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WO2004012797A1 - Seringue contenant un liquide medical et liquide a usage medical contenu dans la seringue - Google Patents

Seringue contenant un liquide medical et liquide a usage medical contenu dans la seringue Download PDF

Info

Publication number
WO2004012797A1
WO2004012797A1 PCT/JP2003/008130 JP0308130W WO2004012797A1 WO 2004012797 A1 WO2004012797 A1 WO 2004012797A1 JP 0308130 W JP0308130 W JP 0308130W WO 2004012797 A1 WO2004012797 A1 WO 2004012797A1
Authority
WO
WIPO (PCT)
Prior art keywords
center hole
syringe
flange portion
deforming
expanding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2003/008130
Other languages
English (en)
Japanese (ja)
Inventor
Toshio Kumashiro
Yasuhiko Konno
Hiroshi Segawa
Tadaki Seto
Shigeru Fujiwara
Sumio Horiuchi
Masazumi Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to AU2003243998A priority Critical patent/AU2003243998A1/en
Publication of WO2004012797A1 publication Critical patent/WO2004012797A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw

Definitions

  • the present invention relates to a syringe for lubrication with a luer lock and a syringe preparation using the syringe.
  • So-called syringe preparations in which a syringe is pre-filled with a drug solution such as a contrast agent are widely distributed.
  • a syringe preparation can be used by attaching an injection needle or the like to the tapered portion of the syringe and connecting the plunger rod to the inner screw of the plunger. If the viscosity of the drug solution is high, the internal pressure of the syringe must be considerably increased in order to inject the drug solution.Therefore, a luer lock is used to prevent the needle etc. from detaching from the taper. You can.
  • a luer lock adapter fixed to a base end of a tapered portion by a flange having a cutout in a center hole is disclosed in Japanese Patent Application Laid-Open No. Hei 7-18499.
  • a notch 4 is formed in the center hole of the flange, which makes it easy to deform the flange, and the luer port adapter is tapered with a small pressing force. It can be fitted to the part.
  • the luer lock adapter is originally intended to prevent the injection needle or the like from coming off from the tapered portion.
  • the luer lock adapter is provided for facilitating attachment.
  • An object of the present invention is to solve such a problem of the prior art.
  • a lure lock adapter can be easily attached to a tapered portion, and the luer lock adapter can be easily detached from the tapered portion even when a large pressure is applied during injection.
  • An object of the present invention is to provide a syringe for filling a drug solution that does not come off, and a syringe formulation using the syringe.
  • a barrel having an internal space for filling a drug solution, a taper portion formed at a tip of the barrel and for mounting a connector, A circumferential groove formed on the base end side of the tapered portion; a cylindrical member surrounding at least a part of the tapered portion; and a screw formed on an inner circumferential surface of the cylindrical member and capable of engaging with an external screw of the connector.
  • a luer-mouth adapter having an engagement portion that engages with the circumferential groove, wherein the engagement portion of the luer-mouth adapter is formed on a base-side inner peripheral surface of the cylindrical member of the luer-mouth adapter.
  • a flange portion having a center hole, which is engaged with the circumferential groove on an inner peripheral surface of the center hole, and the center is formed without forming a cutout opening in the center hole in the flange.
  • hole Expansion or a gist of drug solution filling Syringe having a means for enabling deformation.
  • the term “connector” includes a base end of an injection needle having an external thread engageable with a Luer lock adapter, a connection part of a three-way cock, a connection part of a catheter, and the like.
  • a barrel having an internal space for filling a drug solution, a taper portion formed at a tip of the barrel and mounting a connector, A peripheral groove formed on the base end side of the tapered portion; a cylindrical member surrounding at least a part of the tapered portion; an internal screw formed on an inner peripheral surface of the cylindrical member and capable of engaging with an external screw of the connector.
  • a luer lock adapter having an engaging portion that engages with the circumferential groove; a cap attached to the tapered portion to seal the opening of the tapered portion in a liquid-tight manner; and a rear end of the barrel.
  • a plunger that slidably and liquid-tightly seals an inner peripheral surface of a portion adjacent to the side opening, wherein an inner space of the barrel is filled with a chemical solution, and an engagement portion of the luer lock adapter is provided.
  • the A flange having a center hole formed in the inner peripheral surface on the base end side of the cylindrical member of the earring adapter; the inner peripheral surface of the central hole is adapted to engage with the peripheral groove;
  • a syringe preparation is provided which has means for expanding or deforming the center hole without forming a cutout in the flange at the center hole.
  • the flange portion is arranged so as to be inclined from a plane perpendicular to the central axis of the luer lock adapter so that the center hole of the flange portion approaches the tip end direction of the tapered portion;
  • At least a portion of the center hole adjacent to the inner peripheral surface is formed to be thin.
  • the area of the flange portion is reduced, and the center hole of the flange portion is easily expanded or deformed.
  • the size and number of the through holes are such that the center hole can be expanded or deformed without damaging the tapered portion, and the through hole is not easily detached after the lure mouth adapter is attached to the tapered portion. If it is a thing, it will not be limited.
  • the luer lock adapter is formed by inclining a center hole of the flange portion from a plane perpendicular to a center axis of the luer mouth adapter so as to approach a tip end of the taper portion.
  • the taper portion is prevented from being damaged when the taper is mounted on the taper portion. Further, by this, when the luer lock adapter is urged forward when injecting a drug solution or the like, the flange portion effectively opposes the forward urging force, and Separation from the tapered portion is effectively prevented.
  • the flange portion may be formed so as to become thinner as approaching the center hole.
  • liquid-tight means “to prevent leakage of the chemical solution”.
  • the flange part is The center hole of the flange portion is formed so as to be inclined from the plane perpendicular to the center axis of the adapter so as to approach the tip end of the taper portion.
  • At least a portion of the center hole adjacent to the inner peripheral surface By combining two or more of the four means having a small thickness to prevent the tapered portion from being damaged, and to easily detach after attaching the luer lock adapter to the tapered portion.
  • the central hole may be expanded or deformed so as not to be disturbed.
  • the bottom of the flange can be chamfered along the center hole (the barrel side when the luer lock adapter is attached).
  • a recess may be formed at the bottom of the flange to partially reduce the thickness of the flange to facilitate deformation of the flange.
  • the lure port adapter can be attached to the tapered part while preventing it.
  • the engaging portion engages with the circumferential groove of the tapered portion over the entire circumference, so that the engaging portion is formed in the circumferential groove. Can be tightly engaged.
  • the radial dimension of the engaging portion can be improved.
  • FIG. 1 is a sectional view of a syringe for filling a chemical solution according to a preferred embodiment of the present invention.
  • FIG. 2 is an enlarged cross-sectional view of the tapered portion to which the luer lock adapter is attached.
  • FIG. 3A is a cross-sectional view of the lure-jack adapter shown in FIG.
  • FIG. 3B is a sectional view of a luer lock adapter according to another embodiment.
  • FIG. 3C is a cross-sectional view of a lure hook adapter according to still another embodiment.
  • FIG. 4 is a cross-sectional view of a luer-jack adapter according to still another embodiment.
  • FIG. 5A is a half cross-sectional view of the flange portion of the ' ⁇ ⁇ lock adapter according to the embodiment in which the bottom of the flange portion of FIG. 3A is chamfered along the center hole.
  • FIG. 5A is a half sectional view of the flange portion of the luer adapter according to the embodiment in which the bottom of the flange portion of FIG. 3B is chamfered along the center hole.
  • FIG. 5C is a half sectional view of the flange portion of the luer lock adapter according to the embodiment in which the bottom of the flange portion of FIG. 4 is chamfered along the center hole.
  • FIG. 6 (b) is a bottom view of the lure-jack adapter showing a plurality of through holes randomly arranged in the flange portion.
  • FIG. 6B is a bottom view of the lure-jack adapter showing eight through holes arranged at equal intervals around the center hole.
  • FIG. 6C is a bottom view of the luer-jack adapter showing four through holes arranged at equal intervals around the center hole.
  • FIG. 9 is a bottom view of the luer adapter, showing a relatively large through hole formed in a substantially semicircular shape on the outer peripheral portion of the flange portion.
  • FIG. 7A is a half cross-sectional view of the flange portion of the luer lock adapter according to the embodiment in which an annular thick portion is formed along the inner peripheral surface of the flange portion.
  • FIG. 7B is an annular recess at the bottom of the flange portion.
  • FIG. 4 is a half sectional view of a flange portion of the lure-jack adapter according to the embodiment in which the is formed.
  • the barrel 12 has a barrel 12 defining an internal space 24 for filling the space, and a tapered portion 14 is formed at the tip of the barrel 12.
  • a circumferential groove 14 a that can be engaged with an engaging portion of a luer-jack adapter 16 described later is formed.
  • the distal end is a part near the outlet of the chemical solution, and the proximal end is a part near the opposite barrel.
  • the tapered portion 14 is formed so that its diameter gradually increases from the distal end to the proximal end, and has a maximum diameter at a portion adjacent to the peripheral groove 14 a in the chemical solution outlet direction.
  • the opening 14 b of the tapered portion 14 is sealed liquid-tight by a rubber cap 18 after the luer lock adapter 16 is attached, and the portion adjacent to the rear end opening 12 a of the barrel 12
  • the inner peripheral surface is sealed in a liquid-tight manner by a rubber plunger 22. That is, after attaching the luer lock adapter 16 to the taper section 14 and attaching the cap 18, the internal space 24 is filled with the chemical solution, and the barrel 12 is opened at the rear end side. By inserting the plunger 22 from the mouth 12a, the chemical solution is held in the internal space 24 without leaking.
  • a drug solution distributed in a state filled in a syringe in this way is generally called a syringe preparation.
  • the cap 18 is removed and a connector is mounted on the tapered portion 14.
  • the plunger rod is connected to the plunger 22 by screwing an outer screw formed at the tip of a plunger rod (not shown) to the inner screw 22 a formed in the plunger 22. You.
  • the outer cylinder 20 is mounted after being sealed with a rubber cap 18.
  • the luer lock includes a luer lock adapter 16 having an engaging portion that engages with the circumferential groove 14 a of the tapered portion 14.
  • the luer lock adapter 16 has a substantially cylindrical member surrounding at least a part of the taper portion 14 as shown in FIGS. 1 and 2, and is engaged with the circumferential groove 14a of the taper portion 14.
  • a flange portion 16a as a mating engagement portion and an internal screw 16b engageable with an external screw formed on a connector (not shown) are formed (see FIG. 2).
  • the flange portion 16a is arranged on the base end side of the luer lock adapter 16 and has a center hole 16c for passing the tapered portion 14 at the center (see FIG. 3A).
  • the inner diameter of the central hole 16c which is the radial dimension of the engaging portion, is smaller than the maximum diameter existing in the chemical solution outlet direction than the circumferential groove of the tapered portion 14, and the outer diameter of the circumferential groove 14a (the circumferential groove) (The diameter of the bottom of 14a).
  • the luer lock adapter 16 engages with the circumferential groove 14a along the circumferential surface of the center hole 16c when mounted on the tapered portion 14. It has become.
  • the entire luer lock adapter 16 may be formed of a relatively flexible material, or only the flange portion 16a may be formed of a relatively flexible material. Furthermore, a portion adjacent to the inner peripheral surface of the center hole 16c, more specifically, a dimension larger than the difference between the maximum outer diameter of the tapered portion 14 and the outer diameter of the bottom of the circumferential groove 14a. Accordingly, only the portion extending in the radial direction from the inner peripheral surface of the center hole 16c may be formed of a relatively flexible material. As still another "means for expanding or deforming the center hole 16c", at least one through hole may be formed in the flange portion.
  • the central portion of the flange portion may be inclined from a plane perpendicular to the central axis of the luer lock adapter so that the center hole of the flange portion approaches the tip end of the tapered portion, and at least the central hole is adjacent to the inner peripheral surface.
  • the thickness of the portion to be formed may be thin.
  • the luer mouth adapter and the flange portion used in the present invention may be formed of a plastic material, rubber, or the like.
  • the relatively flexible material include a relatively flexible plastic material, rubber, and the like.
  • a rigid material such as a hard plastic material can be used.
  • the plastic materials used for the lure port adapter and the flange section 16 include polycarbonate, polypropylene, polyurethane, polystyrene, ABS resin, silicone, and polymethylmethacrylate ( PMMA), fluorine resin, polyester, nylon, urine resin, melamine resin, aryl resin, unsaturated polyester, epoxy resin, polyimide, polyamideimide , Polyetherimide polyacetal, polyethersulfone, polyphenylene oxide, polyphenylene sulfide, polysulfone, polyacrylamide, and the like. Expand the center hole As a relatively flexible plastic material used as a means to make it openable or deformable, ABS resin, polypropylene, polyurethane, silicone, etc.
  • ABS resin polypropylene, polycarbonate, PMMA, polystyrene, urea resin, melamine resin, aryl resin, unsaturated polyester, epoxy resin, polyimide, polyamide imide, Polyether imidopolyacetal, polyether sulfone, polyphenylene oxide, polyphenylene sulfide, polysulfone, polyacrylamide, and the like are preferable.
  • polycarbonate, silicone, polypropylene, ABS resin, polyurethane, PMMA, and polyurethane it is necessary to use polycarbonate, silicone, polypropylene, ABS resin, polyurethane, PMMA, and polyurethane.
  • Fats, melamine resins, aryl resins, unsaturated polyesters, epoxy resins, polyimides, polyamide imides, polyether imide polyacetals, polyethylene phenols, polyethylene phenols, Polyphenylene sulfide, polysulfone, polyacrylamide, etc. are desirable, and among them, a transparent or translucent plastic material such as polycarbonate, PMMA, polyurethane, polypropylene, silicone, etc. , Urea resin, melamine resin, aryl resin, unsaturated polyester, epoxy resin, Polyimide, polyamide, polyetherimide polyacetal, polyethersulfone, polyphenylene oxide, polyphenylenesulfide, polysnolefon, and polyacrylamide are preferred.
  • the outer cylinder 20 is tightly mounted to protect 18.
  • the outer peripheral surface of the outer cylinder 20 has an intermediate portion in the axial direction, particularly preferably A notch or fragile portion 20a extending in the circumferential direction is formed between the arc lock adapter 16 and the cap 18 and a front portion 20b in the axial direction of the fragile portion 20a.
  • the rear part 20 c In use, the front part 20b of the outer cylinder 20 is separated from the rear part 20c at the weak part 20a, and the cap 18 is removed together with the front part 20b by a taper part 14 force. . At this time, the rear part 20 c is left on the outer peripheral surface of the luer lock adapter 16.
  • the flange portion 16a as the engagement portion of the luer lock adapter 16 is shown to be substantially perpendicular to the central axis of the luer lock adapter 16
  • the flange portion 1 16 a of the luer lock adapter 1 16 has a tapered center hole in the flange portion from a plane perpendicular to the central axis O of the luer lock adapter 1 16. It is formed in the shape of a disc spring so as to be inclined so as to approach the tip end of the portion, that is, the direction of the exit of the chemical solution.
  • the steam may be effectively passed through the luer lock adapters 16 and 116, and the luer lock adapters 16 and 116 may be effectively dried.
  • FIG. 4 is an example in which the thickness becomes thinner as approaching the center hole together with the inclination of the flange portion.
  • FIGS. 5A to 5C show the bottom portion of the flange portion chamfered along the center hole. It is an example.
  • the ventilation holes are not shown in the embodiment shown in FIGS. 4 to 5, it should be noted that ventilation holes similar to the ventilation holes 16 d and 116 d in FIGS. 3A to 3C may be provided. Needless to say.
  • the flange portions 16a and 116a as the engaging portions may have only the center holes 16c and 116c, but the present invention is not limited to this.
  • at least one through-hole may be formed in the flange portion as a means for expanding or deforming the center hole.
  • At least one through-hole in this flange part facilitates the flow of steam in the autoclave treatment, while at the same time making the center hole expandable or deformable, and a luer lock adapter 16, 11. It has the effect of promoting the drying in 6. If the means for expanding or deforming the center hole has already been achieved by a method other than the through hole, (by reducing the total area of the through hole), the flow of the steam and the drying are performed.
  • the through-hole may be provided for the purpose of promoting the penetration.
  • FIGS. 6A to 6D various embodiments of the through-hole formed in the flange portion are shown.
  • the flange portion 216a of the Luer lock adapter 216 has at least one through hole 218 randomly arranged around the center hole 216c. ing.
  • the flange portion 316a of the luer lock adapter 316 has eight through holes 318 arranged at equal intervals around the center hole 316c. I have.
  • the luer lock adapter 4 16 The flange portion 416a has four through holes 418 arranged at equal intervals around the center hole 416c.
  • the flange portion 516a of the luer lock adapter 516 has four through holes 518 arranged at equal intervals around the center hole 516c.
  • the through-hole 518 is relatively large and formed in a substantially semicircular shape on the outer periphery of the flange portion 516a.
  • the parts 2 16 a, 3 16 a, 4 16 a, and 5 16 a have means for expanding or deforming the center hole, so that the luer lock adapters 2 16 and 3 16 , 4 16 and 5 16 can be easily mounted on the tapered portion 14.
  • the center hole does not expand or deform by forming the through holes 218, 318, 418, 518. What is necessary is just to have a means for expanding and deforming the center hole shown in the present invention other than providing the center hole.
  • an annular thick wall is formed along the center hole of the flange portion.
  • annular recess may be formed at the bottom of the flange (the barrel side when the luer lock adapter is mounted) to partially reduce the thickness of the flange. it can. This facilitates deformation of the center hole.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne une seringue (10) contenant un liquide à usage médical. Cette seringue comprenant un cylindre (12) comprenant un espace (24) interne qui contient un liquide à usage médical, une partie conique (14) formée à l'extrémité du cylindre (12) et sur laquelle est installée un connecteur, une rainure périphérique (14a) formée sur le bout de la partie conique (14) et un adaptateur à verrouillage forcé. La périphérie interne de l'orifice central (16c) d'une partie collerette (16a) de l'adaptateur (16) à verrouillage forcé vient s'engager dans la rainure périphérique (14a). Aucune découpure n'est formée à partir de l'orifice central (16c) de la partie collerette (16a). La partie collerette (16a) comprend des moyens permettant l'expansion ou la déformation de l'orifice central (14c).
PCT/JP2003/008130 2002-06-26 2003-06-26 Seringue contenant un liquide medical et liquide a usage medical contenu dans la seringue Ceased WO2004012797A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003243998A AU2003243998A1 (en) 2002-06-26 2003-06-26 Syringe for containing medical liquid and medical liquid in syringe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002186728 2002-06-26
JP2002-186728 2002-06-26

Publications (1)

Publication Number Publication Date
WO2004012797A1 true WO2004012797A1 (fr) 2004-02-12

Family

ID=31492003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/008130 Ceased WO2004012797A1 (fr) 2002-06-26 2003-06-26 Seringue contenant un liquide medical et liquide a usage medical contenu dans la seringue

Country Status (2)

Country Link
AU (1) AU2003243998A1 (fr)
WO (1) WO2004012797A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010052517A1 (fr) * 2008-11-06 2010-05-14 Becton Dickinson France Récipient à médicaments amélioré
EP1733749A4 (fr) * 2004-04-07 2013-09-04 Jms Co Ltd Seringue avec raccord, raccord pour seringue et seringue

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676530A (en) * 1983-04-07 1987-06-30 Warner-Lambert Company Coupling assembly for use in fluid flow systems
JPH0237647U (fr) * 1988-09-06 1990-03-13
JPH07184999A (ja) * 1993-12-28 1995-07-25 Top:Kk 薬液充填用シリンジ及びシリンジ製剤とその製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676530A (en) * 1983-04-07 1987-06-30 Warner-Lambert Company Coupling assembly for use in fluid flow systems
JPH0237647U (fr) * 1988-09-06 1990-03-13
JPH07184999A (ja) * 1993-12-28 1995-07-25 Top:Kk 薬液充填用シリンジ及びシリンジ製剤とその製造方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1733749A4 (fr) * 2004-04-07 2013-09-04 Jms Co Ltd Seringue avec raccord, raccord pour seringue et seringue
WO2010052517A1 (fr) * 2008-11-06 2010-05-14 Becton Dickinson France Récipient à médicaments amélioré

Also Published As

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