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WO2004024707A3 - Procede permettant de preparer des benzofuranes a substitution amine - Google Patents

Procede permettant de preparer des benzofuranes a substitution amine Download PDF

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Publication number
WO2004024707A3
WO2004024707A3 PCT/US2003/028396 US0328396W WO2004024707A3 WO 2004024707 A3 WO2004024707 A3 WO 2004024707A3 US 0328396 W US0328396 W US 0328396W WO 2004024707 A3 WO2004024707 A3 WO 2004024707A3
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
preparing amine
amine type
cyanophenyl
pyrrolidinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/028396
Other languages
English (en)
Other versions
WO2004024707A2 (fr
Inventor
Yi-Yin Ku
Yu-Ming Pu
Marlon D Cowart
Timothy A Grieme
Ashok K Gupta
Daniel J Plata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/654,897 external-priority patent/US6822101B2/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of WO2004024707A2 publication Critical patent/WO2004024707A2/fr
Publication of WO2004024707A3 publication Critical patent/WO2004024707A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des procédés permettant de préparer des benzofuranes à substitution amine, et plus particulièrement, du 4-(2-{2-[(2R)-2-méthyl-1-pyrrolidinyl]éthyl}-1-benzofurane-5-yl)benzonitrile, et des sels associés. Les composés préparés selon les procédés décrits dans cette invention présentent une activité en tant que ligands des récepteurs de l'histamine-3.
PCT/US2003/028396 2002-09-16 2003-09-10 Procede permettant de preparer des benzofuranes a substitution amine Ceased WO2004024707A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24423402A 2002-09-16 2002-09-16
US10/244,234 2002-09-16
US10/654,897 US6822101B2 (en) 2002-09-16 2003-09-05 Process for preparing amine-substituted benzofurans
US10/654,897 2003-09-05

Publications (2)

Publication Number Publication Date
WO2004024707A2 WO2004024707A2 (fr) 2004-03-25
WO2004024707A3 true WO2004024707A3 (fr) 2004-08-12

Family

ID=31996745

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/028396 Ceased WO2004024707A2 (fr) 2002-09-16 2003-09-10 Procede permettant de preparer des benzofuranes a substitution amine

Country Status (1)

Country Link
WO (1) WO2004024707A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008248168B2 (en) * 2007-05-03 2013-03-21 Cephalon, Inc. Processes for preparing (R)-2-methylpyrrolidine and (S)-2-methylpyrrolidine and tartrate salts thereof
CN119677747A (zh) * 2022-08-12 2025-03-21 豪夫迈·罗氏有限公司 用于治疗癌症的杂芳基化合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0567967A1 (fr) * 1992-04-28 1993-11-03 Dr. Karl Thomae GmbH Composés marqués au tritium utilisé comme antagonistes de récepteur de fibrinogen et leur préparation
EP0721947A1 (fr) * 1995-01-11 1996-07-17 Adir Et Compagnie Nouveaux composés (hétéro)cycliques alkylés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US20020183309A1 (en) * 2001-03-16 2002-12-05 Cowart Marlon D. Novel amines as histamine-3 receptor ligands and their therapeutic applications
WO2003059342A1 (fr) * 2002-01-11 2003-07-24 Abbott Laboratories Ligands de recepteur d'histamine-3 pour traiter des etats diabetiques

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0567967A1 (fr) * 1992-04-28 1993-11-03 Dr. Karl Thomae GmbH Composés marqués au tritium utilisé comme antagonistes de récepteur de fibrinogen et leur préparation
EP0721947A1 (fr) * 1995-01-11 1996-07-17 Adir Et Compagnie Nouveaux composés (hétéro)cycliques alkylés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US20020183309A1 (en) * 2001-03-16 2002-12-05 Cowart Marlon D. Novel amines as histamine-3 receptor ligands and their therapeutic applications
WO2003059342A1 (fr) * 2002-01-11 2003-07-24 Abbott Laboratories Ligands de recepteur d'histamine-3 pour traiter des etats diabetiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KELLY S M: "LATERALLY SUBSTITUTED PHENYL BENZOATES INCORPORATING A TRANS-1,4- DISUBSTITUTED CYCLOHEXANE RING", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA. BASEL, CH, vol. 72, no. 3, 3 May 1989 (1989-05-03), pages 594 - 607, XP000368698, ISSN: 0018-019X *

Also Published As

Publication number Publication date
WO2004024707A2 (fr) 2004-03-25

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