04-14
WO2005007665A3 true WO2005007665A3 (en) 2005-08-18

Family

ID=34084654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/019497 Ceased WO2005007665A2 (en) 2003-06-17 2004-06-17 Lincomycin derivatives possessing antibacterial activity

Country Status (3)

Country Link
EP (1) EP1654268A2 (en)
CA (1) CA2528596A1 (en)
WO (1) WO2005007665A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1315859C (en) 2002-08-15 2007-05-16 维库罗恩医药品公司 Lincomycin derivatives possessing antibacterial activity
US7199105B2 (en) 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
US7361743B2 (en) 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
JP5356223B2 (en) * 2007-05-31 2013-12-04 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 Lincomycin derivatives and antibacterial agents containing the same as active ingredients
WO2008146919A1 (en) * 2007-05-31 2008-12-04 Meiji Seika Kaisha, Ltd. Lincosamide derivative, and antibacterial agent comprising the same as active ingredient
CN109627299B (en) * 2018-11-03 2022-02-18 北京工商大学 Bacteriocin Gr17 with broad-spectrum antibacterial activity and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282917A (en) * 1964-08-17 1966-11-01 Upjohn Co Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3555007A (en) * 1968-07-22 1971-01-12 Upjohn Co 7-deoxy-7-halo lincomycin d derivatives
WO2004016632A2 (en) * 2002-08-15 2004-02-26 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
WO2005012320A2 (en) * 2003-06-17 2005-02-10 Vicuron Pharmaceuticals, Inc. Novel lincomycin derivatives possessing antimicrobial activity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3282917A (en) * 1964-08-17 1966-11-01 Upjohn Co Methyl n-(1-alkyl-4-alkoxy-prolyl)-alpha-thiolincosaminide compounds and process therefor
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3555007A (en) * 1968-07-22 1971-01-12 Upjohn Co 7-deoxy-7-halo lincomycin d derivatives
WO2004016632A2 (en) * 2002-08-15 2004-02-26 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
WO2005012320A2 (en) * 2003-06-17 2005-02-10 Vicuron Pharmaceuticals, Inc. Novel lincomycin derivatives possessing antimicrobial activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIRKENMEYER R D ET AL: "Synthesis and antimicrobial activity of clindamycin analogues: pirlimycin, a potent antibacterial agent", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 27, no. 2, 1984, pages 216 - 223, XP002174848, ISSN: 0022-2623 *
MAGERLEIN B J: "LINCOMYCIN. VII. 4'-DEPROPYL-4'-ETHOXYLINCOMYCINS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 10, no. 6, November 1967 (1967-11-01), pages 1161 - 1163, XP001205532, ISSN: 0022-2623 *
SZTARICSKAI F ET AL: "SEMISYNTHESIS MODIFICATION OF ANTIBIOTIC LINCOMYCIN", JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. TOKYO, JP, vol. 49, no. 9, 1996, pages 941 - 943, XP009044907, ISSN: 0021-8820 *

Also Published As

Publication number Publication date
EP1654268A2 (en) 2006-05-10
CA2528596A1 (en) 2005-01-27
WO2005007665A8 (en) 2005-04-14
WO2005007665A2 (en) 2005-01-27

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