[go: up one dir, main page]

WO2004037166A3 - Therapeutic guanidines - Google Patents

Therapeutic guanidines Download PDF

Info

Publication number
WO2004037166A3
WO2004037166A3 PCT/US2003/028950 US0328950W WO2004037166A3 WO 2004037166 A3 WO2004037166 A3 WO 2004037166A3 US 0328950 W US0328950 W US 0328950W WO 2004037166 A3 WO2004037166 A3 WO 2004037166A3
Authority
WO
WIPO (PCT)
Prior art keywords
guanidines
therapeutic
ires
infections
viral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/028950
Other languages
French (fr)
Other versions
WO2004037166A2 (en
Inventor
Elizabeth Anne Jefferson
Punit Seth
Dale E Robinson Jr
Michael Todd Migawa
Richard H Griffey
Eric Edward Swayze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Priority to AU2003298582A priority Critical patent/AU2003298582A1/en
Publication of WO2004037166A2 publication Critical patent/WO2004037166A2/en
Publication of WO2004037166A3 publication Critical patent/WO2004037166A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention is directed, in part, to guanidine derivatives of formula (I), or pharmaceutically acceptable salt forms thereof, compositions thereof, and uses thereof related to, for example, the inhibition of IRES-mediated translation and the treatment of viral and other infections.
PCT/US2003/028950 2002-09-17 2003-09-16 Therapeutic guanidines Ceased WO2004037166A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003298582A AU2003298582A1 (en) 2002-09-17 2003-09-16 Therapeutic guanidines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41159802P 2002-09-17 2002-09-17
US60/411,598 2002-09-17

Publications (2)

Publication Number Publication Date
WO2004037166A2 WO2004037166A2 (en) 2004-05-06
WO2004037166A3 true WO2004037166A3 (en) 2005-01-06

Family

ID=32176445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/028950 Ceased WO2004037166A2 (en) 2002-09-17 2003-09-16 Therapeutic guanidines

Country Status (2)

Country Link
AU (1) AU2003298582A1 (en)
WO (1) WO2004037166A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
WO2007022964A2 (en) * 2005-08-24 2007-03-01 Abbott Gmbh & Co. Kg Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors
DK2474525T3 (en) 2006-12-26 2020-07-13 Lantheus Medical Imaging Inc Ligands for imaging cardiac innervation
US8697694B2 (en) 2008-08-20 2014-04-15 Merck Sharp & Dohme Corp. Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
JP5674661B2 (en) * 2008-08-20 2015-02-25 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ethynyl-substituted pyridine and pyrimidine derivatives and their use in the treatment of viral infections
US8470834B2 (en) 2008-08-20 2013-06-25 Merck Sharp & Dohme Corp. AZO-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
JP5619743B2 (en) 2008-08-20 2014-11-05 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ethenyl substituted pyridine and pyrimidine derivatives and their use in the treatment of viral infections
ES2763815T3 (en) * 2010-05-11 2020-06-01 Lantheus Medical Imaging Inc Compositions, methods and systems for the synthesis and use of imaging agents
TWI568714B (en) 2011-09-09 2017-02-01 藍瑟斯醫學影像公司 Composition, method and system for synthesizing and using contrast agent

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880932A (en) * 1983-03-04 1989-11-14 Bayer Aktiengesellschaft Substituted guanidine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880932A (en) * 1983-03-04 1989-11-14 Bayer Aktiengesellschaft Substituted guanidine derivatives

Also Published As

Publication number Publication date
AU2003298582A8 (en) 2004-05-13
WO2004037166A2 (en) 2004-05-06
AU2003298582A1 (en) 2004-05-13

Similar Documents

Publication Publication Date Title
WO2003053368A3 (en) Chalcone derivatives and their use to treat diseases
WO2002062290A3 (en) Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
WO2003053344A3 (en) Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
AUPR213700A0 (en) Antiviral agents
WO2004005286A3 (en) Viral inhibitors
BR0212042A (en) Compound, pharmaceutical composition, method of treating or preventing disease, and use of a compound
WO1998056761A3 (en) Benzimidazole derivatives
GB0114286D0 (en) Nucleoside Derivatives
WO2003000695A8 (en) Pyrrolopyrimidines as protein kinase inhibitors
WO2005028479A3 (en) Hiv replication inhibiting purine derivatives
EP2431379A3 (en) HCV inhibitors
WO2008054454A3 (en) Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents
WO2002088124A3 (en) Pyrazolo'1,5-a!pyridine derivatives
WO2003037860A3 (en) Purine analogs having hsp90-inhibiting activity
WO2001066564A3 (en) Gamma-secretase inhibitors
DK1317459T3 (en) Bicyclic pyrrolylamides as glucogen phosphorylase inhibitors
ATE371656T1 (en) HETEROARYL-PYRIMIDINE DERIVATIVES AS JAK INHIBITORS
WO2004046159A8 (en) Antiviral nucleoside derivatives
WO2006011050A3 (en) Pyridine derivatives
WO2003053359A3 (en) 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders
NO20045042L (en) 7-aryl -3,9-diazabicyclo (3.1.1) non-6-ene derivatives and their use as renin. inhibitors in the treatment of hypertension, cardiovascular and kidney disease
WO2003047520A3 (en) SUBSTITUTED AMINO METHYL FACTOR Xa INHIBITORS
MXPA03010761A (en) Pharmaceutical combinations.
WO2004043362A3 (en) Acyl guanidine compounds and use thereof
MXPA04006041A (en) Pyridoquinoxaline antivirals.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP