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WO2005060437A3 - Composition combinations and methods for treating, preventing, reversing and inhibiting pain - Google Patents

Composition combinations and methods for treating, preventing, reversing and inhibiting pain Download PDF

Info

Publication number
WO2005060437A3
WO2005060437A3 PCT/US2004/036187 US2004036187W WO2005060437A3 WO 2005060437 A3 WO2005060437 A3 WO 2005060437A3 US 2004036187 W US2004036187 W US 2004036187W WO 2005060437 A3 WO2005060437 A3 WO 2005060437A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitor
reversing
treating
preventing
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/036187
Other languages
French (fr)
Other versions
WO2005060437A2 (en
Inventor
Daniela Salvemini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metaphore Pharmaceuticals Inc
Original Assignee
Metaphore Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metaphore Pharmaceuticals Inc filed Critical Metaphore Pharmaceuticals Inc
Publication of WO2005060437A2 publication Critical patent/WO2005060437A2/en
Anticipated expiration legal-status Critical
Publication of WO2005060437A3 publication Critical patent/WO2005060437A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/32—Tin compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides a combination of compositions for treating, preventing, reversing or inhibiting pain, wherein at least one composition comprises a nitration inhibitor. Further provided is a method wherein the nitration inhibitor is selected from the group consisting of a SO generating system inhibitor, SO scavenger, NOS inhibitor, NO generating system inhibitor, NO scavenger, peroxynitrite generating system inhibitor, peroxynitrite scavenger, and any combination thereof. Preferably, the nitration inhibitor is combined with a pain inhibitor. The pain inhibitor is still more preferably an opioid.
PCT/US2004/036187 2003-10-31 2004-10-31 Composition combinations and methods for treating, preventing, reversing and inhibiting pain Ceased WO2005060437A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51616503P 2003-10-31 2003-10-31
US60/516,165 2003-10-31

Publications (2)

Publication Number Publication Date
WO2005060437A2 WO2005060437A2 (en) 2005-07-07
WO2005060437A3 true WO2005060437A3 (en) 2013-07-11

Family

ID=34710033

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/036187 Ceased WO2005060437A2 (en) 2003-10-31 2004-10-31 Composition combinations and methods for treating, preventing, reversing and inhibiting pain

Country Status (1)

Country Link
WO (1) WO2005060437A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8598150B1 (en) 2008-04-02 2013-12-03 Jonathan R. Brestoff Composition and method for affecting obesity and related conditions
US8987245B2 (en) 2008-04-02 2015-03-24 Jonathan R. Brestoff Parker Composition and method for affecting obesity and related conditions
US9102636B2 (en) * 2010-03-10 2015-08-11 Galleon Pharmaceuticals, Inc. Analgesic compounds, compositions, and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *

Also Published As

Publication number Publication date
WO2005060437A2 (en) 2005-07-07

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121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
122 Ep: pct app. not ent. europ. phase