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WO2005072776A3 - Liposomal formulations of the antineoplastic agents - Google Patents

Liposomal formulations of the antineoplastic agents Download PDF

Info

Publication number
WO2005072776A3
WO2005072776A3 PCT/PL2005/000007 PL2005000007W WO2005072776A3 WO 2005072776 A3 WO2005072776 A3 WO 2005072776A3 PL 2005000007 W PL2005000007 W PL 2005000007W WO 2005072776 A3 WO2005072776 A3 WO 2005072776A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid components
antineoplastic agents
liposomal formulations
integer
bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/PL2005/000007
Other languages
French (fr)
Other versions
WO2005072776A2 (en
Inventor
Arkadiusz Kozubek
Grzegorz Grynkiewicz
Wieslaw Szelejewski
Piotr Slifirski
Jerzy Gubernator
Maria Stasiuk
Krzysztof Wisniewski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instytut Farmaceutiyczny
Original Assignee
Instytut Farmaceutiyczny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL364657A external-priority patent/PL197939B1/en
Priority claimed from PL368029A external-priority patent/PL197938B1/en
Application filed by Instytut Farmaceutiyczny filed Critical Instytut Farmaceutiyczny
Publication of WO2005072776A2 publication Critical patent/WO2005072776A2/en
Publication of WO2005072776A3 publication Critical patent/WO2005072776A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to the liposomal formulation of an antineoplastic agent encapsulated in the liposomal vesicles which are the composition of lipid components, wherein the ratio of a therapeutically active agent to the lipid components is between about 1:10 and about 1:30 (w/w). The composition of lipid components contains at least one phospholipid derivative and at least one alkylphenol derivative presented by a general formula (I) , wherein: n is an integer 1 - 17; m is an integer 0-15; X is -C=O, -0- or a bond; Y is a group of formula -NR2R3, a monosaccharide moiety or a bond; Z is H, -0-, -N-, -OR4, -NR4 or a monosaccharide moiety, R5 is H or COOH.
PCT/PL2005/000007 2004-01-30 2005-01-28 Liposomal formulations of the antineoplastic agents Ceased WO2005072776A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PL364657A PL197939B1 (en) 2004-01-30 2004-01-30 Anti-cancer liposome preparation, method for its manufacture and compound pharmaceutical containing such preparation
PLP-364657 2004-01-30
PL368029A PL197938B1 (en) 2004-05-17 2004-05-17 Liposome preparation of a substance counteracting cancer, method for its manufacture and pharmaceutical compound containing such preparation
PLP-368029 2004-05-17

Publications (2)

Publication Number Publication Date
WO2005072776A2 WO2005072776A2 (en) 2005-08-11
WO2005072776A3 true WO2005072776A3 (en) 2006-07-06

Family

ID=34829563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2005/000007 Ceased WO2005072776A2 (en) 2004-01-30 2005-01-28 Liposomal formulations of the antineoplastic agents

Country Status (1)

Country Link
WO (1) WO2005072776A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1987813A1 (en) * 2007-05-04 2008-11-05 Pharmatex Italia Srl Injectable pharmaceutical formulation of taxoids in stable liposomes
EP2945483A4 (en) * 2013-01-18 2016-11-30 Univ City New York Res Found METHOD FOR ENHANCING AMIDOHYDROLASE ACTIVITY OF FATTY ACID AMIDE HYDROLASE
CN104208024A (en) * 2013-06-04 2014-12-17 杜雨霏 Idarubicin liposome and preparation method thereof
PE20181445A1 (en) * 2016-01-07 2018-09-12 Univ Western Health Sciences FORMULATIONS FOR THE TREATMENT OF BLADDER CANCER

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006442A1 (en) * 1987-03-05 1988-09-07 The Liposome Company, Inc. High drug:lipid formulations of liposomal-antineoplastic agents
JPH06227966A (en) * 1993-01-29 1994-08-16 Advanced Sukin Res Kenkyusho:Kk Temperature-sensitive liposome pharmaceutical preparation
WO1999015153A1 (en) * 1997-09-23 1999-04-01 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
WO2002002078A2 (en) * 2000-06-30 2002-01-10 Inex Pharmaceuticals Corporation Improved liposomal camptothecins and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988006442A1 (en) * 1987-03-05 1988-09-07 The Liposome Company, Inc. High drug:lipid formulations of liposomal-antineoplastic agents
JPH06227966A (en) * 1993-01-29 1994-08-16 Advanced Sukin Res Kenkyusho:Kk Temperature-sensitive liposome pharmaceutical preparation
WO1999015153A1 (en) * 1997-09-23 1999-04-01 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
WO2002002078A2 (en) * 2000-06-30 2002-01-10 Inex Pharmaceuticals Corporation Improved liposomal camptothecins and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199437, Derwent World Patents Index; Class B05, AN 1994-299680, XP002374652 *

Also Published As

Publication number Publication date
WO2005072776A2 (en) 2005-08-11

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