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WO2005090608A3 - Sondes haute affinite pour analyse de l'expression du papillomavirus humain - Google Patents

Sondes haute affinite pour analyse de l'expression du papillomavirus humain Download PDF

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Publication number
WO2005090608A3
WO2005090608A3 PCT/US2005/006999 US2005006999W WO2005090608A3 WO 2005090608 A3 WO2005090608 A3 WO 2005090608A3 US 2005006999 W US2005006999 W US 2005006999W WO 2005090608 A3 WO2005090608 A3 WO 2005090608A3
Authority
WO
WIPO (PCT)
Prior art keywords
affinity probes
high affinity
human papillomavirus
hpv
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/006999
Other languages
English (en)
Other versions
WO2005090608A2 (fr
Inventor
Henrik Stender
Mark Fiandaca
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AdvanDx Inc
Original Assignee
AdvanDx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AdvanDx Inc filed Critical AdvanDx Inc
Publication of WO2005090608A2 publication Critical patent/WO2005090608A2/fr
Priority to US11/516,409 priority Critical patent/US20070111960A1/en
Anticipated expiration legal-status Critical
Publication of WO2005090608A3 publication Critical patent/WO2005090608A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/708—Specific hybridization probes for papilloma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention concerne des méthodes, des trousses et des compositions se rapportant à l'utilisation de sondes haute affinité pour applications diagnostiques. Cette invention concerne également l'utilisation des sondes haute affinité pour détecter des souches du papillomavirus humain (PVH) importantes d'un point de vue clinique. Les sondes haute affinité permettent de mettre en oeuvre des méthodes diagnostiques rapides et d'obtenir une spécificité d'hybridation suffisante pour distinguer les souches de PVH étroitement associées. Cette invention donne des exemples de sondes haute affinité qui sont spécifiquement destinées à la détection des zones E6 et E7 et de variants d'épissage de l'ARNm du PVH.
PCT/US2005/006999 2004-03-05 2005-03-04 Sondes haute affinite pour analyse de l'expression du papillomavirus humain Ceased WO2005090608A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/516,409 US20070111960A1 (en) 2005-03-04 2006-09-05 High affinity probes for analysis of human papillomavirus expression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55069604P 2004-03-05 2004-03-05
US60/550,696 2004-03-05

Publications (2)

Publication Number Publication Date
WO2005090608A2 WO2005090608A2 (fr) 2005-09-29
WO2005090608A3 true WO2005090608A3 (fr) 2006-10-12

Family

ID=34963893

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/006999 Ceased WO2005090608A2 (fr) 2004-03-05 2005-03-04 Sondes haute affinite pour analyse de l'expression du papillomavirus humain

Country Status (1)

Country Link
WO (1) WO2005090608A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100285443A1 (en) * 2006-12-15 2010-11-11 Oncomethylome Sciences Sa Diagnostic Methods for Diseases Caused by a HPV Infection Comprising Determining the Methylation Status of the HPV Genome
GB201908481D0 (en) * 2019-06-13 2019-07-31 Kit Science & Service Ltd In-situ concatenation of oligo-nucleotide probes for target detection

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004748A1 (fr) * 1993-08-09 1995-02-16 Isis Pharmaceuticals, Inc. Oligomeres servant a moduler des processus viraux
US5580970A (en) * 1989-12-01 1996-12-03 Amoco Corporation Detection of HPV transcripts
US5888733A (en) * 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
WO2000034466A1 (fr) * 1998-12-07 2000-06-15 University College London Traitement du cancer du col de l'uterus
WO2001094632A2 (fr) * 2000-06-02 2001-12-13 Bayer Corporation Detection et localisation tres sensibles de gene, a l'aide d'une hybridation in situ d'adn ramifie
US20030108866A1 (en) * 2000-04-03 2003-06-12 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580970A (en) * 1989-12-01 1996-12-03 Amoco Corporation Detection of HPV transcripts
WO1995004748A1 (fr) * 1993-08-09 1995-02-16 Isis Pharmaceuticals, Inc. Oligomeres servant a moduler des processus viraux
US5888733A (en) * 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
WO2000034466A1 (fr) * 1998-12-07 2000-06-15 University College London Traitement du cancer du col de l'uterus
US20030108866A1 (en) * 2000-04-03 2003-06-12 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
WO2001094632A2 (fr) * 2000-06-02 2001-12-13 Bayer Corporation Detection et localisation tres sensibles de gene, a l'aide d'une hybridation in situ d'adn ramifie

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
GALLAZZI FABIO ET AL: "Synthesis of radiometal-labeled and fluorescent cell-permeating peptide-PNA conjugates for targeting the bcl-2 proto-oncogene.", BIOCONJUGATE CHEMISTRY, vol. 14, no. 6, November 2003 (2003-11-01), pages 1083 - 1095, XP002390585, ISSN: 1043-1802 *
KENNY DARYN ET AL: "Detection of viral infection and gene expression in clinical tissue specimens using branched DNA (bDNA) in situ hybridization.", THE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY : OFFICIAL JOURNAL OF THE HISTOCHEMISTRY SOCIETY. SEP 2002, vol. 50, no. 9, September 2002 (2002-09-01), pages 1219 - 1227, XP002390589, ISSN: 0022-1554 *
KO JESANG ET AL: "Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 22, no. 30, 24 July 2003 (2003-07-24), pages 4679 - 4689, XP002332525, ISSN: 0950-9232 *
KRINKA DAGNI ET AL: "In situ hybridisation of chick embryos with p53-specific probe and their immunostaining with anti-p53 antibodies", ANATOMY AND EMBRYOLOGY, vol. 204, no. 3, September 2001 (2001-09-01), pages 207 - 215, XP002390588, ISSN: 0340-2061 *
LIZARD GERARD ET AL: "In situ hybridization detection of single-copy human papillomavirus on isolated cells, using a catalyzed signal amplification system: GenPointTM", DIAGNOSTIC CYTOPATHOLOGY, vol. 24, no. 2, February 2001 (2001-02-01), pages 112 - 116, XP009053918, ISSN: 8755-1039 *
NABER S P ET AL: "STRATEGIES FOR THE ANALYSIS OF ONCOGENE OVEREXPRESSION STUDIES OF THE NEU ONCOGENE IN BREAST CARCINOMA", AMERICAN JOURNAL OF CLINICAL PATHOLOGY, vol. 94, no. 2, 1990, pages 125 - 136, XP009068915, ISSN: 0002-9173 *
NINKINA NATALIA N ET AL: "A novel Brn3-like POU transcription factor expressed in subsets of rat sensory and spinal cord neurons", NUCLEIC ACIDS RESEARCH, vol. 21, no. 14, 1993, pages 3175 - 3182, XP002376348, ISSN: 0305-1048 *
ROLAND ET AL: "The differential expression of the HER-2/neu oncogene among high-risk human papillomavirus-infected glandular lesions of the uterine cervix", AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY, MOSBY, ST LOUIS, MO, US, vol. 177, no. 1, July 1997 (1997-07-01), pages 133 - 137, XP005144669, ISSN: 0002-9378 *
SHIN DONG HOON ET AL: "Localization of bcl-2 mRNA in the rabbit central nervous system", NEUROSCIENCE LETTERS, vol. 278, no. 1-2, 7 January 2000 (2000-01-07), pages 73 - 76, XP002390586, ISSN: 0304-3940 *
STENDER HENRIK ET AL: "PNA for rapid microbiology", JOURNAL OF MICROBIOLOGICAL METHODS, vol. 48, no. 1, January 2002 (2002-01-01), pages 1 - 17, XP002390590, ISSN: 0167-7012 *
TUBBS R R ET AL: "Concomitant oncoprotein detection with fluorescence in situ hybridization (CODFISH): a fluorescence-based assay enabling simultaneous visualization of gene amplification and encoded protein expression.", THE JOURNAL OF MOLECULAR DIAGNOSTICS : JMD. MAY 2000, vol. 2, no. 2, May 2000 (2000-05-01), pages 78 - 83, XP002390587, ISSN: 1525-1578 *
WICKSTROM ERIC ET AL: "Receptor-specific targeting with complementary peptide nucleic acids conjugated to peptide analogs and radionuclides", LETTERS IN PEPTIDE SCIENCE, vol. 10, no. 3-4, 2003, pages 191 - 214, XP009068948, ISSN: 0929-5666 *
WU Q -J ET AL: "Detection of human papillomavirus-16 in ovarian malignancy.", BRITISH JOURNAL OF CANCER, vol. 89, no. 4, 18 August 2003 (2003-08-18), pages 672 - 675, XP002376347, ISSN: 0007-0920 *

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