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WO2005076005A3 - A method for classifying a tumor cell sample based upon differential expression of at least two genes - Google Patents

A method for classifying a tumor cell sample based upon differential expression of at least two genes Download PDF

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Publication number
WO2005076005A3
WO2005076005A3 PCT/EP2005/000858 EP2005000858W WO2005076005A3 WO 2005076005 A3 WO2005076005 A3 WO 2005076005A3 EP 2005000858 W EP2005000858 W EP 2005000858W WO 2005076005 A3 WO2005076005 A3 WO 2005076005A3
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WO
WIPO (PCT)
Prior art keywords
classifying
cell sample
tumor cell
genes
differential expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/000858
Other languages
French (fr)
Other versions
WO2005076005A2 (en
Inventor
Christian Stratowa
Ulrich Koenig
Peter Steinlein
Stefan Amatschek
Herbert Auer
Wolfgang Sommergruber
Martin Schreiber
Agnes Gruenfelder
Margit Pacher-Zavisin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medizinische Universitaet Wien
Original Assignee
Medizinische Universitaet Wien
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medizinische Universitaet Wien filed Critical Medizinische Universitaet Wien
Publication of WO2005076005A2 publication Critical patent/WO2005076005A2/en
Anticipated expiration legal-status Critical
Publication of WO2005076005A3 publication Critical patent/WO2005076005A3/en
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Described is a method for classifying a cell sample as being a tumor cell comprising detecting a difference in the expression by said cell sample of at least one gene of Table 4 relative to at least one control cell and classifying the cell sample as a tumor cell, if the at least one gene of Table 4 shows at least 1,5-fold higher expression than the control cell.
PCT/EP2005/000858 2004-01-30 2005-01-28 A method for classifying a tumor cell sample based upon differential expression of at least two genes Ceased WO2005076005A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04450020 2004-01-30
EP04450020.5 2004-01-30

Publications (2)

Publication Number Publication Date
WO2005076005A2 WO2005076005A2 (en) 2005-08-18
WO2005076005A3 true WO2005076005A3 (en) 2009-02-05

Family

ID=34833853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/000858 Ceased WO2005076005A2 (en) 2004-01-30 2005-01-28 A method for classifying a tumor cell sample based upon differential expression of at least two genes

Country Status (1)

Country Link
WO (1) WO2005076005A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107312854A (en) * 2017-07-20 2017-11-03 北京泱深生物信息技术有限公司 A kind of diagnosis marker and its therapeutic targets of larynx squamous carcinoma

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1570080A4 (en) 2002-11-15 2006-03-01 Genomic Health Inc Gene expression profiling of egfr positive cancer
NZ593224A (en) 2006-01-11 2012-10-26 Genomic Health Inc Gene expression markers (fap) for colorectal cancer prognosis
WO2007123772A2 (en) 2006-03-31 2007-11-01 Genomic Health, Inc. Genes involved in estrogen metabolism
US8765383B2 (en) 2009-04-07 2014-07-01 Genomic Health, Inc. Methods of predicting cancer risk using gene expression in premalignant tissue
SG175832A1 (en) 2009-05-01 2011-12-29 Genomic Health Inc Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer and response to chemotherapy
CA3081061C (en) 2010-07-27 2023-01-03 Genomic Health, Inc. Method for using expression of klk2 to determine prognosis of prostate cancer
WO2012154983A2 (en) 2011-05-10 2012-11-15 Biocare Medical, Llc Systems and methods for anti-pax8 antibodies
CA2863040C (en) 2012-01-31 2022-04-19 Genomic Health, Inc. Gene expression profile algorithm and test for determining prognosis of prostate cancer
DK2900265T3 (en) 2012-09-27 2018-08-20 Biocare Medical Llc Anti-Uroplakin II Antibodies, Systems and Methods
US10429390B2 (en) 2012-12-18 2019-10-01 Biocare Medical, Llc Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer
WO2014134587A1 (en) 2013-02-28 2014-09-04 Biocare Medical, Llc Anti-p40 antibodies systems and methods
US9816997B2 (en) 2013-10-03 2017-11-14 Biocare Medical, Llc Anti-SOX10 antibody systems and methods
IT201700109459A1 (en) * 2017-09-29 2019-03-29 Univ Degli Studi Di Perugia METHOD TO PERFORM PROGNOSIS OF BREAST CANCER, KITS AND THE USE OF THESE
CN111159409B (en) * 2019-12-31 2023-06-02 腾讯科技（深圳）有限公司 Text classification method, device, equipment and medium based on artificial intelligence
CN112816431A (en) * 2020-09-22 2021-05-18 西华师范大学 Dual-wavelength capillary electrophoresis detection system for detecting tumor marker
CN120366453A (en) * 2020-12-22 2025-07-25 复旦大学附属华山医院 Gene set for prognosis evaluation of adrenocortical carcinoma
CN117594133A (en) * 2024-01-19 2024-02-23 普瑞基准科技（北京）有限公司 Screening method of biomarker for distinguishing uterine lesion type and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074405A1 (en) * 2000-03-31 2001-10-11 Gene Logic, Inc. Gene expression profiles in esophageal tissue
WO2001094629A2 (en) * 2000-06-05 2001-12-13 Avalon Pharmaceuticals Cancer gene determination and therapeutic screening using signature gene sets

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074405A1 (en) * 2000-03-31 2001-10-11 Gene Logic, Inc. Gene expression profiles in esophageal tissue
WO2001094629A2 (en) * 2000-06-05 2001-12-13 Avalon Pharmaceuticals Cancer gene determination and therapeutic screening using signature gene sets

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AMATSCHEK STEFAN ET AL: "Tissue-wide expression profiling using cDNA subtraction and microarrays to identify tumor-specific gene.", CANCER RESEARCH, vol. 64, no. 3, 1 February 2004 (2004-02-01), pages 844 - 856, XP001206325, ISSN: 0008-5472 *
CHANG K ET AL: "FREQUENT EXPRESSION OF THE TUMOR ANTIGEN CAK1 IN SQUAMOUS-CELL CARCINOMAS", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 51, no. 4, 19 June 1992 (1992-06-19), pages 548 - 554, XP002038952, ISSN: 0020-7136 *
HUDELIST GERNOT ET AL: "Use of high-throughput protein array for profiling of differentially expressed proteins in normal and malignant breast tissue.", BREAST CANCER RESEARCH AND TREATMENT. AUG 2004, vol. 86, no. 3, August 2004 (2004-08-01), pages 281 - 291, XP001206326, ISSN: 0167-6806 *
NEMOTO TETSUO ET AL: "Overexpression of protein tyrosine kinases in human esophageal cancer", PATHOBIOLOGY, vol. 65, no. 4, July 1997 (1997-07-01), pages 195 - 203, XP009048170, ISSN: 1015-2008 *
SÁNCHEZ-CARBAYO MARTA: "Use of high-throughput DNA microarrays to identify biomarkers for bladder cancer.", CLINICAL CHEMISTRY. JAN 2003, vol. 49, no. 1, January 2003 (2003-01-01), pages 23 - 31, XP001206327, ISSN: 0009-9147 *
VAN HEEK N TJARDA ET AL: "Gene expression profiling identifies markers of ampullary adenocarcinoma.", CANCER BIOLOGY & THERAPY. JUL 2004, vol. 3, no. 7, July 2004 (2004-07-01), pages 651 - 656, XP009048026, ISSN: 1538-4047 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107312854A (en) * 2017-07-20 2017-11-03 北京泱深生物信息技术有限公司 A kind of diagnosis marker and its therapeutic targets of larynx squamous carcinoma

Also Published As

Publication number Publication date
WO2005076005A2 (en) 2005-08-18

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