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WO2004109280A3 - System and method for multidimensional evaluation of combinations of compositions - Google Patents

System and method for multidimensional evaluation of combinations of compositions Download PDF

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Publication number
WO2004109280A3
WO2004109280A3 PCT/US2004/018155 US2004018155W WO2004109280A3 WO 2004109280 A3 WO2004109280 A3 WO 2004109280A3 US 2004018155 W US2004018155 W US 2004018155W WO 2004109280 A3 WO2004109280 A3 WO 2004109280A3
Authority
WO
WIPO (PCT)
Prior art keywords
arrays
assay
constituent
constructing
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/018155
Other languages
French (fr)
Other versions
WO2004109280A2 (en
Inventor
Grant Zimmermann
Raymond A Molnar
Joseph Lehar
Jason Fong
Curtis T Keith
George Serbedzija
Margaret S Lee
Edward R Jost-Price
Nicole Hurst
Alexis Borisy
Michael A Foley
Brent Stockwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zalicus Inc
Original Assignee
CombinatoRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CombinatoRx Inc filed Critical CombinatoRx Inc
Priority to CA002528508A priority Critical patent/CA2528508A1/en
Priority to JP2006509084A priority patent/JP2007526438A/en
Priority to EP04754696A priority patent/EP1631799A2/en
Publication of WO2004109280A2 publication Critical patent/WO2004109280A2/en
Publication of WO2004109280A3 publication Critical patent/WO2004109280A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/00756—Compositions, e.g. coatings, crystals, formulations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Embodiments of the invention are directed toward methods and devices for constructing assay arrays including a combination of constituent compositions from constituent arrays. The combined compositions are evaluated, in some embodiments of the invention, to identify combinations with a combination effect. Other embodiments of the invention are directed toward constructing constituent arrays in various configurations to facilitate the production of assay arrays. Such embodiments include : constructing constituent arrays and assay arrays with corresponding composition and assay control sets; constructing constituent arrays with a unique set of origin locations and corresponding sets of derivative locations; varying the concentrations utilized for a constituent composition; and composing assay arrays corresponding to a virtual sparse assay array. Other embodiments of the invention are directed towards systems and method of evaluating the activity of combined compositions in an assay array.
PCT/US2004/018155 2003-06-06 2004-06-07 System and method for multidimensional evaluation of combinations of compositions Ceased WO2004109280A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002528508A CA2528508A1 (en) 2003-06-06 2004-06-07 System and method for multidimensional evaluation of combinations of compositions
JP2006509084A JP2007526438A (en) 2003-06-06 2004-06-07 System and method for multidimensional evaluation of composition combinations
EP04754696A EP1631799A2 (en) 2003-06-06 2004-06-07 System and method for multidimensional evaluation of combinations of compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47634203P 2003-06-06 2003-06-06
US60/476,342 2003-06-06

Publications (2)

Publication Number Publication Date
WO2004109280A2 WO2004109280A2 (en) 2004-12-16
WO2004109280A3 true WO2004109280A3 (en) 2005-10-13

Family

ID=33511777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/018155 Ceased WO2004109280A2 (en) 2003-06-06 2004-06-07 System and method for multidimensional evaluation of combinations of compositions

Country Status (5)

Country Link
US (2) US20040253627A1 (en)
EP (1) EP1631799A2 (en)
JP (1) JP2007526438A (en)
CA (1) CA2528508A1 (en)
WO (1) WO2004109280A2 (en)

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US20050148029A1 (en) * 2003-09-29 2005-07-07 Biosite, Inc. Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
US7879764B2 (en) * 2004-12-28 2011-02-01 Intel Corporation Electrically active combinatorial chemical (EACC) chip for biochemical analyte detection
US7420561B2 (en) * 2005-07-01 2008-09-02 Honeywell International Inc. Diagnostic visual tools and methods for graphical comparison of data point and historical data density
US7911339B2 (en) 2005-10-18 2011-03-22 Apple Inc. Shoe wear-out sensor, body-bar sensing system, unitless activity assessment and associated methods
WO2009020565A1 (en) * 2007-08-03 2009-02-12 Lixte Biotechnology, Inc. Use of phosphates to treat neuroblastomas and medullogastomas
US9164978B2 (en) * 2008-06-17 2015-10-20 Microsoft Technology Licensing, Llc Identifying objects within a multidimensional array
JP5564980B2 (en) * 2010-02-23 2014-08-06 日本電気株式会社 Security screening system and security screening method
DE102020202529A1 (en) * 2020-02-27 2021-09-02 Robert Bosch Gesellschaft mit beschränkter Haftung Method for identifying a combination of active ingredients

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WO1998057174A1 (en) * 1997-06-09 1998-12-17 Nce Pharmaceuticals,Inc. Synthetic antibiotics
EP1170591A2 (en) * 2000-07-07 2002-01-09 CombinatoRx, Incorporated Methods for identifying combinations of entities as therapeutics

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US5641814A (en) * 1991-03-01 1997-06-24 Warner-Lambert Company Antikeratolytic-wound healing compositions and methods for preparing and using same
AU3419995A (en) * 1994-09-19 1996-04-09 Du Pont Merck Pharmaceutical Company, The Combination of an opioid antagonist and a selective serotonin reuptake inhibitor for treatment of alcoholism and alcohol dependence
US5968983A (en) * 1994-10-05 1999-10-19 Nitrosystems, Inc Method and formulation for treating vascular disease
US5985356A (en) * 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6329139B1 (en) * 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5612060A (en) * 1995-05-25 1997-03-18 Alexander; J. Wesley Enhancement of transplant graft survival through nutritional immunomodulation and immunosuppressive therapy
US5756304A (en) * 1995-07-14 1998-05-26 Molecular Solutions Screening of microorganisms for bioremediation
US5989835A (en) * 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
EP0950184A1 (en) * 1996-06-27 1999-10-20 Cellstat Technologies, Inc. High-throughput screening method and apparatus
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US6030942A (en) * 1996-08-30 2000-02-29 The Trustees Of The University Of Pennsylvania Peptides peptide analogs peptidomimetics and other small molecules useful for inhibiting the activity of ribonucleotide reductase
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WO1998057174A1 (en) * 1997-06-09 1998-12-17 Nce Pharmaceuticals,Inc. Synthetic antibiotics
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Also Published As

Publication number Publication date
US20040253642A1 (en) 2004-12-16
CA2528508A1 (en) 2004-12-16
WO2004109280A2 (en) 2004-12-16
US20040253627A1 (en) 2004-12-16
EP1631799A2 (en) 2006-03-08
JP2007526438A (en) 2007-09-13

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