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WO2004038039A3 - Imagerie optique de l'expression de genes rapporteurs de luciferase renilla chez des organismes vivants - Google Patents

Imagerie optique de l'expression de genes rapporteurs de luciferase renilla chez des organismes vivants Download PDF

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Publication number
WO2004038039A3
WO2004038039A3 PCT/US2003/033443 US0333443W WO2004038039A3 WO 2004038039 A3 WO2004038039 A3 WO 2004038039A3 US 0333443 W US0333443 W US 0333443W WO 2004038039 A3 WO2004038039 A3 WO 2004038039A3
Authority
WO
WIPO (PCT)
Prior art keywords
imagiong
optical
renilla luciferase
gene expression
reporter gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/033443
Other languages
English (en)
Other versions
WO2004038039A2 (fr
Inventor
Sanjiv Sam Gambhir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Priority to AU2003285930A priority Critical patent/AU2003285930A1/en
Publication of WO2004038039A2 publication Critical patent/WO2004038039A2/fr
Publication of WO2004038039A3 publication Critical patent/WO2004038039A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés de détection et de localisation de la bioluminescence de la luciférase Renilla (RL) produite par un animal. L'invention concerne également des procédés de ciblage de l'émission de lumière de la luciférase Renilla vers des zones sélectionnées, ainsi que des procédés de localisation d'entités dans l'animal.
PCT/US2003/033443 2002-10-21 2003-10-21 Imagerie optique de l'expression de genes rapporteurs de luciferase renilla chez des organismes vivants Ceased WO2004038039A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003285930A AU2003285930A1 (en) 2002-10-21 2003-10-21 Optical imagiong of renilla luciferase reporter gene expression in living organisms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42041902P 2002-10-21 2002-10-21
US60/420,419 2002-10-21

Publications (2)

Publication Number Publication Date
WO2004038039A2 WO2004038039A2 (fr) 2004-05-06
WO2004038039A3 true WO2004038039A3 (fr) 2004-07-08

Family

ID=32176565

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033443 Ceased WO2004038039A2 (fr) 2002-10-21 2003-10-21 Imagerie optique de l'expression de genes rapporteurs de luciferase renilla chez des organismes vivants

Country Status (2)

Country Link
AU (1) AU2003285930A1 (fr)
WO (1) WO2004038039A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2308978B8 (fr) 2003-10-10 2015-04-08 Promega Corporation Biocapteur à la luciférase
EP2327768B1 (fr) 2006-04-03 2015-09-09 Promega Corporation Biocapteurs de luciférase permutés et non permutés
US9045730B2 (en) 2008-05-19 2015-06-02 Promega Corporation Luciferase biosensors for cAMP
JP5961163B2 (ja) 2010-05-11 2016-08-02 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 増強された検出特性を有する変異プロテアーゼバイオセンサー
US9290794B2 (en) 2010-05-11 2016-03-22 Promega Corporation Mutant protease biosensors with enhanced detection characteristics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059400A1 (en) * 2001-07-31 2003-03-27 Szalay Aladar A. Light emitting microorganisms and cells for diagnosis and therapy of tumors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030059400A1 (en) * 2001-07-31 2003-03-27 Szalay Aladar A. Light emitting microorganisms and cells for diagnosis and therapy of tumors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BHAUMIK S, ET AL: "OPTICAL IMAGING OF RENILLA LUCIFERASE REPORTER GENE EXPRESSION IN LIVING MICE", PROC. NATL. ACAD. SCI. USA, vol. 99, no. 1, 8 January 2002 (2002-01-08), pages 377 - 382, XP002977218 *
WANG W, ET AL: "BIOLUMINESCENT MOLECULAR IMAGING OF ENDOGENOUS AND EXOGENOUS P53-MEDIATED TRANSCRIPTION IN VITRO AND IN VIVO USING AN HCT116 HUMAN COLON CARCINOMA XENOGRAFT MODEL", CANCER BIOLOGY & THERAPY, vol. 2, no. 2, March 2003 (2003-03-01), pages 196 - 202, XP002977219 *
WANG Y, ET AL: "A STUDY OF PROTEIN-PROTEIN INTERACTIONS IN LIVING CELLS USING LUMINESCENCE RESONANCE ENERGY TRANSFER (LRET) FROM RENILLA LUCIFERASE TO AEQUOREA GFP", MOL.GEN.GENET., vol. 264, no. 5, January 2001 (2001-01-01), pages 578 - 587, XP001029977 *
WANG Y, ET AL: "RENILLA LUCIFERASE-AEQUOREA GFP (RUC-GFP) FUSION PROTEIN, A NOVEL DUAL REPORTER FOR REAL-TIME IMAGING OF GENE EXPRESSION IN CELL CULTURES AND IN LIVE ANIMALS", MOLECULAR GENETICS AND GENOMICS, vol. 268, no. 2, October 2002 (2002-10-01), pages 160 - 168, XP002977220 *

Also Published As

Publication number Publication date
AU2003285930A1 (en) 2004-05-13
WO2004038039A2 (fr) 2004-05-06
AU2003285930A8 (en) 2004-05-13

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