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WO2004028438A2 - Dispositif d'emballage analogique et systeme de controle de l'utilisation du contenu - Google Patents

Dispositif d'emballage analogique et systeme de controle de l'utilisation du contenu Download PDF

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Publication number
WO2004028438A2
WO2004028438A2 PCT/CA2003/001419 CA0301419W WO2004028438A2 WO 2004028438 A2 WO2004028438 A2 WO 2004028438A2 CA 0301419 W CA0301419 W CA 0301419W WO 2004028438 A2 WO2004028438 A2 WO 2004028438A2
Authority
WO
WIPO (PCT)
Prior art keywords
cpu
package
receptacles
electrically conducting
packaging device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2003/001419
Other languages
English (en)
Other versions
WO2004028438A3 (fr
Inventor
Michael Petersen
Allan Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intelligent Devices Inc Barbados
Original Assignee
Intelligent Devices Inc Barbados
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intelligent Devices Inc Barbados filed Critical Intelligent Devices Inc Barbados
Priority to AU2003266890A priority Critical patent/AU2003266890A1/en
Publication of WO2004028438A2 publication Critical patent/WO2004028438A2/fr
Publication of WO2004028438A3 publication Critical patent/WO2004028438A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0481—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
    • A61J7/0436—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system resulting from removing a drug from, or opening, a container

Definitions

  • This invention relates to an improvement on an analog method for monitoring the use of blister packaged contents, especially but not limited to patient compliance in taking blister- packaged medication.
  • Blister (form-fill-seal) packaging is an increasingly common means of packaging individual units of many types. Blister packaging is particularly relevant to the packaging of unit doses of medications.
  • an analog packaging device for monitoring use of packaged contents.
  • the packaging device comprises a blister package, a central processing unit (CPU), and electrically conducting paths integrated in the package.
  • the package has one or more sealable receptacles, compartments or blisters for accommodating contents.
  • Two analog methodologies are described. In both, a number of receptacles can be accommodated on one electrically conducting path to the CPU, with each receptacle having its own associated electrically conducting path. Expelling the contents of the receptacle results in the conducting path associated with that particular receptacle being broken, changing the electrical characteristics of the circuit in accordance with Ohm's Law.
  • the CPU monitors one or more of the electrical characteristics (voltage, resistance, current) of the conducting path, and generates content use data when changes of a predetermined magnitude are detected.
  • the receptacles and their associated electrically conducting paths are arranged as resistances in parallel. In the second described embodiment they act as resistances in series.
  • the time of expulsion (and other data of interest) can later be retrieved from the memory by an interested party.
  • the system may incorporate its own antenna, infrared port, or other means to permit active downloading of data when required, as described in Applications Nos. 2,353,350 and 2,366,687.
  • the present invention may also be enhanced by the provision of one or more reference resistors in the conducting path or paths to accommodate variations in the paths that are printed on the substrate of the blister pack. Such reference resistors would provide a baseline resistance value for the circuit in question, which baseline would be based on the circuit as printed.
  • the CPU would initially check to see whether the resistance across the reference resistor(s) has changed from the baseline value and if there is any change it would be taken into consideration by the CPU as it decides whether a recordable event has taken place.
  • Another enhancement would be the provision off a voltage divider circuit, printed on the substrate, which circuit would permit the CPU to enter a power-conserving "sleep" mode during periods of inactivity. Only when a recordable event takes place would the CPU “wake up” to take cognizance of the event.
  • FIG. 1 schematically illustrates a blister package with an electrically conducting analog path (circuit) laid out in such a way that the blisters and their associated electrically conducting paths act as resistances in parallel in the circuit, and a central processing unit (CPU) with analog-to-digital converter (ADC), in accordance with a first embodiment of the present invention
  • FIG. 2 schematically illustrates a blister package with an electrically conducting analog path (circuit) laid out in such a way that the blisters and their associated electrically conducting paths act as resistances in series in the circuit, and a central processing unit (CPU) with analog-to-digital converter (ADC), in accordance with a second embodiment of the present invention
  • FIGS. 3 and 3A schematically illustrate a unit dose blister packaged medication with analog monitoring system using longitudinally arranged blisters (roll format) and their associated electrically conducting paths as resistances in parallel;
  • FIG. 4 illustrates the provision of a voltage divider option for the present invention.
  • FIG. 1 schematically illustrates a package device 10 in accordance with a first embodiment of the present invention.
  • the package device 10 comprises a package 12 and a content use monitoring system 14.
  • the monitoring system 14 comprises an embedded central processing unit (CPU) 16 in the form of an electronic chip with an analog-to-digital converter (ADC) and an electrically conducting path or circuit 18 provided on the package.
  • CPU central processing unit
  • ADC analog-to-digital converter
  • the conducting elements of the conducting path 18 may be of wire, metal foil, conducting printed (ink) path, or other suitable electrically conducting material.
  • Across each receptacle 20 is arranged a further electrically conducting path or element 24 such that the receptacles and their corresponding paths comprise a plurality of resistances in parallel between the inputs 22 of the CPU 16. Expelling the contents of the receptacle breaks the associated parallel trace, path or element, thereby changing the electrical characteristics of the circuit in accordance with Ohm's Law.
  • the conducting path may be applied or printed to either surface of the lidstock or to either surface of the backing sheet if such is provided.
  • the CPU 16 and its associated ADC monitor the electrical characteristics of the circuit either continuously or at intervals of interest. Voltage, resistance, current, or any combination of these characteristics can be monitored.
  • In the program memory of the CPU are stored predetermined changes or thresholds that are to be considered as representing content expulsion events. When the CPU detects such changes, the time and other characteristics of interest are stored in the data memory.
  • the data memory can be either volatile or nonvolatile with the latter being preferred.
  • FIG. 1 shows a single electrically conducting circuit connected to two input pins of the CPU.
  • FIG. 2 depicts an analog methodology using resistances in series. In some applications it may prove superior to the embodiment using parallel resistances shown in FIG. 1 as it is a means of improving on the design in FIG. 1 to increase the sensitivity and accuracy of detecting changes in the electrical characteristics of the circuit caused by content expulsions.
  • the electrically conducting paths are printed on the blister package backing, its associated cardboard over-packaging or lidstock, or on the plastic of the blister, there may be process variations due to different manners of expelling contents or small differences in locations of the paths in reference to their associated blisters. For example, if the path is printed across a perforated area in the cardboard backing, the resistance change occasioned by expelling the content will depend on the extent to which the perforation may have cut into the conducting path.
  • the number of blister contents that can be monitored by a single analog circuit is a function of: the range of electrical changes that can be detected by the CPU, which in turn depends on the voltage that can be applied; and the signal-to-noise ratio required to detect reliably a change in the electrical characteristics of the circuit representative of an expulsion event. Any variability in the resistances across the blisters will introduce noise into the system, requiring a larger signal to be used as the criterion for an expulsion event.
  • FIG. 2 shows a means of increasing the accuracy of detecting content expulsion events.
  • the resistances associated with the blisters 20 are arranged in series in the circuit. For each blister there is an associated low resistance conducting path 26 and an associated high resistance path 28.
  • the high resistance path can be located anywhere on the package, as long as it remains connected to the grid after the expulsion event has occurred. Expelling a blister's contents breaks the associated low resistance path 26, redirecting the current through the associated high resistance path 28 and thus altering the electrical characteristics of the circuit.
  • This embodiment allows for more accurate printing or other application of resistors as they can be located at the best place for this according to the production process used. In addition, there will be less process variability due to varied means of expelling blister contents, or having the path resistances altered by such production variability as location of perforations or bleed through of inks and other conductive materials into other package substrates.
  • resistances in series is preferable to using resistances in parallel because of the linear nature of series resistance as compared to the exponential nature of resistances in parallel. This may permit the use of lower signal to noise ratios, increasing the range of changes (steps) that can be detected in a circuit of a given voltage. This in turn may allow monitoring the content of larger numbers of blisters by a single analog circuit.
  • FIG. 2 has a further advantage.
  • a different resistance can be associated with each blister, or a subset of blisters, allowing collection of data specific to an individual blister or subset of blisters.
  • analog aspects of this invention using resistances in parallel and resistances in series can both be adapted to monitoring specific areas of a package by adding additional electrical circuits terminating on other input pins of the CPU.
  • the CPU can be disposable or reusable and requires an associated ADC, either internal or external, to permit monitoring of the electrical characteristics of the circuits), the CPU can be secured directly to the lidstock close to, or separated from, the blister zone of the package. It could even be mounted within its own blister.
  • FIGS. 3 and 3A depict a roll or strip 30 of unit dose medication provided in blisters or receptacles 40, such as is often used by hospital pharmacies to package patient medications, but which can be used to package other unit contents.
  • the user tears the end package 32 off the roll along the perforations 34.
  • a circuit 36 of electrically conducting paths is arranged so that the package and its associated conducting paths form resistances in parallel within the electrical circuit monitored by the CPU 38. Tearing one or more packages from the roll causes changes in the electrical characteristics of the circuit 36, which is monitored by the ADC and CPU for such changes.
  • the time and other characteristics of the event are stored in the CPU's data memory, to be retrieved later by an interested party, as described above.
  • One such enhancement involves the printing of one or more reference resistors on the package substrate.
  • the CPU is required to detect changes in the electrical characteristics of a circuit comprising in whole or part paths printed with electrically conductive ink.
  • the number of steps or events that a CPU, via its ADC, can differentiate is a function of the variability inherent in the circuitry.
  • the number of steps is limited only by the ability of the CPU and ADC to discriminate changes in the electrical characteristics of the circuit.
  • Circuits involving paths of conductive ink are subject to many sources of variation. The printing process can be imprecise, possibly giving rise to variations in thickness and width of the printed paths.
  • the electrical characteristics of printed conductive ink circuitry may change over the course of a print run due to changes in the ink over time. For example, suspended conductive particles may settle, or the viscosity of the ink may change, affecting the electrical characteristics of the resulting printed circuitry.
  • flexible substrates such as paper and paperboard are subject to dimensional changes resulting from changes in their water content as a result of environmental humidity. Such changes affect the physical dimensions and electrical characteristics of any adherent conductive ink paths.
  • Reference resistors can be used to control for such variability. These resistors are printed as part of the printing process, using the same conductive ink as the circuitry. They are of fixed size, with dimensions that can be adjusted according to the concerns of interest, and they can be located anywhere on the substrate, including at multiple locations, to control for positional effects on the printed substrate. The resistors are subject to the same effects described above for the printed circuitry.
  • the CPU via its ADC measures the resistance across the printed reference resistor(s) through a separate circuit, establishing an initial reference resistance baseline for each printed sample.
  • the CPU first checks to see if the resistance across the reference resistor(s) has changed from the baseline value. The resistance measured across the printed electrical circuit is then adjusted by the CPU to account for changes in the reference resistor circuit.
  • Reference resistors printed on each sheet of substrate reflect the variability in electrical characteristics of the printed circuitry at that point in the printing process, allowing the CPU monitoring that sheet of circuitry to be tuned initially to its precise electrical characteristics.
  • changes across a single printed sheet can be monitored by reference resistors printed, for example, in the four corners of the sheet.
  • reference resistors printed, for example, in the four corners of the sheet.
  • Such multiple resistors could have their resistances averaged for the given sheet or they could be monitored individually.
  • the average resistance over the multiple resistors could be used to adjust changes in resistance detected across the printed conductive ink circuitry.
  • This adjustment process could be made more precise by monitoring the four reference resistors described above individually, and using changes in resistance from their baselines to adjust the resistances across the four respective quadrants of the sheet of printed circuitry.
  • a voltage divider circuit is formed by a reference resistor R ref and the resistance offered by the printed conductive ink path R-r between logic 1 and logic 0 potentials.
  • the middle of the voltage divider circuit is connected to an input of the CPU and can interrupt the CPU's sleep mode when a specified change in potential occurs. This allows the CPU to operate in two modes. During sleep mode the CPU draws minimal current, preserving battery power.
  • the voltage divider allows the CPU to be awakened to full operating mode by a change in resistance in the circuit such as might be occasioned by a user expelling a medication dose from its blister.
  • Additional functionality can be added to the system by adding light-emitting diodes (LEDs), speakers, or other warning devices to alert the user about use or misuse of the package and/or its contents.
  • Functionality can also be increased by adding sensors or other devices to monitor exposure of the package to other environmental variables such as, but not limited to, temperature, humidity, light, radiation, shock, and vibration.
  • Functionality can further be increased by varying the method of data transmission to and from the CPU's procedure and/or data memories by an interested party, for example by radiofrequency (RF) or infrared (IR) transmission, direct contact interface, or other methods, that do not affect the function of the analog methods previously described, according to the requirements of the user or the package system.
  • RF radiofrequency
  • IR infrared

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Arrangements For Transmission Of Measured Signals (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un dispositif d'emballage permettant de contrôler l'utilisation de contenus emballés au moyen d'une méthode analogique. Le dispositif d'emballage décrit dans cette invention comprend un boîtier (12), un chemin de conduction électrique (18) et une unité centrale (CPU) (14), un convertisseur analogique-numérique étant incorporé dans le boîtier. Le boîtier comprend un ou plusieurs réceptacles scellables (20) conçus pour renfermer les contenus. Le chemin de conduction électrique est associé à chaque réceptacle de telle sorte que les réceptacles et leurs chemins associés comprennent soit des résistances en parallèle, soit des résistances en série dans le circuit. L'ouverture du réceptacle scellé et l'expulsion de son contenu modifient les caractéristiques électriques du circuit. L'unité centrale (CPU) et son convertisseur analogique-numérique contrôlent les modifications des caractéristiques électriques du chemin de conduction électrique et ils génèrent des données d'utilisation du contenu lorsque des modifications des caractéristiques électriques du circuit sont détectées.
PCT/CA2003/001419 2002-09-24 2003-09-17 Dispositif d'emballage analogique et systeme de controle de l'utilisation du contenu Ceased WO2004028438A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003266890A AU2003266890A1 (en) 2002-09-24 2003-09-17 Analog packaging device and content use monitoring system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA 2404805 CA2404805A1 (fr) 2002-09-24 2002-09-24 Dispositif analogique d'integration et systeme de surveillance de l'utilisation du contenu
CA2,404,805 2002-09-24

Publications (2)

Publication Number Publication Date
WO2004028438A2 true WO2004028438A2 (fr) 2004-04-08
WO2004028438A3 WO2004028438A3 (fr) 2004-06-24

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PCT/CA2003/001419 Ceased WO2004028438A2 (fr) 2002-09-24 2003-09-17 Dispositif d'emballage analogique et systeme de controle de l'utilisation du contenu

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AU (1) AU2003266890A1 (fr)
CA (1) CA2404805A1 (fr)
WO (1) WO2004028438A2 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005043087A1 (fr) * 2003-11-03 2005-05-12 Intelligent Devices Inc. Procede de production de capteurs de pression et d'humidite a couche mince appliquee sur un support par impression flexographique
WO2006002667A1 (fr) * 2004-06-30 2006-01-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Emballage-blister
WO2009000424A3 (fr) * 2007-06-22 2009-03-05 Alcan Tech & Man Ltd Système pour contrôler un processus de prise de médicaments
WO2012049446A1 (fr) * 2010-10-14 2012-04-19 Future Technology (Uk) Ltd Joints d'étanchéité
WO2012110701A1 (fr) * 2011-02-15 2012-08-23 Stora Enso Oyj Boîtier intelligent et procédé pour fabriquer le boîtier
EP2826456A1 (fr) * 2013-06-28 2015-01-21 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Membrane et système de contrôle d'une ouverture de la membrane
WO2016070272A1 (fr) * 2014-11-04 2016-05-12 Intelligent Devices Sezc Inc. Moyens pour contrôler la compliance, faciliter la distribution automatique et protéger les enfants de médicaments conditionnés en bande
WO2017186314A1 (fr) * 2016-04-29 2017-11-02 Hp Indigo B.V. Circuit de surveillance
US10610454B2 (en) 2015-08-25 2020-04-07 Rajwant Singh Mahal System for delivery and control of medications and related methods
CN113406705A (zh) * 2021-06-21 2021-09-17 杭州录鸣科技有限公司 一种基于薄膜电路的物品监测系统和监测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3335301C2 (de) * 1983-06-25 1985-05-02 Udo 8500 Nürnberg Simon Arzneimittelbehälter
FR2753089B1 (fr) * 1996-09-09 1999-02-12 Biostat Pilulier electronique de poche a compartiments multiples
CA2272017A1 (fr) * 1998-05-29 1999-11-29 Alusuisse Technology & Management Ltd. Opercule avec bandes conductrices

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005043087A1 (fr) * 2003-11-03 2005-05-12 Intelligent Devices Inc. Procede de production de capteurs de pression et d'humidite a couche mince appliquee sur un support par impression flexographique
WO2006002667A1 (fr) * 2004-06-30 2006-01-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Emballage-blister
WO2009000424A3 (fr) * 2007-06-22 2009-03-05 Alcan Tech & Man Ltd Système pour contrôler un processus de prise de médicaments
US8973773B2 (en) 2010-10-14 2015-03-10 Future Technology (Uk) Ltd Seals
WO2012049446A1 (fr) * 2010-10-14 2012-04-19 Future Technology (Uk) Ltd Joints d'étanchéité
CN103415448A (zh) * 2010-10-14 2013-11-27 未来技术（英国）有限公司 密封件
CN103415448B (zh) * 2010-10-14 2015-07-15 未来技术（英国）有限公司 用于储存和分发消费品的容器及与其一起使用的密封件
AU2011315317B2 (en) * 2010-10-14 2015-01-22 Future Technology (Uk) Ltd Seals
WO2012110701A1 (fr) * 2011-02-15 2012-08-23 Stora Enso Oyj Boîtier intelligent et procédé pour fabriquer le boîtier
US9622942B2 (en) 2011-02-15 2017-04-18 Stora Enso Oyj Smart package and method for manufacturing the package
EP2826456A1 (fr) * 2013-06-28 2015-01-21 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Membrane et système de contrôle d'une ouverture de la membrane
WO2016070272A1 (fr) * 2014-11-04 2016-05-12 Intelligent Devices Sezc Inc. Moyens pour contrôler la compliance, faciliter la distribution automatique et protéger les enfants de médicaments conditionnés en bande
US10588826B2 (en) 2014-11-04 2020-03-17 Intelligent Devices Sezc Inc. Means for monitoring compliance, facilitating automatic dispensing and childproofing strip packaged medications
US10610454B2 (en) 2015-08-25 2020-04-07 Rajwant Singh Mahal System for delivery and control of medications and related methods
WO2017186314A1 (fr) * 2016-04-29 2017-11-02 Hp Indigo B.V. Circuit de surveillance
CN108603904A (zh) * 2016-04-29 2018-09-28 惠普深蓝有限责任公司 监控电路
US11016131B2 (en) 2016-04-29 2021-05-25 Hp Indigo B.V. Monitoring circuitry
US11686752B2 (en) 2016-04-29 2023-06-27 Hp Indigo B.V. Monitoring circuitry
CN113406705A (zh) * 2021-06-21 2021-09-17 杭州录鸣科技有限公司 一种基于薄膜电路的物品监测系统和监测方法

Also Published As

Publication number Publication date
WO2004028438A3 (fr) 2004-06-24
AU2003266890A8 (en) 2004-04-19
AU2003266890A1 (en) 2004-04-19
CA2404805A1 (fr) 2004-03-24

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