[go: up one dir, main page]

WO2005087312A1 - Dispositif permettant une commande peristaltique - Google Patents

Dispositif permettant une commande peristaltique Download PDF

Info

Publication number
WO2005087312A1
WO2005087312A1 PCT/EP2005/051110 EP2005051110W WO2005087312A1 WO 2005087312 A1 WO2005087312 A1 WO 2005087312A1 EP 2005051110 W EP2005051110 W EP 2005051110W WO 2005087312 A1 WO2005087312 A1 WO 2005087312A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrode
stimulation
electrodes
gastrointestinal tract
control unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/051110
Other languages
English (en)
Inventor
Cristian Sevcencu
Nico J. M. Rijkhoff
Thomas Sinkjaer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aalborg Universitet AAU
Original Assignee
Aalborg Universitet AAU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aalborg Universitet AAU filed Critical Aalborg Universitet AAU
Publication of WO2005087312A1 publication Critical patent/WO2005087312A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode

Definitions

  • the present invention relates to electric stimulation of the gastrointestinal tract for artificially inducing peristaltic movement.
  • Colon peristalsis could be induced by electrical stimulation of parasympathetic nerves controlling colon motility.
  • the pelvic parasympathetic branches - which innervate part of the transverse, and the entire descending colon - are usually destroyed after a colostomy operation.
  • the alternative is to create artifi- cially induced peristalsis in the remaining part of the colon. Our experiments show this is doable by sequential stimulation of consecutive colon segments, using intramurally implanted electrodes.
  • the stimulation system and pattern used to activate consecutive colon segments is presented in the following.
  • All active electrodes were placed along the longitudinal axis of the colon, with the reference counterparts implanted parallel and diametrically opposite on the other side. The distance between 2 neighboring pairs was of 1.5 cm. Stimulation was performed sequentially, according to the following stimulation pattern: bipolar voltage trains of 10 ms, 50 Hz, 20 V rectangular pulses, 18 s stimulus duration, 9 s phase lag between the stimuli applied to successive electrode sets.
  • U. S. Patent No. 6,238,423 B1 describes an apparatus and method to supply electrical stimuli to the muscles associated with a target portion of the patient's gut, from the esophagus to the anus, through an electrical lead and several pairs of electrodes.
  • the stimuli may be provided sequentially, in a proximal to caudal direction, in order to initiate, enhance or artificially produce peristalsis.
  • the device comprises an array of electrode comprising electrode pairs, which consist of electrodes with non-variable polarity, each electrode having one contact.
  • the device described by Mintchev et al. in U. S. Patent No. 6,449,511 B1 also uses for stimulation electrode pairs with non-variable polarity.
  • current is flowing in a direction transverse to the longitudinal direc- tion of the gastrointestinal tract.
  • Fig 1 shows a schematic representation of the stimulation system coupled to an intestine portion.
  • Fig. 2 shows the configuration of an electrode positioned into the colon wall, relative to the longitudinal axis of the intestine.
  • Fig 3 shows a schematic representation of the timing of a stimulation sequence.
  • Fig 4 shows a schematic representation of a part of a stimulation session.
  • the present invention relates to a device for inducing serial contractions in a section of the gastrointestinal tract, said section of the gastrointestinal tract, defining a lumen and comprising a proximal end portion with a proximal opening, a distal end portion with a distal opening, and an intermediate portion extending between said proximal end portion and said distal end portion, said device comprising • a set of electrodes comprising a distal electrode adapted to be placed in said distal end portion, a proximal electrode adapted to be placed in said proximal end portion and at least one intermediate electrode adapted to be placed in said intermediate portion, each of said electrodes comprising at least one contact, • a contol unit for creating a potential difference between a contact of at least one first electrode, and a contact of at least one second electrode, said first electrode and said second electrode constituting an electrode pair for performing a stimulation session, wherein each intermediate electrode is comprised in two electrode pairs.
  • the section of the gastrointestinal tract may comprise a part of the esophagus, the stomach, the small bowel, the colon, the rectum and/or the anal sphincter.
  • the section of the gastrointestinal tract may also comprise a part made by surgery, such as a stoma, e.g. colostomy.
  • said section of the gastrointestinal tract comprises at least a part of the colon.
  • Said section of the gastrointestinal tract may also comprise at least a part of a colostomy.
  • the section of the gastrointestinal tract has a lumen encircled by a tube-like wall of the section of the gastrointestinal tract, said wall extending from a proximal end to a distal end of the section of the gastrointestinal tract.
  • the section of the gastrointestinal tract may be divided in a proximal end portion having a proximal opening and a distal end portion having a distal opening, said proximal opening and said distal opening connecting the lumen of said section of the gastrointestinal tract with lumens of adjacent parts of the gastrointestinal tract.
  • a center axis of the section of the gastrointestinal tract may be defined roughly by the direction of mass transport through the gastrointestinal tract. As the gastrointestinal tract comprises curved sections, the center axis may also have a curvature. For a roughly cylinder-shaped section of the gastrointestinal tract, such as a part of the colon, the center axis and the longitudinal direction of the gastrointestinal tract coincide.
  • the electrodes are adapted to be positioned serially, i.e. in a row in a longitudinal direction along the walls of the section of the gastrointestinal tract, the distal electrode being positioned in a distal end portion of said section of the gastrointestinal tract, the proximal electrode being positioned in a proximal end portion of said section of the gastrointestinal tract and the at least one intermedi- ate electrode being positioned in an intermediate portion of said section of the gastrointestinal tract, said intermediate portion extending between said distal end portion and said proximal end portion.
  • each intermediate electrode will have two neighbour electrodes, namely the two nearest electrodes being a distal neighbour electrode and a proximal neighbour electrode respectively.
  • the distal electrode has only one neighbour electrode, being a proximal neighbour electrode and similarly the proximal electrode has only one neighbour electrode, being a distal neighbour electrode.
  • An electrode pair may typically be constituted by one electrode and one of its neighbour electrodes.
  • each electrode pair is constituted by a first electrode and a second electrode, said second electrode being one of the neighbour electrodes of said first electrode.
  • the electrodes may be adapted to be implanted such that a pair of electrodes comprising a first electrode and a second electrode, defines a ring-shaped segment of the section of the gastrointestinal tract, said ring-shaped segment being bounded by a first cross section of the intestinal tract, said first cross section comprising the contacts of the first electrode, and a second cross section of the intestinal tract, said second cross section comprising the contacts of the second electrode.
  • the cross sections are not necessarily plane as the contacts need not define a plane.
  • One or both of the cross sections may be essentially perpendicu- lar to the longitudinal direction of gastrointestinal tract. However for some applications it is desirable that one or both cross sections are not perpendicular to the gastrointestinal tract, the segment thus having at least one oblique end portion.
  • one electrode comprises two or more contacts. Electrodes having two or more contacts distributed around a circumference of the section of the gastrointestinal tract are advantageous in order to induce contractions in all parts of a ring-shaped segment of said section of the gastrointestinal tract.
  • One electrode may e.g. comprise three contacts, or even more than three contacts, such as 5, 10, 20 or even more than 20 contacts. By using many contacts evenly distributed in said ring-shapecfsegment, a more uniform contraction may be obtained in said segment, which may lead to more efficient propulsion.
  • the electrodes could all have the same number of contacts. Alternatively the number of contacts could vary from one electrode to the other, e.g. in order to keep the distance between contacts roughly constant in spite of varying circumference of the gastrointestinal tract, or in order to stimulate some segment more than other segments. .
  • the contacts may be connected serially.
  • An electrode may e.g. be made from a lead, said lead being de-insulated at a number of locations, each de-insulated portion of the lead corresponding to a contact.
  • the electrode may be adapted to encircle the lumen of the section of the gastrointestinal tract, such that the elec- trade defines a loop around the said lumen.
  • the contacts are thus distributed around said lumen of said section of the gastrointestinal tract.
  • the contacts may be elongated, having an appreciable length compared to the dimensions of the section of the gastrointestinal tract, such as in the order of 0.5 or even 1 cm. Due to this, the electrode may be exposed to mechanical stress when the section of the gastrointestinal tract is contracting and expanding.
  • the contacts are elongated and the contacts are adapted to be implanted such that the direction of elongation is oblique relative to the longitudinal direction of the gastrointestinal tract at the implantation site.
  • the direction of elongation may e.g. form an angle of 20-70°, such as 30-60°, such as 40-50°, such as around 45°, with the longitudinal direction of the gastrointestinal tract at the implantation site.
  • the contacts of at least one electrode are serially connected, the electrode being capable of forming a loop encircling the section of the gastrointestinal tract in a loop.
  • the center axis defines an acute angle with the plane of said loop, such as an angle of 20-70°, such as 30-60°, such as 40-50°, such as an angle around 45°. This configuration is advantageous in order to obtain an oblique direction of the contacts relative to the longitudinal direction of the section of the gastrointestinal tract.
  • the loop may also be perpendicular to the longitudinal direction of the colon.
  • the control unit is adapted to activate the electrodes in order to perform at least one stimulation session.
  • the control unit may comprise a pulse generator, for generating a pulsed signal.
  • the pulse generator may comprise a current source.
  • the serial stimulation sequence comprises stimulating consecutive segments of the section of the gastrointestinal tract.
  • a device according to this embodiment of the invention may be operated to perform a serial stimulation sequence comprising the steps of: 1. providing a first electrode with a first polarity, said first electrode being the proximal electrode, 2. providing a second electrode with the opposite polarity, said second electrode being the distal neighbour of said first electrode, 3. performing a stimulation session activating the electrode pair comprising said first electrode and said second electrode, 4. inactivating the first electrode, 5. switching the polarity of the second electrode, said second electrode taking the place of the first electrode in the following stimulation session,
  • Steps 2-5 are repeated a number of times depending on the number of electrodes, such that in the last repetition, the second electrode of the electrode pair is the distal electrode. In the last repetition step 5 is replaced by a step in which the second electrode is inactivated.
  • This stimulation sequence may induce serial contractions propagating from the proximal end to a distal end of the gastrointestinal tract.
  • serial propulsive contractions may be induced, i.e. expulsion of a part of the content of the gastrointestinal tract may be obtained.
  • the device may thus be adapted to perform at least a first stimulation sequence for inducing propulsive contractions, for expulsion of a part of the content of the gastrointestinal tract.
  • a reversed stimulation sequence in order to avoid expulsion of the content of the gastrointestinal tract.
  • the device is capable of performing a second stimulation sequence for avoiding expulsion of the con- tent of the gastrointestinal tract.
  • the order of stimulation sessions may be reversed as compared to the first stimulation se- quence.
  • the device may e.g. be used to promote emptying of the colon as well as providing faecal continence between episodes of emptying.
  • a reversed serial stimulation sequence may be obtained by an operation of the device similar to the operation summarised in the above described procedure, replacing in step 1 the proximal electrode with the distal electrode, in step 2 the distal neighbour electrode with the proximal neighbour of the first electrode. Furthermore in the last repetition, the second electrode of the electrode pair should be the proximal electrode rather than the distal electrode.
  • the device is capable of switching the polarity of said intermediate electrodes. This is advantageous as contractions seems to propagate within a segment from one electrode to the other, the direction of propagation depending on the polarity of the electrodes. Thus the direction of propagation of contractions within one segment should preferably coincide with the direction corresponding to the consecutive order of stimulation sessions in a stimulation sequence.
  • control unit may comprise a switchboard for switching the polarity of the intermediate electrodes.
  • the stimulation session comprises a number of electric pulses and a number of pulse intervals between said electric pulses, the electrode receiving no appreciable signal from the control unit during the pulse intervals.
  • the electrodes are essentially inactive except for a passive discharge.
  • a difference in potential will build up in the tissue during a pulse.
  • the pulse intervals allow a passive discharge, whereby current may flow in a direction opposite to the direction of current flow during the pulse. In a few milliseconds this passive discharge result in a reduction or elimi- nation of said difference in potential within the tissue. Allowing the discharge by means of the pulse intervals has the advantage that the need for accurately bal- ancing the current e.g. by application of very uniform pulses of alternating polarity, is eliminated.
  • the stimulation session may comprise only one pulse. However the stimulation session typically comprises at least two pulses, e.g. a number of pulses in the range of 10-100.
  • the pulses may be rectangular. However other pulse shapes may also be used.
  • the pulses of a stimulation session may be of the same polarity.
  • the pulses of a stimulation session may further be of the same duration and/or the same amplitude and/or of the same pulse shape.
  • the pulses of a stimulation session are essentially identical.
  • the pulse intervals between pulses comprised in a stimulation session may also be of essentially the same duration.
  • the pulse duration may be 0.01 to 30 ms, such as 0.1 to 10 ms, such as 0.3 to 5 ms. In one embodiment of the invention the pulse duration is around 3 ms. A short pulse duration is desirable in order to avoid inducing irreversible changes in the tissue.
  • the duration of each pulse interval is at least 20 ms, such as at least 25 ms, such as at least 50 ms, such as between 25 and 500 ms, such as 50-200 ms, such as in the order of 100 ms. It is advantageous to provide a stimulation session in which the duration of the pulse interval is relatively long as this reduces the exposure of the tissue to charges and will allow the tissue to recover between the electric pulses, e.g. by restoring the original ion distribution.
  • the duration of each pulse interval is at least twice the duration of the previous pulse. It may be advantageous to provide a stimulation session in which the duration of each pulse interval is at least three times the duration of the previous pulse, such as at least five times, at least ten times or even at least thirty times the duration of the previous pulse.
  • the control unit may comprise a current source for delivering the current for the stimulation sessions.
  • the current amplitude of the pulse may be 2 to 50 mA, such as 5 to 30 mA, such as 10-20 mA, such as in the order of 15 mA. For some applications the current amplitude may be around 5 mA.
  • a device may be adapted to perform a stimulation sequence comprising at least two stimulation sessions, such as at least three stimulation sessions, or even at least five stimulation sessions.
  • each electrode pair perform one stimulation session in the stimulation sequence.
  • a serial stimulation sequence may be obtained by performing the stimulation sessions in consecutive order corresponding to the consecutive order of serially arranged electrode pairs. The stimulation sequence may be repeated a number of times in order to provide the desired result, e.g. faecal discharge.
  • the device is adapted to perform a stimulation sequence comprising at least two stimulation sessions, the timing of the stimulation sessions being such that within the stimulation sequence one stimulation session starts immediately after the termination of the previous stimu- lation session, only one session being performed at a time.
  • a second aspect of the invention relates to a device for inducing serial contractions in a section of the gastrointestinal tract, said section of the gastrointestinal tract, defining a lumen and comprising a proximal end portion with a proximal opening, a distal end portion with a distal opening, and an intermediate portion extending between said proximal end portion and said distal end portion, said device comprising • a set of electrodes, each electrode comprising at least one contact, • a contol unit for creating a potential difference between a contact of at least one first electrode, and a contact of at least one second electrode, said first electrode and said second electrode constituting an electrode pair for performing a stimulation session, said set of electrodes constituting at least three electrode pairs, said electrode pairs being adapted to be arranged serially in the longitudinal direction of the gastrointestinal tract, said device being capable of delivering a serial stimulation sequence comprising at least two stimulation sessions, each stimulation session involving one electrode pair, wherein a stimulation session comprises a number of electric pulses and a number
  • the electrode pairs may be adapted to be arranged serially along the gastrointestinal tract, a proximal pair being placed in the proximal end portion, a distal pair being placed in the distal end portion and at least one intermediate pair being placed in the intermediate portion of the section of the gastrointestinal tract.
  • the electrode pairs may be arranged so that current flow essentially in the longitudinal direction of the gastrointestinal tract. It may be advantageous to arrange the electrodes such that current flow in the longitudinal direction of the gastrointesti- nal tract as contractions induced in a stimulation session seems to propagate from one electrode to the other of the pair of electrodes performing a stimulation session, thus enhancing the propulsive movement.
  • the electrode pairs may alternatively be arranged so that current flow essentially transverse relative to the longitudinal direction of the gastrointestinal tract.
  • the serial stimulation sequence comprises stimulating consecutive segments of the section of the gastrointestinal tract.
  • a device according to the invention may be operated to perform a serial stimulation sequence comprising a number of stimulation sessions, each stimulation session involving one pair of electrodes, the order of stimulation sessions corresponding to the order of electrodes pairs.
  • any feature or parameter related to the stimulation session as previously described may also be a feature of a device according to the second aspect of the invention.
  • the timing of the stimulation sessions may be such that within the stimulation sequence one stimulation session starts immediately after the termination of the previous stimulation session, only one session being performed at a time.
  • the set of electrodes comprises a distal electrode, a proximal electrode and at least one intermediate electrode, each of said intermediate electrodes being comprised in two electrode pairs.
  • the device may further have any feature previously described for a device according to the first aspect of the invention.
  • At least a part of a device according to the first or the second aspect of the invention is implantable.
  • the implantable part of the device may at least comprise the electrodes.
  • the electrodes are preferably implanted in the serosa.
  • the control unit may be an external member. In this case, the electrode leads could be percutaneously brought outside the body and connected to the external control unit.
  • the implantable part of the device may also comprise at least a part of the control unit.
  • the control unit may be operated by an external control member, e.g. via an inductive link.
  • a third aspect of the invention relates to a method of inducing serial contractions in a section of the gastrointestinal tract, the method comprising applying at least one serial stimulation sequence to said section of the gastrointestinal tract, said stimulation sequence comprising at least one stimulation session, said stimulation session comprising a number of electric pulses and a number of pulse intervals between said electric pulses.
  • serial stimulation sequence and the stimulation session applied in a method according to the third aspect of the invention may have any features previously described in relation to the first and second aspect of the invention.
  • serial stimulation sequence may be produced by a device according to the first or second aspect of the invention.
  • a fourth aspect of the invention relates to a kit comprising - a set of electrodes capable of generating electric pulses when controlled by a control unit, and - instructions for using the electrodes in a method according to the third aspect of the invention.
  • the kit further comprises a package holding the set of electrodes and the instructions.
  • the electrodes may be disposable in the sense that they are used for one patient only, being implanted in said patient only one time.
  • a fifth aspect of the invention relates to a kit comprising - a control unit comprising a pulse generator operable for being connected to at least two electrodes for stimulation of intestinal smooth muscle, and - instructions for using the control unit in a method according to the third aspect of the invention.
  • the kit further comprises a package holding the control unit and the instructions.
  • the control unit may be disposable in the sense that is used for one patient only, being implanted in said patient only one time.
  • a sixth aspect of the invention relates to a kit comprising - a set of electrodes capable of generating electric pulses when controlled by a control unit, - a control unit comprising a pulse generator operable for being connected to at least two electrodes for stimulation of intestinal smooth muscle, - instructions for using the electrodes and/or the control unit in a method according to the third aspect of the invention.
  • the kit further comprises a package holding the set of electrodes, the control unit and the instructions.
  • the control unit and/or the set of electrodes may be disposable in the sense that is used for one patient only, being implanted in said patient only one time.
  • a seventh aspect of the invention relates to the use of at least two electrodes for the preparation of an implantable, disposable medical device for producing peristaltic movement of intestinal smooth muscle by a method according to the third aspect of the invention.
  • An eighth aspect of the invention relates to the use of a control unit comprising a pulse generator for the preparation of an implantable, disposable medical device for producing peristaltic movement of intestinal smooth muscle by a method a method according to the third aspect of the invention.
  • a ninth aspect of the invention relates to the use of at least two electrodes and a control unit comprising a pulse generator for the preparation of an implantable, disposable medical device for producing peristaltic movement of intestinal smooth muscle by a method according to the third aspect of the invention.
  • the stimulation system comprises a control unit 1 connected by the leads 41-4n to an array of electrodes 51-5n located serially along an intes- tine portion 7.
  • the leads 4 are flexible wires coated with biocompatible isolator, such as Teflon coated multistranded stainless steel wires, 0.3 mm in diameter (AS634 Cooner Wire Inc. Chatwoth, CA). Electrodes 51-5n may be formed by removing the insulation at the tip of the leads.
  • the tip of a wire 4 is deinsulated at 3 locations 611, 612, and 613. These locations represent the contacts of the electrode. Each contact has a length of 10 mm. Between the contacts, the Teflon insulation is preserved.
  • Each of the 2 insulated portions 621 and 622 has a length of 20 mm.
  • the electrodes are adapted to be placed intramurally, in oblique direction relative to the longitudinal axes of the intestine (the angle ⁇ is about 45°).
  • Fig. 2. b. shows an electrode attached to the colon wall.
  • the contacts of the elec- trade are located under the colon serosa 8, whereas the insulated portions remain outside the colon.
  • the insulated portions can be longer than 20 mm, and coil- shaped.
  • the knots 9 serve to secure the electrode to the colon serosa.
  • the electrode is semi- spirally placed around and in the intestine wall. The semi-spiral positioning of the electrode reduces the mechanical stress exerted on the wire during longitudinal and circular contractions. Thus, the risk of electrode breaking is minimized.
  • the solution was tested with good results in acute experiments on the descending colon of the pig. However, stimulation using electrodes placed perpendicular to the longitudinal axis of the colon (angle ⁇ in Fig. 2. c. has about 90°) is also possible, and was tested with similar good results in acute experiments on rats and P'gs-
  • a suitable distance d between 2 neighboring electrodes is of about 20 mm.
  • the first electrode 51 should be placed orally to the hepatic flexure and the last electrode 5 ⁇ in the proximity of the stoma.
  • the total number of the electrodes will depend on the distance d and on the length of the colon subjected to stimulation.
  • the control unit 1 comprises a current source 2 coupled to a switchboard 3.
  • the current source generates charge balanced rectangular pulses of controlled amplitude, duration and frequency.
  • the switchboard switches distribution of current pulses to consecutive electrode pairs in the array, simultaneously changing the polarity of the electrodes shared by consecutive electrode pairs.
  • Fig. 3 shows a stimulation sequence constituted by stimulation sessions S1-Sn sequentially applied to the colon segments s1-sn through consecutive electrode pairs consisting of the electrodes 51 -5n.
  • the first stimulation session uses electrodes 51 and 52, and induces contraction in the stimulated segment s1.
  • the electrode 51 is the cathode and the electrode 52 is the anode.
  • distribution of the current pulses is switched to the second pair consisting of electrodes 52 and 53, and stimulation session S2 starts.
  • the polarity of the electrode 52 is switched from positive (anode) to negative (cathode).
  • contraction in the stimulated segment s2 follows.
  • All of the stimulation sessions have the same duration.
  • the termination of one stimulation session coincides with the start of next stimulation session. Thus, no time delay between 2 consecutive stimulation sessions occurs.
  • the consecutive contractions of adjacent intestine segments result in a continuous contraction wave.
  • Fig 4 shows a part of a stimulation session comprising rectangular pulses of a pulse amplitude A, a pulse of pulse duration PD and a pulse interval of duration PI.
  • One pulse and one pulse interval constitute a pulse cycle of duration PC.

Landscapes

  • Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

La présente invention concerne un dispositif permettant de produire artificiellement un mouvement péristaltique par stimulation électrique du côlon. Plus particulièrement, cette invention concerne un dispositif dans lequel deux paires d'électrodes consécutives partagent une électrode intermédiaire.
PCT/EP2005/051110 2004-03-11 2005-03-11 Dispositif permettant une commande peristaltique Ceased WO2005087312A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200400398 2004-03-11
DKPA200400398 2004-03-11

Publications (1)

Publication Number Publication Date
WO2005087312A1 true WO2005087312A1 (fr) 2005-09-22

Family

ID=34961660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/051110 Ceased WO2005087312A1 (fr) 2004-03-11 2005-03-11 Dispositif permettant une commande peristaltique

Country Status (1)

Country Link
WO (1) WO2005087312A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009076019A1 (fr) * 2007-12-13 2009-06-18 Zassi Medical Evolutions, Inc. Appareil et procédé pour empêcher une stomie gastro-intestinale d'être incontinente
ES2547024R1 (es) * 2014-03-31 2015-11-02 Fundación Centro De Cirugía De Mínima Invasión Jesús Usón Dispositivo para la restauración de ondas peristálticas en pacientes con constipación crónica

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6238423B1 (en) * 1997-01-13 2001-05-29 Medtronic, Inc. Apparatus and method for treating chronic constipation
US20020055761A1 (en) * 1998-07-06 2002-05-09 Mann Carla M. Implantable stimulator systems and methods for treatment of incontinence and pain
US6453199B1 (en) * 1996-04-01 2002-09-17 Valery Ivanovich Kobozev Electrical gastro-intestinal tract stimulator
US20040039425A1 (en) * 2002-05-29 2004-02-26 Beverley Greenwood-Van Meerveld Spinal cord stimulation as treatment for functional bowel disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6453199B1 (en) * 1996-04-01 2002-09-17 Valery Ivanovich Kobozev Electrical gastro-intestinal tract stimulator
US6238423B1 (en) * 1997-01-13 2001-05-29 Medtronic, Inc. Apparatus and method for treating chronic constipation
US20020055761A1 (en) * 1998-07-06 2002-05-09 Mann Carla M. Implantable stimulator systems and methods for treatment of incontinence and pain
US20040039425A1 (en) * 2002-05-29 2004-02-26 Beverley Greenwood-Van Meerveld Spinal cord stimulation as treatment for functional bowel disorders

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009076019A1 (fr) * 2007-12-13 2009-06-18 Zassi Medical Evolutions, Inc. Appareil et procédé pour empêcher une stomie gastro-intestinale d'être incontinente
US7765007B2 (en) 2007-12-13 2010-07-27 Leto Medical, Llc Apparatus and method for providing continence to a gastrointestinal ostomy
US7765006B2 (en) 2007-12-13 2010-07-27 Leto Medical, Llc Method and apparatus for providing continence to a gastrointestinal ostomy
ES2547024R1 (es) * 2014-03-31 2015-11-02 Fundación Centro De Cirugía De Mínima Invasión Jesús Usón Dispositivo para la restauración de ondas peristálticas en pacientes con constipación crónica

Similar Documents

Publication Publication Date Title
US6615084B1 (en) Process for electrostimulation treatment of morbid obesity
Mintchev et al. Microprocessor-controlled movement of solid gastric content using sequential neural electrical stimulation
US6449511B1 (en) Gastrointestinal electrical stimulator having a variable electrical stimulus
US6895279B2 (en) Method and apparatus to treat disorders of gastrointestinal peristalsis
US6901295B2 (en) Method and apparatus for electrical stimulation of the lower esophageal sphincter
US7519433B2 (en) Gastrointestinal stimulation lead
US20040015201A1 (en) Process for electrostimulation treatment of obesity
CN1713933A (zh) 改进的电刺激治疗病态性肥胖症的方法
US6238423B1 (en) Apparatus and method for treating chronic constipation
US8744584B2 (en) Electrical stimulation of the colon to treat chronic constipation
US20040093039A1 (en) Gastrointestinal pacemaker
US20060206160A1 (en) Process and electrostimulation device for treating obesity and/or gastroesophageal reflux disease
AU2002241715A1 (en) Improved process for electrostimulation treatment of morbid obesity
US20070288077A1 (en) Self-anchoring electrical lead with multiple electrodes
US20120053653A1 (en) Gastrointestinal device
WO2009017647A1 (fr) Dispositif non chirurgical et procédés pour une stimulation trans-oesophagienne du nerf vague
US20090259093A1 (en) Artificial sphincter with piezoelectric actuator
WO2003099375A2 (fr) Butee d'ancrage reglable et implantable pour fixation par saisie
CZ292197A3 (cs) Elektrický stimulační prostředek pro zažívací trakt
US7930033B2 (en) Appendicular and rectal stimulator device for digestive and eating disorders
US20100305655A1 (en) Methods and apparatus for treating gastrointestinal disorders using electrical signals
WO2007146060A2 (fr) Fil électrique auto-accrocheur à électrodes multiples
WO2005087312A1 (fr) Dispositif permettant une commande peristaltique
Sevcencu A review of electrical stimulation to treat motility dysfunctions in the digestive tract: effects and stimulation patterns
Konsten et al. Feasibility of stoma continence, using electrically stimulated rectus abdominis muscle in pigs

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase