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WO2004018711A3 - Diagnostic test - Google Patents

Diagnostic test Download PDF

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Publication number
WO2004018711A3
WO2004018711A3 PCT/GB2003/003637 GB0303637W WO2004018711A3 WO 2004018711 A3 WO2004018711 A3 WO 2004018711A3 GB 0303637 W GB0303637 W GB 0303637W WO 2004018711 A3 WO2004018711 A3 WO 2004018711A3
Authority
WO
WIPO (PCT)
Prior art keywords
dyskaryotic
cin
persistence
progression
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/003637
Other languages
French (fr)
Other versions
WO2004018711A2 (en
Inventor
Du Ming-Qing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College London
Original Assignee
University College London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0219890A external-priority patent/GB0219890D0/en
Application filed by University College London filed Critical University College London
Priority to AU2003255823A priority Critical patent/AU2003255823A1/en
Publication of WO2004018711A2 publication Critical patent/WO2004018711A2/en
Publication of WO2004018711A3 publication Critical patent/WO2004018711A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to the prognosis of patients suffering from cervical intraepithelial neoplasia (CIN). Accordingly, the invention provides methods for diagnosing the susceptibility of such a patient to persistence or progression of the CIN. In particular, the invention provides a method of diagnosing susceptibility to persistence or progression of cervical intraepithelial neoplasia (CIN) in an individual suffering therefrom; the method comprising: d) providing a sample of dyskaryotic cells from said individual and a sample of non-dyskaryotic cells from said individual; b) detecting an allelic deletion in one or more genes selected from FHIT, PR, DLEC 1 and TRIM 29 by comparing the FHIT, PR, DLEC 1 and/or TRIM 29 polynucleotides or proteins present in the samples of step a) derived, respectively, from the non-dyskaryotic and dyskaryotic sample, wherein detection of an allelic deletion between the non-dyskaryotic and dyskaryotic samples is correlated with a susceptibility to persistence or progression of CIN.
PCT/GB2003/003637 2002-08-24 2003-08-20 Diagnostic test Ceased WO2004018711A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003255823A AU2003255823A1 (en) 2002-08-24 2003-08-20 Diagnostic test

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0219890.1 2002-08-24
US40571702P 2002-08-26 2002-08-26
US60/405,717 2002-08-26
GB0219890A GB0219890D0 (en) 2002-08-27 2002-08-27 Diagnostic test

Publications (2)

Publication Number Publication Date
WO2004018711A2 WO2004018711A2 (en) 2004-03-04
WO2004018711A3 true WO2004018711A3 (en) 2004-07-22

Family

ID=31979987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/003637 Ceased WO2004018711A2 (en) 2002-08-24 2003-08-20 Diagnostic test

Country Status (2)

Country Link
AU (1) AU2003255823A1 (en)
WO (1) WO2004018711A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2937696B1 (en) 2012-12-20 2018-06-06 National University Corporation Hokkaido University Method for detecting prostatic basal cells
WO2016046635A1 (en) * 2014-09-25 2016-03-31 Institut Pasteur Methods for characterizing human papillomavirus associated cervical lesions
CN110229895A (en) * 2019-06-04 2019-09-13 广州鼓润医疗科技有限公司 A kind of molecular marked compound of uterine neck intraepithelial neoplasia that predicting human papilloma virus positive patient

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10109259A1 (en) * 2000-02-25 2001-09-13 Giesing Michael Characterizing increased dedifferentiation of cancer cells useful for diagnosing cancer, particularly early cervical cancer, comprises applying body fluids to a foil covered slide and detecting dye-marked cells by laser

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10109259A1 (en) * 2000-02-25 2001-09-13 Giesing Michael Characterizing increased dedifferentiation of cancer cells useful for diagnosing cancer, particularly early cervical cancer, comprises applying body fluids to a foil covered slide and detecting dye-marked cells by laser

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BUTLER D ET AL: "Deletion of the FHIT gene in neoplastic and invasive cervical lesions is related to high-risk HPV infection but is independent of histopathological features.", THE JOURNAL OF PATHOLOGY. ENGLAND DEC 2000, vol. 192, no. 4, December 2000 (2000-12-01), pages 502 - 510, XP008025270, ISSN: 0022-3417 *
BUTLER DAVID ET AL: "Loss of Fhit expression as a potential marker of malignant progression in preinvasive squamous cervical cancer.", GYNECOLOGIC ONCOLOGY. UNITED STATES AUG 2002, vol. 86, no. 2, August 2002 (2002-08-01), pages 144 - 149, XP002263548, ISSN: 0090-8258 *
CHUNG T K ET AL: "Loss of heterozygosity at the short arm of chromosome 3 in microdissected cervical intraepithelial neoplasia.", CANCER LETTERS. IRELAND 30 JUN 2000, vol. 154, no. 2, 30 June 2000 (2000-06-30), pages 189 - 194, XP002263549, ISSN: 0304-3835 *
GUO Z ET AL: "Analysis of intratumoral heterogeneity of chromosome 3p deletions and genetic evidence of polyclonal origin of cervical squamous carcinoma.", MODERN PATHOLOGY: AN OFFICIAL JOURNAL OF THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY, INC. UNITED STATES FEB 2001, vol. 14, no. 2, February 2001 (2001-02-01), pages 54 - 61, XP002263550, ISSN: 0893-3952 *
HERZOG C R ET AL: "Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas.", MOLECULAR CARCINOGENESIS. UNITED STATES MAR 2001, vol. 30, no. 3, March 2001 (2001-03-01), pages 159 - 168, XP008025343, ISSN: 0899-1987 *
LARSON A A ET AL: "Genetic alterations accumulate during cervical tumorigenesis and indicate a common origin for multifocal lesions.", CANCER RESEARCH. UNITED STATES 1 OCT 1997, vol. 57, no. 19, 1 October 1997 (1997-10-01), pages 4171 - 4176, XP001160971, ISSN: 0008-5472 *
LUFT F ET AL: "Frequent allelic imbalance of tumor suppressor gene loci in cervical dysplasia.", INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY: OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF GYNECOLOGICAL PATHOLOGISTS. UNITED STATES OCT 1999, vol. 18, no. 4, October 1999 (1999-10-01), pages 374 - 380, XP008025278, ISSN: 0277-1691 *
MULLER C Y ET AL: "Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type.", JOURNAL OF THE NATIONAL CANCER INSTITUTE. UNITED STATES 18 MAR 1998, vol. 90, no. 6, 18 March 1998 (1998-03-18), pages 433 - 439, XP008025279, ISSN: 0027-8874 *
WISTUBA I I ET AL: "Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma.", CANCER RESEARCH. UNITED STATES 1 AUG 1997, vol. 57, no. 15, 1 August 1997 (1997-08-01), pages 3154 - 3158, XP001160991, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
WO2004018711A2 (en) 2004-03-04
AU2003255823A1 (en) 2004-03-11

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