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WO2005098030A3 - Method for the identification of fungicidally-effective compounds based on thioredoxin reductases - Google Patents

Method for the identification of fungicidally-effective compounds based on thioredoxin reductases Download PDF

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Publication number
WO2005098030A3
WO2005098030A3 PCT/EP2005/002951 EP2005002951W WO2005098030A3 WO 2005098030 A3 WO2005098030 A3 WO 2005098030A3 EP 2005002951 W EP2005002951 W EP 2005002951W WO 2005098030 A3 WO2005098030 A3 WO 2005098030A3
Authority
WO
WIPO (PCT)
Prior art keywords
identification
fungicidally
compounds based
effective compounds
thioredoxin reductases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/002951
Other languages
German (de)
French (fr)
Other versions
WO2005098030A2 (en
Inventor
Edda Koopmann
Ruediger Suelmann
Peter Schreier
Birgitta Leuthner
Thorsten Leicher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer CropScience AG
Original Assignee
Bayer CropScience AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer CropScience AG filed Critical Bayer CropScience AG
Publication of WO2005098030A2 publication Critical patent/WO2005098030A2/en
Publication of WO2005098030A3 publication Critical patent/WO2005098030A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a method for the identification of fungicides, the use of fungal thioredoxin reductases for the identification of fungicides and the use of thioredoxin reductase inhibitors as fungicides.
PCT/EP2005/002951 2004-04-02 2005-03-19 Method for the identification of fungicidally-effective compounds based on thioredoxin reductases Ceased WO2005098030A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004016252.2 2004-04-02
DE200410016252 DE102004016252A1 (en) 2004-04-02 2004-04-02 Method for identifying fungicidally active compounds based on thioredoxin reductases

Publications (2)

Publication Number Publication Date
WO2005098030A2 WO2005098030A2 (en) 2005-10-20
WO2005098030A3 true WO2005098030A3 (en) 2006-04-20

Family

ID=34961813

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/002951 Ceased WO2005098030A2 (en) 2004-04-02 2005-03-19 Method for the identification of fungicidally-effective compounds based on thioredoxin reductases

Country Status (2)

Country Link
DE (1) DE102004016252A1 (en)
WO (1) WO2005098030A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004479A1 (en) * 2001-07-06 2003-01-16 Cancer Research Technology Limited 4-aryl quinols and analogs thereof as therapeutic agents
WO2004006866A2 (en) * 2002-07-12 2004-01-22 K.K. Gni Antifungal therapeutic targets

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004479A1 (en) * 2001-07-06 2003-01-16 Cancer Research Technology Limited 4-aryl quinols and analogs thereof as therapeutic agents
WO2004006866A2 (en) * 2002-07-12 2004-01-22 K.K. Gni Antifungal therapeutic targets

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANKRI SERGE ET AL: "Antimicrobial properties of allicin from garlic", MICROBES AND INFECTION, ELSEVIER, PARIS, FR, vol. 1, no. 2, February 1999 (1999-02-01), pages 125 - 129, XP002289130, ISSN: 1286-4579 *
KUTTY G ET AL: "Characterization of thioredoxin reductase genes (trr1) from Pneumocystis carinii and Pneumocystis jiroveci", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES, ELSEVIER SCIENCE PUBLISHERS, BARKING, GB, vol. 310, 22 May 2003 (2003-05-22), pages 175 - 183, XP004430579, ISSN: 0378-1119 *
MISSALL TRICIA A ET AL: "Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans", EUKARYOTIC CELL, vol. 4, no. 2, February 2005 (2005-02-01), pages 487 - 489, XP002340315, ISSN: 1535-9778 *
PEDRAJAS JOSE R ET AL: "Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 10, 5 March 1999 (1999-03-05), pages 6366 - 6373, XP002340316, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
DE102004016252A1 (en) 2005-10-13
WO2005098030A2 (en) 2005-10-20

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