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WO2005046674A3 - Antibacterial compositions - Google Patents

Antibacterial compositions Download PDF

Info

Publication number
WO2005046674A3
WO2005046674A3 PCT/GB2004/004624 GB2004004624W WO2005046674A3 WO 2005046674 A3 WO2005046674 A3 WO 2005046674A3 GB 2004004624 W GB2004004624 W GB 2004004624W WO 2005046674 A3 WO2005046674 A3 WO 2005046674A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxypyrrolizidine
aminopyrrolizidine
hydroxy
methylaminopyrrolizidine
methylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2004/004624
Other languages
French (fr)
Other versions
WO2005046674A2 (en
Inventor
Robert James Nash
Paul Wolferstan
George William John Fleet
Ameijde Jeroen Van
Graeme Horne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MNL Pharma Ltd
Original Assignee
MNL Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MNL Pharma Ltd filed Critical MNL Pharma Ltd
Publication of WO2005046674A2 publication Critical patent/WO2005046674A2/en
Publication of WO2005046674A3 publication Critical patent/WO2005046674A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Antibacterial (alkyl)aminopyrrolizidine compounds for use in therapy or prophylaxis may be pharmaceutically acceptable derivatives of loline. Examples include 2,7-dihydroxy-l-methylaminopyrrolizidine, 2,7-dihydroxy-1-aminopyrrolizidine, 2-hydroxy-l-aminopyrrolizidine, 2-hydroxy-1-methylaminopyrrolizidine, 7-hydroxy-1-aminopyrrolizidine, 7-hydroxy-l-methylaminopyrrolizidine, 1α-methylamino-2β-hydroxypyrrolizidine, lα-methylamino-7β-hydroxypyrrolizidine, 1α-amino-2β-hydroxypyrrolizidine, lα-amino-7β-hydroxypyrrolizidine, 1α-amino-2,7β-hydroxypyrrolizidine and lα-methylamino-2,7β-hydroxypyrrolizidine. The compounds may be used to treat infection with MRSA, including C-MSRA1, C-MRSA2, C-MRSA3, C-MSRA4, Belgian MRSA, Swiss MRSA and any of the EMRSA strains.
PCT/GB2004/004624 2003-11-04 2004-11-03 Antibacterial compositions Ceased WO2005046674A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0325655.9 2003-11-04
GBGB0325655.9A GB0325655D0 (en) 2003-11-04 2003-11-04 Antibacterial compositions

Publications (2)

Publication Number Publication Date
WO2005046674A2 WO2005046674A2 (en) 2005-05-26
WO2005046674A3 true WO2005046674A3 (en) 2005-07-14

Family

ID=29725872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2004/004624 Ceased WO2005046674A2 (en) 2003-11-04 2004-11-03 Antibacterial compositions

Country Status (2)

Country Link
GB (1) GB0325655D0 (en)
WO (1) WO2005046674A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201639458A (en) 2014-12-11 2016-11-16 先正達合夥公司 Methods of preparing alkaloid-containing compositions and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185028A (en) * 1991-08-19 1993-02-09 The United States Of America, As Represented By The Secretary Of Agriculture N-acyl loline derivatives as insecticides and herbicides
US5372818A (en) * 1993-02-01 1994-12-13 Clemson University Method of treating fescue toxicosis with domperidone
US5468486A (en) * 1992-01-21 1995-11-21 The University Of Tennessee Research Corporation Vaccine containing a protein alkaloid conjugate for the treatment of fescue toxicosis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5185028A (en) * 1991-08-19 1993-02-09 The United States Of America, As Represented By The Secretary Of Agriculture N-acyl loline derivatives as insecticides and herbicides
US5468486A (en) * 1992-01-21 1995-11-21 The University Of Tennessee Research Corporation Vaccine containing a protein alkaloid conjugate for the treatment of fescue toxicosis
US5372818A (en) * 1993-02-01 1994-12-13 Clemson University Method of treating fescue toxicosis with domperidone

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARSOUM ET AL: "Synthesis of novel 1H pyrrolizine-5-carboxamides and their anti microbial properties.", BOLLETINO CHIMICO FARMACEUTICO, vol. 142, no. 4, 2003 - 2003, pages 160 - 166, XP009046840 *
PETROSKI ET AL: "Isolation, semi synthesis and nmr sprectral studies of loline alkaloids.", J.NATURAL PRODUCTS, vol. 52, no. 4, 1989 - 1989, pages 810 - 817, XP002325999 *

Also Published As

Publication number Publication date
WO2005046674A2 (en) 2005-05-26
GB0325655D0 (en) 2003-12-10

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