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WO2004026475A1 - Plateau d'echantillonnage - Google Patents

Plateau d'echantillonnage Download PDF

Info

Publication number
WO2004026475A1
WO2004026475A1 PCT/AU2003/001222 AU0301222W WO2004026475A1 WO 2004026475 A1 WO2004026475 A1 WO 2004026475A1 AU 0301222 W AU0301222 W AU 0301222W WO 2004026475 A1 WO2004026475 A1 WO 2004026475A1
Authority
WO
WIPO (PCT)
Prior art keywords
wells
sample plate
film
sheet
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2003/001222
Other languages
English (en)
Inventor
Josef Pfistershammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AG-ID Pty Ltd
Original Assignee
AG-ID Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AG-ID Pty Ltd filed Critical AG-ID Pty Ltd
Priority to AU2003260182A priority Critical patent/AU2003260182A1/en
Publication of WO2004026475A1 publication Critical patent/WO2004026475A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/08—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using ultrasonic vibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/114—Single butt joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/20—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines
    • B29C66/24—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight
    • B29C66/242—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours
    • B29C66/2422—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being circular, oval or elliptical
    • B29C66/24221—Particular design of joint configurations particular design of the joint lines, e.g. of the weld lines said joint lines being closed or non-straight said joint lines being closed, i.e. forming closed contours being circular, oval or elliptical being circular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/302—Particular design of joint configurations the area to be joined comprising melt initiators
    • B29C66/3022—Particular design of joint configurations the area to be joined comprising melt initiators said melt initiators being integral with at least one of the parts to be joined
    • B29C66/30223—Particular design of joint configurations the area to be joined comprising melt initiators said melt initiators being integral with at least one of the parts to be joined said melt initiators being rib-like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
    • B29C66/5346—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat
    • B29C66/53461—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially flat joining substantially flat covers and/or substantially flat bottoms to open ends of container bodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles

Definitions

  • the present invention relates to sample plates. More particularly, the sample plate of the present invention is intended to prevent contamination of reagents or samples contained therein and to allow use with optical scanning techniques conducted from below the sample plate.
  • sample plates or titre plates are designed to receive samples in an array of wells in the plate.
  • the content of these wells may then be investigated optically and/or by a sample being drawn from the wells and a test performed on those samples.
  • the applications for these sample plates are many and varied in the sciences and particularly biotechnology applications.
  • oligonucleotide probe such as that described in International Patent Application PCT/AU 01/01246 (WO 02/29085). It is vital that the integrity of such probes be protected as far as possible during handling of the plate, including its storage and handling. Any interference with such probes will impact upon the reproducibility of any tests.
  • a sample plate characterised by having provided therein an array of wells open to an upper surface of the plate, the upper surface of the plate having provided thereacross a film or sheet sealing the wells from contamination and/or contact.
  • a base of at least a portion of the wells are at least in part transparent, such that a lower surface of the sample plate may be placed on or in close proximity to an optical measuring device whereby an optical measurement of activity within the wells may be undertaken from beneath the sample plate.
  • an inner surface of the film or sheet is reflective such that light incident upon the inner surface is reflected downwardly into the well below it.
  • the film or sheet is preferably sealed to the upper surface of the sample plate.
  • a plurality of contact points upstanding from the upper surface of the sample plate are preferably provided for sealing with the film or sheet.
  • the sides of the wells are preferably at least opaque to prevent light transmission between adjacent wells.
  • the sheet or film is formed of a material that may be pierced without substantially interfering with the integrity of the sheet or film, such that a sample or reagent may be introduced into one or more of the wells without destroying the integrity of the sheet or film.
  • a method for the optical measurement of an array of samples characterised by a sample plate containing an array of discreet wells, at least a portion of the wells containing a sample to be measured, the sample plate being positioned above a charged coupled device whereby an optical image of the samples within the wells can be obtained from beneath so as to determine an activity or similar measurement within the well, the charged coupled device being such that all wells of the sample plate are measured simultaneously.
  • the charge coupled device utilised is capable of imaging a plate containing 324 wells in an 18 x 18 array.
  • Figure 1 is a cross-sectional side or end view of a sample plate in accordance with the present invention, showing the sheet or film in position thereon;
  • Figure 2 is a plan view of the sample plate of Figure 1 , showing the sheet or film having been removed to expose the wells.
  • FIGS 1 and 2 there is shown a sample plate 10 of generally square configuration, the sample plate 10 having a plate body 12 defining edges 14, an upper surface 16 and a lower surface 18.
  • the plate body 12 in turn comprises upper and lower portions, 11 and 13 respectively.
  • the upper portion 11 of the plate body 12 has provided therein an 18 x 18 array of wells 20 extending through the full thickness thereof.
  • the wells 20 extend from their opening at the upper surface 16 to end at the lower portion 13, forming a base 22 therein.
  • Each well 20 is further provided with walls 24 that diverge from the base 22 towards the upper surface 16.
  • each well 20 is of generally inverted frusto-conical form.
  • the upper portion 11 is formed of an opaque material whilst the lower portion 13 is formed of a transparent or at least translucent material.
  • the upper surface 16 has provided at its edges 14 an upstanding contact point or rim 26 extending thereabout. In addition to the rim 26 there are also provided a series of additional upstanding contact points 28 spread across the upper surface 16 in between various of the wells 20.
  • a film or sheet 30 is attached to the rim 26 and contact points 28, for example by way of ultrasonic welding, such that the upper surface 16 and wells 20 of the sample plate 10 are hermetically sealed.
  • the film or sheet 30 is provided with a reflective inner surface, being the surface adjacent the upper surface 16 of the plate body 12. It is envisaged that the film or sheet 30 may be formed of silicon rubber.
  • the walls 24 of the wells 20 are at least substantially opaque such that light from one well 20 does not penetrate into an adjacent well 20.
  • the base 22 of each well 20 is at least in part transparent. Further, at least the portion of the lower surface 18 of the plate body 12 adjacent each base 22 is transparent such that the sample plate 10 may be placed on an optical measuring device, for example a charge coupled device (CCD), and an optical measurement of activity within the well 20 may be undertaken.
  • CCD charge coupled device
  • sample plate 10 of the present invention were, for example, to be utilised in the method described in International Patent Application PCT/AU01/01246 (WO 02/29085), the content of which is incorporated herein by reference, this would allow oligonucleotide probes for three single nucleotide polymorphisms to be applied to the wells 20 across each row thereof such that diallelic polymorphisms are investigated three times across that row.
  • the film or sheet 30 is ultrasonically welded to the rim 26 and contact points 28 to hermetically seal and protect the upper surface 16 and the wells 20 of the plate body 12.
  • One or more reagents 32 may be injected into the wells 20 by the punching of a small hole through the film or sheet 30 adjacent each well 20, without substantially interfering with the reflective nature of the inner surface, nor with the integrity of the film or sheet 30.
  • the relevant investigation is the detection of the cleavage of a 3' base from the oligonucleotide probe and the subsequent primer extension by way of a DNA polymerase.
  • Such a method may include the use of ATP sulfurylase and firefly luciferase (Nyren, 1987, Anal. Biochem. 167: 235). These comprise a means of converting pyrophosphate to ATP, the ATP being hydrolysed by the luciferase to produce light.
  • the cleavage event is typically detected by optical means, including the use of a charge coupled device • (CCD) or digital camera.
  • CCD charge coupled device •
  • the image that is generated by the optical means is typically then processed by a computer equipped with suitable software to convert that image into desired and meaningful information.
  • any light generated in a well 20 may be detected through the base 22 of the well 20 and the lower surface 18 by the CCD on which the plate 10 sits, largely due to the substantially transparent nature thereof.
  • light generated within one well 20 is not passed into adjacent wells 20.
  • the reflective nature of the inner surface of the film or sheet 30 adds to the sensitivity of any such method using the sample plate 10 of the present invention, as light generated is reflected downwardly back into the well 20 for potential detection by the CCD.
  • each well is 0.8 mm in diameter
  • each well 20 is about 2 mm deep
  • the plate body 12 is 4 mm thick
  • each well base 22 is 0.7 mm in diameter
  • the sample plate is 25 x 25 mm.
  • the wall 24 of the wells 20 need not diverge and may be substantially parallel.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Optical Measuring Cells (AREA)

Abstract

L'invention concerne un plateau d'échantillonnage (10) présentant un réseau de puits (20) ouvert sur une surface supérieure (16) du plateau (10). La surface supérieure (16) du plateau (10) présente un film ou une feuille (30) posée sur celle-ci, ce qui permet de réaliser l'étanchéité des puits (20), les protégeant ainsi de toute contamination et/ou de tout contact. L'invention concerne également une méthode de mesure optique d'un réseau d'échantillons. Cette méthode consiste à fournir un plateau d'échantillonnage (10) contenant un réseau de puits discrets (20), au moins une partie de ces puits (20) contenant un échantillon à mesurer. Le plateau d'échantillonnage (10) est positionné au-dessus d'un dispositif couplé chargé. Une image optique des échantillons situés à l'intérieur des puits (20) peut être obtenue, par en-dessous, de sorte à déterminer une activité ou une mesure similaire à l'intérieur du puits (20). Le dispositif couplé chargé est tel que tous les puits (20) du plateau d'échantillonnage (10) sont mesurés simultanément.
PCT/AU2003/001222 2002-09-17 2003-09-17 Plateau d'echantillonnage Ceased WO2004026475A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003260182A AU2003260182A1 (en) 2002-09-17 2003-09-17 Sample plate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2002951424A AU2002951424A0 (en) 2002-09-17 2002-09-17 Sample plate
AU2002951424 2002-09-17

Publications (1)

Publication Number Publication Date
WO2004026475A1 true WO2004026475A1 (fr) 2004-04-01

Family

ID=28047181

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2003/001222 Ceased WO2004026475A1 (fr) 2002-09-17 2003-09-17 Plateau d'echantillonnage

Country Status (2)

Country Link
AU (1) AU2002951424A0 (fr)
WO (1) WO2004026475A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011047754A (ja) * 2009-08-26 2011-03-10 Shimadzu Corp 反応容器
US8988677B2 (en) 2009-04-23 2015-03-24 Avacta Limited Cuvette and optical method
WO2025121727A1 (fr) * 2023-12-06 2025-06-12 바디텍메드(주) Cartouche jetable utilisée dans un équipement de diagnostic in vitro liquide par chimioluminescence

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0203443B1 (fr) * 1985-05-14 1991-12-04 Orion Corporation Ltd Trousse d'essai pour exécuter les analyses chimiques
WO1992020448A1 (fr) * 1991-05-15 1992-11-26 Packard Instrument Company, Inc. Microplaquette pour le stockage d'echantillons radioactifs
WO1996039481A2 (fr) * 1995-05-31 1996-12-12 Chiron Corporation Couvercle amovible pour plaque a alveoles multiples
US5789251A (en) * 1994-06-16 1998-08-04 Astle; Thomas W. Multi-well bioassay tray with evaporation protection and method of use
GB2322121A (en) * 1997-02-13 1998-08-19 Porvair Plc Multi-well plate closure
EP1122181A2 (fr) * 2000-02-02 2001-08-08 Soltec, Inc Plaque flexible de bouchons à septum pour ensemble de récipients d'échantillons
WO2001092461A1 (fr) * 2000-05-26 2001-12-06 Whatman, Inc. Utilisation d'une membrane de couverture servant a empecher une contamination croisee dans un traitement multiple d'isolation de materiaux biologiques
GB2369086A (en) * 2000-11-20 2002-05-22 Herfurth Laser Technology Ltd Reaction plate
WO2002045843A2 (fr) * 2000-12-04 2002-06-13 General Electric Company Plaque de reaction permeable et procede associe
US6426215B1 (en) * 2001-04-06 2002-07-30 Pe Corporation (Ny) PCR plate cover and maintaining device
US20020141906A1 (en) * 2001-03-30 2002-10-03 American Type Culture Collection Microtiter plate sealing cover with well identifiers
US6475774B1 (en) * 2001-09-18 2002-11-05 Hemant Gupta Reaction plate sealing means

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0203443B1 (fr) * 1985-05-14 1991-12-04 Orion Corporation Ltd Trousse d'essai pour exécuter les analyses chimiques
WO1992020448A1 (fr) * 1991-05-15 1992-11-26 Packard Instrument Company, Inc. Microplaquette pour le stockage d'echantillons radioactifs
US5789251A (en) * 1994-06-16 1998-08-04 Astle; Thomas W. Multi-well bioassay tray with evaporation protection and method of use
WO1996039481A2 (fr) * 1995-05-31 1996-12-12 Chiron Corporation Couvercle amovible pour plaque a alveoles multiples
GB2322121A (en) * 1997-02-13 1998-08-19 Porvair Plc Multi-well plate closure
EP1122181A2 (fr) * 2000-02-02 2001-08-08 Soltec, Inc Plaque flexible de bouchons à septum pour ensemble de récipients d'échantillons
WO2001092461A1 (fr) * 2000-05-26 2001-12-06 Whatman, Inc. Utilisation d'une membrane de couverture servant a empecher une contamination croisee dans un traitement multiple d'isolation de materiaux biologiques
GB2369086A (en) * 2000-11-20 2002-05-22 Herfurth Laser Technology Ltd Reaction plate
WO2002045843A2 (fr) * 2000-12-04 2002-06-13 General Electric Company Plaque de reaction permeable et procede associe
US20020141906A1 (en) * 2001-03-30 2002-10-03 American Type Culture Collection Microtiter plate sealing cover with well identifiers
US6426215B1 (en) * 2001-04-06 2002-07-30 Pe Corporation (Ny) PCR plate cover and maintaining device
US6475774B1 (en) * 2001-09-18 2002-11-05 Hemant Gupta Reaction plate sealing means

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8988677B2 (en) 2009-04-23 2015-03-24 Avacta Limited Cuvette and optical method
JP2011047754A (ja) * 2009-08-26 2011-03-10 Shimadzu Corp 反応容器
WO2025121727A1 (fr) * 2023-12-06 2025-06-12 바디텍메드(주) Cartouche jetable utilisée dans un équipement de diagnostic in vitro liquide par chimioluminescence

Also Published As

Publication number Publication date
AU2002951424A0 (en) 2002-10-03

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