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WO2004112739A1 - Compostions antitranspiration - Google Patents

Compostions antitranspiration Download PDF

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Publication number
WO2004112739A1
WO2004112739A1 PCT/GB2003/002644 GB0302644W WO2004112739A1 WO 2004112739 A1 WO2004112739 A1 WO 2004112739A1 GB 0302644 W GB0302644 W GB 0302644W WO 2004112739 A1 WO2004112739 A1 WO 2004112739A1
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WO
WIPO (PCT)
Prior art keywords
emulsion
weight
aliphatic
emulsion according
emulsifier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/002644
Other languages
English (en)
Inventor
Zarah Geron Del Rosario
Satish Kumar Goel
Renato Mallar
Katherine Miranda-Mendoza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hindustan Unilever Ltd
Unilever NV
Original Assignee
Hindustan Lever Ltd
Unilever NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hindustan Lever Ltd, Unilever NV filed Critical Hindustan Lever Ltd
Priority to PCT/GB2003/002644 priority Critical patent/WO2004112739A1/fr
Priority to AU2003241058A priority patent/AU2003241058A1/en
Publication of WO2004112739A1 publication Critical patent/WO2004112739A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants

Definitions

  • the present invention relates to cosmetic compositions, particularly to antiperspirant compositions and more particularly to fluid compositions having an intermediate viscosity.
  • Antiperspirant formulations have been made or proposed for manufacture in many physical forms, and in particular as solids, and as fluids, the latter ranging from aerosols in which an active material is conveyed via a gas propellant out of an aerosol can, via liquids such as contact application from a roll on, to thickened creams that are commonly applied from a dedicated dispenser.
  • Such dispensers can be very effective at applying an antiperspirant to a target area, such as under the arms, but inevitably the dispenser itself forms a significant fraction of the cost of making the product.
  • the disposable income of a significant fraction of its population is quite low, so that it would be inherently desirable identify a means of producing an effective antiperspirant more cheaply, and one of achieving that aim would be to employ less expensive packaging.
  • One distribution means that has been employed to only a limited extent comprises the fingers, especially the finger-tips of the user, or possibly those of a friend or partner. Although the use of fingers can enable less expensive packaging to be contemplated, such a use imposes constraints upon a fluid antiperspirant composition and upon any packaging intended to dispense its contents onto finger for application.
  • One form of packaging that has been contemplated to only a limited extent for antiperspirant formulations comprises a sachet.
  • antiperspirant compositions In addition there are formulation considerations for antiperspirant compositions to make allowance for as well. It is inherently desirable for the composition to be efficacious. At the same time, it is also desirable for the product to have acceptable sensory characteristics on application to the skin. Water from some viewpoints represents a desirable vehicle for conveying an antiperspirant active onto the skin because it enables the active to be presented in dissolved form onto the skin, but thickened water systems as external phase can be sticky, i.e. demonstrate poor sensory characteristics. The sensory properties of systems containing significant proportions of water can be modified by emulsification.
  • Good sensory properties can be attained in a number of instances by dispersing the aqueous phase within an external continuous organic phase, but that itself can carry the risk of impairing antiperspirant efficacy if the antiperspirant is trapped such that does not readily come into skin contact.
  • an oil in water emulsion comprising: a) a major proportion by weight of a continuous aqueous containing from 5% to 30% by weight of an antiperspirant active and b) a minor proportion of a disperse oil phase including an emulsifying proportion of an organic nonionic emulsifier system containing at least one emulsifier having an HLB value of at least 6,
  • proportions by weight herein being based on the total weight of the emulsion which emulsion has a viscosity of from 80,000 to 120,000 mPa.
  • an antiperspirant composition in the form of an oil in water emulsion having a viscosity within the stated range, it is possible to meet simultaneously the objectives of produce a composition which retains efficacy, has acceptable sensory properties and is suitable for employment by fingers. Such compositions can readily be contained within and dispensed from a sachet .
  • a cosmetic antiperspirant product in accordance with claim 28.
  • the present invention provides an emulsion in which the external continuous phase is aqueous.
  • the emulsifier system is so chosen that an oil in water emulsion is obtained and the contents of the emulsion are selected such that it has an intermediate viscosity.
  • the aqueous phase constitutes the major fraction of the emulsion, in many desirable embodiments from 75 to 95% by weight and in a number of very suitable embodiments from 85 to 90% by weight. Herein all percentages and proportions are based on the complete emulsion unless otherwise stated.
  • the aqueous phase includes not only water, which usually is the main constituent, but also any water soluble co-solvent such as a low molecular weight aliphatic alcohol, e.g. ethanol, or a dihydric alcohol such as propylene glycol .. This latter, if present, can be contemplated in an amount of, for example, up to 20% by weight.
  • the weight of the aqueous phase also includes the weight of the antiperspirant active which is dissolved therein, which is selected in the range of from 5 to 30%, in many instances at least 10% and especially is at least 12.5% of the emulsion. Commonly, the emulsion contains up to 25% by weight antiperspirant active.
  • the antiperspirant can be introduced into the composition as a solid which is then dissolved in the liquid constituent or constituents or a fraction thereof, or, which in some ways is more convenient, as a pre-formed solution in the liquid constituent or constituents or a fraction thereof, at the discretion of the producer.
  • the antiperspirant active can be chosen from a wide range of actives.
  • Antiperspirant actives for use herein are often selected from astringent active salts, including in particular aluminium, zirconium and mixed aluminium/zirconium salts, including both inorganic salts, salts with organic anions and complexes.
  • Preferred astringent salts include aluminium, zirconium and aluminium/zirconium halides and halohydrate salts, such as chlorohydrates, including, particularly desirably, aluminium chlorohydrates .
  • the halohydrate is a chlorohydrate, and aluminium chlorohydrates are readily available commercially, e.g. from B K Giulini, either in solid or in dissolved form.
  • the solutions be they in water or in a dihydric alcohol such as propylene glycol, often contain the antiperspirant active at a concentration of from 30 to 60% by weight, excluding the weight of any water of hydration and based on the weight of the solution.
  • a dihydric alcohol such as propylene glycol
  • Zirconium actives can usually be represented in their solid state by the empirical general formula: ZrO (OH) 2n-n Z B z .wH 2 0 in which z is a variable in the range of from 0.9 to 2.0 so that the value 2n-nz is zero or positive, n is the valency of B, and B is selected from the group consisting of chloride, other halide, sulphamate, sulphate and mixtures thereof. Possible hydration to a variable extent is represented by wH 2 0. Preferable is that B represents chloride and the variable z lies in the range from 1.5 to 1.87. In practice, such zirconium salts are usually not employed by themselves, but as a component of a combined aluminium and zirconium-based antiperspirant .
  • zirconium salts may be present as polymeric species, mixtures or complexes.
  • zirconium hydroxy salts often represent a range of salts having various amounts of the hydroxy group.
  • Zirconium aluminium chlorohydrate in some embodiments is particularly preferred.
  • Antiperspirant complexes based on the above-mentioned astringent aluminium and/or zirconium salts can be employed.
  • the complex often employs a compound with a carboxylate group, and advantageously this is an amino acid.
  • suitable amino acids include dl- tryptophan, dl-/3-phenylalanine, dl-valine, dl-methionine and /3-alanine, and preferably glycine which has the formula CH 2 (NH 2 )COOH.
  • ZAG actives generally contain aluminium, zirconium and chloride with an Al/Zr ratio in a range from 2 to 10, especially 2 to 6, an Al/Cl ratio from 2.1 to 0.9 and a variable amount of glycine. Actives of this preferred type are available from Westwood, from Summit and from Reheis.
  • the disperse phase comprises the minor fraction of the emulsion, especially from 4 to 25% by weight and in a number of very suitable embodiments from 10 to 15% by weight. It normally comprises a plurality of compounds selected from hydrophobic organic compounds and emulsifiers. It is especially desirable for at least a fraction of such organic compounds to be self-emulsifying, and preferably a major weight proportion. Compounds are considered to be self- emulsifying if they have a very low HLB value. They tend to be dominated by an hydrophobic moiety, such a hydrocarbon group of at least 12 carbons, but contain also a small hydrophilic moiety, often comprising an hydroxyl, carboxylic acid or short polyhydric ester moiety.
  • the self-emulsifying compounds and emulsifiers together constitute the major weight fraction of the oil phase, more preferably at least 70% and in a number of valued compositions, at least 90% by weight.
  • the term emulsion encompasses not only formulations in which the disperse phase is in the form of liquid droplets, but also formulations in which such droplets have solidified at ambient or storage temperatures. Indeed, in some especially preferred embodiments, the disperse phase comprises such solidified droplets.
  • the disperse phase commonly contains one or more water- immiscible aliphatic alcohols and particularly alcohols having a melting point of below 20°C.
  • Such alcohols include linear aliphatic alcohols containing from 12 to 25 carbon atoms, such as myristyl, cetyl, stearyl, eicosinyl and behenyl alcohols, or mixtures of any two or more of them, such as cetyl and stearyl , stearyl and behenyl or cetyl , stearyl and behenyl.
  • the proportion of the aliphatic alcohol in the disperse phase is often chosen in the range of from 5 to 15% by weight based on the weight of the disperse phase. In many instances, the weight of the aliphatic alcohol in the emulsion is from 0.5 to 2%.
  • the disperse phase often contains one or more water- immiscible aliphatic acids, particularly aliphatic acids containing from 12 to 25 linear carbon atoms. Such compounds in practice have a melting point of above 20°C. Desirable aliphatic acids include myristic acid, cetic acid, stearic acid and behenic acid, of which steariuc acid is especially desirable.
  • the proportion of the aliphatic acid in the disperse phase is often chosen in the range of from 10 to 30% by weight based on the weight of the disperse phase. In many instances, the weight of the aliphatic • alcohol in the emulsion is from 1 to 4%.
  • aliphatic ester of a polyhydric aliphatic alcohol can desirably be dihydric or trihydric, and preferably contains from 3 to 6 carbons. Examples include propylene glycol and especially glycerol .
  • a mono-ester is particularly suitable.
  • the acid moiety in the ester is preferably derived from aliphatic acids containing from 12 to 25 linear carbons, including laurate, myristate, and stearate. It will be recognised that such esters can perform a dual function. Not only can they act as an emulsifier having a low HLB value
  • hydrophylic/lypophylic balance value commonly in the region of 2.5 to 5 (sometimes considered to be a co- emulsifier) , but they also have emollient properties. In consequence, they can not only assist in the formation of an emulsion, but also can contribute to desirable sensory properties of the eventual composition.
  • the proportion of said ester in the disperse phase is often chosen in the range of from 35 to 75% by weight based on the weight of the disperse phase. In many instances, the weight of the ester in the emulsion is from 5 to 10%.
  • the emulsion contains the aliphatic alcohol, the aliphatic acid and the aliphatic ester, for example in a weight selected in the range of 1:1:3.5 to 1:4:10.
  • a further essential constituent of the emulsion is a nonionic emulsifier having an HLB value of at least 6.
  • a nonionic emulsifier having an HLB value of at least 6.
  • Such an emulsifier is incorporated in an amount that can result in the eventual composition having the form of an oil-in- water emulsion at ambient/storage temperatures, often considered to be in the region of 20 to 30°C. Whilst the choice of such an emulsifier is at the discretion of the producer, it is especially desirable to choose an emulsifier having an HLB value of at least 10. Many desirable emulsifiers have an HLB value of up to 18.
  • nonionic emulsifiers having such an HLB value are ethoxylated or optionally ethoxylated/propoxylated, that is to say comprise a hydrophylic moiety containing repeat units of - (C 2 H 4 0) - or -(C 3 H 6 0)-, and often selected in the range of at least 10 up to 150 repeat units.
  • the high HLB emulsifier contain a hydrophobic moiety which preferably is a hydrocarbon that comprises from 12 to 25 carbon atoms, desirably linear, of which convenient and suitable examples comprise moieties having 16 or especially 18 linear carbons. It is particularly suitable for such high HLB emulsifier to be an ether.
  • preferred high HLB value emulsifiers include ceteth-20, steareth-20, steareth- 21, steareth-100 and ceteareth-20.
  • the proportion of high HLB emulsifier is often selected in the range of from 0.3 to 1.0% by weight .
  • the emulsifier system present in the invention emulsions comprises at least one emulsifier having a low HLB value, i.e. having an HLB of below 6 and especially from 2.5 to 5 or 5.5.
  • an emulsifier can comprise a polyhydric alcohol ester, such as glyceryl monostearate, but alternatively or additionally, it can comprise an ethoxylate or propoxylate nonionic surfactant containing a relatively low number or repeat - (C 2 H 4 0) - or - (C 3 H 6 0) - units such as from 2 to 4.
  • the low HLB ethoxylate emulsifier contains a hydrophobic moiety which preferably is a hydrocarbon which comprises from 12 to 25 carbon atoms, desirably linear, of which convenient and suitable examples comprise moieties having 16 or especially 18 linear carbons. It is particularly suitable for such a low HLB emulsifier to be an ether.
  • Preferred low HLB value ether emulsifiers include steareth-2 and oleth-2. The proportion of such ether emulsifiers is often selected in the range of from 1.0 to 3.0% by weight.
  • the low HLB component of the emulsifier system comprises both an ester emulsifier such as has been described hereinabove and an ether emulsifier such as has been described hereinabove, conveniently in a weight ratio of from 10:1 to 25:1.
  • emulsions according to the present invention comprise an aliphatic alcohol, an aliphatic acid, an aliphatic ester and an emulsifier system that includes an ether ethoxylate having an HLB value of from 10 to 18 and includes an ether ethoxylate having an HLB value of from 2.5 to 5.5.
  • An essential aspect of an emulsion according to present invention is its viscosity, which is within the range of from 80000 to 120000 mPa.s (which has previously been cps) .
  • the viscosity quoted herein is that as measured at 25°C by Brookfield TM RVT viscometer equipped with a spindle suitable for such a viscosity range, rotated at a suitable speed, , such as a TE bar rotated at 5 rpm.
  • viscosity measurements quoted are obtained using such apparatus or if obtained using other apparatus are converted to measurements made by the Brookfield viscometer.
  • the viscosity within the range is obtained by appropriate selection of the proportions of the constituents and by controlling processing conditions, such as in particular the rate of shear of the emulsion as it cools towards ambient, for example controlling the rate of shear in the vicinity of the solidification temperature of the disperse phase.
  • the oil in water emulsion comprises a combination of from 5 to 10% by weight aliphatic alcohols, aliphatic acids and self-emulsifying aliphatic esters which together solidify at a temperature above 40°C in the presence of an ethoxylated non-ionic emulsifier, and the emulsion is sheared at a temperature between the molten temperature of the oil constituents which is commonly at least 70°C or preferably at least 10°C lower and 50°C, (e.g. 50 to 60°C, the resultant emulsion having a viscosity in the range 80,000 to 120,000 mPa . s .
  • the emulsion contains a sensorially-enhancing proportion of a silicone elastomer, considered herein as part of the oil phase.
  • a silicone elastomer indicates that polysiloxane chains are crosslinked to form a matrix, a three-dimensional molecular structure. Cross linking can be achieved conveniently by hydrosilation of vinyl silicone fluids by hydrosiloxane or MQ hydride fluids.
  • the elastomer is non-emulsifying, which is to say that it lacks any hydrophilic substituents such as polyoxyethylene substituents.
  • Silicone elastomers often have an average number molecular weight in excess of 10,000, preferably in excess of 1,000,000 and optimally will range from 10,000 to 20 million.
  • Illustrative of the elastomer is a material with the CTFA name of crosslinked Stearyl Methyl- Dimethyl Siloxane Copolymer. Such materials are available, for example from Dow Corning as DC9040.
  • Emulsifying elastomers from Dow Corning include DC9010 and DC9050.
  • Other suitable elastomers are available from Shisitsu, for example under their grade designations KSG15, KSG16, KSG18, all non- emulsifying and as emulsifying elastomers KSDG21, KSG31 and KSG 32. Even a very small proportion of silicone elastomer can be beneficial, such as from 0.02 to 0.1% by weight, and particularly from 0.04 to 0.08% by weight.
  • the silicone elastomer is very conveniently introduced into the composition containing an absorbed compatible organic carrier fluid, such as advantageously a volatile silicone.
  • suitable volatile fluids include cyclomethicones of empirical formula (SiMe 2 0) n in which n is 4 or preferably
  • the weight ratio of absorbed volatile fluid to elastomer is selected in the range of from 2:1 to 20:1, and in a number of highly desirable embodiments is from 3:1 to 15:1.
  • the presence of the fluid within the elastomer causes it to swell.
  • the weight of swollen elastomer plus fluid that is employed in the emulsions herein is advantageously from 0.2 to 1%.
  • the incorporation the silicone elastomer has been found not only to form an oil in water emulsion that exhibits highly desirable sensory properties, but also exhibits superior antiperspirant efficacy.
  • compositions can optionally incorporate a particulate water- insoluble inorganic material, such as a clay, talc, silica or metal oxide pigment up to 3%, and often not more than 1%, for example from 0.1 to 0.4% by weight.
  • a further optional constituent comprises a fragrance, typically at a concentration of up to 2.5% by weight, and in many instances from 0.1 to 1.5%, such as from 0.5 to 1%.
  • the oil phase in the invention compositions can optionally comprise a minor fraction of a water-insoluble organic oil.
  • This oil can be a hydrocarbon oil or can comprise one or more natural water-insoluble oils, such as plant seed oils comprising one or more triglycerides of unsaturated fatty acids, including derivatives of petroselinic acid, linoleic acid and linolenic acid, such as, by way of example only coriander seed oil, sunflower oil, borage oil and evening primrose oil.
  • Such oils or their hydrogenated derivatives can comprise, if desired from 0.1 to 4% by weight of the total formulation, or from 0.5 to 15%, in some instances 1 to 10% of the oil phase by weight.
  • the invention emulsions can be made by a process in which the constituents are mixed together in liquid or molten form.
  • the organic constituents are heated, desirably in the presence of any liquid oils, until a molten mixture is obtained, commonly at a temperature within the range of from 60 to 95°C, the precise temperature depending on the particular constituents selected. It is convenient to include all the emulsifiers into the molten phase.
  • a solution of the constituents of the continuous phase can be prepared separately, either by dissolving solid antiperspirant active into an aqueous liquid or by diluting a pre-formed aqueous solution of antiperspirant with further aqueous liquid. It is desirable to heat the aqueous phase to a similar temperature to that of the molten organic phase prior to the mixing of the two phases .
  • the antiperspirant active is incorporated into the aqueous phase prior to the introduction of the oil phase, it is preferable to carry out the process in two stages.
  • a fraction of the aqueous phase such as from 40 to 60% by volume is employed and mixed with the oil phase and in the second stage, the remainder of the aqueous phase is mixed into the already formed oil/water mixture, the second stage preferably occurring at a temperature that is from 50 to 70°C.
  • the second stage aqueous introduction to contain all or at least the major fraction of the antiperspirant active, such as from 80 to 100% of the active.
  • the mixture is subjected to an homogenisation step in which it is subjected to high shear.
  • High shear apparatus is available commercially, for example a SilversonTM or SonolatorTM mixer.
  • the term high shear is one that is well understood in the field of fluid cosmetics preparation. It is preferable to carry out homogenisation at a temperature of from 40 to 60°C, i.e. commonly at a temperatures that is from 10 to 30°C below that at which the oil phase was rendered molten.
  • the two liquid mixtures are then mixed together, for example by introducing the organic mixture progressively with agitation into the aqueous phase, advantageously avoiding excessive shear conditions.
  • any fragrance shortly before the product is dispensed into the eventual container, be it bottle, jar, or, especially, sachet, and at a temperature that is preferably in the range of from 35 to 50°C.
  • compositions preferably comprise heating the constituents that are mixed together to a temperature at which the oil phase constituents are molten and thereafter progressively lowering the temperature in a series of steps at which successive processing operations occur.
  • compositions obtained herein are especially suitable for application by fingers, being of suitable viscosity not to run off the fingers, but not excessively viscous. This viscosity also renders then particularly suitable for incorporation into and dosing of an effective dosage from within a sachet.
  • a dosage per arm pit is often in the region of 0.25 to lg, and in many instances from 0.35 to 0.75g. If the viscosity is outside the designated range, there is an increased risk that either the contents will pour too quickly out of the sachet because the viscosity is too low or that excess pressure will be needed because the viscosity is too high so that there is an increased risk that a much larger blob than is needed would be dispensed, wastefully.
  • a sachet herein is small pouch, commonly formed by sealing two sheets along their perimeter edges to enclose within a small volume of contents.
  • the volume within the sachet is at the discretion of the producer, but often is selected in the range of from 2.5 to 25 mis, and in many instances from 4 to lOmls.
  • the sheets conveniently are made from a thermoplastic such as polyethylene, often having a wall thickness in the region of about 0.05mm to 0.2mm.
  • Such sheets can be sealed by heat welding, preferably initially leaving about l/6 h to l/3 rd of the perimeter unsealed to permit the sachet to be filled, and thereafter sealing the unsealed perimeter.
  • Other suitable sheet materials include thin metal foil, optionally laminated with a thin thermoplastic sheet or water-proofed paper. Such sheets can be sealed by a continuous glue band adjacent to the perimeter of the sheet .
  • the shape of the sachet is at the discretion of the producer.
  • Convenient shapes include circular, oval, a regular or irregular polygon having at least three sides, optionally with radiussed corners, including triangular, square, rectangular, rhombohedral, pentagonal or hexagonal.
  • the shape can also resemble a well-known object, such as a dove.
  • the sachet can be opened by cutting away a section of the perimeter seal, for example between about l/l0 th to % so as to permit the sachet contents to be squeezed out.
  • the wall of the sachet adjacent to a similar length of the perimeter can be weakened, so that the section can be torn off.
  • the exterior faces of the sheets may conveniently carry a label to indicate the origin of the product and the contents of the sachet, or more conveniently the sheets themselves can be directly printed, thereby avoiding the need for a separate label .
  • a main vessel was charged with demineralised water, and the pigment, titanium dioxide, and heated about 75°C.
  • all the organic/oil constituents including any silicone elastomer, but excluding the fragrance, were charged into a second vessel, mixed continuously and heated until they formed a molten mass, in the region of 75 to 80°C, The molten oil mass was then mixed slowly into the aqueous phase and the mixture cooled to about 55 to 60°C.
  • the antiperspirant active, aluminium chlorohydrate was then introduced, the resultant bulk mixture was homogenised by passage through a high shear mixer and then cooled to about 45°C, whereupon the fragrance mixed in and the mixture was cooled to about 30 to 35°C.
  • the fragranced mixture was passed to a filling station for filling sachets, each with 5g product. Table 1
  • Example 1 each had a viscosity of 100,000 mPa.s measured at 25°C using a Brookfield RVT viscometer equipped with TE bar spindle at 5rpm.
  • the antiperspirant efficacy of the formulations was measured in a conventional test by comparing the sweat produced from a dosed armpit with an undosed armpit of a panel of ladies between the ages of 20 and 50, using a balanced left/right dosing regime in a temperature controlled room for a standard time period.
  • the formulation Example 1 had an efficacy of 46% sweat removal which was the same using as an oil in water cream having the same concentration of the same antiperspirant active, but a substantially higher viscosity of around 140,000 mPa.s.
  • the formulation of Example 2 had a significantly higher sweat reduction of 59%.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

Pour assurer l'efficacité ainsi que de bonnes propriétés sensorielles et un potentiel prêt à l'emploi dans un sachet, l'invention concerne une émulsion huile dans eau dans laquelle la phase aqueuse continue renferme un agent antitranspiration actif dissous, et la phase organique dispersée renferme un émulsifiant de valeur HLB au moins égale à 6. L'émulsion a une viscosité comprise entre 80 000 et 120 000 mPa. s. De préférence, la phase dispersée est solidifiée à température ambiante. L'invention concerne également un sachet qui renferme l'émulsion considérée.
PCT/GB2003/002644 2003-06-18 2003-06-18 Compostions antitranspiration Ceased WO2004112739A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/GB2003/002644 WO2004112739A1 (fr) 2003-06-18 2003-06-18 Compostions antitranspiration
AU2003241058A AU2003241058A1 (en) 2003-06-18 2003-06-18 Antiperspirant compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2003/002644 WO2004112739A1 (fr) 2003-06-18 2003-06-18 Compostions antitranspiration

Publications (1)

Publication Number Publication Date
WO2004112739A1 true WO2004112739A1 (fr) 2004-12-29

Family

ID=33523121

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/002644 Ceased WO2004112739A1 (fr) 2003-06-18 2003-06-18 Compostions antitranspiration

Country Status (2)

Country Link
AU (1) AU2003241058A1 (fr)
WO (1) WO2004112739A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009056479A3 (fr) * 2007-11-01 2009-06-18 Unilever Plc Composition et produit anti-transpirants
WO2008114189A3 (fr) * 2007-03-16 2011-01-20 The Procter & Gamble Company Compositions déodorantes
WO2014128060A2 (fr) 2013-02-21 2014-08-28 L'oreal Émulsion huile-dans-eau comprenant au moins un mélange spécifique de tensioactifs non ioniques, une cire comprenant au moins un ester et un polysaccharide soluble dans l'eau
WO2014128058A2 (fr) 2013-02-21 2014-08-28 L'oreal Émulsion huile-dans-eau de consistance molle ou solide comprenant un mélange de tensioactifs non ioniques, un polysaccharide soluble dans l'eau et une cire comprenant au moins un ester
GB2549352A (en) * 2015-10-28 2017-10-18 Henkel Ag & Co Kgaa Antiperspirant O/W emulsions having cross-linked silicone polymers
US10111824B2 (en) 2014-12-29 2018-10-30 Kimberly-Clark Worldwide, Inc. Cosmetic emulsions
WO2019112587A1 (fr) * 2017-12-07 2019-06-13 Colgate-Palmolive Company Composition de soins personnels
US10406081B2 (en) 2014-12-29 2019-09-10 Kimberly-Clark Worldwide, Inc. Multifunctional base emulsion
EP3544577A1 (fr) * 2016-12-27 2019-10-02 Colgate-Palmolive Company Agent nacrant et compositions nacrées
FR3117791A1 (fr) 2020-12-22 2022-06-24 L'oreal Composition aqueuse soft-solid comprenant un sel de magnésium de grade léger

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5989531A (en) * 1998-11-13 1999-11-23 Colgate-Palmolive Company Antiperspirant formulation for porous applicator
US6261543B1 (en) * 1998-10-15 2001-07-17 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Antiperspirant compositions
US6403069B1 (en) * 2000-10-20 2002-06-11 Colgate-Palmolive Company High oil clear emulsion with elastomer
US6468512B1 (en) * 2000-11-22 2002-10-22 Avon Products, Inc. Gel compositions
US20020155078A1 (en) * 2001-04-20 2002-10-24 Esther Avendano Two-phase roll-on cosmetic product

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261543B1 (en) * 1998-10-15 2001-07-17 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Antiperspirant compositions
US5989531A (en) * 1998-11-13 1999-11-23 Colgate-Palmolive Company Antiperspirant formulation for porous applicator
US6403069B1 (en) * 2000-10-20 2002-06-11 Colgate-Palmolive Company High oil clear emulsion with elastomer
US6468512B1 (en) * 2000-11-22 2002-10-22 Avon Products, Inc. Gel compositions
US20020155078A1 (en) * 2001-04-20 2002-10-24 Esther Avendano Two-phase roll-on cosmetic product

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008114189A3 (fr) * 2007-03-16 2011-01-20 The Procter & Gamble Company Compositions déodorantes
WO2009056479A3 (fr) * 2007-11-01 2009-06-18 Unilever Plc Composition et produit anti-transpirants
WO2014128060A2 (fr) 2013-02-21 2014-08-28 L'oreal Émulsion huile-dans-eau comprenant au moins un mélange spécifique de tensioactifs non ioniques, une cire comprenant au moins un ester et un polysaccharide soluble dans l'eau
WO2014128058A2 (fr) 2013-02-21 2014-08-28 L'oreal Émulsion huile-dans-eau de consistance molle ou solide comprenant un mélange de tensioactifs non ioniques, un polysaccharide soluble dans l'eau et une cire comprenant au moins un ester
US10111824B2 (en) 2014-12-29 2018-10-30 Kimberly-Clark Worldwide, Inc. Cosmetic emulsions
US10406081B2 (en) 2014-12-29 2019-09-10 Kimberly-Clark Worldwide, Inc. Multifunctional base emulsion
GB2549352A (en) * 2015-10-28 2017-10-18 Henkel Ag & Co Kgaa Antiperspirant O/W emulsions having cross-linked silicone polymers
EP3544577A1 (fr) * 2016-12-27 2019-10-02 Colgate-Palmolive Company Agent nacrant et compositions nacrées
WO2019112587A1 (fr) * 2017-12-07 2019-06-13 Colgate-Palmolive Company Composition de soins personnels
CN111372658A (zh) * 2017-12-07 2020-07-03 高露洁-棕榄公司 个人护理组合物
US11540986B2 (en) 2017-12-07 2023-01-03 Colgate-Palmolive Company Personal care composition
FR3117791A1 (fr) 2020-12-22 2022-06-24 L'oreal Composition aqueuse soft-solid comprenant un sel de magnésium de grade léger

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