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WO2005074797A1 - Bobine combinant des elements a resonance magnetique et optiques et permettant un diagnostic par imagerie du cancer de la prostate, du col de l'uterus et du rectum - Google Patents

Bobine combinant des elements a resonance magnetique et optiques et permettant un diagnostic par imagerie du cancer de la prostate, du col de l'uterus et du rectum Download PDF

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Publication number
WO2005074797A1
WO2005074797A1 PCT/US2005/002864 US2005002864W WO2005074797A1 WO 2005074797 A1 WO2005074797 A1 WO 2005074797A1 US 2005002864 W US2005002864 W US 2005002864W WO 2005074797 A1 WO2005074797 A1 WO 2005074797A1
Authority
WO
WIPO (PCT)
Prior art keywords
optical
anatomical
imaging unit
combined
magnetic resonance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/002864
Other languages
English (en)
Inventor
Wilhelm Durr
Ralph Gareus
Arne Hengerer
Ralph Weissleder
Bogdan Von Rueckmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens AG
Siemens Corp
Original Assignee
Siemens AG
Siemens Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/048,312 external-priority patent/US7894876B2/en
Application filed by Siemens AG, Siemens Corp filed Critical Siemens AG
Priority to JP2006551520A priority Critical patent/JP2007519493A/ja
Publication of WO2005074797A1 publication Critical patent/WO2005074797A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00174—Optical arrangements characterised by the viewing angles
    • A61B1/00183—Optical arrangements characterised by the viewing angles for variable viewing angles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/285—Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/043—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances for fluorescence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission

Definitions

  • the present invention relates generally to the field of medical imaging, and, more particularly, to combined magnetic resonance-optical coil for prostate, cervix and rectum imaging.
  • MR magnetic resonance
  • CT computer tomography
  • US ultrasound
  • nuclear medicine e.g., Positron Emission Tomography
  • PET Positron Emission Tomography
  • SPECT Single Photon Emission Computed Tomography
  • a more accurate diagnosis can be provided by combining the different imaging techniques.
  • anatomical information e.g., bones and organs
  • optical information from an optical imaging technique.
  • the different imaging techniques are typically combined during postprocessing. Post-processing is generally time-consuming. Further, accurate combinations of anatomical and optical modalities are generally only possible with rigid structures, such as the brain. However, even the brain has minor movement, which can potentially render the combinations inaccurate.
  • an apparatus for providing anatomical and optical diagnostic imaging includes an anatomical imaging unit for inserting into a body cavity, wherein the anatomical imaging unit acquires anatomical images of the body cavity; and an optical imaging unit operatively connected to the anatomical imaging unit, wherein the optical imaging unit acquires optical information of the body cavity.
  • an apparatus for providing anatomical and optical diagnostic imaging is provided.
  • the apparatus includes a sheath encompassing a magnetic resonance coil. Optical compounds are integrated into the coil to facilitate the detection of fluorescence, preferably near infra red fluorescence.
  • a method is provided. The method includes inserting a combined anatomical-optical device into a body cavity; and receiving a combined image from the combined anatomical- optical device, wherein the combined image displays anatomical imaging- based information and optical imaging-based information
  • Figure 1 depicts a combined MR-Optical device, in accordance with one exemplary embodiment of the present invention.
  • DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS Illustrative embodiments of the invention are described below. In the interest of clarity, not all features of an actual implementation are described in this specification. It will of course be appreciated that in the development of any such actual embodiment, numerous implementation-specific decisions must be made to achieve the developers' specific goals, such as compliance with system-related and business-related constraints, which will vary from one implementation to another.
  • a system combining anatomical imaging technologies (e.g., MR) with optical imaging technologies.
  • the system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning.
  • Image guidance may include guiding a biopsy.
  • a prostatectomy potentially has severe side effects, such as impotence and incontinence.
  • a histologically-confirmed diagnosis such as one provided from a biopsy, may prevent unnecessary prostatectomy.
  • Image guidance may also include guiding minimal invasive therapy.
  • the present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.
  • MR-Optical combined magnetic resonance-optical
  • An optical probe is integrated into a magnetic resonance (“MR") coil for enriching magnetic resonance-based images with optical-based information.
  • the combined MR-Optical device may be inserted into a body cavity and a combined image displaying anatomical imaging-based information and optical imaging-based information is received.
  • the combined image may be used for any of a variety of practical applications, as contemplated by those skilled in the art, such as diagnostics (e.g., cancer diagnostics), application guiding and therapy planning.
  • the Optical-MR device 100 includes an optical probe 105, an MR coil 110, a sheath 115, and a handheld component 120.
  • the optical probe 105 may be a trans-rectal optical transducer.
  • the optical probe 105 may be pushed and/or pulled relative to the MR coil.
  • the optical probe 105 may also rotate independently of the MR coil 110.
  • the handheld component 120 allows a user to easily grip and handle the MR-Optical device 100.
  • Optical compounds could be integrated into the coil.
  • the optics facilitate the detection of fluorescence, preferably near infra red fluorescence.
  • the measured fluorescence could be due to auto-fluorescence or an applied fluorescence probe (contract agent), which could be specific for the cancer type under investigation.
  • the device could be used to detect activatable probes (smart probes).
  • the sheath 115 comprises a rigid housing, preferably transluminescent and filled with a coupling liquid (not shown).
  • the coupling liquid preferably has the same optical index as the surrounding material to prevent bending of illumination light beams (described in greater detail below).
  • the MR-Optical device 100 includes an optical wire 125 operatively connected to an optical device 130.
  • the MR-Optical device 100 further includes an MR wire 135 operatively connected to an amplifier 140.
  • the optical wire could be lead through the center of MR coil 110 to the terminal detector/illuminator lead (optical probe 105).
  • the optical wire 125 and the MR wire 135 may be parallel.
  • the optical wire connects the head with an external light source and detector 130.
  • the amplifier 140 may be a component of a magnetic resonance tomography ("MRT") unit, as known to those skilled in the art.
  • MRT magnetic resonance tomography
  • the Optical wire and the MR wire may include more than one wire, as contemplated by those skilled in the art.
  • the MR coil 110 is preferably constructed to be translucent (e.g., the spacing between the wires may be made out of a translucent plastic, the coil wires are constructed to be stable without a matrix support).
  • the sheath 115 may be replaced with a light transparent balloon (not shown).
  • the balloon may comprise a foldable investigation head with a liquid pump that fuels rotation.
  • the sheath 115 and the balloon encompass the assembly of MR coil 110.
  • the sheath 115 and the balloon may fix the MR- Optical device 100 to the body cavity.
  • the balloon may be inflated.
  • the balloon is preferably inflated with a coupling liquid, but, in an alternate embodiment, may be inflated with air.
  • the MR coil 110 may be a flexible coil, such as the MRInnervu ® commercially distributed by MEDRAD ® Incorporated.
  • the sheath 115 and the balloon may be any of a variety of shapes (e.g. toric) as contemplated by those skilled in the art.
  • the sheath 115 and the balloon are preferably shaped such that the MR-Optical device 110 can easily penetrate the particular body cavity being examined.
  • the optics can cover a 360 degree view or any limited angle.
  • the lead might be revolved from outside (independently of the the MR coil).
  • the optical lead can be push/pulled relatively to the MR coil.
  • the balloon may not cover the optical lead. Illumination and light detection is not restricted by the balloon or by the coil.
  • the balloon might be toric or two balloons might be used. Illumination and fluorescent light could be guided by two separate wires. Alternative modulation techniques could be used to distinguish between illumination and fluorescent light.
  • a particular design might operate in a CW (continues Wave) mode.
  • Other designs might apply TD (time domain) measurements, OCT (optical tomography) or 2-Photone measurements.
  • Tomographic methods might be applied to increase signal-to- noise or increase tissue penetration.
  • For the design of the optics three general embodiments of the optics are possible.
  • Light wire feeds a circular diffuser or discrete microscopic lenses assembled in a circle.
  • the optical head is moved along the MR axis to get a good coverage of the cavity.
  • There is a rotating mirror at the end of the light wire which projects the illumination light circularly on the cavity wall (e.g. rectum epithelia) and captures fluorescent light.
  • the mirror is connected to a cardan shaft and motor that is located outside of the magnetic field.
  • the optical head is moved along the MR axis to get a good coverage of the cavity.
  • DMA Digital Mirror Array
  • the following light sources are possible; broadband light source (e.e. xenonlamp or mercury lamp), LED or LED array, or a laser.
  • the detector could be a CCD camera or a CMOS. All materials for the optics are nonconductive. If this is not feasible, conductive material has to be as small and thin as possible to keep HP coupling minimal.
  • the intra-rectal measurements obtained from the MR-Optical device 100 are preferably combined with an external phased array coils (not shown) for increasing signal-to-noise and increasing the area of the body cavity being examined.
  • the external phased array coils are a typical component of a standard MRT unit. In one embodiment, the external phased array coils may be body arrays, providing ventral and dorsal receiver channels.
  • the body arrays expand the viewable area in the body cavity, which provides information of lymph nodes for, for example, staging.
  • the MR-Optical device 100 may also be combined with monocrystaline iron oxide nanoparticles ("MION"), which is an MR contrast agent.
  • MION monocrystaline iron oxide nanoparticles
  • the MION may be dually labeled with a fluorescence dye, which is an optical contrast agent.
  • the MR data set i.e., the image obtained from the MRT unit using the present invention

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Endocrinology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

La présente invention se rapporte, dans des modes de réalisation présentés en exemple, à un système combinant des techniques d'imagerie anatomique (par exemple, la résonance magnétique RM) à des techniques d'imagerie optique. Ce système peut être utilisé dans une variété d'applications, notamment, mais non exclusivement, pour (1) le diagnostic du cancer et la détermination du stade d'avancement d'un cancer; (2) un guidage imagé; et (3) la planification d'une radiothérapie. Le guidage imagé peut consister à guider une biopsie. Une prostatectomie peut, par exemple, présenter éventuellement des effets secondaires graves, du type impuissance et incontinence. Ainsi, un diagnostic confirmé par voie histologique, ainsi que cela est le cas à partir d'une biopsie, peut permettre d'empêcher une prostatectomie non nécessaire. Le guidage imagé peut également inclure un guidage d'une thérapie avec invasion minimale, du type ultrasons focalisés par curiethérapie. La présente invention peut être utilisée pour planifier une radiothérapie, par exemple, par détection du tissu sain permettant d'épargner à ce dernier l'exposition au rayonnement.
PCT/US2005/002864 2004-02-02 2005-02-02 Bobine combinant des elements a resonance magnetique et optiques et permettant un diagnostic par imagerie du cancer de la prostate, du col de l'uterus et du rectum Ceased WO2005074797A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006551520A JP2007519493A (ja) 2004-02-02 2005-02-02 前立腺がん、子宮頸がんおよび直腸がんイメージングのための磁気共鳴‐光学コンビネーション装置

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US54110204P 2004-02-02 2004-02-02
US60/541,102 2004-02-02
US11/048,312 US7894876B2 (en) 2004-02-02 2005-02-01 Combined MR-optical coil for prostate, cervix and rectum cancer imaging diagnostics
US11/048,312 2005-02-01

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WO2005074797A1 true WO2005074797A1 (fr) 2005-08-18

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007045988A1 (de) 2007-09-26 2008-10-23 Siemens Ag Spektroskopieeinheit zur Durchführung einer magnetresonanzgeführten Lichtspektroskopie im Innern eines Untersuchungsobjektes sowie System zur magnetresonanzgeführten Lichtspektroskopie
JP2010502332A (ja) * 2006-09-06 2010-01-28 ドイチェス クレブスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェンレヒツ 二重モダリティ撮像法
JP2010509976A (ja) * 2006-11-21 2010-04-02 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 解剖構造における組織のイメージングのためのシステム、方法、コンピュータ読取可能媒体及び使用
US10226232B2 (en) 2012-12-12 2019-03-12 Nucletron Operations B.V. Brachytherapy instrument, an imaging system and a method of image acquisition

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008062354A1 (fr) * 2006-11-21 2008-05-29 Koninklijke Philips Electronics N.V. Système, dispositif, procédé support lisible par ordinateur, utilisation pour l'imagerie in vivo de tissu dans une structure anatomique

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US5427103A (en) * 1992-06-29 1995-06-27 Olympus Optical Co., Ltd. MRI apparatus for receiving nuclear-magnetic resonance signals of a living body
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010502332A (ja) * 2006-09-06 2010-01-28 ドイチェス クレブスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェンレヒツ 二重モダリティ撮像法
JP2010509976A (ja) * 2006-11-21 2010-04-02 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 解剖構造における組織のイメージングのためのシステム、方法、コンピュータ読取可能媒体及び使用
DE102007045988A1 (de) 2007-09-26 2008-10-23 Siemens Ag Spektroskopieeinheit zur Durchführung einer magnetresonanzgeführten Lichtspektroskopie im Innern eines Untersuchungsobjektes sowie System zur magnetresonanzgeführten Lichtspektroskopie
US10226232B2 (en) 2012-12-12 2019-03-12 Nucletron Operations B.V. Brachytherapy instrument, an imaging system and a method of image acquisition

Also Published As

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