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WO2005097672A3 - Procede de production de nanotubes en carbone remplis en partie par voie ferromagnetique, qui portent des biomolecules, et leur utilisation en matiere de diagnostic et de therapie - Google Patents

Procede de production de nanotubes en carbone remplis en partie par voie ferromagnetique, qui portent des biomolecules, et leur utilisation en matiere de diagnostic et de therapie Download PDF

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Publication number
WO2005097672A3
WO2005097672A3 PCT/EP2005/003790 EP2005003790W WO2005097672A3 WO 2005097672 A3 WO2005097672 A3 WO 2005097672A3 EP 2005003790 W EP2005003790 W EP 2005003790W WO 2005097672 A3 WO2005097672 A3 WO 2005097672A3
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WIPO (PCT)
Prior art keywords
carbon nanotubes
diagnosis
therapy
production
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/003790
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German (de)
English (en)
Other versions
WO2005097672A2 (fr
Inventor
Jens Ingolf Moench
Axel Meye
Albrecht Leonhardt
Gerd Hammermann
Manfred P Wirth
Bernd Buechner
Kai Kraemer
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Technische Universitaet Dresden
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Technische Universitaet Dresden
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Application filed by Technische Universitaet Dresden filed Critical Technische Universitaet Dresden
Priority to EP05731324A priority Critical patent/EP1747018A2/fr
Publication of WO2005097672A2 publication Critical patent/WO2005097672A2/fr
Publication of WO2005097672A3 publication Critical patent/WO2005097672A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1268—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules host-guest, closed hollow molecules, inclusion complexes, e.g. with cyclodextrins, clathrates, cavitates, fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé permettant de produire des nanotubes en matière plastique à une ou à plusieurs parois, remplis en partie par voie ferromagnétique (nanotubes en carbone (CNT)), qui sont remplis de fer, de cobalt, de nickel ou d'un alliage desdits éléments ou d'un alliage de ces éléments avec du platine et portent des biomolécules. Les biomolécules sont enfermées dans les tubes et/ou sont associées à la surface extérieure desdits tubes. Dans un mode de réalisation préféré, les nanotubes selon l'invention peuvent contenir deux principes actifs ou davantage dans les tubes, lesdits principes actifs étant libérés successivement lorsqu'ils sont utilisés dans le corps. L'invention concerne également l'utilisation des nanotubes en carbone selon l'invention, remplis en partie par voie ferromagnétique, dans le cadre de diagnostics et de thérapies, en particulier pour diagnostiquer et traiter des tumeurs.
PCT/EP2005/003790 2004-04-07 2005-04-07 Procede de production de nanotubes en carbone remplis en partie par voie ferromagnetique, qui portent des biomolecules, et leur utilisation en matiere de diagnostic et de therapie Ceased WO2005097672A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05731324A EP1747018A2 (fr) 2004-04-07 2005-04-07 Procede de production de nanotubes en carbone remplis en partie par voie ferromagnetique, qui portent des biomolecules, et leur utilisation en matiere de diagnostic et de therapie

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004017705A DE102004017705A1 (de) 2004-04-07 2004-04-07 Ferromagnetische Kohlenstoff-Nanoröhren, die Biomoleküle tragen, Verfahren zu deren Herstellung und deren Verwendung in Diagnose und Therapie
DE102004017705.8 2004-04-07

Publications (2)

Publication Number Publication Date
WO2005097672A2 WO2005097672A2 (fr) 2005-10-20
WO2005097672A3 true WO2005097672A3 (fr) 2006-05-18

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PCT/EP2005/003790 Ceased WO2005097672A2 (fr) 2004-04-07 2005-04-07 Procede de production de nanotubes en carbone remplis en partie par voie ferromagnetique, qui portent des biomolecules, et leur utilisation en matiere de diagnostic et de therapie

Country Status (3)

Country Link
EP (1) EP1747018A2 (fr)
DE (1) DE102004017705A1 (fr)
WO (1) WO2005097672A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection
US9103775B2 (en) 2002-01-16 2015-08-11 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US9291613B2 (en) 2002-06-21 2016-03-22 Nanomix, Inc. Sensor having a thin-film inhibition layer

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005005704B4 (de) * 2005-02-03 2010-08-12 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Verwendung von Partikeln für die Ermittlung der lokalen Temperatur in organischen und nichtorganischen Körpern
EP2394639B1 (fr) * 2006-05-25 2014-07-30 Wake Forest University Health Sciences Technologies hyperthermiques et leurs utilisations thérapeutiques
US8501233B2 (en) 2007-03-13 2013-08-06 Wake Forest University Compositions and methods for treating cancer
US20100197783A1 (en) * 2007-03-26 2010-08-05 Tour James M Radiation Protection Using Single Wall Carbon Nanotube Derivatives
US8784866B2 (en) 2007-03-26 2014-07-22 William Marsh Rice University Water-soluble carbon nanotube compositions for drug delivery and medicinal applications
WO2009070380A2 (fr) * 2007-10-03 2009-06-04 William Marsh Rice University Compositions de nanotubes de carbone solubles dans l'eau pour l'administration d'un médicament et applications médicales
CN102000349B (zh) * 2010-10-27 2013-11-27 上海师范大学 一种碳纳米管/聚合物/磁性铁酸盐纳米复合材料及其制备方法
CN102134732B (zh) * 2010-12-21 2013-03-06 北京化工大学 一种析氢模板法制备镍及镍基合金一维超结构纳米功能材料的方法
CN114522242B (zh) * 2022-02-28 2023-02-03 深圳大学 磁驱螺旋微纳米马达及其制备方法和应用
CN116196416A (zh) * 2023-03-03 2023-06-02 罗馨 一种基于一维磁性纳米材料的肿瘤治疗系统

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9103775B2 (en) 2002-01-16 2015-08-11 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US9291613B2 (en) 2002-06-21 2016-03-22 Nanomix, Inc. Sensor having a thin-film inhibition layer
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection

Also Published As

Publication number Publication date
EP1747018A2 (fr) 2007-01-31
DE102004017705A1 (de) 2005-11-03
WO2005097672A2 (fr) 2005-10-20

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