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WO2004111011A3 - Synthesis of 2-aryl pyrimidine 4-carboxylic acid amides - Google Patents

Synthesis of 2-aryl pyrimidine 4-carboxylic acid amides Download PDF

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Publication number
WO2004111011A3
WO2004111011A3 PCT/US2004/016859 US2004016859W WO2004111011A3 WO 2004111011 A3 WO2004111011 A3 WO 2004111011A3 US 2004016859 W US2004016859 W US 2004016859W WO 2004111011 A3 WO2004111011 A3 WO 2004111011A3
Authority
WO
WIPO (PCT)
Prior art keywords
carboxylic acid
acid amides
aryl
synthesis
aryl pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/016859
Other languages
French (fr)
Other versions
WO2004111011A2 (en
Inventor
Jeffrey M Marra
R Richard Goehring
Julio Perez
Linas R Stasaitis
Yanbing Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of WO2004111011A2 publication Critical patent/WO2004111011A2/en
Publication of WO2004111011A3 publication Critical patent/WO2004111011A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4 substituted 2-oxo-3-butenyl amide. Also disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4-substituted 2-oxo-3-butenyl ester and converting the resulting ester to an amide. Additionally disclosed is a method for the preparation of 4 substituted 2 oxo-3 butenoic esters.
PCT/US2004/016859 2003-05-30 2004-05-28 Synthesis of 2-aryl pyrimidine 4-carboxylic acid amides Ceased WO2004111011A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47422103P 2003-05-30 2003-05-30
US60/474,221 2003-05-30

Publications (2)

Publication Number Publication Date
WO2004111011A2 WO2004111011A2 (en) 2004-12-23
WO2004111011A3 true WO2004111011A3 (en) 2005-03-24

Family

ID=33551484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/016859 Ceased WO2004111011A2 (en) 2003-05-30 2004-05-28 Synthesis of 2-aryl pyrimidine 4-carboxylic acid amides

Country Status (1)

Country Link
WO (1) WO2004111011A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102675215A (en) * 2012-05-17 2012-09-19 盛世泰科生物医药技术(苏州)有限公司 Synthesis method of ethyl 2-methylpyrimidyl-4-carboxylate
EP3666274A1 (en) 2013-03-15 2020-06-17 Purdue Pharma LP Carboxamide derivatives and use thereof
EP3039019B1 (en) 2013-08-26 2020-04-22 Purdue Pharma L.P. Azaspiro[4.5]decane derivatives and use thereof
CN110615751B (en) * 2018-06-19 2021-08-17 上海医药工业研究院 A kind of preparation method of 2-oxothiopropionamide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3764598A (en) * 1969-09-24 1973-10-09 Takeda Chemical Industries Ltd Pyrimidopyridazine derivatives
WO2001068612A2 (en) * 2000-03-10 2001-09-20 Euro-Celtique S.A. Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3764598A (en) * 1969-09-24 1973-10-09 Takeda Chemical Industries Ltd Pyrimidopyridazine derivatives
WO2001068612A2 (en) * 2000-03-10 2001-09-20 Euro-Celtique S.A. Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; XP002304000 *
F.KUNCKELL UND .ZUMBUSCH: "Über die Einwirkung von Mucobrom- und Mucochlor-Saüre auf Benzamidin", CHEM.BER., vol. 35, 1902, pages 3164 - 3168, XP008038054 *
T.A.RILEY, W.J.HENNEN, N.K:DALLEY AND B.E.WILSON: "Synthesis of 2-(beta-ribofuranosyl)pyrimidines, a new class of C-nucleosides", J. HETEROCYCLIC CHEM., vol. 24, 1987, pages 955 - 964, XP002303985 *
TIETZE, LUTZ-F.; MEIER, HEINRICH; VOSS, EDGAR, SYNTHESIS, vol. 4, 1988, pages 274 - 277 *

Also Published As

Publication number Publication date
WO2004111011A2 (en) 2004-12-23

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