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WO2005000260A1 - Composition de dentifrice - Google Patents

Composition de dentifrice Download PDF

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Publication number
WO2005000260A1
WO2005000260A1 PCT/JP2004/009377 JP2004009377W WO2005000260A1 WO 2005000260 A1 WO2005000260 A1 WO 2005000260A1 JP 2004009377 W JP2004009377 W JP 2004009377W WO 2005000260 A1 WO2005000260 A1 WO 2005000260A1
Authority
WO
WIPO (PCT)
Prior art keywords
zeolite
granules
particle size
dentifrice composition
average particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2004/009377
Other languages
English (en)
Japanese (ja)
Inventor
Kouichi Sugawara
Hiroyuki Shimizu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to KR1020057023497A priority Critical patent/KR101181379B1/ko
Priority to JP2005511120A priority patent/JP4482767B2/ja
Publication of WO2005000260A1 publication Critical patent/WO2005000260A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a dentifrice composition containing zeolite, which has an appropriate abrasiveness that does not damage teeth and has an excellent calculus formation inhibiting effect.
  • zeolite has been known to have an effect of preventing tartar formation and bad breath, and oral compositions containing the same have been proposed (Japanese Patent Application Laid-Open No. Hei 11-38017, 6 3—1 4 6 8 0 9 Publication). Also, due to the nature of zeolite, it is known that a smaller particle size adsorbs the causes of tartar and bad breath better and is more effective. However, zeolite has higher powder abrasive properties as its particle size is smaller due to its powder properties, and its abrasive properties against teeth are higher than inorganic powders generally used as toothpaste abrasives. It is easily damaged and cannot be blended in large amounts.
  • zeolite is effective in preventing tartar formation and bad breath when incorporated into a dentifrice composition.
  • a dentifrice has been proposed in which an inorganic abrasive is granulated and granules having a controlled particle size and disintegration strength are blended (Japanese Patent Publication No. 6-21053, Japanese Patent Application Laid-open No.
  • An object of the present invention is to provide a dentifrice composition that has appropriate tooth polishing properties that do not damage teeth, and that exerts zeolite-derived efficacy satisfactorily and has an excellent tartar formation preventing effect. I do.
  • zeolite was made to contain silica anhydride as a binder, the average particle size was 150 to 800 ⁇ m, and the average disintegration strength was 15 to 15.
  • the particle size was 100 gZ, the increase in abrasiveness due to zeolite is suppressed, and surprisingly, when aluminum oxide is mixed and granulated into the granules, the abrasiveness due to zeolite blending is increased.
  • the content of zeolite in the granules is 50 to 99% by mass, the content of aluminum oxide is 0.5 to 25% by mass, and the content of gay anhydride is 0.5 to 25% by mass.
  • FIG. 1 is a schematic diagram of a pH change amount measuring device used for evaluating calcium capturing ability in an example of the present invention.
  • the dentifrice composition of the present invention is characterized by containing zeolite, aluminum oxide, and silicic anhydride, and containing granules having a specific average particle size and average disintegration strength (hereinafter, referred to as zeolite granules).
  • zeolite used in the present invention compositions, W m Z n 0 2 n 's H 2 0 (W is N a, C a, K, with B a or S r, Z is S i + A 1 (S i: A 1> 1 s is not fixed), and there are both natural and synthetic aluminosilicates, about 40 of which are natural and those which are synthetic.
  • any of these zeolites can be used
  • natural zeolites and synthetic zeolites are exemplified as useful zeolites as natural zeolites.
  • the synthetic zeolites are A (3A, 4A, 5A, etc.) type zeolites. , L There are zeolites, faujasites (X-type zeolites, Y-type zeolites), offaleites, erionites, mordenites, etc. However, natural zeolites contain contaminants and lack homogeneity, so synthetic zeolites are preferred.
  • a (3A, 4A, 5A) type zeolites, X type zeolites, Y type zeolites, and L type zeolites are preferable, and the effect when blended in an oral composition is preferable.
  • A-type zeolite is more preferable in view of the above point.
  • 4A-type zeolite is superior to other A-type zeolites in calcium-capturing power and is particularly preferable in terms of tartar-preventing effect.
  • A-type zeolites are commercially available, for example, Sasil (Degussa), Toyobuilder, Zeolam (Tohoku Soichi Co., Ltd.), Shilton (Mizusawa Chemical Industries) Co., Ltd.), and the like.
  • the average particle size of zeolite used as a raw material for zeolite granules is not particularly limited, but is preferably from 1 to 100 m. If the particle size is smaller than 1, the granule strength may be low, and appropriate abrasiveness may not be maintained. In addition, if it is larger than 100 m, the effectiveness of zeolite in zeolite granules may be reduced.
  • the average particle size was measured using a Microtrac particle size analyzer (manufactured by Nikkiso Co., Ltd.). It is a fixed value (the same applies hereinafter).
  • the content of this zeolite in zeolite granules is preferably from 50 to 99% (mass%, the same applies hereinafter), particularly preferably from 70 to 90%.
  • Aluminum oxide is produced by the Pier method and has a sintering temperature of 1,000 to 1,200.
  • the degree of pregelatinization is 50 to 70% . If the degree of pregelatinization is high, the polishing power may not be able to be maintained properly and the polishing power may be too high. On the other hand, if it is too low, the effectiveness of the zeolite granules may be reduced.
  • the average particle size (average particle size according to the same measuring method as for the above zeolite) is preferably from 0.1 to 106 m, more preferably from 0.5 to 3 m. If the particle size is larger than 10 ⁇ m, the polishing power may be too high, and if it is smaller than 0.1 m, the zeolite effectiveness of the zeolite granules may be reduced.
  • the content of aluminum oxide is preferably 0.5 to 25%, particularly preferably 1 to 20% of the whole raw material used for zeolite granulation, and if it exceeds 25%, the amount of zeolite becomes relatively small, Zeolite may be less effective. Also,
  • the average particle size (average particle size according to the same measuring method as for the above zeolite) is preferably 0.1 to 50 °, more preferably 1 to 20 m. If the dry acid method is used, or if the particle size is larger than 50 m or smaller than 0.1 m, the disintegration strength of the granules may be weak and the abrasiveness may be too large. .
  • the content of the silicic acid anhydride in the zeolite granules is preferably 0.5 to 25%, and particularly preferably 1 to 20% . If the content is less than 0.5%, the disintegration strength of the granules will be low, and the abrasiveness will be low. May be too large, and if it exceeds 25%, the amount of zeolite is relatively small, and the effectiveness of zeolite may be reduced.
  • insoluble materials in addition to the aluminum oxide and the caustic anhydride as the zeolite granule raw material, various insoluble materials may be used as long as the performance of the zeolite granules is not hindered. It is possible to add optional components such as Specifically, dibasic calcium phosphate (dihydrate or anhydride), dibasic calcium phosphate, tribasic calcium phosphate, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, magnesium carbonate, tribasic magnesium phosphate, insoluble sodium metaphosphate And insoluble potassium metaphosphate, titanium oxide, zirconium silicate and the like. The amount of the insoluble material is preferably 20% or less.
  • the coloring agent is preferably a water-insoluble one such as titanium oxide, gunjiyou, konjiyo, bengalara, mica titanium, and lake dye.
  • the zeolite granules according to the present invention can be obtained by adding aluminum oxide and citric anhydride, and if necessary, the above-mentioned optional components to the above-mentioned zeolite, and granulating the zeolite so as to have a specific average particle size and average disintegration strength. Obtainable.
  • the average particle size of the zeolite granules is determined by sieving with a JIS sieve and calculating the 50% particle size from the particle size distribution, where the average particle size is 150 to 800 m, preferably 2%. It is in the range of 0 to 500 jm. If the average particle size is smaller than 150 m, the polishing ability cannot be controlled and the polishing power becomes too large. If the average particle size exceeds 800 m, the feeling of use of the compounded toothpaste is impaired.
  • the average disintegration strength of zeolite granules was determined by measuring the automatic breaking strength of 30 granules with a rheometer (Sun Rheometer CR-200D) manufactured by Sun Science Co., Ltd. The measured value of the load when the zeolite granules collapse when compressed at a pressure in the range of 15 to 100 gZ, preferably 20 to 50 g / piece, as the average value of Use If the average disintegration strength is less than 15, the abrasiveness cannot be controlled, and the abrasive power becomes too large. If the average disintegration strength exceeds 100 g, the feeling of use of the toothpaste deteriorates.
  • Examples of a method for forming zeolite granules include a compression molding method, an extrusion molding method, and a spray drying method.
  • a sintering method is preferable because granules having the above strength range can be easily obtained.
  • the dentifrice composition of the present invention one or more zeolite granules are arranged.
  • the compounding amount is preferably 1 to 50%, particularly preferably 2 to 30% of the whole composition. If the amount is less than 1%, the effectiveness of the zeolite granule may not be sufficiently exhibited, and if it exceeds 50%, the feeling of use of the toothpaste may be deteriorated.
  • the dentifrice composition of the present invention can be prepared into various types of dentifrices such as toothpaste, moist dentifrice, and liquid dentifrice in which the above zeolite granules are dispersed, and preferably a dentifrice having thixotropic properties to a liquid dentifrice. .
  • various optional components other than the above-mentioned zeolite granules usually used for a dentifrice composition can be blended.
  • Other ingredients that can be included include abrasives, thickeners (humectants), binders, surfactants, sweeteners, flavors, preservatives, and the like. Since the required components and the amounts of these other components differ depending on the dosage form, the selection of the components and the amounts of the components are carried out in the same manner as in the previous case, and within the range that does not impair the effects of the present invention. It is necessary.
  • dibasic calcium phosphate dihydrate or anhydrous
  • dibasic calcium phosphate tribasic calcium phosphate
  • calcium pyrophosphate calcium carbonate
  • aluminum hydroxide aluminum hydroxide
  • alumina magnesium carbonate
  • magnesium phosphate tribasic Water
  • insoluble sodium metaphosphate insoluble potassium metaphosphate
  • titanium oxide anhydrous caic acid
  • hydrated caic acid titanium gayate
  • zirconium silicate and synthetic resin-based abrasives.
  • the amount of the abrasive is preferably 5 to 80%, more preferably 10 to 50% of the whole composition.
  • polyphosphates such as pyrophosphate and tripolyphosphate
  • alkaline agents such as sodium bicarbonate and sodium carbonate
  • organic acids such as citric acid, malic acid, tartaric acid, ascorbic acid, lactic acid, and acetic acid
  • the salts can also be incorporated in effective amounts.
  • Binders include carrageenan, sodium carboxymethylcellulose, methylcellulose, ethylcellulose, cellulose acetate, sodium hydroxyethylcellulose, sodium alginate, xanthan gum, tragacanth gum, karaja gum, arabia gum, locust bean gum, polyvinyl alcohol, Examples thereof include sodium polyacrylate, lipoxyvinyl polymer, polyvinylpyrrolidone, carbopol, silica gel, aluminum silica gel, thickening silica, veegum, laponite and the like (the blending amount is usually 0.1 to 5.0%).
  • thickener examples include glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, lactol, and the like (the compounding amount is usually 1 to 80%).
  • Surfactants can include anionic surfactants, cationic surfactants, nonionic surfactants, and zwitterionic surfactants.
  • anionic surfactants include sodium lauryl sulfate, sodium myristyl sulfate, Sodium N-lauroylzalucosinate, sodium N-myristoylsarcosinate, sodium dodecylbenzenesulfonate, sodium hydrogenated coconut fatty acid monodaliceride monosulfate, sodium lauryl sulfoacetate, sodium olefinesulfonate, Examples thereof include N-acyl daltamate such as sodium N-palmitoyl glutamate, and N-acyl taurate such as N-methyl-N-acyl sodium phosphate.
  • Nonionic surfactants include sucrose fatty acid esters such as sucrose fatty acid esters and maltose fatty acid esters, sugar alcohol fatty acid esters such as maltitol fatty acid esters and lactol fatty acid esters, alkylol amide, and polyoxetylene sorbitan.
  • Polyoxyethylene sorbitan fatty acid esters such as monostearate, polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, fatty acid ethanolamides such as lauric mono- or diethanolamide, sorbitan fatty acid esters, and polyoxyethylene higher alcohol esters Ter, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, polyglycerin fatty acid ester, pull mouth nick, etc. It is done.
  • amphoteric surfactant examples include N-alkyl-N-potassium oxymethyl-N-hydroxyethylimidazolymbetaine, N-radiaryldiaminoethyldaricin, and N-myristyldiaminoethyldaricin. Examples thereof include alkyldiaminoethyldaricin and sodium N-alkyl-1-hydroxyethylimidazoline betaine. These surfactants may be used alone or in combination of two or more.
  • the amount of the surfactant to be incorporated is preferably from 0.001 to 10%, more preferably from 0.01 to 5%, particularly preferably from 0.1 to 2% of the whole composition.
  • Sweeteners include saccharin sodium, stepioside, stevia extract, Examples include paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, perillartin, glycyrrhizin, thaumatin, and asparatyl phenylalanine methyl ester, which can be added in an effective amount.
  • fragrances As fragrances, menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, (-one tvneol, citronellilla acetate, cineole, linalool, etil linalool, peniline, thymol, spearmint oil, peppermint oil, lemon Examples include oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, laurel oil, perilla oil, winter green oil, clove oil, and yurikuri oil, which can be incorporated in effective amounts.
  • nonionic antibacterial agents such as sodium benzoate and triclosan
  • cationic antibacterial agents such as benzethonium chloride and cetylpyridinium chloride
  • essential oil components can be formulated in effective amounts.
  • the active ingredients include enzymes such as dextranase, amylase, proteinase, and mutanase; alkaline metal monofluorophosphates such as sodium monofluorophosphate; fluorides such as sodium fluoride and stannous fluoride; Tranexamic acid, epsilon aminocaproic acid, aluminum chlorohydroxy allantoin, azulene, glycyrrhizinate, glycyrrhetinic acid, sodium chloride, vitamin (:,
  • Anti-inflammatory agents such as E, copper chlorophyll, copper dalconate, cetyl pyridium chloride, benzalkonium chloride, triclosan, hinokitiol, lysozyme chloride, and other bactericides; anticalculus agents such as polyphosphates; polyethylene glycol, polyvinyl pyridone And other hypersensitivity preventive agents such as aluminum lactate and potassium nitrate.
  • the amount of the active ingredient can be an effective amount.
  • the dentifrice composition of the present invention can be prepared by a conventional method according to the dosage form by mixing the above components.
  • the material of the container for containing the dentifrice composition is not particularly limited, and the container used for the dentifrice composition can be used. Specifically, plastics such as polyethylene, polypropylene, polyethylene terephthalate, and nylon can be used. Container, lamine
  • the dentifrice composition of the present invention suppresses an increase in abrasiveness due to zeolite blending, has an appropriate tooth abrasiveness that does not damage teeth, and has an effect of preventing calculus formation derived from zeolite. It is effective for preventing tartar formation.
  • Granules containing the components shown in Table 1 and zeolite in the compounding ratio were prepared by a sintering method to obtain granules having the following average disintegration strength and average particle size.
  • the average crushing strength and average particle size of the granules were measured by the following methods. The results are shown in Table 1.
  • a dentifrice composition having the composition shown in Table 2 was prepared by a conventional method, and calcium scavenging ability was measured by the following method to evaluate the abrasiveness and the tartar prevention effect. did. Table 2 shows the results.
  • Test method 1 (Abrasiveness):
  • Test method 2 (calcium capturing ability):
  • 0.02 g of the prepared toothpaste was dispersed in 20 OmL of a saturated solution of calcium ions and phosphate ions, and the pH was adjusted to 7.41 with 0.1 ml of sodium hydroxide.
  • the test solution was transferred to an apparatus as shown in FIG. 1, and the time-dependent change in pH after adding the hydroxyapatite powder was measured. During the measurement of pH over time, the air in the container was replaced with nitrogen, and the solution was stirred with a stirrer. That is, in the apparatus shown in FIG.
  • a test solution 2 is put in a container 1, a pH electrode 3 is inserted, and a nitrogen introduction tube 4 Nitrogen is introduced into the container, and in this container 1, the time-dependent change in pH is measured while stirring the test solution 2 with a stirrer 6 in a thermostat 5 at 37 ° C. At this time, since the change in pH becomes smaller as the calcium-capturing ability becomes higher, the amount of pH change after 3 hours was calculated, and the calcium-capturing ability was evaluated.
  • a dentifrice composition having the composition shown in Table 3 was prepared by a conventional method, and the calcium capturing ability was evaluated in the same manner as described above. Table 3 shows the results. As the zeolite granules, those shown in Table 4 were used.
  • the dentifrice composition of the present invention had a small pH change amount, had an excellent calcium capturing ability, and satisfactorily exhibited the effectiveness of zeolite.
  • all the dentifrice compositions showed almost the same polishing properties as the case of Example 1 as compared with the dentifrice composition containing no zeolite granules. No change was observed, confirming that the polishing property was suppressed.
  • ⁇ 1 or more and less than 0.2

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de dentifrice caractérisée en ce qu'elle comprend une zéolithe, de l'oxyde d'aluminium et un anhydride d'acide silicique, sous forme de granules présentant un diamètre moyen de particule compris entre 150 et 800 µm et une résistance à la dégradation comprise entre 15 et 100g/pièce.
PCT/JP2004/009377 2003-06-27 2004-06-25 Composition de dentifrice Ceased WO2005000260A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020057023497A KR101181379B1 (ko) 2003-06-27 2004-06-25 치약 조성물
JP2005511120A JP4482767B2 (ja) 2003-06-27 2004-06-25 歯磨組成物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003184251 2003-06-27
JP2003-184251 2003-06-27

Publications (1)

Publication Number Publication Date
WO2005000260A1 true WO2005000260A1 (fr) 2005-01-06

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ID=33549604

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PCT/JP2004/009377 Ceased WO2005000260A1 (fr) 2003-06-27 2004-06-25 Composition de dentifrice

Country Status (4)

Country Link
JP (1) JP4482767B2 (fr)
KR (1) KR101181379B1 (fr)
CN (1) CN100393297C (fr)
WO (1) WO2005000260A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007099701A (ja) * 2005-10-05 2007-04-19 Kao Corp 口腔用組成物
WO2013080762A1 (fr) * 2011-11-30 2013-06-06 ライオン株式会社 Composition de dentifrice
JP2013147431A (ja) * 2010-12-21 2013-08-01 Kao Corp 歯磨剤用顆粒
JP2013155160A (ja) * 2012-01-31 2013-08-15 Kao Corp 歯磨剤
JP2013155165A (ja) * 2012-01-31 2013-08-15 Kao Corp 歯磨剤
JP2013181012A (ja) * 2012-03-02 2013-09-12 Kao Corp 歯磨剤

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200812637A (en) * 2006-09-15 2008-03-16 jun-er Wang Vegetable composition for cleaning oral cavity
WO2009020010A1 (fr) * 2007-08-09 2009-02-12 Lion Corporation Composition orale liquide et procédé pour améliorer l'activité bactéricide d'un agent bactéricide cationique
JP6217628B2 (ja) * 2012-05-28 2017-10-25 ライオン株式会社 洗口剤
US9186307B2 (en) * 2012-11-19 2015-11-17 J.M. Huber Corporation Treated silicas and metal silicates for improved cleaning in dentifrice
CN102920613A (zh) * 2012-11-23 2013-02-13 董德华 一种防龋牙膏的组合物
CN103446008B (zh) * 2013-08-13 2016-02-24 上海方木精细化工有限公司 碳酸镁型牙膏
CN109745235A (zh) * 2019-03-20 2019-05-14 北京周整无为健康管理有限责任公司 一种基于拉长石的牙膏及其用途
CN119263295B (zh) * 2024-12-11 2025-05-16 洛阳建龙微纳新材料股份有限公司 一种球形分子筛及其制备方法和应用

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EP0269966A1 (fr) * 1986-11-25 1988-06-08 Kao Corporation Composition granulaire et dentifrice contenant cette composition
JPH01299211A (ja) * 1988-05-25 1989-12-04 Kao Corp 歯磨剤
JPH03271215A (ja) * 1990-03-20 1991-12-03 Kao Corp 歯磨剤
US5206010A (en) * 1991-01-25 1993-04-27 Kao Corporation Composition for use in oral cavity
JPH092927A (ja) * 1995-06-22 1997-01-07 Kao Corp 歯磨剤
JPH10316547A (ja) * 1997-05-20 1998-12-02 Kao Corp 歯磨剤組成物
EP1123694A2 (fr) * 2000-02-10 2001-08-16 Clariant GmbH Produits de soins bucco-dentaires
JP2003128528A (ja) * 2001-10-24 2003-05-08 Lion Corp 口腔用組成物
JP2003335646A (ja) * 2002-05-20 2003-11-25 Lion Corp 歯磨組成物

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Publication number Priority date Publication date Assignee Title
JPS5524112A (en) * 1978-08-09 1980-02-21 Toyo Soda Mfg Co Ltd Dentifrice zeolite
EP0269966A1 (fr) * 1986-11-25 1988-06-08 Kao Corporation Composition granulaire et dentifrice contenant cette composition
JPH01299211A (ja) * 1988-05-25 1989-12-04 Kao Corp 歯磨剤
JPH03271215A (ja) * 1990-03-20 1991-12-03 Kao Corp 歯磨剤
US5206010A (en) * 1991-01-25 1993-04-27 Kao Corporation Composition for use in oral cavity
JPH092927A (ja) * 1995-06-22 1997-01-07 Kao Corp 歯磨剤
JPH10316547A (ja) * 1997-05-20 1998-12-02 Kao Corp 歯磨剤組成物
EP1123694A2 (fr) * 2000-02-10 2001-08-16 Clariant GmbH Produits de soins bucco-dentaires
JP2003128528A (ja) * 2001-10-24 2003-05-08 Lion Corp 口腔用組成物
JP2003335646A (ja) * 2002-05-20 2003-11-25 Lion Corp 歯磨組成物

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007099701A (ja) * 2005-10-05 2007-04-19 Kao Corp 口腔用組成物
JP2013147431A (ja) * 2010-12-21 2013-08-01 Kao Corp 歯磨剤用顆粒
WO2013080762A1 (fr) * 2011-11-30 2013-06-06 ライオン株式会社 Composition de dentifrice
JP2013112654A (ja) * 2011-11-30 2013-06-10 Lion Corp 歯磨剤組成物
JP2013155160A (ja) * 2012-01-31 2013-08-15 Kao Corp 歯磨剤
JP2013155165A (ja) * 2012-01-31 2013-08-15 Kao Corp 歯磨剤
JP2013181012A (ja) * 2012-03-02 2013-09-12 Kao Corp 歯磨剤

Also Published As

Publication number Publication date
JP4482767B2 (ja) 2010-06-16
JPWO2005000260A1 (ja) 2006-08-03
KR20060023547A (ko) 2006-03-14
KR101181379B1 (ko) 2012-09-19
CN1812760A (zh) 2006-08-02
CN100393297C (zh) 2008-06-11

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