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WO2005005403A3 - Process for preparation of oxetan-2-ones - Google Patents

Process for preparation of oxetan-2-ones Download PDF

Info

Publication number
WO2005005403A3
WO2005005403A3 PCT/IB2004/002305 IB2004002305W WO2005005403A3 WO 2005005403 A3 WO2005005403 A3 WO 2005005403A3 IB 2004002305 W IB2004002305 W IB 2004002305W WO 2005005403 A3 WO2005005403 A3 WO 2005005403A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxetan
ones
preparation
present
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2004/002305
Other languages
French (fr)
Other versions
WO2005005403A2 (en
Inventor
Yatendra Kumar
Mohan Prasad
Keshav Deo
Anand Pandey
Kilol Patel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Priority to EP04743966A priority Critical patent/EP1651627A2/en
Publication of WO2005005403A2 publication Critical patent/WO2005005403A2/en
Publication of WO2005005403A3 publication Critical patent/WO2005005403A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)

Abstract

The present invention relates to a process for the preparation of diastereomerically and enantiomerically pure oxetan-2-ones. The present invention also relates to a process for the preparation of ester derivatives of oxetan-2-ones. The present invention further relates to compounds prepared by such processes.
PCT/IB2004/002305 2003-07-15 2004-07-15 Process for preparation of oxetan-2-ones Ceased WO2005005403A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04743966A EP1651627A2 (en) 2003-07-15 2004-07-15 Process for preparation of oxetan-2-ones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN900/DEL/2003 2003-07-15
IN900DE2003 2003-07-15

Publications (2)

Publication Number Publication Date
WO2005005403A2 WO2005005403A2 (en) 2005-01-20
WO2005005403A3 true WO2005005403A3 (en) 2005-04-07

Family

ID=34044520

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/002305 Ceased WO2005005403A2 (en) 2003-07-15 2004-07-15 Process for preparation of oxetan-2-ones

Country Status (2)

Country Link
EP (1) EP1651627A2 (en)
WO (1) WO2005005403A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006035296A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Process for the preparation of an orlistat derivative useful as reference standard in the determination of the purity of orlistat and process for the preparation of orlistat
US20090171104A1 (en) * 2005-10-05 2009-07-02 Killol Patel Process for the preparation of orlistat
KR101504777B1 (en) * 2007-06-06 2015-03-20 랜박시 래보러터리스 리미티드 Manufacturing method of orlistat
CN112625009A (en) * 2020-12-18 2021-04-09 植恩生物技术股份有限公司 Refining method of orlistat key intermediate

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202824A (en) * 1978-05-25 1980-05-13 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Physiologically active derivatives of esterastin
US4931463A (en) * 1984-12-21 1990-06-05 Hoffmann-La Roche Inc. Oxetanones
US4983746A (en) * 1984-12-21 1991-01-08 Hoffmann-La Roche Inc. Oxetanones and process for their production
US5412110A (en) * 1992-07-06 1995-05-02 Chemie Linz Gesellschaft M.B.H. Enzymatic process to separate racemic mixtures of delta valerolactones
US5902886A (en) * 1997-01-23 1999-05-11 Schick; Hans Method for synthesizing oxetan-2-ones and intermediates for their preparation
EP1127886A1 (en) * 2000-02-04 2001-08-29 F. Hoffmann-La Roche Ag Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-2H-pyran-2one
WO2002032850A1 (en) * 2000-10-16 2002-04-25 John Jason Gentry Mullins Process for making (2s, 3s, 5s) oxetanone derivatives

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202824A (en) * 1978-05-25 1980-05-13 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Physiologically active derivatives of esterastin
US4931463A (en) * 1984-12-21 1990-06-05 Hoffmann-La Roche Inc. Oxetanones
US4983746A (en) * 1984-12-21 1991-01-08 Hoffmann-La Roche Inc. Oxetanones and process for their production
US5412110A (en) * 1992-07-06 1995-05-02 Chemie Linz Gesellschaft M.B.H. Enzymatic process to separate racemic mixtures of delta valerolactones
US5902886A (en) * 1997-01-23 1999-05-11 Schick; Hans Method for synthesizing oxetan-2-ones and intermediates for their preparation
EP1127886A1 (en) * 2000-02-04 2001-08-29 F. Hoffmann-La Roche Ag Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-2H-pyran-2one
WO2002032850A1 (en) * 2000-10-16 2002-04-25 John Jason Gentry Mullins Process for making (2s, 3s, 5s) oxetanone derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ISHIHARA, TAKASHI; ICHIHARA, KAZUYOSHI, YAMANAKA, HIROKI: "Highly Selective Aldol Reaction of Metal Enolates of alpha-Fluoropropanethioates with Aldehydes Affording erythro-alpha-Fluoro-alpha-methyl-beta-hydroxy Alkanethionates", TETRAHEDRON LETTERS, vol. 36, no. 45, 1995, pages 8267 - 8270, XP002300391 *

Also Published As

Publication number Publication date
EP1651627A2 (en) 2006-05-03
WO2005005403A2 (en) 2005-01-20

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