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WO2004014556A1 - Appareil et procede pour collecter les sediments d'un echantillon de fluide - Google Patents

Appareil et procede pour collecter les sediments d'un echantillon de fluide Download PDF

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Publication number
WO2004014556A1
WO2004014556A1 PCT/US2002/025050 US0225050W WO2004014556A1 WO 2004014556 A1 WO2004014556 A1 WO 2004014556A1 US 0225050 W US0225050 W US 0225050W WO 2004014556 A1 WO2004014556 A1 WO 2004014556A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
diameter
insert
fluid sample
sediment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/025050
Other languages
English (en)
Other versions
WO2004014556A9 (fr
Inventor
John Liseo
Richard H. Hawley
Todd Dematteo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diasys Corp
Original Assignee
Diasys Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diasys Corp filed Critical Diasys Corp
Priority to AU2002324635A priority Critical patent/AU2002324635A1/en
Priority to PCT/US2002/025050 priority patent/WO2004014556A1/fr
Publication of WO2004014556A1 publication Critical patent/WO2004014556A1/fr
Publication of WO2004014556A9 publication Critical patent/WO2004014556A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/007—Devices for taking samples of body liquids for taking urine samples

Definitions

  • the present disclosure generally relates to the field of body fluid specimen collection for medical diagnosis, and more particularly, to a fluid collection apparatus that employs an insert to collect sediment, cellular components and other particulate matter from a fluid sample.
  • Medical diagnosis of a patient condition for disease, illness, etc. often includes collection of body fluids, such as, for example, urine, blood, cerebrospinal fluid, etc. for testing.
  • body fluids such as, for example, urine, blood, cerebrospinal fluid, etc.
  • One such diagnostic procedure is urinalysis.
  • Typical urinalysis testing is performed in most hospitals, doctors' offices and commercial laboratories. There are approximately 200 million such procedures performed annually in the United States, and by some estimates over 1 billion performed worldwide.
  • Urinalysis may be employed to detect various diseases such as, for example, cancerous cellular matter, tumors, stones, diabetes mellitus, glomerulonephritis, urinary tract infections and other inflammatory diseases.
  • Urinalysis typically includes collection of a urine sample having urinary sediment.
  • Urinary sediment consist of cells and particulate matter disposed with the urinary tract.
  • Urinary sediment can include red blood cells, white blood cells, epithelial cells, casts, etc.
  • the sediment may also include bacteria, yeast and parasites.
  • Examination during urinalysis may include direct visual observation and chemical analysis.
  • Chemical analysis of urine is performed using one of many different urine dip sticks available from a variety of manufacturers. These dip sticks or reagent strips consist of a plastic strip which contains one or more chemically impregnated reaction pads. A color reaction develops upon contact of the urine and the reagent pads.
  • Chemical analyses can suffer from reliability and integrity drawbacks. For example, a doctor, nurse, or assistant is capable of misreading or misinterpreting the results.
  • bacteria in the sediments may destroy glucose and pH changes that may occur if the urine is allowed to stand.
  • Another method of analyzing urine and urinary sediments is microscopic urinalysis.
  • a sample of well-mixed urine typically 10-15 milliliters, is centrifuged in a test tube at relatively low speed, approximately, 2000-3000 revolutions per minute, for 5-10 minutes until a moderately cohesive button (concentration of urine sediment) is produced at the bottom of the test tube.
  • a clinician pours off or decants all of the excess fluid, namely supernatant.
  • the supernatant is decanted and a volume of 0.2 to 0.5 ml is left inside the tube.
  • the clinician draws an amount of the button, using for example, a pipette
  • the sediment is resuspended in the remaining supernatant.
  • a drop of resuspended sediment is disposed onto a glass slide and coverslipped.
  • the glass slide is positioned onto a stage of a microscope and examined. At the end of the examination, the glass slide, cover slip and pipette are thrown away.
  • Various urinalysis devices are known for collection of urine and urinary sediment.
  • a fluid collection apparatus including an insert that collects sediment, cellular components and other particulate matter from a fluid sample while reducing associated labor and cost burdens. It would be highly desirable if the insert collected at least a portion of a fluid sample to facilitate various forms of urinalysis. It is contemplated that the fluid collection apparatus is easily and efficiently manufactured and assembled.
  • a fluid collection apparatus includes an insert that collects sediment, cellular components and other particulate matter from a fluid sample while reducing associated labor and cost burdens to overcome the disadvantages and drawbacks of the prior art.
  • the insert collects at least a portion of a fluid sample to facilitate various forms of urinalysis.
  • the fluid collection apparatus is easily and efficiently manufactured and assembled. The present disclosure resolves related disadvantages and drawbacks experienced in the art.
  • some of the advantages of the present disclosure include an air pocket chamber designed to hold a sufficient amount of a fluid sample, such as, one milliliter (ml) after a decanting procedure is performed so that the remaining fluid sample can mix with sediment collected at a closed end of a test tube to perform further testing. Sediment collected adjacent to the closed end may also be resuspended in the remaining fluid sample. Further, the insert can be advantageously dimensioned to facilitate use of chemical test strips.
  • a fluid collection apparatus including a tube defining a longitudinal axis and extending therealong from a closed end to an open end.
  • the tube further defines an inner surface.
  • An insert is configured for disposal within the tube and recessed from the open end.
  • the insert includes a first diameter configured and dimensioned for engagement with the inner surface of the tube and a second diameter configured and dimensioned to form a chamber with the inner surface of the tube.
  • the insert may define an interior cavity.
  • the insert may include a transition diameter disposed intermediate the first diameter and the second diameter.
  • the transition diameter can be substantially tapered relative to the longitudinal axis.
  • the second diameter may include at least one radially extending rib being configured and dimensioned to engage the inner surface of the tube.
  • the first diameter may have a larger dimension relative to the second diameter.
  • the insert can be disposed adjacent the closed end.
  • the tube is tapered relative to the longitudinal axis thereof.
  • a method for collecting sediment from a fluid sample including the steps of: providing a fluid collection apparatus, similar to that described, disposing a fluid sample within a tube of the fluid collection apparatus; collecting a concentration of sediment from the fluid sample adjacent a closed end of the tube; inverting an orientation of the tube such that at least a portion of the concentration of sediment is disposed with a chamber defined by the test tube and the insert.
  • the method may further include the step of decanting a supernatant portion of the fluid sample.
  • the method may further include the step of suspending the portion of the concentration of sediment in a portion of the fluid sample.
  • the method may further include the step of disposing the portion of the concentration of sediment on a microscope slide.
  • the step of collecting may include centrifuging the fluid sample disposed in the tube.
  • FIG. 1 is a side view of a fluid collection apparatus, in accordance with the principles of the present disclosure
  • FIG. 2 is an alternate side view, in part cross-section, of the fluid collection apparatus shown in FIG. 1 ;
  • FIG. 3 is a side view of an insert of the fluid collection apparatus shown in FIG. 1;
  • FIG. 4 is an enlarged side cross-sectional view of the insert shown in FIG. 3;
  • FIG. 5 is a bottom view of the insert shown in FIG. 3;
  • FIG. 6 is a top view of the insert shown in FIG. 3;
  • FIG. 7 is a side view of the fluid collection apparatus shown in FIG. 1 in an upright position having a fluid sample disposed therein; and FIG. 8 is a side view of the fluid collection apparatus shown in FIG. 7 in an inverted position.
  • the exemplary embodiments of the fluid collection apparatus and methods of operation disclosed are discussed in terms of body fluid specimen collection for medical diagnosis, and more particularly, in terms of a fluid collection apparatus that employs an insert to collect sediment, cellular components and other particulate matter from a fluid sample. It is contemplated that the fluid collection apparatus of the present disclosure is employed for collection of a urine sample having urinary sediment for performing urinalysis. Testing and corresponding diagnosis associated with the urinalysis procedure is used to detect various diseases such as, for example, cancerous cellular matter, tumors, stones, diabetes mellitus, glomerulonephritis, urinary tract infections and other inflammatory diseases. Glucose levels may also be detected.
  • the fluid collection apparatus may facilitate various methods of testing associated with urinalysis such as, for example, direct visual observation, chemical analysis, other macroscopic analyses and microscopic analyses. It is further envisioned that the present disclosure also finds application for the collection of body fluids, such as, for example, blood, cerebral fluid, spinal fluid, etc. for testing.
  • body fluids such as, for example, blood, cerebral fluid, spinal fluid, etc. for testing.
  • the term "fluid sample” will refer to a collected body fluid that may include sediment. It is contemplated that the sediment, as discussed herein, may include cellular components and other particulate matter.
  • the term "subject” refers to a patient undergoing a procedure that requires a fluid sample from the subject.
  • the term “practitioner” refers to an individual collecting the fluid sample from the subject, performing various steps in a procedure, etc., or otherwise employing the fluid collection apparatus, and may include support personnel.
  • the component parts of the fluid collection apparatus are fabricated from materials suitable for fluid sample collection, testing and diagnosis, such as, for example, medical grade glass, polymerics or metals, such as stainless steel, depending on the particular fluid collection apparatus application and/or preference of a practitioner.
  • materials suitable for fluid sample collection, testing and diagnosis such as, for example, medical grade glass, polymerics or metals, such as stainless steel, depending on the particular fluid collection apparatus application and/or preference of a practitioner.
  • Semi-rigid and rigid polymerics are contemplated for fabrication, as well as resilient materials, such as molded medical grade polypropylene. It is contemplated that the component parts of the fluid collection apparatus may be integrally assembled or, alternatively, monolithically formed according to the specifications and cost constraints of a particular fluid sample testing and diagnostic application.
  • One skilled in the art will realize that other materials and fabrication methods suitable for assembly and manufacture, in accordance with the present disclosure, also would be appropriate.
  • FIGS. 1 and 2 there is illustrated a fluid collection apparatus 10, in accordance with the principles of the present disclosure.
  • Fluid collection apparatus 10 includes a test tube 12 defining a longitudinal axis x.
  • Test tube 12 extends along longitudinal axis x from a closed end 14 to an open end 16.
  • Test tube 12 further defines an inner surface 18.
  • An insert 20 is configured for disposal with test tube 12 and recessed from open end 16.
  • Insert 20 includes a first diameter such as, for example, base portion 22 that is configured and dimensioned for engagement with inner surface 18.
  • Insert 20 further includes a second diameter such as, for example, barrel portion 24 that is configured and dimensioned to form a chamber 26 with inner surface 18.
  • Insert 20 is disposed within test tube 12 for collecting sediment from a fluid sample F (FIGS. 7 and 8). Insert 20 advantageously reduces the amount of labor required for a fluid collection application, which thereby reduces the potential for practitioner error.
  • Insert 20 is also configured to retain a portion of fluid sample F, allowing resuspension of sediment S (FIGS. 7 and 8) and facilitating various urinalysis procedures, as will be discussed.
  • Test tube 12 is cylindrical and configured for centrifuge of fluid sample F disposed therein. It is contemplated that a commercially available test tube vessel is employed although other laboratory vessels, flasks, etc. may be used according to the specific requirements of a fluid collection analysis. It is further contemplated that test tube 12 may have other geometric cross-sectional configurations such as, for example, elliptical, rectangular, etc. Closed end 14 includes a nose portion 28 configured to collect sediment S separated from fluid sample F after centrifuge. A wall portion 30 of test tube 12 is tapered, from closed end 14 to open end 16 at an angular orientation a relative to longitudinal axis x. Tapered wall portion 30 facilitates a sealing engagement with insert 20, as will be discussed, allowing collection of sediment S from fluid sample F. It is contemplated that wall portion 30 may be tapered at various angular orientations, or alternatively, in substantially parallel alignment with longitudinal axis x. Test tube 12 includes visual indicators such as label 32 and graduations 34. Label
  • Graduations 34 provide an indication of sample volume facilitating adjustment of concentration and dilution ratios.
  • Insert 20 extends from base portion 22 to barrel portion 24 via an intermediate transition diameter 36.
  • Base portion 22 has a larger relative dimension to barrel portion 24.
  • transition diameter 36 is substantially tapered at an angular orientation b relative to longitudinal axis x.
  • the tapered configuration of transition diameter 36 in cooperation with the relative dimension of base portion 22 and barrel portion 24 facilitates support of base portion 22 by inner surface 18 of test tube 12. In turn, this allows barrel portion 24 to form chamber 26, which facilitates collection of sediment S.
  • insert 20 may be manufactured in a manner, size and shape, which presents a frictional fit or bias on the inner surface 18 of the test tube 12. It is also contemplated herein that insert 20 be ultrasonically welded or fastened using adhesive with inner surface 18 of test tube 12.
  • test tube 12 and insert 20 be monolithically or separately formed from polymeric materials.
  • Base portion 22 includes an outer surface 38, which is configured for flush engagement with inner surface 18. This engagement provides a fluid seal which allows insert 20 to collect a portion of fluid sample F and sediment S within chamber 26.
  • Base portion 22 also includes a flange 40 that facilitates passage of fluid sample F to closed end 14.
  • Barrel portion 24 includes outer surface 42 that cooperates with inner surface 18 to form chamber 26.
  • Chamber 26 is sufficiently dimensioned to collect a portion of fluid sample F and sediment S.
  • chamber 26 is dimensioned to collect one (1) ml of fluid sample F after decanting such that sediment S can be resuspended for testing.
  • Barrel portion 24 includes radially extending ribs 44 that are configured and dimensioned to engage inner surface 18 of test tube 12. Ribs 44 engage inner surface 18 to facilitate stability and support of insert 20 within test tube 12. Ribs 44 also section chamber
  • Ribs also extend along transition diameter 36. It is contemplated that one or a plurality of ribs 44 may be employed. It is further contemplated that ribs 44 may be variously disposed about insert 20 and can have an intermittent, offset, etc. configuration.
  • Base portion 22 and barrel portion 24 cooperate to define an interior cavity 46 of insert 20.
  • Interior cavity 46 facilitates passage of fluid sample F to closed end 14 and, upon decanting, back toward open end 16.
  • Barrel portion 24 sufficiently reduces the dimension of interior cavity 46 to facilitate collection of a portion of fluid sample F and sediment S .
  • Insert 20 is disposed within test tube 12 adjacent closed end 14. This recessed configuration of insert 20 advantageously facilitates capture and collection of sediment disposed adjacent closed end 14 after centrifuge, thereby reducing the effect of practitioner error in the decanting process. It is contemplated that insert 20 may be recessed at various depths within test tube 12 according to the particular requirements of a fluid collection analysis application.
  • Fluid collection apparatus 10 also includes a cap 48, which is removably mounted to open end 16 of test tube 12.
  • Cap 48 encloses fluid sample F within test tube 12 to retain fluid sample F and prevent hazardous exposure thereto. It is contemplated cap 48 may be threaded, interference fit, etc. with open end 16. It is further contemplated that any or all of the component parts of fluid collection apparatus 10 are disposable.
  • a fluid collection apparatus 10 similar to that described, is assembled, properly sterilized and otherwise prepared for storage, shipment and use in a urinalysis procedure.
  • Insert 20 is disposed within test tube 12 forming chamber
  • Cap 48 is attached to open end 16 to initially prevent contamination and undesired engagement therewith.
  • Cap 48 is removed and fluid sample F having sediment S, of well-mixed urine from a subject is disposed within test tube 12. It is envisioned that a chemical test of the un-spun fluid sample F may be performed via test strip, etc.
  • Fluid sample F is centrifuged in test tube 12 until a moderately cohesive button (concentration of urine sediment S, such as a formed bead, pellet, etc.) is produced adjacent closed end 14 of test tube 12.
  • a liquid portion of fluid sample F such as, for example, supernatant rises and forms above insert 20 within test tube 12.
  • a practitioner manipulates test tube 12 in an upright position, as shown in FIG. 7. The practitioner inverts test tube 12, as shown in FIG. 8, to pour off or decant the supernatant.
  • the button of sediment S comes to rest within chamber 26 as facilitated by barrel portion 24.
  • a portion of fluid sample F, approximately 1 ml, remains within chamber 26.
  • the remaining fluid sample F not captured by chamber 26 passes through interior cavity 46 and is poured off along with the supernatant that form above insert 20, described above.
  • This configuration of fluid collection apparatus 10 advantageously facilitates decanting of supernatant while capturing sediment S.
  • the button of sediment S is resuspended in the remaining 1 ml portion of fluid sample F. It is contemplated that resuspension may be achieved by, for example, engaging, striking or shaking test tube 12, employing a pipette to aspirate and purge the button and sample in a mixing operation, etc.
  • the practitioner draws an amount of the resuspended button of sediment S and fluid sample F, using for example, a pipette (not shown).
  • a drop of resuspended sediment S and fluid sample F is disposed onto a glass microscope slide (not shown) and coverslipped (not shown).
  • the glass slide is positioned onto a stage of a microscope (not shown) and examined. It is contemplated that further testing may be performed, including visual inspection, chemical test strips, etc., utilizing fluid collection apparatus 10 in accordance with the principles of the present disclosure.
  • the resuspended button of sediment S and fluid sample F may be aspirated into a laboratory fluid analysis workstation, as is known to one skilled in the art, for urinalysis.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un appareil de collecte de fluides comprenant un tube définissant un axe longitudinal et s'étendant d'une extrémité fermée à une extrémité ouverte. Le tube définit de plus une surface interne. Un insert est configuré de façon à être disposé dans le tube et en retrait de l'extrémité ouverte. Ledit insert comprend un premier diamètre configuré et dimensionné de façon à s'enclencher avec la surface interne du tube et un second diamètre configuré et dimensionné de façon à former une chambre avec la surface interne du tube. Ledit insert peut définir une cavité interne. Ledit insert peut comprendre un diamètre de transition disposé entre le premier et le second diamètre. Ledit diamètre de transition peut être sensiblement effilé par rapport à un axe longitudinal. Le second diamètre peut comprendre au moins une nervure s'étendant radialement, cette dernière étant configurée et dimensionnée de manière à s'enclencher dans la surface interne du tube. Le premier diamètre peut présenter une dimension plus large par rapport au second diamètre. Ledit insert peut être disposé de manière adjacente à l'extrémité fermée. L'invention concerne un procédé pour collecter les sédiments d'un échantillon de fluide.
PCT/US2002/025050 2002-08-07 2002-08-07 Appareil et procede pour collecter les sediments d'un echantillon de fluide Ceased WO2004014556A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002324635A AU2002324635A1 (en) 2002-08-07 2002-08-07 Apparatus and method for collecting sediment from a fluid sample
PCT/US2002/025050 WO2004014556A1 (fr) 2002-08-07 2002-08-07 Appareil et procede pour collecter les sediments d'un echantillon de fluide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/025050 WO2004014556A1 (fr) 2002-08-07 2002-08-07 Appareil et procede pour collecter les sediments d'un echantillon de fluide

Publications (2)

Publication Number Publication Date
WO2004014556A1 true WO2004014556A1 (fr) 2004-02-19
WO2004014556A9 WO2004014556A9 (fr) 2004-06-17

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PCT/US2002/025050 Ceased WO2004014556A1 (fr) 2002-08-07 2002-08-07 Appareil et procede pour collecter les sediments d'un echantillon de fluide

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AU (1) AU2002324635A1 (fr)
WO (1) WO2004014556A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014002010A1 (fr) 2012-06-27 2014-01-03 Olgun Abdullah Appareil de collecte et d'analyse d'urine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001122A (en) * 1973-08-22 1977-01-04 Telan Corporation Method and device for separating blood components
US5725832A (en) * 1992-03-25 1998-03-10 Gundelsheimer; Peter Laboratory test tubes for the dosing of liquids
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US20020057996A1 (en) * 2000-04-10 2002-05-16 Bass Leland L. Centrifuge tube assembly
US6401552B1 (en) * 2000-04-17 2002-06-11 Carlos D. Elkins Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001122A (en) * 1973-08-22 1977-01-04 Telan Corporation Method and device for separating blood components
US5725832A (en) * 1992-03-25 1998-03-10 Gundelsheimer; Peter Laboratory test tubes for the dosing of liquids
US5840502A (en) * 1994-08-31 1998-11-24 Activated Cell Therapy, Inc. Methods for enriching specific cell-types by density gradient centrifugation
US20020057996A1 (en) * 2000-04-10 2002-05-16 Bass Leland L. Centrifuge tube assembly
US6401552B1 (en) * 2000-04-17 2002-06-11 Carlos D. Elkins Centrifuge tube and method for collecting and dispensing mixed concentrated fluid samples

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014002010A1 (fr) 2012-06-27 2014-01-03 Olgun Abdullah Appareil de collecte et d'analyse d'urine

Also Published As

Publication number Publication date
AU2002324635A8 (en) 2004-02-25
AU2002324635A1 (en) 2004-02-25
WO2004014556A9 (fr) 2004-06-17

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