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WO2005054183A3 - Quinolinone based protein kinase inhibitors - Google Patents

Quinolinone based protein kinase inhibitors Download PDF

Info

Publication number
WO2005054183A3
WO2005054183A3 PCT/US2004/040148 US2004040148W WO2005054183A3 WO 2005054183 A3 WO2005054183 A3 WO 2005054183A3 US 2004040148 W US2004040148 W US 2004040148W WO 2005054183 A3 WO2005054183 A3 WO 2005054183A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
kinase inhibitors
based protein
quinolinone
quinolinone based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/040148
Other languages
French (fr)
Other versions
WO2005054183A2 (en
Inventor
Congxin Liang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of WO2005054183A2 publication Critical patent/WO2005054183A2/en
Publication of WO2005054183A3 publication Critical patent/WO2005054183A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Hydroxy carboxy quinolinone based derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
PCT/US2004/040148 2003-12-01 2004-12-01 Quinolinone based protein kinase inhibitors Ceased WO2005054183A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52594503P 2003-12-01 2003-12-01
US60/525,945 2003-12-01
US54572104P 2004-02-18 2004-02-18
US60/545,721 2004-02-18

Publications (2)

Publication Number Publication Date
WO2005054183A2 WO2005054183A2 (en) 2005-06-16
WO2005054183A3 true WO2005054183A3 (en) 2005-09-29

Family

ID=34657205

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/040148 Ceased WO2005054183A2 (en) 2003-12-01 2004-12-01 Quinolinone based protein kinase inhibitors
PCT/US2004/040346 Ceased WO2005053692A1 (en) 2003-12-01 2004-12-01 Advanced quinolinone based protein kinase inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2004/040346 Ceased WO2005053692A1 (en) 2003-12-01 2004-12-01 Advanced quinolinone based protein kinase inhibitors

Country Status (1)

Country Link
WO (2) WO2005054183A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001293233A1 (en) 2000-09-01 2002-03-13 Chiron Corporation Aza heterocyclic derivatives and their therapeutic use
ES2302106T3 (en) 2000-09-11 2008-07-01 Novartis Vaccines And Diagnostics, Inc. PROCEDURE FOR PREPARATION OF BENCIMIDAZOL-2-IL QUINOLINE DERIVATIVES.
BR0313743A (en) 2002-08-23 2005-07-05 Chiron Corp Benzimidazole quinolinones and uses of these
WO2005082340A2 (en) * 2004-02-20 2005-09-09 Chiron Corporation Modulation of inflammatory and metastatic processes
JP2007523929A (en) * 2004-02-26 2007-08-23 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング Benzimidazolyl derivatives
WO2010114896A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted indolo-pyridinone compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800760B2 (en) * 2000-09-11 2004-10-05 Chiron Corporation Quinolinone derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001028993A2 (en) * 1999-10-19 2001-04-26 Merck & Co. Inc. Tyrosine kinase inhibitors
HUP0203323A3 (en) * 1999-10-19 2004-01-28 Merck & Co Inc Tyrosine kinase inhibitors and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800760B2 (en) * 2000-09-11 2004-10-05 Chiron Corporation Quinolinone derivatives

Also Published As

Publication number Publication date
WO2005053692A1 (en) 2005-06-16
WO2005054183A2 (en) 2005-06-16

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