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WO2004037192A3 - Identification of antimycobacterial targets and the inhibition thereof as a treatment for infectious diseases - Google Patents

Identification of antimycobacterial targets and the inhibition thereof as a treatment for infectious diseases Download PDF

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Publication number
WO2004037192A3
WO2004037192A3 PCT/US2003/033524 US0333524W WO2004037192A3 WO 2004037192 A3 WO2004037192 A3 WO 2004037192A3 US 0333524 W US0333524 W US 0333524W WO 2004037192 A3 WO2004037192 A3 WO 2004037192A3
Authority
WO
WIPO (PCT)
Prior art keywords
antimycobacterial
targets
inhibition
identification
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/033524
Other languages
French (fr)
Other versions
WO2004037192A2 (en
Inventor
David Howard Avarbock
Harvey Rubin
Andrew Brian Avarbock
Edward Weinstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Priority to AU2003285946A priority Critical patent/AU2003285946A1/en
Publication of WO2004037192A2 publication Critical patent/WO2004037192A2/en
Anticipated expiration legal-status Critical
Publication of WO2004037192A3 publication Critical patent/WO2004037192A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to methods for treating mycobacteria infections, especially M. tuberculosis. The present invention also provides inhibitors and methods of using same to treat and detect mycobacteria infections.
PCT/US2003/033524 2002-10-22 2003-10-22 Identification of antimycobacterial targets and the inhibition thereof as a treatment for infectious diseases Ceased WO2004037192A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003285946A AU2003285946A1 (en) 2002-10-22 2003-10-22 Identification of antimycobacterial targets and the inhibition thereof as a treatment for infectious diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42013102P 2002-10-22 2002-10-22
US60/420,131 2002-10-22

Publications (2)

Publication Number Publication Date
WO2004037192A2 WO2004037192A2 (en) 2004-05-06
WO2004037192A3 true WO2004037192A3 (en) 2006-09-14

Family

ID=32176517

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2003/033692 Ceased WO2004037997A2 (en) 2002-10-22 2003-10-22 Fragments and activity of rel protein in m. tuberculosis adn other uses thereof
PCT/US2003/033524 Ceased WO2004037192A2 (en) 2002-10-22 2003-10-22 Identification of antimycobacterial targets and the inhibition thereof as a treatment for infectious diseases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2003/033692 Ceased WO2004037997A2 (en) 2002-10-22 2003-10-22 Fragments and activity of rel protein in m. tuberculosis adn other uses thereof

Country Status (2)

Country Link
AU (2) AU2003285946A1 (en)
WO (2) WO2004037997A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9371329B2 (en) 2009-07-27 2016-06-21 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
US9403782B2 (en) 2011-05-10 2016-08-02 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
US11834697B2 (en) 2017-09-15 2023-12-05 Oxford University Innovation Limited Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2246349A1 (en) * 2009-04-20 2010-11-03 BKG Pharma ApS Treatment of infectious diseases
ES2529119T3 (en) 2010-07-02 2015-02-17 Gilead Sciences, Inc. Condensed heterocyclic compounds as ion channel modulators
UY34171A (en) 2011-07-01 2013-01-31 Gilead Sciences Inc FUSIONED HETEROCYCLIC COMPOUNDS AS IONIC CHANNEL MODULATORS
NO3175985T3 (en) 2011-07-01 2018-04-28
WO2013043744A2 (en) 2011-09-21 2013-03-28 Inception 1, Inc. Tricyclic compounds useful as neurogenic and neuroprotective agents
CN103232447B (en) * 2013-04-02 2015-06-03 陕西科技大学 3-acetyl-5-acetylimino-2-(N-phenothiazinyl)-1,3,4-thiadiazole, and preparation method and application thereof
CN109385439A (en) * 2018-09-18 2019-02-26 上海晶诺生物科技有限公司 The one recombination TM4 phage library and its application for constructing nadh dehydrogenase gene family missing mycobacterium tuberculosis
WO2023201199A2 (en) * 2022-04-11 2023-10-19 The Johns Hopkins University Tuberculosis vaccines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834279A (en) * 1996-03-07 1998-11-10 Trustees Of The University Of Pennsylvania Methods of identifying compounds that inhibit DNA synthesis in mycobacterium tuberculosis and compositions, reagents and kits for performing the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AMARAL L. ET AL.: "Activity of phemathiazines against antibioticOresistant Mycobacterium tuberculosis: A review supporting further studies that mayy elucidate the potential use of thioridazine an anti-tuberculosis therapy", JOURNAL OF ANTIMICROBIAL CHEMPTHERAPY, vol. 47, no. 5, May 2001 (2001-05-01), pages 505 - 511, XP008048568 *
AMARAL L. ET AL.: "Phenothizzines: an alternative to conventional therapy for the initial mangemnt of suspected multidrug resistant tuberculosis", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol. 14, no. 3, April 2000 (2000-04-01), pages 173 - 176 *
CROWLE A. J. ET AL.: "Chlorpromazine a drug potentially useful for treating mycobacterial infections", CHEMOTHERAPY, vol. 38, no. 6, 1992, pages 410 - 419, XP008048689 *
VIVEIROS M. ET AL.: "Enhancement of antibiotic activity against poly-drug resistant mycobacterium tuberculosis by phenothiazines", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol. 17, no. 3, May 2001 (2001-05-01), pages 225 - 228 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9371329B2 (en) 2009-07-27 2016-06-21 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
US9403782B2 (en) 2011-05-10 2016-08-02 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
US11834697B2 (en) 2017-09-15 2023-12-05 Oxford University Innovation Limited Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria

Also Published As

Publication number Publication date
AU2003294235A1 (en) 2004-05-13
WO2004037192A2 (en) 2004-05-06
AU2003285946A8 (en) 2004-05-13
WO2004037997A3 (en) 2004-11-18
AU2003285946A1 (en) 2004-05-13
AU2003294235A8 (en) 2004-05-13
WO2004037997A2 (en) 2004-05-06

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