[go: up one dir, main page]

WO2004018997A3 - Methods and compositions for modulating amyloid beta - Google Patents

Methods and compositions for modulating amyloid beta Download PDF

Info

Publication number
WO2004018997A3
WO2004018997A3 PCT/US2003/026173 US0326173W WO2004018997A3 WO 2004018997 A3 WO2004018997 A3 WO 2004018997A3 US 0326173 W US0326173 W US 0326173W WO 2004018997 A3 WO2004018997 A3 WO 2004018997A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
modulating
amyloid beta
modulating amyloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/026173
Other languages
French (fr)
Other versions
WO2004018997A2 (en
Inventor
Maria Kounnas
Aaron Patrick
Gonul Velicelebi
Steven Wagner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TorreyPines Therapeutics Inc
Original Assignee
TorreyPines Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TorreyPines Therapeutics Inc filed Critical TorreyPines Therapeutics Inc
Priority to AU2003259965A priority Critical patent/AU2003259965A1/en
Publication of WO2004018997A2 publication Critical patent/WO2004018997A2/en
Anticipated expiration legal-status Critical
Publication of WO2004018997A3 publication Critical patent/WO2004018997A3/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Provided herein are methods and compositions for detecting, assessing and modulating β-amyloid peptide (Aβ) levels and/or processing of amyloid precursor protein. Methods for screening and/or identifying agents that modulate processing of APP or the levels of β-amyloid peptides, and methods for assessing presenilin activity and for modulating lipoprotein receptor-related protein (LRP), are also provided.
PCT/US2003/026173 2002-08-20 2003-08-20 Methods and compositions for modulating amyloid beta Ceased WO2004018997A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003259965A AU2003259965A1 (en) 2002-08-20 2003-08-20 Methods and compositions for modulating amyloid beta

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40541702P 2002-08-20 2002-08-20
US60/405,417 2002-08-20
US41197402P 2002-09-18 2002-09-18
US60/411,974 2002-09-18

Publications (2)

Publication Number Publication Date
WO2004018997A2 WO2004018997A2 (en) 2004-03-04
WO2004018997A3 true WO2004018997A3 (en) 2005-06-23

Family

ID=31949893

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/026173 Ceased WO2004018997A2 (en) 2002-08-20 2003-08-20 Methods and compositions for modulating amyloid beta

Country Status (2)

Country Link
AU (1) AU2003259965A1 (en)
WO (1) WO2004018997A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1563066A4 (en) * 2002-11-04 2006-06-07 Bioarctic Neuroscience Ab Methods for the identification of agents that modulate the structure and processing of beta-amyloid precursor protein
EP1563067A4 (en) * 2002-11-04 2006-06-07 Icogenex Corp Methods for the identification of agents that modulate the structure and processing of a membrane bound precursor protein
CA2525547C (en) 2003-05-14 2012-07-03 Torreypines Therapeutics, Inc. Compounds and uses thereof in modulating amyloid beta
CA2604057C (en) 2005-04-06 2014-02-11 Randall John Bateman Methods for measuring the metabolism of neurally derived biomolecules in vivo
WO2008070284A2 (en) 2006-10-16 2008-06-12 Johnnie B. Byrd, Sr. Alzheimer's Center And Research Institute Amyloid beta peptides and methods of uses thereof
US7618944B2 (en) 2007-03-01 2009-11-17 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
NZ585528A (en) 2007-11-21 2012-08-31 Pharmaxis Ltd Haloallylamine inhibitors of ssao/vap-1 and uses therefor
CA2725326A1 (en) * 2008-05-23 2009-11-26 University Of Rochester Compositions and methods relating to detection of soluble e-cadherin in neurodegenerative disease
EP2258398A1 (en) 2009-05-26 2010-12-08 Araclón Biotech, S. L. Albumin-amyloid peptide conjugates and uses thereof
WO2011057214A2 (en) 2009-11-09 2011-05-12 Neurogenetic Pharmaceuticals, Inc. Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor
JP6069661B2 (en) 2010-06-24 2017-02-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Compositions and uses thereof in the regulation of various amyloid beta peptide alloform levels
EP2603524A1 (en) 2010-08-14 2013-06-19 AbbVie Inc. Amyloid-beta binding proteins
SG10201707020TA (en) 2012-05-02 2017-10-30 Boehringer Ingelheim Int Substituted 3-haloallylamine inhibitors of ssao and uses thereof
US9938263B2 (en) 2013-03-12 2018-04-10 The General Hospital Corporation Gamma-secretase modulators
EP3200832B1 (en) 2014-09-30 2020-07-29 Washington University Tau kinetic measurements
JP6672296B2 (en) 2014-10-31 2020-03-25 ザ ジェネラル ホスピタル コーポレイション Powerful gamma-secretase modulator

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750324B1 (en) * 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
US6787637B1 (en) * 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6750324B1 (en) * 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
US6787637B1 (en) * 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HORKOSHI Y ET AL: "Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant", BIOCHEMICAL AND BIOPHYSICAL RESEARCH, vol. 313, no. 3, 2 July 2004 (2004-07-02), pages 733 - 737, XP004512500 *
JENSEN M. ET AL: "Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems", MOLECULAR MEDICINE, vol. 6, no. 4, April 2000 (2000-04-01), pages 291 - 302, XP008011178 *
MCLAURIN J. ET AL: "Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis", NATURE MEDICINE, vol. 8, no. 11, November 2002 (2002-11-01), pages 1263 - 1269, XP002288573 *
MESTRE-FRANCES ET AL: "Immunohistochemical analysis of cerebral cortical and vascular lesions in the primate Microcebus murinus reveal distinct amyloid beta1-42 and beta1-40 immunoreactivity profiles", NEUROBIOLOGY OF DISEASE, vol. 7, no. 1, 2000, pages 1 - 8 *
SCHENK D. ET AL: "Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse", NATURE, vol. 400, no. 6740, 8 July 1999 (1999-07-08), pages 173 - 177, XP002154168 *
WALKER L.C ET AL: "Labeling of Cerebral Amyloid In Vivo with Monoclonal Antibody", JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, vol. 53, no. 4, July 1994 (1994-07-01), pages 377 - 383, XP000872784 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US8497072B2 (en) 2005-11-30 2013-07-30 Abbott Laboratories Amyloid-beta globulomer antibodies
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US9359430B2 (en) 2006-11-30 2016-06-07 Abbvie Inc. Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
US9394360B2 (en) 2006-11-30 2016-07-19 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins

Also Published As

Publication number Publication date
AU2003259965A1 (en) 2004-03-11
AU2003259965A8 (en) 2004-03-11
WO2004018997A2 (en) 2004-03-04

Similar Documents

Publication Publication Date Title
WO2004018997A3 (en) Methods and compositions for modulating amyloid beta
WO2002099055A3 (en) Cips as modifiers of the p53 pathway and method of use
IL172674A0 (en) Isoforms of brain natriuretic peptide
WO2005114221A8 (en) Compositions and methods for quantification of serum glycoproteins
WO2003039467A3 (en) Monoclonal antibodies specific for beta-amyloid.
DK1521831T3 (en) Transgenic animals expressing truncated Alzheimer's tau protein
WO2002065134A3 (en) Modulators of p53-p300 interactions and screening methods therefor
WO2007084264A3 (en) Methods for myocardial imaging
WO2004031229A3 (en) P53 binding polypeptide
WO2002004949A3 (en) Reagents and methods for identification of binding agents
WO1999064587A8 (en) Polypeptides with beta-secretase type activity
WO2007103788A3 (en) Yeast reporter system based on fusion proteins of sup35p
WO2005012330A3 (en) AMYLOID β-PEPTIDE AND METHODS OF USE
WO2000034447A3 (en) Human ubiquitin ligase e3 for the modulation of nf-kappa b
WO2004017992A3 (en) Ptk7 protein involvement in carcinoma
WO2001029220A3 (en) Mage-a12 antigenic peptides and uses thereof
DK1169058T3 (en) Insulin-like growth factor binding protein-4 protease
WO2004075839A3 (en) Methods and compositions for modulating apoptosis
WO2004083241A3 (en) Btc-interacting proteins and use thereof
WO2002025279A3 (en) Use of amyloid precursor protein for treating brain amyloidosis
ATE390440T1 (en) NEUROACTIVE PEPTIDES
WO2007067512A3 (en) Method for identifying modulators of adprh useful for treating alzheimer's disease
WO2004016737A3 (en) Novel htnfsf13b protein variants
WO2003012103A3 (en) Nucleic acids coding for novel fbox proteins, their diagnostic and therapeutic uses
WO2005111070A3 (en) Mucin3 egf-like domains

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP