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WO2004019045A3 - Method for the diagnosis of alzheimer disease - Google Patents

Method for the diagnosis of alzheimer disease Download PDF

Info

Publication number
WO2004019045A3
WO2004019045A3 PCT/EP2003/009300 EP0309300W WO2004019045A3 WO 2004019045 A3 WO2004019045 A3 WO 2004019045A3 EP 0309300 W EP0309300 W EP 0309300W WO 2004019045 A3 WO2004019045 A3 WO 2004019045A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnosis
alzheimer disease
neuregulin
determining
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/009300
Other languages
French (fr)
Other versions
WO2004019045A2 (en
Inventor
Andre Schrattenholz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ProteoSys AG
Original Assignee
ProteoSys AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ProteoSys AG filed Critical ProteoSys AG
Priority to AU2003266302A priority Critical patent/AU2003266302A1/en
Publication of WO2004019045A2 publication Critical patent/WO2004019045A2/en
Publication of WO2004019045A3 publication Critical patent/WO2004019045A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a method for the diagnosis of Alzheimer disease in a body fluid comprising determining the presence and/or amount of specific forms of neuregulin-,β.
PCT/EP2003/009300 2002-08-23 2003-08-21 Method for the diagnosis of alzheimer disease Ceased WO2004019045A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003266302A AU2003266302A1 (en) 2002-08-23 2003-08-21 Method for the diagnosis of alzheimer disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40530002P 2002-08-23 2002-08-23
US60/405,300 2002-08-23

Publications (2)

Publication Number Publication Date
WO2004019045A2 WO2004019045A2 (en) 2004-03-04
WO2004019045A3 true WO2004019045A3 (en) 2004-04-01

Family

ID=31946851

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/009300 Ceased WO2004019045A2 (en) 2002-08-23 2003-08-21 Method for the diagnosis of alzheimer disease

Country Status (2)

Country Link
AU (1) AU2003266302A1 (en)
WO (1) WO2004019045A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010084150A1 (en) * 2009-01-23 2010-07-29 Proteosys Ag Diagnostic method for detecting neurodegenerative diseases
EP2603524A1 (en) 2010-08-14 2013-06-19 AbbVie Inc. Amyloid-beta binding proteins

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004919A1 (en) * 1996-07-25 1998-02-05 The Mclean Hospital Corporation Use of presenilin-1 for diagnosis of alzheimer's disease
WO2001026607A2 (en) * 1999-10-08 2001-04-19 Uab Research Foundation Smdf and ggf neuregulin splice variant isoforms and uses thereof
WO2001058948A2 (en) * 2000-02-11 2001-08-16 Proteosys Ag USE OF NEUREGULIN-β AS AN INDICATOR AND/OR TARGET
WO2003014156A2 (en) * 2001-08-06 2003-02-20 Proteosys Ag NEUREGULIN-β ISOFORMS ASSOCIATED WITH NEURONAL PROCESSES

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998004919A1 (en) * 1996-07-25 1998-02-05 The Mclean Hospital Corporation Use of presenilin-1 for diagnosis of alzheimer's disease
WO2001026607A2 (en) * 1999-10-08 2001-04-19 Uab Research Foundation Smdf and ggf neuregulin splice variant isoforms and uses thereof
WO2001058948A2 (en) * 2000-02-11 2001-08-16 Proteosys Ag USE OF NEUREGULIN-β AS AN INDICATOR AND/OR TARGET
WO2003014156A2 (en) * 2001-08-06 2003-02-20 Proteosys Ag NEUREGULIN-β ISOFORMS ASSOCIATED WITH NEURONAL PROCESSES

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FALLS DOUGLAS L: "Neuregulins: Functions, forms, and signaling strategies", EXPERIMENTAL CELL RESEARCH, SAN DIEGO, CA, US, vol. 284, no. 1, 10 March 2003 (2003-03-10), pages 14 - 30, XP002262024, ISSN: 0014-4827 *
LU HSIENG S ET AL: "Studies on the structure and function of glycosylated and nonglycosylated neu differentiation factors: Similarities and differences of the alpha and beta isoforms", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 9, 1995, pages 4784 - 4791, XP002266596, ISSN: 0021-9258 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US9359430B2 (en) 2006-11-30 2016-06-07 Abbvie Inc. Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
US9394360B2 (en) 2006-11-30 2016-07-19 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins

Also Published As

Publication number Publication date
AU2003266302A1 (en) 2004-03-11
WO2004019045A2 (en) 2004-03-04

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