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WO2004031742A1 - Systeme d'imagerie de particules - Google Patents

Systeme d'imagerie de particules Download PDF

Info

Publication number
WO2004031742A1
WO2004031742A1 PCT/GB2003/004230 GB0304230W WO2004031742A1 WO 2004031742 A1 WO2004031742 A1 WO 2004031742A1 GB 0304230 W GB0304230 W GB 0304230W WO 2004031742 A1 WO2004031742 A1 WO 2004031742A1
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
purging
optical component
particles
light source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/004230
Other languages
English (en)
Inventor
Martyn Richard Huw Knowles
Adam Whybrew
Heather Booth
Edward Butcher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Lasers Ltd
Original Assignee
Oxford Lasers Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Lasers Ltd filed Critical Oxford Lasers Ltd
Priority to AU2003269226A priority Critical patent/AU2003269226A1/en
Publication of WO2004031742A1 publication Critical patent/WO2004031742A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N15/0205Investigating particle size or size distribution by optical means
    • G01N15/0227Investigating particle size or size distribution by optical means using imaging; using holography
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15Preventing contamination of the components of the optical system or obstruction of the light path
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N2015/0294Particle shape
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/15Preventing contamination of the components of the optical system or obstruction of the light path
    • G01N2021/151Gas blown

Definitions

  • the present invention relates to an imaging system for producing images of particles, for example for measuring the sizes of particles and/or the velocities of particles in a fluid.
  • the drug in the manufacture of many pharmaceuticals, is crystallized out of solution, and the structure of the crystals may vary depending upon conditions such as the temperature and the concentration of the solution.
  • the drug is formulated from powders, or ground down from solids, for example. It would be highly desirable to many pharmaceutical companies to be able accurately to determine, as the process progresses, whether or not the correct crystal structure is being formed, since the discovery at the end of the process that the process has failed can waste an enormous amount of time and money. This is also true of many other processes, for example the production of cement, since the particle size distribution of the cement particles needs to be within a certain defined range in order for the cement to have the required physical and chemical characteristics. Numerous other processes would also benefit from an accurate method of determining the size and/or shape of particles in a fluid.
  • Imaged based sizing is an important technique for measuring particle sizes. Particles from (for example) 1 micron in diameter and larger (up to hundreds of millimetres) can be measured.
  • the only other technique routinely used for sizing of solids in this size range in industrial processes is laser diffraction. Compared with laser diffraction, image based sizing can measure larger particles and/or more dense distributions and/or give shape information. It can be non-invasive and generally produces unambiguous, easily verifiable results.
  • a typical image based system uses a camera (or other imaging device) fitted with one or more suitable lenses to capture images of the individual particles. These images are then analysed by computer software to produce parameters such as the number of particles, particle diameters and distributions.
  • Illumination of the particles can be front or back-illumination and can be from a laser or non-laser light source.
  • the camera is often a CCD (charge coupled device) or CMOS (complementary metal oxide semiconductor) camera to enable easy interface with the computer.
  • image based sizing is the analysis of particle size distribution during the production of the particles. This is of relevance to the producer of any product which is a particle or powder, or is made from a particle or powder (for example the pharmaceutical industry and the cement industry). Typically the powder is produced in one machine, perhaps a mill, and then conveyed to a subsequent machine for packaging or further processing. In many cases the size and the size distribution of the particles is an important aspect of the quality of the product. Techniques exist for measuring samples of the particles or powders but these are off-line or at- line techniques (rather than in-line) and so are inconvenient and can not generate data fast enough to form part of a feedback system to control the machine that makes the powder.
  • the sample may be unrepresentative of the particles produced, as a whole.
  • image based sizing can generate immediate data that can be used to monitor the process in real time or to control the producing machine.
  • the powders produced adhere to the pipe or window through which the imaging is being performed.
  • the image quality is degraded and eventually the pipe or window becomes opaque or translucent.
  • the present invention seeks to provide a practicable and efficient solution to this problem.
  • a first aspect of the present invention provides an imaging system for producing images of particles in a fluid, comprising:
  • an optical component assembly situated, at least in use, between the light source or the imaging device and the particles to be imaged, the optical component assembly comprising a light transmissive optical component and a fluid purging device arranged to supply a flow of purging fluid adjacent to the optical component to prevent the particles adhering thereto.
  • the purging fluid is a purging gas, for example air or nitrogen.
  • a purging gas for example air or nitrogen.
  • the fluid is inert, and more preferably it is inert gas.
  • United States Patent No. 4,784,491 discloses an optical sensor head for guiding an arc welding process, in which long cylindrical housings extending beyond optical lens and window arrangements are provided with spiral grooves which are intended to provide a swirling motion to a gas which flows towards the welding process, in order to shield the optical arrangement from weld spatter and smoke.
  • United States Patent No. 4,836,689 discloses a radiation pyrometer for monitoring the temperature of turbine blades of a gas turbine. The pyrometer includes a gas purge system for keeping an optical lens of the pyrometer free from contaminants from the gas turbine.
  • the system disclosed in US 4,784,491 directs a gas towards a welding process via long cylindrical housings which are oriented directly at the welding process.
  • the system disclosed in US 4,836,689 is enclosed in a long sight tube and the purging gas flows through the tube past the pyrometer lens towards the turbine blades.
  • Neither system would be suitable for use with a light source and/or imaging device of an imaging system, and neither system would be modifiable by the skilled person (and the skilled person would not attempt such modification) for use with such an imaging system.
  • a second aspect of the present invention provides a method of producing images of particles in a fluid by means of the imaging system according to the first aspect of the invention, the method comprising supplying a flow of purging fluid adjacent to the optical component by means of the fluid purging device, thereby preventing the particles adhering to the optical component.
  • particles in the present specification, may be solid, liquid, or gaseous (or they may even be of intermediate phase, for example gelatinous particles).
  • the particles may be solid particles in a liquid or a gas, or they may be liquid droplets in a gas, or they may be gas bubbles in a liquid.
  • the particles may even have the same phase as the fluid in which they are present, for example they may comprise immiscible liquid droplets in a liquid. Most commonly, however, the particles will be solid particles in a gas.
  • the light source emits electromagnetic radiation preferably in the visible region of the spectrum; however, at least in the broadest aspects of the invention, "light” (and the associated term “optical”) may refer to non-visible wavelengths of the electromagnetic spectrum, for example infrared, microwave, or ultraviolet wavelengths. Consequently, although the image generated by the imaging device will normally be a visible image (or at least an image formed from the detection of visible light), in other embodiments of the invention, the image generated by the imaging device may be invisible to the human eye until it has been processed and presented as an image in the visible region of the spectrum. Furthermore, the expression “illuminated” will normally mean that the particles are illuminated with visible light, but in other embodiments they may be “illuminated” with invisible electromagnetic radiation.
  • Illumination is required in the present imaging system (as with any imaging system) and the subject can be front or back illuminated. Either technique may be used, but back illumination is generally preferred so that the particles are viewed in shadow; this improves the contrast and therefore improves the accuracy of the imaging.
  • the light source may be a laser of any type, fluorescence produced from laser light, a lamp or LED, or other light sources such as arcs and discharges or natural or ambient light.
  • highly intense, short duration illumination can be used as from a pulsed laser or flashlamp or LED. It is preferable to use a diffuse and/or incoherent light source to avoid speckle coherence and diffraction effects especially when imaging small particles at high magnification.
  • the duration of the exposure or illumination to prevent significant blurring depends upon the velocity and size of the particle, but is generally less than 1 microsecond.
  • the imaging device may comprise a camera, especially an electronic camera.
  • Preferred imaging devices include CCD and CMOS cameras, for example.
  • the imaging device may comprise at least one lens (or lens assembly), preferably a high magnification lens having a long working distance.
  • Figure 1 is a schematic illustration of the main components and the arrangement of a preferred embodiment of an imaging system according to the invention
  • Figure 2 is an exploded illustration of part of a preferred embodiment of an imaging system according to the invention, showing in detail the components thereof.
  • Figure 1 shows, schematically, a length of steel pipe 107 which forms part of the imaging system of the invention and which has replaced an identical length of pipe in an industrial process.
  • the industrial process may, for example, be the production of a pharmaceutical or the production of cement, or substantially any process in which particles 106 flowing through a process pipe (in the direction indicated by the arrow) need to be monitored by the imaging systems.
  • each short pipe is sealed and provided with a transparent window 103,110 (i.e. a transmissive optical component).
  • a line of sight i.e. an optical transmission path
  • the windows 103 and 110 preferably are optically flat, but they could instead provide substantially any optical manipulation, e.g. one or both of them could be lenses, prisms beamsplitters, of the like.
  • the windows 103 and 110 are formed from glass, and preferably the short pipes 114 and 115 are formed from steel (and are welded to the pipe 107).
  • the camera 101 which preferably is a digital camera (preferably having a high number and density of pixels, e.g. an array of 1000 x 1000 pixels, each of 9 microns square), includes a lens 102 (preferably a high magnification, long working distance lens).
  • the laser 113 preferably comprises a Nd: YAG laser which preferably is frequency doubled to operate at 532 nm and preferably also is Q-switched to produce a pulse duration of the order of nanoseconds or microseconds (e.g. 5 nanoseconds).
  • the laser light beam is guided by means of beam delivery optics 112, and passes through a fluorescing and diffusing device 111 (for example as describe in co-pending UK patent application no. 0117989.4 from Oxford Lasers Limited) which destroys the coherence of the beam and thereby prevents the occurrence of laser speckle on the image.
  • Each window 103,110 is part of an optical component assembly comprising the window (i.e. the optical component) and first and second fluid purging devices adjacent thereto.
  • First and second fluid purging devices 104 and 105 are adjacent to window 103, and first and second fluid purging devices 109 and 108 are adjacent to window 110.
  • Each fluid purging device preferably comprises a gas purging device which supplies a flow of purging gas adjacent to its respective window to prevent the particles 106 adhering thereto.
  • Figure 2 shows in detail the various components of one of the optical component assemblies shown only schematically in Figure 1.
  • the components are:- 1 tube, 2 fixing plate, 3 cross tube, 4 large gasket, 5 plate gasket, 6 swirl plate (i.e. the second fluid purging device), 7 air distribution plate unit, 8 dowel, 9 air distribution plate (i.e. the first fluid purging device), 10 purging gas supply tube, 11 washer, 12 gasket, 13, bolt, 14 gland, 15 window gasket, 16 ferrule, 17 window housing, 18 nut and 19 window (i.e. the optical component).
  • the air distribution plate 9 comprises the first fluid purging device, and it has a plurality of radially directed slots through which the purging gas is supplied radially across the window 19, thereby providing a "cushion" of the purging gas adjacent to the window, to repel particles from the window.
  • the swirl plate 6, however, is provided with a plurality of non-radial slots (i.e. the slots have a tangential component, as well as a radial component, to their directivity) through the purging gas is supplied, and which cause the purging gas to swirl or revolve (and/or which create turbulence in the supplied purging gas) in order to trap and fling the particles away from the window.
  • the swirl plate 6 comprises the second fluid purging device.
  • One advantage of the invention is that the amount of gas flow required to keep the windows clean is normally quite low. For example, with cornstarch flowing through a 50 mm internal diameter pipe at a rate of 100 kg per hour, gas flow rates of 8 litres per minute per cushion injector and 6 litres per minute per swirl injector are sufficient to keep the windows clean. This is of great significance because a gas transportation system used to convey powder products from one machine to the next can not always tolerate the addition of significant amounts of extra gas. That is, it is not possible to simply use extremely high purging gas flow rates to keep the windows clean.
  • An additional feature of the invention is that should the windows become contaminated over a long period of time or if a gas feed to an injector fails, then it is possible to clean the windows and flange area by briefly increasing the gas flow rate. In the case of cornstarch, for example, a flow rate of 15 litres per minute is sufficient to clean the windows and flange. This is an advantageous feature of the invention compared to having to disassemble the system for cleaning.
  • a further feature of the system according to the invention is that by comparing the position of a particle in one camera frame with its position in the next frame or by double exposing a single camera frame, it is possible to calculate velocity data about the particles.

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

L'invention concerne un système d'imagerie permettant de produire des images de particules dans un fluide, qui comprend: (a) une source lumineuse et/ou un dispositif d'imagerie; et (b) un ensemble composant optique conçu pour être disposé, au moins en cours d'utilisation, entre la source lumineuse ou le dispositif d'imagerie et les particules à imager, ledit ensemble composant optique comprenant un composant optique émetteur de lumière et un dispositif de purge de fluide conçu pour fournir un écoulement de fluide de purge adjacent au composant optique pour empêcher les particules d'adhérer à ce dernier.
PCT/GB2003/004230 2002-10-05 2003-10-01 Systeme d'imagerie de particules Ceased WO2004031742A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003269226A AU2003269226A1 (en) 2002-10-05 2003-10-01 Particle imaging system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0223162.9 2002-10-05
GB0223162A GB2396023A (en) 2002-10-05 2002-10-05 Imaging system with purging device to prevent adhesion of particles

Publications (1)

Publication Number Publication Date
WO2004031742A1 true WO2004031742A1 (fr) 2004-04-15

Family

ID=9945387

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004230 Ceased WO2004031742A1 (fr) 2002-10-05 2003-10-01 Systeme d'imagerie de particules

Country Status (3)

Country Link
AU (1) AU2003269226A1 (fr)
GB (1) GB2396023A (fr)
WO (1) WO2004031742A1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006132980A3 (fr) * 2005-06-06 2007-02-15 Particle Measuring Syst Compteur de particules comprenant une mosaique de detecteurs a image amelioree
WO2008124016A1 (fr) * 2007-04-05 2008-10-16 Parata Systems, Llc Procédés et appareil pour distribuer des articles pharmaceutiques solides
NL2001061C2 (nl) * 2007-12-06 2009-06-09 Friesland Brands Bv Werkwijze en inrichting voor het bereiden van kaas.
WO2010091664A1 (fr) * 2009-02-10 2010-08-19 Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Dispositif et procédé pour relier un dispositif de mesure optique à un volume de mesure
US8054086B2 (en) 2009-06-25 2011-11-08 Parata Systems, Llc Apparatus for dispensing and detecting solid pharmaceutical articles and related methods of operation
US8467899B2 (en) 2007-05-18 2013-06-18 Parata Systems, Llc Apparatus for dispensing solid pharmaceutical articles
CN103244849A (zh) * 2013-04-19 2013-08-14 中国科学院长春光学精密机械与物理研究所 一种出射准直平行光的光源装置
WO2014131611A1 (fr) * 2013-02-26 2014-09-04 Siemens Aktiengesellschaft Conduite à poussière avec capteur optique et procédé pour mesurer la composition de la poussière
DE102014201763A1 (de) * 2014-01-31 2015-08-06 Siemens Aktiengesellschaft Probenaufnahme für eine Messeinrichtung zum Messen einer Staubprobe
JP2017173152A (ja) * 2016-03-24 2017-09-28 ヤンマー株式会社 ガス濃度計測装置
CN108490213A (zh) * 2018-02-08 2018-09-04 上海理工大学 高温气冷堆颗粒流速度场测量装置及方法
WO2020142138A1 (fr) * 2018-12-31 2020-07-09 Dow Global Technologies Llc Sonde optique à haute température
CN112147047A (zh) * 2020-10-26 2020-12-29 浙江四点灵机器人股份有限公司 一种高速流体内颗粒浓度检测装置及方法
CN113008802A (zh) * 2019-12-19 2021-06-22 利萨·德雷克塞迈尔有限责任公司 用于光学检测电导线的检测系统
JP2023539472A (ja) * 2020-08-24 2023-09-14 マズライト インコーポレイテッド 高速移動粒子の特性評価のための方法、システム、及び照明モジュール

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Publication number Priority date Publication date Assignee Title
GB202206168D0 (en) * 2022-04-28 2022-06-15 Avansys Llp Optical detection devices

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Cited By (25)

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GB2441272A (en) * 2005-06-06 2008-02-27 Particle Measuring Syst Particle counter with improved image sensor array
US7456960B2 (en) 2005-06-06 2008-11-25 Particle Measuring Systems, Inc. Particle counter with improved image sensor array
WO2006132980A3 (fr) * 2005-06-06 2007-02-15 Particle Measuring Syst Compteur de particules comprenant une mosaique de detecteurs a image amelioree
WO2008124016A1 (fr) * 2007-04-05 2008-10-16 Parata Systems, Llc Procédés et appareil pour distribuer des articles pharmaceutiques solides
US8813997B2 (en) 2007-05-18 2014-08-26 Parata Systems, Llc Apparatus for dispensing solid pharmaceutical articles
US8467899B2 (en) 2007-05-18 2013-06-18 Parata Systems, Llc Apparatus for dispensing solid pharmaceutical articles
NL2001061C2 (nl) * 2007-12-06 2009-06-09 Friesland Brands Bv Werkwijze en inrichting voor het bereiden van kaas.
WO2009088283A1 (fr) * 2007-12-06 2009-07-16 Friesland Brands B.V. Procédé et appareil de préparation de fromage
WO2010091664A1 (fr) * 2009-02-10 2010-08-19 Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) Dispositif et procédé pour relier un dispositif de mesure optique à un volume de mesure
US8896322B2 (en) 2009-06-25 2014-11-25 Parata Systems, Llc Apparatus for dispensing and detecting solid pharmaceutical articles and related methods of operation
US8054086B2 (en) 2009-06-25 2011-11-08 Parata Systems, Llc Apparatus for dispensing and detecting solid pharmaceutical articles and related methods of operation
WO2014131611A1 (fr) * 2013-02-26 2014-09-04 Siemens Aktiengesellschaft Conduite à poussière avec capteur optique et procédé pour mesurer la composition de la poussière
CN105008894A (zh) * 2013-02-26 2015-10-28 西门子公司 具有光学传感器的粉尘管和用于测量粉尘组成的方法
US9599557B2 (en) 2013-02-26 2017-03-21 Siemens Aktiengesellschaft Dust line with optical sensor, and method for measuring the composition of dust
CN103244849A (zh) * 2013-04-19 2013-08-14 中国科学院长春光学精密机械与物理研究所 一种出射准直平行光的光源装置
DE102014201763A1 (de) * 2014-01-31 2015-08-06 Siemens Aktiengesellschaft Probenaufnahme für eine Messeinrichtung zum Messen einer Staubprobe
JP2017173152A (ja) * 2016-03-24 2017-09-28 ヤンマー株式会社 ガス濃度計測装置
CN108490213A (zh) * 2018-02-08 2018-09-04 上海理工大学 高温气冷堆颗粒流速度场测量装置及方法
CN108490213B (zh) * 2018-02-08 2020-05-19 上海理工大学 高温气冷堆颗粒流速度场测量装置及方法
WO2020142138A1 (fr) * 2018-12-31 2020-07-09 Dow Global Technologies Llc Sonde optique à haute température
CN113348360A (zh) * 2018-12-31 2021-09-03 陶氏环球技术有限责任公司 高温光学探头
US12007330B2 (en) 2018-12-31 2024-06-11 Dow Global Technologies Llc High-temperature optical probe
CN113008802A (zh) * 2019-12-19 2021-06-22 利萨·德雷克塞迈尔有限责任公司 用于光学检测电导线的检测系统
JP2023539472A (ja) * 2020-08-24 2023-09-14 マズライト インコーポレイテッド 高速移動粒子の特性評価のための方法、システム、及び照明モジュール
CN112147047A (zh) * 2020-10-26 2020-12-29 浙江四点灵机器人股份有限公司 一种高速流体内颗粒浓度检测装置及方法

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Publication number Publication date
GB2396023A (en) 2004-06-09
AU2003269226A1 (en) 2004-04-23
GB0223162D0 (en) 2002-11-13

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