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WO2004038368A3 - Dispositif et procede pour surveiller la migration des leucocytes - Google Patents

Dispositif et procede pour surveiller la migration des leucocytes Download PDF

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Publication number
WO2004038368A3
WO2004038368A3 PCT/US2003/033177 US0333177W WO2004038368A3 WO 2004038368 A3 WO2004038368 A3 WO 2004038368A3 US 0333177 W US0333177 W US 0333177W WO 2004038368 A3 WO2004038368 A3 WO 2004038368A3
Authority
WO
WIPO (PCT)
Prior art keywords
leukocyte migration
vivo
invention further
further provides
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/033177
Other languages
English (en)
Other versions
WO2004038368A2 (fr
Inventor
Gregory L Kirk
Enoch Kim
Emanuele Ostuni
Olivier Schueller
Paul Sweetnam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surface Logix Inc
Original Assignee
Surface Logix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surface Logix Inc filed Critical Surface Logix Inc
Priority to EP03774884A priority Critical patent/EP1558076A4/fr
Priority to JP2004546913A priority patent/JP2006503581A/ja
Priority to CA002503203A priority patent/CA2503203A1/fr
Priority to AU2003282950A priority patent/AU2003282950A1/en
Publication of WO2004038368A2 publication Critical patent/WO2004038368A2/fr
Publication of WO2004038368A3 publication Critical patent/WO2004038368A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5029—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell motility
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Toxicology (AREA)
  • Composite Materials (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un dispositif utilisé pour surveiller la migration des leucocytes, ainsi qu'un procédé d'utilisation de ce dispositif pour surveiller la migration des leucocytes en présence d'un flux de cisaillement physiologique et donc pour simuler les conditions physiologiques d'un vaisseau sanguin in vivo. L'invention concerne également un procédé d'utilisation de ce dispositif pour le criblage à haut débit d'une pluralité d'agents de test. De plus, l'invention concerne un système d'essai flexible et de nombreux essais pouvant être utilisés pour tester des interactions biologiques et des systèmes. Des gradients de flux laminaires sont utilisés pour reproduire des situations de gradient existant in vivo.
PCT/US2003/033177 2002-10-22 2003-10-21 Dispositif et procede pour surveiller la migration des leucocytes Ceased WO2004038368A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03774884A EP1558076A4 (fr) 2002-10-22 2003-10-21 Dispositif et procede pour surveiller la migration des leucocytes
JP2004546913A JP2006503581A (ja) 2002-10-22 2003-10-21 白血球遊走をモニタリングするための装置及び方法
CA002503203A CA2503203A1 (fr) 2002-10-22 2003-10-21 Dispositif et procede pour surveiller la migration des leucocytes
AU2003282950A AU2003282950A1 (en) 2002-10-22 2003-10-21 Device and method for monitoring leukocyte migration

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41997602P 2002-10-22 2002-10-22
US41998002P 2002-10-22 2002-10-22
US60/419,976 2002-10-22
US60/419,980 2002-10-22

Publications (2)

Publication Number Publication Date
WO2004038368A2 WO2004038368A2 (fr) 2004-05-06
WO2004038368A3 true WO2004038368A3 (fr) 2004-07-29

Family

ID=32179774

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/033146 Ceased WO2004038367A2 (fr) 2002-10-22 2003-10-21 Tests biologiques utilisant des gradients formes dans des systemes microfluidiques
PCT/US2003/033177 Ceased WO2004038368A2 (fr) 2002-10-22 2003-10-21 Dispositif et procede pour surveiller la migration des leucocytes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033146 Ceased WO2004038367A2 (fr) 2002-10-22 2003-10-21 Tests biologiques utilisant des gradients formes dans des systemes microfluidiques

Country Status (5)

Country Link
EP (2) EP1558076A4 (fr)
JP (2) JP2006503581A (fr)
AU (2) AU2003287170A1 (fr)
CA (2) CA2503186A1 (fr)
WO (2) WO2004038367A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1773978T3 (da) * 2004-05-19 2014-05-26 Univ Pittsburgh Perfunderede, tredimensionelle celle/vævssygdomsmodeller
US7351423B2 (en) 2004-09-01 2008-04-01 Depuy Spine, Inc. Musculo-skeletal implant having a bioactive gradient
KR100873383B1 (ko) 2007-11-13 2008-12-10 이화여자대학교 산학협력단 선충의 주화성 연구용 미세 유체 소자
CN103635587A (zh) * 2008-04-08 2014-03-12 麻省理工学院 三维微流平台和其使用方法
DE102009035502A1 (de) 2009-07-30 2011-02-03 Universitätsklinikum Jena Verfahren und Vorrichtung zur Erfassung der Bewegung und Anlagerung von Zellen und Partikeln an Zell-, Gewebe- und Implantatschichten bei der Simulation von Flussbedingungen
DE102009038520B4 (de) * 2009-08-25 2012-07-05 Universität Rostock Verfahren und Vorrichtung zur Zellprobendiagnostik
CN102580798B (zh) * 2012-02-28 2014-03-05 东北大学 一种微流控芯片溶液梯度稀释装置
US9500642B2 (en) 2012-04-18 2016-11-22 Hemoshear, Llc In vitro model for pathological or physiologic conditions
JP5910282B2 (ja) * 2012-04-20 2016-04-27 大日本印刷株式会社 細胞遊走解析方法および細胞培養物作成方法
KR101433091B1 (ko) * 2012-04-26 2014-08-25 한국과학기술원 박테리아의 주화성 분석용 마이크로 플루이딕 장치, 제조방법 및 이를 이용한 박테리아의 주화성 분석 방법
CA2965114A1 (fr) 2013-10-21 2015-04-30 Hemoshear, Llc Modele in vitro pour micro-environnement tumoral
WO2016065125A1 (fr) * 2014-10-22 2016-04-28 The General Hospital Corporation Procédé et appareil de visualisation d'objets à l'aide d'un rétroéclairage oblique
CN105080627A (zh) * 2015-08-25 2015-11-25 辽宁中医药大学 一种用于药物筛选的集成化微流控芯片及其应用方法
CN106497788A (zh) * 2016-11-28 2017-03-15 南方医科大学珠江医院 体外肝细胞异质性培养装置及其培养方法
JP6931943B2 (ja) * 2017-08-30 2021-09-08 イムプリメド インコーポレイティッドＩｍｐｒｉｍｅｄ，Ｉｎｃ． 化学的及び生化学的化合物の高処理量選別のための製品
CN111019828B (zh) * 2019-12-26 2021-12-21 武汉大学 一种开放式高通量微流控卵母细胞动态三维培养芯片及其应用
WO2022070841A1 (fr) * 2020-09-29 2022-04-07 Nok株式会社 Appareil de piégeage de leucocytes
US12360102B2 (en) 2022-01-28 2025-07-15 Glaxosmithkline Intellectual Property Development Limited High-throughput assay for cell migration, chemotaxis, and function
CN114887034B (zh) * 2022-07-14 2022-10-28 中山莱博瑞辰生物医药有限公司 LLP2A-Ale在制备用于治疗和/或预防外周血淋巴细胞减少症的药物中的用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460945A (en) * 1991-05-30 1995-10-24 Center For Blood Research, Inc. Device and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory response
US20020168757A1 (en) * 2000-11-08 2002-11-14 Gregory Kirk Test device and method of making same
US6632619B1 (en) * 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284753A (en) * 1991-03-20 1994-02-08 Neuro Probe, Inc. Multiple-site chemotactic test apparatus and method
JP2002503336A (ja) * 1997-05-16 2002-01-29 アルバータ リサーチ カウンシル 微量流通システムおよびその使用方法
EP1185871A4 (fr) * 1999-06-01 2003-01-15 Caliper Techn Corp Dosages a micro-echelle et dispositifs microfluidiques destines au controle des activites de transporteur, de gradient induit et de liaison
US7326563B2 (en) * 2000-11-08 2008-02-05 Surface Logix, Inc. Device and method for monitoring leukocyte migration
WO2003078565A1 (fr) * 2002-03-12 2003-09-25 Surface Logix, Inc. Dispositif pour test de motilite et de chimiotaxie, et son procede d'utilisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460945A (en) * 1991-05-30 1995-10-24 Center For Blood Research, Inc. Device and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory response
US6632619B1 (en) * 1997-05-16 2003-10-14 The Governors Of The University Of Alberta Microfluidic system and methods of use
US20020168757A1 (en) * 2000-11-08 2002-11-14 Gregory Kirk Test device and method of making same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
See also references of EP1558076A4 *
TEMPELMAN L.A. ET AL.: "Motion of model leukocytes near a wall in simple shear flow", BIOTECHNOL. PROG., vol. 10, 1994, pages 97 - 108, XP002977146 *
VEREYCKEN-HOLLER V. ET AL.: "Radiation effects on circulating and endothelial cell interactions studied by quantitative real-time videomicroscopy", INT. J. RADIATION BIOL., vol. 78, no. 10, September 2002 (2002-09-01), pages 923 - 930, XP002977145 *

Also Published As

Publication number Publication date
WO2004038368A2 (fr) 2004-05-06
CA2503203A1 (fr) 2004-05-06
EP1558076A2 (fr) 2005-08-03
CA2503186A1 (fr) 2004-05-06
WO2004038367A3 (fr) 2004-11-11
JP2006507815A (ja) 2006-03-09
JP2006503581A (ja) 2006-02-02
EP1578194A4 (fr) 2007-03-21
EP1578194A2 (fr) 2005-09-28
WO2004038367A2 (fr) 2004-05-06
AU2003282950A1 (en) 2004-05-13
EP1558076A4 (fr) 2007-03-21
AU2003287170A1 (en) 2004-05-13

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