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WO2004027421A3 - Dosage adp - Google Patents

Dosage adp Download PDF

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Publication number
WO2004027421A3
WO2004027421A3 PCT/GB2003/004015 GB0304015W WO2004027421A3 WO 2004027421 A3 WO2004027421 A3 WO 2004027421A3 GB 0304015 W GB0304015 W GB 0304015W WO 2004027421 A3 WO2004027421 A3 WO 2004027421A3
Authority
WO
WIPO (PCT)
Prior art keywords
adp
binding protein
labelled
assay
competitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/004015
Other languages
English (en)
Other versions
WO2004027421A2 (fr
Inventor
Nick Gee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innova Biosciences Ltd
Original Assignee
Innova Biosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innova Biosciences Ltd filed Critical Innova Biosciences Ltd
Priority to AU2003264887A priority Critical patent/AU2003264887A1/en
Publication of WO2004027421A2 publication Critical patent/WO2004027421A2/fr
Publication of WO2004027421A3 publication Critical patent/WO2004027421A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/008—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions for determining co-enzymes or co-factors, e.g. NAD, ATP
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD, ATP

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Pulmonology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)

Abstract

La présente invention a trait à un dosage ADP dans lequel l'ADP est détecté au moyen d'une protéine de liaison à l'ADP. On peut utiliser un format de dosage direct dans lequel l'ADP étiqueté est généré à partir d'un précurseur étiqueté. Le signal généré par l'ADP étiqueté est détecté lors de la liaison de l'ADP à la protéine de liaison à l'ADP. En variante, dans un mode de réalisation préféré, on peut utiliser un format de dosage indirect dans lequel un compétiteur de l'ADP est présent. Le compétiteur de l'ADP ou la protéine de liaison à l'ADP est étiqueté(e). Un signal généré lors de la liaison du compétiteur à la protéine de liaison à l'ADP, et le signal est réduit en présence de l'ADP. Si l'ATP est présent dans l'échantillon, le dosage peut également inclure une étape de modification de l'ATP de sorte qu'il ne puisse se lier à la protéine de liaison à l'ADP.
PCT/GB2003/004015 2002-09-17 2003-09-17 Dosage adp Ceased WO2004027421A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003264887A AU2003264887A1 (en) 2002-09-17 2003-09-17 Adp assay

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0221561A GB2394286A (en) 2002-09-17 2002-09-17 An assay for adp using an adp binding protein
GB0221561.4 2002-09-17

Publications (2)

Publication Number Publication Date
WO2004027421A2 WO2004027421A2 (fr) 2004-04-01
WO2004027421A3 true WO2004027421A3 (fr) 2004-06-17

Family

ID=9944237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004015 Ceased WO2004027421A2 (fr) 2002-09-17 2003-09-17 Dosage adp

Country Status (3)

Country Link
AU (1) AU2003264887A1 (fr)
GB (1) GB2394286A (fr)
WO (1) WO2004027421A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8088897B2 (en) 2003-01-30 2012-01-03 BellBrook Labs, Inc. Assay method for group transfer reactions
CA2514877A1 (fr) * 2003-01-30 2004-08-12 Bellbrook Labs, Llc Procede relatif a des essais de reactions a transfert de groupe
US7355010B2 (en) 2003-01-30 2008-04-08 Bellbrook Labs, Llc Assay method for group transfer reactions
EP1869083A1 (fr) * 2005-05-26 2007-12-26 BellBrook Labs, LLC Procede d analyse destine aux reactions a transfert de groupe
WO2010011607A1 (fr) * 2008-07-22 2010-01-28 Promega Corporation Dosage luminescent de la phosphotransférase ou de l’atp hydrolase basé sur la détection de l’adp
GB0817166D0 (en) * 2008-09-19 2008-10-29 Medical Res Council Sensor
EP3204509B1 (fr) 2014-10-08 2019-07-10 Promega Corporation Dosage de détection de succinate bioluminescente
CN111850065B (zh) * 2020-07-29 2022-05-03 江南大学 一种辅助全细胞转化合成l-天冬酰胺的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5531020A (en) * 1978-08-26 1980-03-05 Asahi Chem Ind Co Ltd Preparation of antiserum for coenzyme

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6946244B2 (en) * 2001-08-07 2005-09-20 Euroscreen, S.A. Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5531020A (en) * 1978-08-26 1980-03-05 Asahi Chem Ind Co Ltd Preparation of antiserum for coenzyme

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ADLER J R ET AL: "SOLUBILIZATION AND CHARACTERIZATION OF A PLATELET MEMBRANE ADP BINDING PROTEIN", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 254, no. 10, 1979, pages 3866 - 3872, XP002275432, ISSN: 0021-9258 *
DATABASE WPI Section Ch Week 198016, Derwent World Patents Index; Class B04, AN 1980-28078C, XP002275539 *
DROCOURT J L ET AL: "Antibodies to adenosine 5'-monophosphate: purification and specificity.", EUROPEAN JOURNAL OF BIOCHEMISTRY / FEBS. GERMANY, WEST 1 AUG 1975, vol. 56, no. 1, 1 August 1975 (1975-08-01), pages 149 - 155, XP008029162, ISSN: 0014-2956 *
GRENERT JAMES P ET AL: "The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 38, 1997, pages 23843 - 23850, XP002275431, ISSN: 0021-9258 *
MEYER T ET AL: "Production of anti-(ADP-ribose) antibodies with the aid of a dinucleotide-pyrophosphatase-resistant hapten and their application for the detection of mono(ADP-ribosyl)ated polypeptides.", EUROPEAN JOURNAL OF BIOCHEMISTRY / FEBS. GERMANY, WEST 17 FEB 1986, vol. 155, no. 1, 17 February 1986 (1986-02-17), pages 157 - 165, XP008029164, ISSN: 0014-2956 *
PRODROMOU C ET AL: "Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 90, 11 July 1997 (1997-07-11), pages 65 - 75, XP002211193, ISSN: 0092-8674 *
SCHULTZ V ET AL: "Bioluminometric assay of ADP and ATP at high ATP/ADP ratios: assay of ADP after enzymatic removal of ATP.", ANALYTICAL BIOCHEMISTRY. UNITED STATES DEC 1993, vol. 215, no. 2, December 1993 (1993-12-01), pages 302 - 304, XP002275430, ISSN: 0003-2697 *

Also Published As

Publication number Publication date
WO2004027421A2 (fr) 2004-04-01
GB0221561D0 (en) 2002-10-23
AU2003264887A1 (en) 2004-04-08
GB2394286A (en) 2004-04-21

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