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WO2005058407A1 - Methode et dispositif permettant de liberer des substances chimiques et biologiques de façon controlee au moyen de reactions photochimiques - Google Patents

Methode et dispositif permettant de liberer des substances chimiques et biologiques de façon controlee au moyen de reactions photochimiques Download PDF

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Publication number
WO2005058407A1
WO2005058407A1 PCT/IL2004/001135 IL2004001135W WO2005058407A1 WO 2005058407 A1 WO2005058407 A1 WO 2005058407A1 IL 2004001135 W IL2004001135 W IL 2004001135W WO 2005058407 A1 WO2005058407 A1 WO 2005058407A1
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Prior art keywords
pce
chemical
photochemical
light
matrix
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PCT/IL2004/001135
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English (en)
Inventor
Michael Gordon
Shmuel GORDON
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INOMICROTEC Ltd
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INOMICROTEC Ltd
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Publication of WO2005058407A1 publication Critical patent/WO2005058407A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

Definitions

  • the present invention generally relates to a method for controlled release of chemical and biological substances by photochemical reactions and to a device for said release. According to one embodiment, the present invention relates to an implantable device adapted for in vivo administration of drugs and medications.
  • Another approach is an apparatus containing two compartments separated by a moveable partition, such as the implantable device disclosed in U.S. Pat. No. 5,876,741 to Ron et al. These systems are designed in such a manner that volume expansion of a composition located in one compartment causes a biologically active compound located in the second compartment to be discharged into the biological environment through the passageway.
  • a similar approach as shown in U.S. Pat. No. 6,485,462 to Kriesel, presents an implantable fluid delivery device, containing a heat responsive polymer gel material that, upon being heated by a heating coil, functions as an internal energy source for expelling the medicinal fluids from the device.
  • PCE photochemical emitter
  • This PCE is essentially comprised of (a) at least one chemical or biological matrix; said matrix is capable of releasing at least one product of photochemical reaction; and (b), at least one light emitting device in communication with a sufficient power source; said emitter is adapted to emit light at a specific wave length and intensity, thus said photochemical reaction is provided and said photochemical product is obtained.
  • the aforementioned PCE may additionally comprise one or more modules selected from a programmable chemical selection, adapted to set activation signals to specific light emitters within the PCE; a programmable chemical release timer, adapted to load chemical release schedules; a chemical release message processor, adapted to decode the received spectral signal into a series of control and data bits, so a multi chemical and multi profile release pattern is obtained; at least one thin film rechargeable energy cell, providing an energy source; a radio frequency receiver; adapted to convert low-power high-frequency signals into base-band signals; a thin-film antenna (e.g., a thin-film printed antenna); adapted to receive a weak electro-magnetic waves, and translate them into electric radio frequency signals or any combination thereof.
  • a programmable chemical selection adapted to set activation signals to specific light emitters within the PCE
  • a programmable chemical release timer adapted to load chemical release schedules
  • a chemical release message processor adapted to decode the received spectral signal into a series of control
  • the PCE defined above may comprise a stack of accessories and auxiliaries selected from the group of a programmable chemical selection; programmable chemical release timer; a chemical release message processor; a thin film rechargeable energy cell; a radio frequency receiver; a thin-film antenna or any combination thereof It is in the scope of the present invention wherein the light emitting devices emits ultraviolet light; visible light; infrared radiation or any combination thereof.
  • the aforementioned PCE comprises at least one sensor.
  • This sensor may be adapted to determine one or more environmental inputs selected from physical, chemical and/or biological parameters in such a manner that correlating outputs or reactions are provided.
  • said sensor may be adapted to determine one or more physiological inputs selected from physical, chemical and/or biological parameters in such a manner that correlating outputs or reactions are provided.
  • the inputs are potentially determined adjacent to the PCE, in any remote location or in combination thereof
  • the PCE hereto-defined may hence be adapted to a feedback operational mode; wherein the releasing parameters of the photochemical reaction products are in correlation with the obtained inputs.
  • the releasing parameters may be selected from any of the group of release rate or flux; release onset or offset; type, number, location or identity of the light emitting device or devices; light wavelength and/or light intensity.
  • At least one detector may be in communication with an additional one or more implanted PCEs. The sensor may thus be in inline, offline and/or mediated communication with the PCE.
  • the said PCE may additionally comprise an interface adapted for a remote operation; wherein the said PCE's operation is regulated by at least one remote user, processor, sensor or any combination thereof.
  • the photochemical product is adapted for in vivo administration of drugs and medications.
  • the photochemical product may be adapted for in vivo administration of drugs and medications and said administration may be provided as a feedback to predetermined physiological parameters.
  • This method comprises emitting light of a specific wave length and intensity over a biological or chemical matrix by means of at least one light emitting device, so said photochemical reaction is provided and a photochemical product is obtained.
  • This method may be also adapted for in vivo administration of photochemical products by means of an implantable PCE.
  • the method may be adapted for administration of photochemical products by feedback by means of an implantable PCE , additionally comprising the steps of (a) obtaining a plurality of physiological inputs selected from physical, chemical and/or biological parameters by means of at least one sensor; (b) providing for a plurality of correlated output signals; and (c) emitting light of a specific wave length and intensity over a biological or chemical matrix so the administration of photochemical product is obtained; in such a manner that that said administration is provided in correlation to said predetermined physiological parameters.
  • FIG 1 schematically illustrates the lateral and top view of the photochemical emitter (PCE) according to one embodiment of the present invention comprising inter alia solid chemical block and a UV light source matrix;
  • PCE photochemical emitter
  • figure 2 schematically illustrates the chemical substrate, as viewed by the UV source matrix
  • figure 3 schematically illustrates the Programmable Chemical Selection (PCS) which is programmed to set activation signals to specific UV cells within the PCE, depending on the chemical code numbers in its input;
  • PCS Programmable Chemical Selection
  • FIG 4 schematically illustrates the Programmable Chemical Release Timer (PCRT), which enables loading of complex chemical release schedules;
  • PCT Programmable Chemical Release Timer
  • FIG. 5 schematically illustrates the Chemical Release Message Processor (CRMP) responsible for decoding the received spectral signal into a series of control and data bits, enabling multi chemical and multi profile release pattern;
  • CRMP Chemical Release Message Processor
  • FIG. 6 schematically illustrates the Thin Film Rechargeable Energy Cell (TFREC); which is an optional energy source;
  • TFREC Thin Film Rechargeable Energy Cell
  • figure 7 schematically illustrates the Radio Frequency Receiver/Transmitter of the RFRP, responsible for converting low-power high-frequency signals into base-band signals entering the Processor and converting- up base-band signals to transmittable RF signals;
  • figure 8 schematically illustrates a thin-film Antenna, used to receive weak electromagnetic waves, translate them into electric radio frequency signals and transmit the same;
  • figure 9 schematically illustrates the principle of a thin-film printed antenna pattern
  • figure 10 schematically illustrates the integration of the antenna, receiver, processor and thin-film energy cell functions
  • figure 11 schematically illustrates one possible approach to integrating the chemical layer, the light source layer and the programmable chemical select layer; these subunits are adapted to be in a cascade;
  • figure 12 schematically illustrates the cascaded configuration of the PCE based units of figure 11, and the leading receiver cell, connected using a possible flexible printed conductor; and, figure 13 schematically illustrates a flexible tube, housing and protecting the cascade and the surrounding tissue from negative interaction.
  • PCE photochemical emitter'
  • PCE generally refers' according to the present invention' to any device, which is adapted to release products of photochemical reactions to its surroundings.
  • This PCE is schematically comprised of at least one chemical or biological matrix and at least one light-emitting device.
  • the said matrix is capable of releasing at least one product of photochemical reaction.
  • the said light-emitting device is in communication with a sufficient power source; and is further adapted to emit light at a specific wave length and intensity so said photochemical reaction is provided and said photochemical product is obtained.
  • the term 'PCE' also refers according to the present invention to any device as defined above, further adapted for either integrated or non-integrated mode of operation.
  • Said PCE may thus be a standalone product or an ingredient of a communicated assembly or mechanism.
  • This device may be further adapted to indoor or outdoor operation; to be implanted in other system or systems, to be implanted in living bodies, such as the human body or to be adapted to any topical or cosmetic uses.
  • Said device may be operated by any known means, e.g., remote control, feedback, continuous action, discontinuous action, delayed operational mode etc.
  • FIG 1 illustrating one embodiment of the present invention wherein the photochemical emitter (PCE, 100) is schematically described.
  • the PCE is adapted to emit a UV light of a specific spectra range over a predetermined chemical or biological substrate, or over a plurality of those substrates. It is well in the scope of the present invention wherein said emitter is in communication with a plurality of optional accessories, such as a wireless remote control auxiliary, a self thin-film energy source etc.
  • said PCE comprises a miniature light emitting assembly (6).
  • This assembly is preferably comprised of an array of light emitting diodes (LEDs) and may be selected from blue light-emitting gallium nitride (GaN) LED; a UV-emitting LED; a UV-emitting LED additionally comprising a converter material or device for converting said UV light into a visible spectral range; a visible LED-phosphor, LEDs providing a relatively high-energy photon from a blue LED in such a manner that phosphorescence is obtained in a number of materials; or any combination thereof.
  • LEDs light emitting diodes
  • GaN gallium nitride
  • UV-emitting LED additionally comprising a converter material or device for converting said UV light into a visible spectral range
  • a visible LED-phosphor LEDs providing a relatively high-energy photon from a blue LED in such a manner that phosphorescence is obtained in a number of materials; or any combination thereof.
  • FIG. 1 presenting a top view of a micro LED array, where the miniature light emitting assembly (6) is a sapphire with n X -doped GaN layers.
  • Photolithographic and microelectronic metal deposition methods are used to pattern metal conductors (7) and metal bonding pads (9). All «-pads of the LEDs are arranged on the top and bottom edge of the diode matrix and designated diode column numbers (8), and all ⁇ -pads of the diodes could be arranged on the left and right edges of the matrix designated row numbers. This column/row addressing technique enables the illumination of one or multiple LEDs simultaneously.
  • FIG. 1 a cross section of one embodiment of a PCE (100) is presented in a perspective view.
  • This PCE is comprised of a base portion with the miniature light emitting assembly (6) as defined above, and an upper portion (1).
  • Said base portion is comprised of a base member (6A) and the array of LEDs (6B), potentially covered by means of a transparent glass top (4).
  • a chemical or biological matrix (1) is located on top of said LEDs (6B) and/or the glass top (4).
  • Said sandwich-like packaging (100) is affixed firmly by reversible or irreversible means, comprising one or more mechanical fastening members, e.g., screws, zips, lockable reinforcement devices etc, securing the package through the continuous bore (10A) and (10B).
  • mechanical fastening members e.g., screws, zips, lockable reinforcement devices etc
  • the packaging my be secured by chemical means, such as glues etc.
  • a plurality of fastening auxiliaries such as attachments (5) is possibly used. It is in the scope of the present invention wherein said auxiliaries are selected in a non limiting manner from magnets, magnetic films or ferromagnetic thin films located at the rim of the device.
  • flexible tubing, firmly gripping chemical substrate and LED matrix may be used.
  • controlling and/or processing means are further attached to the aforementioned PCE (100).
  • a Ball Grid Array (BGA) which is preferably located adjacent to base (6A), enables soldering to standard electronic Printed Circuit Boards (PCBs).
  • PCBs Printed Circuit Boards
  • the aforementioned PCE additionally comprises means for remote control, timing abilities, variable energy sources, encoding facilities etc. These means are described in the art and most of them are commercially available, so they fit to the hereto-defined PCE with no intensive alterations.
  • the aforementioned chemical or biological matrix (10) may be selected from any matrix which is comprised of at least one biological, non- biological, organic, inorganic composition, or a combination of any of these compositions or mixtures.
  • Said matrix is either in a continuous, discontinuous form or any combination thereof, and is either homogenous or heterogeneous. It may further be possessed of either isotropic or anisotropy characteristics.
  • This matrix may be comprised of monomers, polymers or any combination thereof.
  • the said matrix is sensitive to a light emitted by any internal or external source at a predetermined range and intensity in such a manner that said light causes the matrix to release, activate or to trigger at least one biological or chemical species, which is further transferred actively or diffused passively to a remote target location.
  • Said release, activation or triggering of the said species is provided in a simultaneous on-line manner and/or in a delayed off-line manner; in vivo, ex vivo, in vitro, in situ or ex situ or any combination thereof.
  • an S-S enriched matrix is useful for releasing sulfur containing active agents in response to a sufficient light emission.
  • Another example is an N-N enriched matrix. It is further in the scope of the present invention wherein the released agent was previously immobilized, encapsulated or entrapped into the said matrix. Additionally or alternatively, the released agent was adsorbed or affixed onto the surface of the matrix.
  • a plurality of chemical agents or biological agents are immobilized by methods known in the art into and/or onto a supporting matrix, wherein a light is emitted in a predetermined manner and hence selectively controls the release of a specific agent. It also controls the specific location on the matrix wherein the agent begins to be released and further regulates the kinetics of its release.
  • agents of two different species are absorbed: one is anchored by means of forming N-N bonds with the supporting matrix and the other is immobilized by means of forming S-S bonds with said matrix.
  • said first agent is subsequently desorbed from the bulk of the matrix, and slowly released to the surroundings.
  • said second agent is rapidly desorbed from the said matrix surface in such a manner that a large initial concentration is provided.
  • a hormone or hormone-like regulating agent is suitable for such an immobilization by said N-N bonds; wherein a biocide (e.g., bactericide, antibiotics, fungicide) is especially useful for being immobilized by said S-S adsorbing bonds.
  • a biocide e.g., bactericide, antibiotics, fungicide
  • the aforementioned matrix may be selected from a bulk material; a conglomerate, a mosaic or a multi-laminar structure of various ingredients; and/or a film, preferably a thin film; e.g., a film characterized by an average thickness of micrometers or less. Many thin films are possible, such as wafer sheet-like structures.
  • the aforementioned PCE (100) is comprised of a plurality of N thin mosaics, wherein N is an integer number equal to one or more; each of which is characterized by a continuous array of different matrices.
  • N is an integer number equal to one or more; each of which is characterized by a continuous array of different matrices.
  • a correlation is made between the locations of the light emitting devices (e.g., LEDs) and the location of said thin matrices, in such a manner that the light is effectively illuminated on a significant portion of the matrix, and/or in such a manner that the matrix is illuminated by the proper light emitting device; at the proper light wavelength -.
  • the aforementioned PCE (100) is characterized by a laminar structure, wherein a base portion comprises two or more faces. Each face comprises its own light emitting devices, adapted to emit light towards an adjacent matrix.
  • a coin-like PCE is provided, one face comprising an S-S bonded matrix and the other face comprising an N-N bonded matrix in such a manner that the first light-emitting device is powered to release the biocide, and vice versa, the second light-emitting device is used to release the hormonelike regulating agent,.
  • Fig. 2. presenting a perspective view of the aforementioned wafer-like matrix (2).
  • Said wafer is possibly made utilizing a multiple set of lithography masks with a step-and -repeat square pattern.
  • the optional alignment bore (3), located at the center of each chip, is either laser drilled or photo cleaved.
  • these thin films are provided on a silicon wafer or other suitable substrate. These films can then be patterned using photolithographic techniques and suitable etching techniques. Suitable materials include silicon dioxide, silicon nitride, polycrystalline silicon etc.
  • a novel Programmable Chemical Selection (i.e., PCS) option is hereto provided. It enables the user to program and re-program predetermined characterizations and thus to enable a specific release rate and substance combination; to combine such release with a given operating code number etc.
  • PCS Programmable Chemical Selection
  • FIG 3 presenting a PCS which is programmed to set activation signals to specific UV cells within the PCE, depending on the chemical code numbers in its input.
  • the chemical substrate surface may exhibit a multiple of chemical sites. Each site could then be sub-divided into smaller sites according to the minimum dose requiring release. Each site is then designated by a code number. Activating said code number is adapted to set all rows and column LEDs in that site, to the "on" state.
  • This code is programmed into a programmable device; one of which may be a standard Electronically Programmable Logic Device (i.e., EPLD), referenced by ALTERA Classic EPLDs.
  • EPLD Electronically Programmable Logic Device
  • the signals setting rows and columns to "on” are captured in a row/column standard logic latch device. This enables the decoding serial processing of multiple chemical sights activation. The actual activation and release will be triggered at the precise timing required.
  • the triggered row/column signal feeds into current driving transistors, able to supply the LED matrix with the variable current required.
  • This logic/current handshake enables significant power saving in the digital circuitry, through the use of micro-power logic.
  • Bond pads are designed at the periphery of the PCS, enabling external sidewall connections to further options of the PCE, or connections to a BGA, should no further options be required.
  • PCRT Programmable Chemical Release Timer
  • the PCRT enables the user to program the PCE to release chemicals at predetermined intervals ranging from seconds to years.
  • a non-limiting example of such a timer is based on a digital oscillator utilizing a resistor - capacitor (i.e., RC) time constant, such as the referenced LM555 data sheet.
  • RC resistor - capacitor
  • Several counters may then be dedicated to counting seconds, minutes, hours, days and weeks.
  • Several more counters may be programmed, according to user settings, for as many chemical release cycles required. Typical counter circuitry is described in reference "Binary Counter with Asynchronous Clear".
  • FIG. 5 schematically illustrating the Chemical Release Message Processor (CRMP, 16) responsible for decoding the received spectral signal into a series of control and data bits, enabling a multi chemical and multi profile release pattern.
  • the processor enables the user to use a composition of complex chemical release profiles, for multi chemical substrate.
  • the processor is adapted to receive a series of information bits including the unique Implant ID number, the number of dose cycles, the chemicals released in each dose, the duration release of each chemical and the amount released.
  • the processor Prior to storing the programmed dose cycles, the processor is adapted to transmit the instructions to the RF Transceiver, for confirmation.
  • the processor may perform additional functions such as control and report, according to specific application requirements.
  • FIG 6 schematically illustrating the Thin Film Rechargeable Energy Cell (i.e., TFREC, 60); which is an optional energy source.
  • the default energy source is adapted to be an implanted lithium energy cell with connecting leads to the PCE and built-in short-circuit protection.
  • a variation to this may be a rechargeable lithium battery, integrated with a charging unit.
  • the charger unit receives energy from a coil transmitter external to the body.
  • the energy cell may be implanted under the skin, similarly to a pacemaker.
  • the TFREC is an option that depends heavily on work done on an invention of an implanted charger unit, not available to date.
  • the TFREC technology is described in the art and may be used with no significant alternations.
  • the cathode film (21), the electrolyte film (22) and the anode (23) are all schematically illustrated in figure 6.
  • FIG 7 schematically illustrating the Radio Frequency Transceiver (70) of the RFRP, responsible for bi-directional conversion of low-power high-frequency signals into base-band signals entering the Processor.
  • the transceiver's main function is to enable reliable wireless transmission of the chemical release cycles from an external controller into the PCE implanted near the therapy-requiring organ of the human body.
  • the aforementioned transceiver would suffice for most utilizations. Nevertheless, it is acknowledged in this respect that due to increasing RF signals surrounding us, unintentional trigger of the activation of the PCE may occur.
  • the transceiver may be adapted to request confirmation and/or verification for each chemical or biological release programming session.
  • Both receive and transmit functions adapted for implant devices have been realized at various frequency bands, modulation schemes and signal bandwidth.
  • One of the primary concerns is the power consumption of the transceiver. It is acknowledged in this respect that for a frequent and high dosage chemical release, the transceiver may consume a high percentage of the total PCE's power requirements. Higher power consumption impacts the battery size, location and lifetime span between replacements.
  • the least power- consuming transceiver configuration would be the Amplitude Shift Keying (i.e., ASK) whereby transmitted RF energy would represent a logic "1" and no RF would be a logic "0". Assuming an equal statistical distribution of ones and zeros, half the time the transmitter is off, saving power.
  • the transceiver circuitry is very simple, and therefore compact and low cost.
  • RF wireless devices may operate in high cost protected licensed RF bands or non-licensed "free-to-all" RF bands.
  • the non-licensed bands are increasingly dense in RF applications, and therefore increasingly vulnerable to mutual interference.
  • the interference is mostly interpreted as high-level noise.
  • the information data bits are multiplied by a known coding sequence, thereby increasing signal bandwidth and hence denoted in the term spread-spectrum.
  • the received signal is multiplied by the same code, thereby creating a processing gain only for the known code signals and not for the general noise signals. This gain differentiates the information signal from the noise.
  • RF transceiver chips are commercially available for the ASK or the coded spread spectrum architectures and their variations, Phase Shift Keying (i.e., PSK) and Frequency Shift Keying (i.e., FSK). Selecting the most suitable available will be done individually for each application of the PCE.
  • PSK Phase Shift Keying
  • FSK Frequency Shift Keying
  • FIG 8 schematically illustrating a thin-film Antenna, used to receive weak electro-magnetic waves, and translate them into electric radio frequency signals.
  • the antenna (31) is usually a printed conductor proportional in length to the wireless frequency band chosen for the PCE application.
  • the printed antenna is on the outward facing surface of the chip, enabling electro-magnetic signal reception on the actual conductor side.
  • FIG 9 schematically illustrating the principle of a thin-film printed antenna pattern. Printing the antenna (31) on a substrate is one useful option. In applications utilizing low frequency bands, it may be more practical to attach a coated antenna wire to the PCE and fold the antenna wire alongside the implanted components.
  • FIG 10 schematically illustrating one embodiment adapted to integrate antenna, receiver, processor and thin-film energy cell functions in one device (1000).
  • This configuration is successfully adapted to minimize the components adjacent to the attended organ.
  • the device according to this embodiment is hence comprised of an antenna (35), an RFTR (26), a TFREC (20), a PCRT (18) and a CRMP (16).
  • FIG 11 schematically illustrating another embodiment of the present invention, wherein chemical or biological thin layer, light source layer and programmable chemical select layer are integrated in one possible cascade.
  • the transceiver and energy source are potentially separated from the PCE, the chemical release package is adapted to include a suitable chemical substrate (1), UV diode matrix (6) etc.
  • FIG 12 schematically illustrating the cascaded configuration of the PCE cells and the leading receiver cell, connected via flexible printed conductors.
  • the chemical release is provided in a relatively narrow, long and curved enclosure, comprising a multiple of PCE's (1), which are interconnected in a cascade formation with a standard flexible multi conductor substrate (40), forming a tree structure.
  • PCEs are interconnected to a single transceiver, processor and energy unit (35).
  • the PCE or the PCE cascade or any of the photochemical emitter defined or described above is comprised of at least one detector.
  • the term 'detector' refers in the present invention to any sensor, or other detecting means adapted to analyze, screen, acquiring images, physiological or environmental parameters, including physical (e.g., temperature, RGB values, radiation etc), chemical, biological or medical quantitive or qualitive inputs.
  • the aforementioned detector may be also in communication with one or more additional implanted PCEs and/or with external devices, adapted to process said inputs to correlated outputs, and then to deliver said outputs towards one or more PCEs.
  • said PCE is adapted to provide for a feedback operational mode; wherein the releasing parameters of the photochemical reaction products or any other measurable parameter, are in correlation with the obtained physiological or environmental inputs. It is acknowledged in this respect that at least a portion of said releasing parameters or feasibly measurable parameters, are selected in a non limiting manner from any of the reactions to the released substance or the group of the rate of said release or its flux; release onset or offset; the type, number, location or identity of the light emitting device or devices; light wavelength and/or light intensity.
  • the aforementioned detector may also be in communication with one or more additional implanted PCEs, so a communication network is provided comprising one or more detectors and one or more PCEs.
  • This communication is provided by means known in the art inline, offline and/or in a mediated manner, e.g., by a supporting means of a transmitter, operator, processor etc., wherein said means are integrated or non- integrated with one or more of said PCEs or detectors.
  • the present invention relates to a method for releasing products of photochemical reactions into the surroundings of a PCE device.
  • This method comprises emitting light of a specific wave length and intensity over a biological or chemical matrix by means of at least one light emitting device, so said photochemical reaction is provided and a photochemical product is obtained. Additionally or alternatively, the said method is especially useful for administrating photochemical products by feedback means of an implantable PCE 1.
  • This method additionally comprises the three steps of (a) obtaining a plurality of either environmental or physiological inputs selected from physical, chemical and/or biological parameters by means of at least one sensor; (b) providing for a plurality of correlated output signals; and then (c) emitting light of a specific wave length and intensity over a biological or chemical matrix so the administration of photochemical product is obtained; in such a manner that that said administration is provided in correlation to said predetermined physiological or environmental parameters.
  • FIG. 13 schematically illustrating a flexible tube, housing and protecting the cascade and the surrounding tissue from negative interactions.
  • the PCE aforementioned tree configuration is housed in a highly flexible, specifically punctured tube or hose (45), designed to assist in applying force on both ends of each PCE, thereby forcing the released chemical molecules, out through a plurality of holes (see 46 for example).
  • said flexible housing is biocompatible, flexible and adapted to be impermeable, isolated and/or sealed to any liquids of the body. It is acknowledged in this respect that said flexible housing is adapted to provide enhanced diffusion of the photochemical product. Hence for example, it is comprised of passive transferring means, such as holes, prosive portions, lipophilic or hydrophilic portions, selective membranes etc; and/or active transferring means, such as pumps, impellers, busters etc.

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  • Electrotherapy Devices (AREA)

Abstract

L'invention concerne un nouvel émetteur photochimique (PCE) utile pour la libération de produits de réactions photochimiques autour dudit émetteur. Ce PCE implantable comprend au moins une matrice chimique ou biologique capable de libérer au moins un produit de réactions photochimiques et au moins un dispositif électroluminescent en communication avec une source d'alimentation suffisante. L'émetteur selon l'invention est conçu pour émettre de la lumière à une longueur d'onde et à une intensité spécifiques de façon à produire la réaction photochimique et à obtenir le produit photochimique. L'invention concerne également une méthode qui permet de libérer les produits des réactions photochimiques autour d'un dispositif PCE. Cette méthode consiste à émettre de la lumière à une longueur et à une intensité spécifiques dans une matrice biologique ou chimique au moyen d'au moins un dispositif électroluminescent de façon à produire la réaction photochimique et à obtenir le produit photochimique.
PCT/IL2004/001135 2003-12-16 2004-12-15 Methode et dispositif permettant de liberer des substances chimiques et biologiques de façon controlee au moyen de reactions photochimiques Ceased WO2005058407A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL15940103A IL159401A0 (en) 2003-12-16 2003-12-16 A method and device for controlled release of chemicals and biological substances by photochemical reactions
IL159401 2003-12-16

Publications (1)

Publication Number Publication Date
WO2005058407A1 true WO2005058407A1 (fr) 2005-06-30

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PCT/IL2004/001135 Ceased WO2005058407A1 (fr) 2003-12-16 2004-12-15 Methode et dispositif permettant de liberer des substances chimiques et biologiques de façon controlee au moyen de reactions photochimiques

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IL (1) IL159401A0 (fr)
WO (1) WO2005058407A1 (fr)

Cited By (4)

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Publication number Priority date Publication date Assignee Title
WO2006130365A3 (fr) * 2005-05-31 2007-01-25 Lumerx Inc Appareil d'eclairage intraluminal
US7261730B2 (en) 2003-11-14 2007-08-28 Lumerx, Inc. Phototherapy device and system
EP2323580A4 (fr) * 2008-08-06 2012-05-09 Jongju Na Procédé, système et appareil de traitement dermatologique
US11406444B2 (en) 2011-06-14 2022-08-09 Jongju Na Electrically based medical treatment device and method

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US5470307A (en) * 1994-03-16 1995-11-28 Lindall; Arnold W. Catheter system for controllably releasing a therapeutic agent at a remote tissue site
US5482719A (en) * 1992-10-30 1996-01-09 Guillet; James E. Drug delivery systems
WO1996023543A1 (fr) * 1995-01-30 1996-08-08 Angiomedics Ii Incorporated Systemes de liberation de medicaments photolytique
US6273904B1 (en) * 1999-03-02 2001-08-14 Light Sciences Corporation Polymer battery for internal light device
WO2001097899A2 (fr) * 2000-06-16 2001-12-27 Wayne State University Procede et dispositif servant a stimuler un tissu neurologique
US20020038137A1 (en) * 1999-04-30 2002-03-28 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US20020188327A1 (en) * 2001-04-26 2002-12-12 Chester Struble Drug delivery for treatment of cardiac arrhythmia

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US5482719A (en) * 1992-10-30 1996-01-09 Guillet; James E. Drug delivery systems
US5470307A (en) * 1994-03-16 1995-11-28 Lindall; Arnold W. Catheter system for controllably releasing a therapeutic agent at a remote tissue site
WO1996023543A1 (fr) * 1995-01-30 1996-08-08 Angiomedics Ii Incorporated Systemes de liberation de medicaments photolytique
US6273904B1 (en) * 1999-03-02 2001-08-14 Light Sciences Corporation Polymer battery for internal light device
US20020038137A1 (en) * 1999-04-30 2002-03-28 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
WO2001097899A2 (fr) * 2000-06-16 2001-12-27 Wayne State University Procede et dispositif servant a stimuler un tissu neurologique
US20020188327A1 (en) * 2001-04-26 2002-12-12 Chester Struble Drug delivery for treatment of cardiac arrhythmia

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7261730B2 (en) 2003-11-14 2007-08-28 Lumerx, Inc. Phototherapy device and system
US7449026B2 (en) 2003-11-14 2008-11-11 Lumerx, Inc. Intra-cavity catheters and methods of use
WO2006130365A3 (fr) * 2005-05-31 2007-01-25 Lumerx Inc Appareil d'eclairage intraluminal
EP2323580A4 (fr) * 2008-08-06 2012-05-09 Jongju Na Procédé, système et appareil de traitement dermatologique
US10869812B2 (en) 2008-08-06 2020-12-22 Jongju Na Method, system, and apparatus for dermatological treatment
US11406444B2 (en) 2011-06-14 2022-08-09 Jongju Na Electrically based medical treatment device and method

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