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WO2005056598A3 - Modulateurs de la laminine-5 et leurs utilisations - Google Patents

Modulateurs de la laminine-5 et leurs utilisations Download PDF

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Publication number
WO2005056598A3
WO2005056598A3 PCT/DK2004/000860 DK2004000860W WO2005056598A3 WO 2005056598 A3 WO2005056598 A3 WO 2005056598A3 DK 2004000860 W DK2004000860 W DK 2004000860W WO 2005056598 A3 WO2005056598 A3 WO 2005056598A3
Authority
WO
WIPO (PCT)
Prior art keywords
laminin
modulators
disorders
disease
exemplary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2004/000860
Other languages
English (en)
Other versions
WO2005056598A2 (fr
Inventor
Ida Stenfeldt Mathiasen
Michael Karl Bauer
Joern Roland Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Priority to EP04803013A priority Critical patent/EP1694839A2/fr
Priority to JP2006543368A priority patent/JP2008502588A/ja
Publication of WO2005056598A2 publication Critical patent/WO2005056598A2/fr
Publication of WO2005056598A3 publication Critical patent/WO2005056598A3/fr
Priority to US11/451,583 priority patent/US20070014788A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des procédés et traitements curatifs ou préventifs de diverses maladies et troubles, par utilisation de modulateurs de la laminine-5. Les pathologies concernées sont essentiellement les maladies intestinales inflammatoires, la rectocolite hémorragique, la maladie de Crohn, ainsi que la polykystite rénale et les cancers associés à l'un au moins des états mentionnés. Ces modulateurs de la laminine-5 sont essentiellement des anticorps monoclonaux dirigés contre la chaîne η2 de la laminine-5 et de séquences d'interférence courtes d'ARN dirigées contre des séquences nucléotides codant la chaîne η2 de la laminine-5. L'invention concerne également des traitements associés reposant sur l'administration d'un modulateur de la laminine-5 et d'au moins un autre agent thérapeutique.
PCT/DK2004/000860 2003-12-12 2004-12-13 Modulateurs de la laminine-5 et leurs utilisations Ceased WO2005056598A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP04803013A EP1694839A2 (fr) 2003-12-12 2004-12-13 Modulateurs de la laminine-5 et leurs utilisations
JP2006543368A JP2008502588A (ja) 2003-12-12 2004-12-13 ラミニン−５調節物質及びその使用
US11/451,583 US20070014788A1 (en) 2004-12-13 2006-06-12 Laminin-5 modulators and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52906703P 2003-12-12 2003-12-12
US60/529,067 2003-12-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/451,583 Continuation US20070014788A1 (en) 2004-12-13 2006-06-12 Laminin-5 modulators and uses thereof

Publications (2)

Publication Number Publication Date
WO2005056598A2 WO2005056598A2 (fr) 2005-06-23
WO2005056598A3 true WO2005056598A3 (fr) 2005-11-03

Family

ID=34676870

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2004/000860 Ceased WO2005056598A2 (fr) 2003-12-12 2004-12-13 Modulateurs de la laminine-5 et leurs utilisations

Country Status (3)

Country Link
EP (1) EP1694839A2 (fr)
JP (1) JP2008502588A (fr)
WO (1) WO2005056598A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8545845B2 (en) 2008-06-18 2013-10-01 Karl Tryggvason Antibodies against domains of laminin-332

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2198884A1 (fr) 2008-12-18 2010-06-23 Centre National de la Recherche Scientifique (CNRS) Anticorps monoclonaux dirigés contre un domaine LG4-5 d'une chaîne alpha-3 de laminine-5 humaine
KR102001582B1 (ko) 2011-08-08 2019-07-18 큐어랩 온콜로지, 인크. 암 치료 및 예방용 p62와 관련된 방법 및 조성물
CN103149371B (zh) * 2013-02-26 2015-12-23 哈药慈航制药股份有限公司 生物标记物在制备预测5-氨基水杨酸治疗溃疡性结肠炎的反馈响应药物中的应用
TWI676681B (zh) * 2017-03-29 2019-11-11 臺北醫學大學 具抗原專一性的t細胞及其用途
CN110646624B (zh) * 2019-10-31 2023-07-07 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） 一种基质素2的elisa试剂诊断盒及其使用方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010646A1 (fr) * 1994-10-04 1996-04-11 Karl Tryggvason Chaines de laminine: utilisation diagnostique et therapeutique
WO2000026342A1 (fr) * 1998-10-30 2000-05-11 Northwestern University Methode permettant d'influencer la proliferation cellulaire
WO2002030465A2 (fr) * 2000-10-12 2002-04-18 University Of Rochester Compositions inhibant la proliferation de cellules cancereuses
WO2003099298A1 (fr) * 2002-05-24 2003-12-04 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Molecules d'arn court induisant l'interference d'arn

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010646A1 (fr) * 1994-10-04 1996-04-11 Karl Tryggvason Chaines de laminine: utilisation diagnostique et therapeutique
WO2000026342A1 (fr) * 1998-10-30 2000-05-11 Northwestern University Methode permettant d'influencer la proliferation cellulaire
WO2002030465A2 (fr) * 2000-10-12 2002-04-18 University Of Rochester Compositions inhibant la proliferation de cellules cancereuses
WO2003099298A1 (fr) * 2002-05-24 2003-12-04 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Molecules d'arn court induisant l'interference d'arn

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOUATROUSS YAMINA ET AL: "Altered expression of laminins in Crohn's disease small intestinal mucosa", AMERICAN JOURNAL OF PATHOLOGY, vol. 156, no. 1, January 2000 (2000-01-01), pages 45 - 50, XP002333418, ISSN: 0002-9440 *
HABERMANN J ET AL: "Ulcerative colitis and colorectal carcinoma: DNA-profile, laminin-5 gamma2 chain and cyclin A expression as early markers for risk assessment", SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, vol. 36, no. 7, July 2001 (2001-07-01), pages 751 - 758, XP008048927, ISSN: 0036-5521 *
MASAKI TADAHIKO ET AL: "Coexpression of matrilysin and laminin-5 gamma2 chain may contribute to tumor cell migration in colorectal carcinomas.", DIGESTIVE DISEASES AND SCIENCES, vol. 48, no. 7, July 2003 (2003-07-01), pages 1262 - 1267, XP008048872, ISSN: 0163-2116 *
PIRILA EMMA ET AL: "Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis).", DIGESTIVE DISEASES AND SCIENCES, vol. 48, no. 1, January 2003 (2003-01-01), pages 93 - 98, XP008048871, ISSN: 0163-2116 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8545845B2 (en) 2008-06-18 2013-10-01 Karl Tryggvason Antibodies against domains of laminin-332

Also Published As

Publication number Publication date
WO2005056598A2 (fr) 2005-06-23
EP1694839A2 (fr) 2006-08-30
JP2008502588A (ja) 2008-01-31

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