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WO2005072641A1 - Fil dentaire a activite antimicrobienne - Google Patents

Fil dentaire a activite antimicrobienne Download PDF

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Publication number
WO2005072641A1
WO2005072641A1 PCT/KR2005/000311 KR2005000311W WO2005072641A1 WO 2005072641 A1 WO2005072641 A1 WO 2005072641A1 KR 2005000311 W KR2005000311 W KR 2005000311W WO 2005072641 A1 WO2005072641 A1 WO 2005072641A1
Authority
WO
WIPO (PCT)
Prior art keywords
dental floss
antimicrobial
xanthorrhizol
teeth
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2005/000311
Other languages
English (en)
Inventor
Jae-Kwan Hwang
Seung-Jin Kim
Sang-Nyun Kim
Hyung-Jin Kim
Jong-Il Kim
Sang-Jin Kang
Wan-Goo Cho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG H&H Co Ltd
Original Assignee
LG Household and Health Care Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LG Household and Health Care Ltd filed Critical LG Household and Health Care Ltd
Publication of WO2005072641A1 publication Critical patent/WO2005072641A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
    • B65H75/00—Storing webs, tapes, or filamentary material, e.g. on reels
    • B65H75/02—Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans, mandrels or chucks
    • B65H75/34—Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans, mandrels or chucks specially adapted or mounted for storing and repeatedly paying-out and re-storing lengths of material provided for particular purposes, e.g. anchored hoses, power cables
    • B65H75/38—Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans, mandrels or chucks specially adapted or mounted for storing and repeatedly paying-out and re-storing lengths of material provided for particular purposes, e.g. anchored hoses, power cables involving the use of a core or former internal to, and supporting, a stored package of material
    • B65H75/40—Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans, mandrels or chucks specially adapted or mounted for storing and repeatedly paying-out and re-storing lengths of material provided for particular purposes, e.g. anchored hoses, power cables involving the use of a core or former internal to, and supporting, a stored package of material mobile or transportable
    • B65H75/42—Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans, mandrels or chucks specially adapted or mounted for storing and repeatedly paying-out and re-storing lengths of material provided for particular purposes, e.g. anchored hoses, power cables involving the use of a core or former internal to, and supporting, a stored package of material mobile or transportable attached to, or forming part of, mobile tools, machines or vehicles
    • B65H75/425—Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans, mandrels or chucks specially adapted or mounted for storing and repeatedly paying-out and re-storing lengths of material provided for particular purposes, e.g. anchored hoses, power cables involving the use of a core or former internal to, and supporting, a stored package of material mobile or transportable attached to, or forming part of, mobile tools, machines or vehicles attached to, or forming part of a vehicle, e.g. truck, trailer, vessel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C15/00—Devices for cleaning between the teeth
    • A61C15/04—Dental floss; Floss holders
    • A61C15/041—Dental floss
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01M—CATCHING, TRAPPING OR SCARING OF ANIMALS; APPARATUS FOR THE DESTRUCTION OF NOXIOUS ANIMALS OR NOXIOUS PLANTS
    • A01M7/00—Special adaptations or arrangements of liquid-spraying apparatus for purposes covered by this subclass
    • A01M7/0082—Undercarriages, frames, mountings, couplings, tanks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
    • B65H75/00—Storing webs, tapes, or filamentary material, e.g. on reels
    • B65H75/02—Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans, mandrels or chucks
    • B65H75/34—Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans, mandrels or chucks specially adapted or mounted for storing and repeatedly paying-out and re-storing lengths of material provided for particular purposes, e.g. anchored hoses, power cables
    • B65H75/38—Cores, formers, supports, or holders for coiled, wound, or folded material, e.g. reels, spindles, bobbins, cop tubes, cans, mandrels or chucks specially adapted or mounted for storing and repeatedly paying-out and re-storing lengths of material provided for particular purposes, e.g. anchored hoses, power cables involving the use of a core or former internal to, and supporting, a stored package of material
    • B65H75/44—Constructional details
    • B65H75/4481—Arrangements or adaptations for driving the reel or the material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
    • B65H2403/00—Power transmission; Driving means
    • B65H2403/20—Belt drives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65H—HANDLING THIN OR FILAMENTARY MATERIAL, e.g. SHEETS, WEBS, CABLES
    • B65H2701/00—Handled material; Storage means
    • B65H2701/30—Handled filamentary material
    • B65H2701/33—Hollow or hose-like material

Definitions

  • the present invention relates to an antimicrobial dental floss for cleaning teeth
  • Human teeth are a kind of continuous beam. When man chews some foods withelastic movement, a space between teeth is widened, thereby the space between teeth is filled with food particles and a dental root is stressed. As mentioned above, food particles in the space between teeth and plaques generated from food not only provide suitable condition for growth of caries-causing microorganisms in oral cavity and various anaerobic microorganisms causing halitosis, but also cause halitosis and periodontal diseases. To remove food between teeth, a toothpick or a toothbrush is commonly used.
  • a dental floss is recommended to use.
  • food particles between teeth may be removed, but caries-causing microorganisms between teeth and various anaerobic microorganisms causing halitosis may not removed easily.
  • caries and periodontal disease are caused in the following ways.
  • protein among the saliva in the mouth is absorbed on the surface of dentine and cement to form a film, on which pathogens such as Streptococcus or
  • Actinomyces grow up to create plaque. As time goes, calcium and phosphorous among the saliva are absorbed onto the plaque to form tartar and at the same time the
  • Cytokine such as activated oxygen, nitrogen oxide,
  • aforementioned antimicrobial substance applies to a dental floss, which is effective in
  • the present invention is designed to solve the problems of the prior art, and
  • an object of the invention is to provide an antimicrobial dental floss for
  • teeth like a conventional dental floss, but also prevent and relieve caries and periodontal
  • an antimicrobial dental floss for solving the above object, an antimicrobial dental floss for
  • cleaning teeth of the present invention contains xanthorrhizol as an effective component.
  • 0.1 - 10wt% of the xanthorrhizol may be included in the form of mixture with wax.
  • xanthorrhizol-containg extract from Curcuma xanthorrhiza was applied to a dental floss
  • the dental floss could not only remove food particles and dental plaques between teeth
  • Curcuma Xanthorrhiza belongs to the ginger family, known as turmeric produced in Jaba, one of the traditional medicinal plants in Indonesia, and it is known to
  • xanthorrhizol may be extracted from the Curcuma xanthorrhiza (see, KR. 2000-0073295). Since xanthorrhizol has excellent antimicrobial activity against
  • bacteria in oral cavity such as Streptococcus mutans, Streptococcus sobrinus, Porphyromonas gingivalis, and so on, it can be used effectively for prevention and
  • wave extracting may be used in addition to the general organic solvent extracting (see
  • Curcuma Xanthorrhiza extracts is manufactured using the following processes: a) drying and grinding purified Curcuma Xantho ⁇ hiza, b) conducting
  • the antimicrobial dental floss for cleaning teeth of the present invention e) freeze-drying the condensed stock solution into dried powder.
  • the antimicrobial dental floss for cleaning teeth of the present invention e) freeze-drying the condensed stock solution into dried powder.
  • invention may be manufactured by passing a fiber for dental floss through a solution of
  • xanthorrhizol dissolved in wax.
  • content of xanthorrhizol is less than 0.1 wt%, antimicrobial effect on oral microorganisms may not be expected.
  • content of xanthorrhizol is more than 10 wt%, its compatibility with wax may be reduced.
  • flavoring agent and another antimicrobial component known to those skilled in the art may be added.
  • the extract containing xanthorrhizol used in the present invention was prepared
  • Mycrstalline wax was added to a mixture of the extract containing xanthorrhizol obtained by aforementioned example 0.38g, mint flavor 5g and menthol 5g to obtain
  • Example 1 except for contents of xanthorrhizol as listed Table 1.
  • a dental floss was manufactured in the same manner as aforementioned Example 1.
  • dental flosses obtained by the Examples 1 — 4 and Comparative Example 1 their antimicrobial effects were tested as follows.
  • 4 kinds of pathogens i.e. dental caries-causing pathogen such as Streptococcus mutans ATCC25175, and oral anaerobic pathogens such as Porphyromomas gingivalis ATCC 33277, Prevotella intermedia ATCC 25611 and Fusobacterium nucleatum ATCC 25586.
  • pathogens i.e. dental caries-causing pathogen such as Streptococcus mutans ATCC25175, and oral anaerobic pathogens such as Porphyromomas gingivalis ATCC 33277, Prevotella intermedia ATCC 25611 and Fusobacterium nucleatum ATCC 25586.
  • the antimicrobial activity tests were conducted after subculturing these pathogens and then preculturing them for 24 hours 3 times. Equal amount of each pathogen culture fluid was smeared in suitable agar medium followed by adding the equal amount of the dental floss obtained by the above Examples and Comparative Example respectively. After cultivating them for 18 hrs, the growth of the pathogens was observed and then the results were summarized in Table 2.
  • the antimicrobial activity of the dental floss was determined by degree of the growth around the dental floss, which was decided as effectiveness when the growth inhibition zone around the dental floss was 1 mm or more.
  • dental flosses containing xanthorrhizol were proven to have excellent antimicrobial effects on all pathogens such as Streptococus mutans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and so on.
  • pathogens such as Streptococus mutans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and so on.
  • the antimicrobial dental floss for cleaning teeth As detailed in the above, the antimicrobial dental floss for cleaning teeth
  • the antimicrobial dental floss for cleaning teeth of the present invention can not only

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)

Abstract

L'invention porte sur un fil dentaire à activité antimicrobienne comportant du xanthorrhizol comme principe actif et assurant non seulement le nettoyage des débris alimentaire et l'élimination de la plaque dentaire comme les fils dentaires usuels, mais présentant de plus une activité contre les micro-organismes causes de caries et de maladies du périodonte et contre l'halitose..
PCT/KR2005/000311 2004-02-02 2005-02-02 Fil dentaire a activite antimicrobienne Ceased WO2005072641A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2004-0006699 2004-02-02
KR1020040006699A KR20050078532A (ko) 2004-02-02 2004-02-02 치아 세정용 항균 치실

Publications (1)

Publication Number Publication Date
WO2005072641A1 true WO2005072641A1 (fr) 2005-08-11

Family

ID=34825064

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2005/000311 Ceased WO2005072641A1 (fr) 2004-02-02 2005-02-02 Fil dentaire a activite antimicrobienne

Country Status (2)

Country Link
KR (1) KR20050078532A (fr)
WO (1) WO2005072641A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000067711A1 (fr) * 1999-05-08 2000-11-16 Hwang, Jae-Kwan Procede de preparation de xanthorrhizol a partir de curcuma xanthorriza roxb et utilisations de ce produit

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000067711A1 (fr) * 1999-05-08 2000-11-16 Hwang, Jae-Kwan Procede de preparation de xanthorrhizol a partir de curcuma xanthorriza roxb et utilisations de ce produit

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DZAKI Y. ET AL: "Antiinflammatory effect of Curcuma xanthorrhiza Roxb, and its active principles", CHEM PHARM BULL, vol. 38, no. 4, April 1990 (1990-04-01), TOKYO, pages 1045 - 1048 *
HWANG J.K. ET AL: "Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogens", FITOTERAPIA, vol. 71, no. 3, June 2000 (2000-06-01), pages 321 - 323 *
LIN S.C. ET AL: "Protective and therapeutic effects of Curcuma xanthorrhiza on hepatotoxin-induced liver damage", AM J CHIN MED., vol. 23, no. 3-4, 1995, pages 243 - 254 *

Also Published As

Publication number Publication date
KR20050078532A (ko) 2005-08-05

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