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WO2004020599A3 - Antagonistes de la voie hedgehog, methodes et applications correspondantes - Google Patents

Antagonistes de la voie hedgehog, methodes et applications correspondantes Download PDF

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Publication number
WO2004020599A3
WO2004020599A3 PCT/US2003/027279 US0327279W WO2004020599A3 WO 2004020599 A3 WO2004020599 A3 WO 2004020599A3 US 0327279 W US0327279 W US 0327279W WO 2004020599 A3 WO2004020599 A3 WO 2004020599A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
hedgehog antagonists
uses related
hedgehog pathway
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/027279
Other languages
English (en)
Other versions
WO2004020599A2 (fr
Inventor
Henryk K Dudek
Irina Karavanov
Carmen Pepicelli
Lee Rubin
Karen Kotkow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curis Inc
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Priority to AU2003265853A priority Critical patent/AU2003265853A1/en
Publication of WO2004020599A2 publication Critical patent/WO2004020599A2/fr
Anticipated expiration legal-status Critical
Publication of WO2004020599A3 publication Critical patent/WO2004020599A3/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne des compositions et des méthodes destinées à l'inhibition de l'angiogenèse et au traitement ou à la prévention de la prolifération cellulaire anormale, y compris des tumeurs, ces méthodes consistant à inhiber la voie hedgehog, à l'aide d'un des antagonistes de la voie hedgehog décrit dans la partie descriptive de la présente demande, par exemple.
PCT/US2003/027279 2002-08-29 2003-08-29 Antagonistes de la voie hedgehog, methodes et applications correspondantes Ceased WO2004020599A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003265853A AU2003265853A1 (en) 2002-08-29 2003-08-29 Hedgehog antagonists, methods and uses related thereto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40714502P 2002-08-29 2002-08-29
US60/407,145 2002-08-29

Publications (2)

Publication Number Publication Date
WO2004020599A2 WO2004020599A2 (fr) 2004-03-11
WO2004020599A3 true WO2004020599A3 (fr) 2006-12-28

Family

ID=31978427

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/027279 Ceased WO2004020599A2 (fr) 2002-08-29 2003-08-29 Antagonistes de la voie hedgehog, methodes et applications correspondantes

Country Status (2)

Country Link
AU (1) AU2003265853A1 (fr)
WO (1) WO2004020599A2 (fr)

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US9290497B2 (en) 2011-01-10 2016-03-22 Infinity Pharmaceuticals, Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
US9708247B2 (en) 2013-03-15 2017-07-18 The Regents Of The University Of California Modulators of the eIF2alpha pathway

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US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
CA2475879A1 (fr) 2002-02-15 2003-08-28 Cytokinetics, Inc. Synthesis de quinazolinones
US7214800B2 (en) 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
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JP2005536475A (ja) 2002-05-23 2005-12-02 サイトキネティクス・インコーポレーテッド 化合物、組成物、および方法
CA2489367A1 (fr) 2002-06-14 2003-12-24 Cytokinetics, Inc. Composes, compositions et procedes
WO2004009036A2 (fr) 2002-07-23 2004-01-29 Cytokinetics, Inc. Composes, compositions et procedes
JP2006501306A (ja) 2002-09-30 2006-01-12 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
EP1692112A4 (fr) 2003-12-08 2008-09-24 Cytokinetics Inc Composes, compositions, et methodes associees
AU2005231692B2 (en) * 2004-03-26 2011-01-27 Curis, Inc. RNA interference modulators of Hedgehog signaling and uses thereof
US20090047282A1 (en) * 2005-03-25 2009-02-19 Hideaki Tojo Prophylactic/Therapeutic Agent for Cancer
EP2386539B1 (fr) 2005-12-23 2016-07-20 Zealand Pharma A/S Dérivés de 4-aminoproline utiles en tant que mimétiques de la lysine
ES2558856T3 (es) 2006-12-21 2016-02-09 Zealand Pharma A/S Síntesis de compuestos de pirrolidina
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
JP5639895B2 (ja) 2007-12-27 2014-12-10 インフィニティ ファーマスーティカルズ、インク． 立体選択的還元方法
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
CL2009000429A1 (es) 2008-02-26 2009-09-25 Takeda Pharmaceuticals Co Compuestos derivados de carbamoil-heterociclos fusionados, en especial pirrolo[3,2-c]piridin-2-carboxamidas, inhibidores de smo; composicion farmaceutica que comprende dichos compuestos; y uso en la profilaxis o tratamiento del cancer.
US20110217294A1 (en) * 2008-04-11 2011-09-08 Daniel Fults Combination of hgf inhibitor and hedgehog inhibitor to treat cancer
AU2009241561B2 (en) 2008-04-29 2013-05-16 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
HRP20130527T1 (en) 2008-11-03 2013-07-31 Eli Lilly And Company Disubstituted phthalazine hedgehog pathway antagonists
CN102216285B (zh) 2008-11-17 2014-08-13 伊莱利利公司 四取代的哒嗪hedgehog途径拮抗剂
ES2446307T3 (es) 2008-11-17 2014-03-07 Eli Lilly And Company Piridazinas tetrasustituidas antagonistas de la ruta de Hedgehog
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
CA2769795C (fr) 2009-08-05 2020-01-07 Infinity Pharmaceuticals, Inc. Transamination enzymatique d'analogues de cyclopamine
US8614208B2 (en) 2009-08-26 2013-12-24 Takeda Pharmaceutical Company Limited Fused heterocyclic ring derivative and use thereof
WO2011024869A1 (fr) 2009-08-26 2011-03-03 武田薬品工業株式会社 Dérivé à noyaux hétérocycliques fusionnés et son utilisation
NZ598749A (en) 2009-08-26 2013-01-25 Takeda Pharmaceutical Fused heterocyclic ring derivative and use thereof
JP5722781B2 (ja) 2009-08-26 2015-05-27 武田薬品工業株式会社 縮合複素環誘導体およびその用途
EP2571357B1 (fr) 2010-05-21 2016-07-06 Infinity Pharmaceuticals, Inc. Composés chimiques, compositions et procédés pour modulation de kinases
US9376447B2 (en) 2010-09-14 2016-06-28 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
CA2817577A1 (fr) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Composes heterocycliques et utilisations de ceux-ci
EP2734520B1 (fr) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
MX2014000648A (es) 2011-07-19 2014-09-25 Infinity Pharmaceuticals Inc Compuestos heterociclicos y sus usos.
KR20140075693A (ko) 2011-08-29 2014-06-19 인피니티 파마슈티칼스, 인코포레이티드 헤테로사이클릭 화합물 및 그의 용도
WO2013049332A1 (fr) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibiteurs de monoacylglycérol lipase et procédés de leur utilisation
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
HUE040126T2 (hu) 2012-11-01 2019-02-28 Infinity Pharmaceuticals Inc Rákok kezelése PI3 kináz izoform modulátorok alkalmazásával
US9844541B2 (en) 2012-11-29 2017-12-19 Strasspharma, Llc Methods of modulating follicle stimulating hormone activity
US20160024051A1 (en) 2013-03-15 2016-01-28 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
US9192609B2 (en) 2013-04-17 2015-11-24 Hedgepath Pharmaceuticals, Inc. Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors
US20160113932A1 (en) 2013-05-30 2016-04-28 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
WO2015051241A1 (fr) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
MX389256B (es) 2013-10-04 2025-03-20 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN104906113A (zh) * 2014-03-12 2015-09-16 淄博赛维医药技术有限公司 一种抗肿瘤药物
WO2015143012A1 (fr) 2014-03-19 2015-09-24 Infinity Pharmaceuticals, Inc. Composés hétérocycliques destinés à être utilisés dans le traitement de troubles médiés par pi3k-gamma
US20150320754A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
WO2015168079A1 (fr) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Dérivés de pyrimidine ou de pyridine utiles en tant qu'inhibiteurs de pi3k
WO2016054491A1 (fr) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Composés hétérocycliques et leurs utilisations
MX387917B (es) 2015-06-04 2025-03-19 Pellepharm Inc Formulaciones topicas para suministrar compuestos inhibidores de hedgehog y uso de los mismos.
EP4585268A3 (fr) 2015-09-14 2025-10-15 Twelve Therapeutics, Inc. Formes solides de dérivés d'isoquinolinone, procédé de fabrication, compositions comprenant celles-ci et leurs procédés d'utilisation
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US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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EP4229828A4 (fr) 2020-10-13 2024-08-28 Endeavor Biomedicines, Inc. Méthodes de traitement de la fibrose
WO2025188802A1 (fr) 2024-03-05 2025-09-12 Endeavor Biomedicines, Inc. Méthodes d'amélioration de la fonction pulmonaire

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9290497B2 (en) 2011-01-10 2016-03-22 Infinity Pharmaceuticals, Inc. Processes for preparing isoquinolinones and solid forms of isoquinolinones
US9708247B2 (en) 2013-03-15 2017-07-18 The Regents Of The University Of California Modulators of the eIF2alpha pathway
US10343981B2 (en) 2013-03-15 2019-07-09 The Regents Of The University Of California Modulators of the eIF2alpha pathway
US11220477B2 (en) 2013-03-15 2022-01-11 The Regents Of The University Of California Modulators of the eIF2alpha pathway

Also Published As

Publication number Publication date
WO2004020599A2 (fr) 2004-03-11
AU2003265853A1 (en) 2004-03-19
AU2003265853A8 (en) 2004-03-19

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