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WO2005046600A3 - Systeme d'application de tulobuterol transdermique, procede et composition correspondants - Google Patents

Systeme d'application de tulobuterol transdermique, procede et composition correspondants Download PDF

Info

Publication number
WO2005046600A3
WO2005046600A3 PCT/US2004/037305 US2004037305W WO2005046600A3 WO 2005046600 A3 WO2005046600 A3 WO 2005046600A3 US 2004037305 W US2004037305 W US 2004037305W WO 2005046600 A3 WO2005046600 A3 WO 2005046600A3
Authority
WO
WIPO (PCT)
Prior art keywords
tulobuterol
transdermal
delivery
skin
adhesive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/037305
Other languages
English (en)
Other versions
WO2005046600A2 (fr
Inventor
David B Lebo
Juny Lee
Vincent Luisi
Je Phil Ryoo
Oliver J Toigo Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexmed Holdings Inc
Original Assignee
Nexmed Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings Inc filed Critical Nexmed Holdings Inc
Publication of WO2005046600A2 publication Critical patent/WO2005046600A2/fr
Publication of WO2005046600A3 publication Critical patent/WO2005046600A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cette invention se rapporte à un système d'application de tulobutérol transdermique, se présentant sous la forme d'un timbre en une seule couche à matrice de médicament incorporé dans l'adhésif, comprenant une concentration relativement faible (moins de 5 % en poids) d'une base de tulobutérol dissoute dans une composition adhésive pour la peau, contenant au moins un agent améliorant la perméation de la peau. Ce système d'application transdermique assure la libération régulée du principe actif, il contient une concentration relativement faible de tulobutérol dans la formulation adhésive en contact avec la peau d'un timbre transdermique et il assure une application transdermique soutenue acceptable du tulobutérol dissout, ainsi que des propriétés de pégosité et de pélliculage acceptables pour le dispositif d'application.
PCT/US2004/037305 2003-11-07 2004-11-05 Systeme d'application de tulobuterol transdermique, procede et composition correspondants Ceased WO2005046600A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51812403P 2003-11-07 2003-11-07
US60/518,124 2003-11-07

Publications (2)

Publication Number Publication Date
WO2005046600A2 WO2005046600A2 (fr) 2005-05-26
WO2005046600A3 true WO2005046600A3 (fr) 2005-12-22

Family

ID=34590221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/037305 Ceased WO2005046600A2 (fr) 2003-11-07 2004-11-05 Systeme d'application de tulobuterol transdermique, procede et composition correspondants

Country Status (1)

Country Link
WO (1) WO2005046600A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100508964C (zh) * 2003-11-21 2009-07-08 积水化学工业株式会社 膏药
WO2006044206A2 (fr) 2004-10-08 2006-04-27 Noven Pharmaceuticals, Inc. Dispositif d'administration transdermique de medicaments avec couche support occlusive
HU227970B1 (en) 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
US20100087768A1 (en) * 2008-10-02 2010-04-08 Forlano Paula Transdermal drug delivery system for liquid active ingredient
WO2012103016A2 (fr) * 2011-01-26 2012-08-02 Csi Gmbh Patchs transdermiques à libération prolongée associant un bêta-agoniste et un anticholinergique et leurs procédés d'utilisation
WO2012103015A2 (fr) * 2011-01-27 2012-08-02 Csi Gmbh Patchs transdermiques à libération prolongée associant un bêta-agoniste et un stéroïde et leurs procédés d'utilisation
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
CN110433146B (zh) * 2018-05-03 2022-03-15 中国医学科学院药物研究所 一种妥洛特罗晶体贮库型透皮贴剂及其制备方法
CA3145206A1 (fr) * 2019-06-28 2020-12-30 Passport Technologies, Inc. Timbre d'administration de medicament transdermique, systeme d'administration de medicament et procede d'administration de medicament
CN112826809B (zh) * 2019-11-22 2023-01-10 北京泰德制药股份有限公司 一种稳定的妥洛特罗经皮吸收制剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866157A (en) * 1994-11-29 1999-02-02 Hisamitsu Pharmaceutical Co., Ltd. Matrix patch formulation
US20020012695A1 (en) * 2000-06-16 2002-01-31 Lee Wan S. Transdermal preparation containing hydrophilic or salt-form drug

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866157A (en) * 1994-11-29 1999-02-02 Hisamitsu Pharmaceutical Co., Ltd. Matrix patch formulation
US20020012695A1 (en) * 2000-06-16 2002-01-31 Lee Wan S. Transdermal preparation containing hydrophilic or salt-form drug

Also Published As

Publication number Publication date
WO2005046600A2 (fr) 2005-05-26

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