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WO2004024330A3 - Appareil de commande - Google Patents

Appareil de commande Download PDF

Info

Publication number
WO2004024330A3
WO2004024330A3 PCT/GB2003/003940 GB0303940W WO2004024330A3 WO 2004024330 A3 WO2004024330 A3 WO 2004024330A3 GB 0303940 W GB0303940 W GB 0303940W WO 2004024330 A3 WO2004024330 A3 WO 2004024330A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample holder
wells
heating
thermocycler
cooling element
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/003940
Other languages
English (en)
Other versions
WO2004024330A2 (fr
Inventor
Mark Ebdon
Brian Wilkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QUANTA BIOTECH Ltd
Original Assignee
QUANTA BIOTECH Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by QUANTA BIOTECH Ltd filed Critical QUANTA BIOTECH Ltd
Priority to AU2003264755A priority Critical patent/AU2003264755A1/en
Publication of WO2004024330A2 publication Critical patent/WO2004024330A2/fr
Publication of WO2004024330A3 publication Critical patent/WO2004024330A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0332—Cuvette constructions with temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/163—Biocompatibility
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/08—Optical fibres; light guides
    • G01N2201/0833—Fibre array at detector, resolving

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

Ce moteur thermique pour thermocycleur comprend au moins un premier dispositif chauffant et refroidissant, un dispositif recevant un porte-prélèvement en contact thermique avec le premier dispositif chauffant et refroidissant et un second dispositif chauffant et refroidissant placé adjacent au dispositif recevant le porte-prélèvement et retiré d'auprès celui-ci afin de permettre, en cours d'utilisation, la mise en place d'un porte-prélèvement entre les deux dispositifs chauffant et refroidissant et en contact thermique avec ceux-ci. Ce moteur est également équipé d'un porte-prélèvement de petit volume, utilisable dans le thermocycleur et pourvu de plusieurs coupelles contenant les prélèvements, le nombre de coupelles étant un multiple de 96 et l'intervalle séparant les centres de coupelles voisines étant, approximativement, de 4.5 mm ou de 2.25 mm. Ces coupelles sont disposées selon une configuration quasiment rectangulaire selon un multiple de 12 coupelles en longueur et de 8 en largeur.
PCT/GB2003/003940 2002-09-12 2003-09-12 Appareil de commande Ceased WO2004024330A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003264755A AU2003264755A1 (en) 2002-09-12 2003-09-12 Thermocycler and sample holder

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221167.0A GB0221167D0 (en) 2002-09-12 2002-09-12 Control apparatus
GB0221167.0 2002-09-12

Publications (2)

Publication Number Publication Date
WO2004024330A2 WO2004024330A2 (fr) 2004-03-25
WO2004024330A3 true WO2004024330A3 (fr) 2004-05-13

Family

ID=9943934

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/003940 Ceased WO2004024330A2 (fr) 2002-09-12 2003-09-12 Appareil de commande

Country Status (3)

Country Link
AU (1) AU2003264755A1 (fr)
GB (1) GB0221167D0 (fr)
WO (1) WO2004024330A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004058394A1 (de) * 2004-12-03 2006-06-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Probenaufnahme für eine Kryoprobe und zugehöriges Untersuchungsverfahren
ES2401437T3 (es) * 2005-04-04 2013-04-19 Roche Diagnostics Gmbh Termociclado de un bloque que comprende múltiples muestras
US7569382B2 (en) * 2005-10-05 2009-08-04 Instantlabs Medical Diagnostic Corp. Disposable reactor module and detection system
US20080280331A1 (en) 2006-02-07 2008-11-13 Stokes Bio Limited Microfluidic Analysis System
EP2331259B1 (fr) 2008-09-23 2013-09-11 Koninklijke Philips Electronics N.V. Procede de cyclage thermique
DK2584344T3 (da) * 2009-01-08 2021-10-04 It Is International Ltd Optisk system til detektering af lys fra polymerasekædereaktioner
WO2011063332A2 (fr) 2009-11-23 2011-05-26 3M Innovative Properties Company Articles à réseau de micropuits et procédés d'utilisation
GB201005704D0 (en) * 2010-04-06 2010-05-19 It Is Internat Ltd Improvements in systems for chemical and/or biochemical reactions
EP2615462B1 (fr) 2010-11-15 2016-12-14 F. Hoffmann-La Roche AG Instrument et procédé pour le traitement thermique automatique d'échantillons liquides
EP2525211B1 (fr) 2011-05-16 2018-01-03 F. Hoffmann-La Roche AG Instrument et procédé de détection d'analytes
JP5820459B2 (ja) * 2013-12-18 2015-11-24 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． サーモサイクルデバイス
GB2591198B (en) * 2014-04-04 2021-10-27 It Is Int Ltd Biochemical reaction system
JP2020022407A (ja) * 2018-08-08 2020-02-13 ソニーセミコンダクタソリューションズ株式会社 計測装置および計測システム
GB202018348D0 (en) * 2020-11-23 2021-01-06 Applied Photophysics Ltd Apparatus for analying a sample
DE102023204533B4 (de) * 2023-05-15 2025-03-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Verfahren für die Durchführung von biochemischen Untersuchungen an Proben
DE102024201487A1 (de) * 2024-02-19 2025-08-21 Robert Bosch Gesellschaft mit beschränkter Haftung Optische Einheit zur Fluoreszenzlichtbilddarstellung, insbesondere für eine Analyseeinrichtung zum Nachweis von Krankheitserregern und Verfahren zum Herstellen einer optischen Einheit

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3915920A1 (de) * 1989-05-16 1990-11-22 Messerschmitt Boelkow Blohm Mikromechanische struktur
US5161609A (en) * 1989-01-20 1992-11-10 Bertin & Cie Method and apparatus for high speed regulation of a wall temperature
JPH07185365A (ja) * 1993-12-27 1995-07-25 Shuji Ueda 焼結体製加熱冷却器
US5496517A (en) * 1989-12-22 1996-03-05 Beckman Instruments, Inc. Laboratory workstation using thermal vaporization control
GB2333250A (en) * 1998-01-16 1999-07-21 Secr Defence Reduced volume heated reaction vessel
US6144448A (en) * 1992-07-17 2000-11-07 Tosoh Corporation Fluorescence detecting apparatus
WO2001024930A1 (fr) * 1999-10-01 2001-04-12 Mwg-Biotech Ag Dispositif pour realiser des reactions chimiques ou biologiques
WO2001051209A1 (fr) * 2000-01-15 2001-07-19 Eppendorf Ag Appareil de regulation de temperature pour laboratoire a bloc thermostatique regule en temperature

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5161609A (en) * 1989-01-20 1992-11-10 Bertin & Cie Method and apparatus for high speed regulation of a wall temperature
DE3915920A1 (de) * 1989-05-16 1990-11-22 Messerschmitt Boelkow Blohm Mikromechanische struktur
US5496517A (en) * 1989-12-22 1996-03-05 Beckman Instruments, Inc. Laboratory workstation using thermal vaporization control
US6144448A (en) * 1992-07-17 2000-11-07 Tosoh Corporation Fluorescence detecting apparatus
JPH07185365A (ja) * 1993-12-27 1995-07-25 Shuji Ueda 焼結体製加熱冷却器
GB2333250A (en) * 1998-01-16 1999-07-21 Secr Defence Reduced volume heated reaction vessel
WO2001024930A1 (fr) * 1999-10-01 2001-04-12 Mwg-Biotech Ag Dispositif pour realiser des reactions chimiques ou biologiques
WO2001051209A1 (fr) * 2000-01-15 2001-07-19 Eppendorf Ag Appareil de regulation de temperature pour laboratoire a bloc thermostatique regule en temperature

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1995, no. 10 30 November 1995 (1995-11-30) *

Also Published As

Publication number Publication date
WO2004024330A2 (fr) 2004-03-25
AU2003264755A1 (en) 2004-04-30
GB0221167D0 (en) 2002-10-23
AU2003264755A8 (en) 2004-04-30

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