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WO2005081997A3 - Isothiazole based protein kinase inhibitors - Google Patents

Isothiazole based protein kinase inhibitors Download PDF

Info

Publication number
WO2005081997A3
WO2005081997A3 PCT/US2005/005859 US2005005859W WO2005081997A3 WO 2005081997 A3 WO2005081997 A3 WO 2005081997A3 US 2005005859 W US2005005859 W US 2005005859W WO 2005081997 A3 WO2005081997 A3 WO 2005081997A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
kinase inhibitors
based protein
isothiazole
isothiazole based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/005859
Other languages
French (fr)
Other versions
WO2005081997A2 (en
Inventor
Congxin Liang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of WO2005081997A2 publication Critical patent/WO2005081997A2/en
Publication of WO2005081997A3 publication Critical patent/WO2005081997A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Hydroxy containing isothiazole base derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
PCT/US2005/005859 2004-02-20 2005-02-22 Isothiazole based protein kinase inhibitors Ceased WO2005081997A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54653804P 2004-02-20 2004-02-20
US60/546,538 2004-02-20

Publications (2)

Publication Number Publication Date
WO2005081997A2 WO2005081997A2 (en) 2005-09-09
WO2005081997A3 true WO2005081997A3 (en) 2006-05-11

Family

ID=34910785

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/005859 Ceased WO2005081997A2 (en) 2004-02-20 2005-02-22 Isothiazole based protein kinase inhibitors
PCT/US2005/005875 Ceased WO2005082001A2 (en) 2004-02-20 2005-02-22 Advanced isothiazole based protein kinase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2005/005875 Ceased WO2005082001A2 (en) 2004-02-20 2005-02-22 Advanced isothiazole based protein kinase inhibitors

Country Status (1)

Country Link
WO (2) WO2005081997A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3184525B1 (en) * 2011-12-28 2020-10-28 Allergan, Inc. 3-phenyl-5-ureidoisothiazole-4-carboxamide derivatives as kinase inhibitors
US9353093B2 (en) 2014-10-07 2016-05-31 Allergan, Inc. Indole-1-carboxamides as kinase inhibitors
US9403803B2 (en) 2014-10-08 2016-08-02 Allergan, Inc. Indole-3-carboxamides as kinase inhibitors
US9371314B2 (en) 2014-10-09 2016-06-21 Allergan, Inc. Pyridyl benzothiophenes as kinase inhibitors
US9359336B2 (en) 2014-10-09 2016-06-07 Allergan, Inc. Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
JP7212781B2 (en) 2018-12-19 2023-01-25 ディスアーム セラピューティクス， インコーポレイテッド Inhibitors of SARM1 in combination with neuroprotective agents
TWI894754B (en) * 2022-12-28 2025-08-21 大陸商蘇州必揚醫藥科技有限公司 A protein tyrosine kinase inhibitor and its medical use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057416A (en) * 1976-06-18 1977-11-08 Fmc Corporation 3-Alkylthio-, 3-alkylsulfinyl-, and 3-alkylsulfonylisothiazole derivatives as herbicides
US6548526B2 (en) * 1998-06-04 2003-04-15 Pfizer Inc Isothiazole derivatives useful as anticancer agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057416A (en) * 1976-06-18 1977-11-08 Fmc Corporation 3-Alkylthio-, 3-alkylsulfinyl-, and 3-alkylsulfonylisothiazole derivatives as herbicides
US6548526B2 (en) * 1998-06-04 2003-04-15 Pfizer Inc Isothiazole derivatives useful as anticancer agents

Also Published As

Publication number Publication date
WO2005081997A2 (en) 2005-09-09
WO2005082001A3 (en) 2006-03-02
WO2005082001A2 (en) 2005-09-09

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