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WO2004011664A3 - Protein or carbohydrate profiling - Google Patents

Protein or carbohydrate profiling Download PDF

Info

Publication number
WO2004011664A3
WO2004011664A3 PCT/SE2003/001244 SE0301244W WO2004011664A3 WO 2004011664 A3 WO2004011664 A3 WO 2004011664A3 SE 0301244 W SE0301244 W SE 0301244W WO 2004011664 A3 WO2004011664 A3 WO 2004011664A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
present
bio
steps
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE2003/001244
Other languages
French (fr)
Other versions
WO2004011664A2 (en
Inventor
Thomas Fehniger
Gyoergy Marko-Varga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Priority to AU2003251261A priority Critical patent/AU2003251261A1/en
Publication of WO2004011664A2 publication Critical patent/WO2004011664A2/en
Publication of WO2004011664A3 publication Critical patent/WO2004011664A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/42—Low-temperature sample treatment, e.g. cryofixation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2873—Cutting or cleaving
    • G01N2001/2886—Laser cutting, e.g. tissue catapult

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

One form of the present invention comprises a biological process whereby high throughput identification of protein and bio-molecules present in tissue sections can be made. This fully integrated process line comprises the steps of: obtaining protein sequences that were specifically isolated and present in diseased tissue. The named process comprises of technology process steps that improves the ease of detection of said protein and bio-molecule sequences. The isolated pulmonary areas that comprise a specific sub-set of cells and microenvironment can be stored afterwards under appropriate conditions.
PCT/SE2003/001244 2002-07-30 2003-07-30 Protein or carbohydrate profiling Ceased WO2004011664A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003251261A AU2003251261A1 (en) 2002-07-30 2003-07-30 Protein or carbohydrate profiling

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0202346-3 2002-07-30
SE0202346A SE0202346D0 (en) 2002-07-30 2002-07-30 Profiling process

Publications (2)

Publication Number Publication Date
WO2004011664A2 WO2004011664A2 (en) 2004-02-05
WO2004011664A3 true WO2004011664A3 (en) 2004-06-24

Family

ID=20288660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2003/001244 Ceased WO2004011664A2 (en) 2002-07-30 2003-07-30 Protein or carbohydrate profiling

Country Status (3)

Country Link
AU (1) AU2003251261A1 (en)
SE (1) SE0202346D0 (en)
WO (1) WO2004011664A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000049410A2 (en) * 1999-02-16 2000-08-24 The Government Of The United States Of America, As Represented By The Secretary Department Of Health & Human Services, The National Institutes Of Health Lcm (laser capture microdissection) for cellular protein analysis
WO2001007915A2 (en) * 1999-07-26 2001-02-01 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health Layered device with capture regions for cellular analysis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000049410A2 (en) * 1999-02-16 2000-08-24 The Government Of The United States Of America, As Represented By The Secretary Department Of Health & Human Services, The National Institutes Of Health Lcm (laser capture microdissection) for cellular protein analysis
WO2001007915A2 (en) * 1999-07-26 2001-02-01 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services, The National Institutes Of Health Layered device with capture regions for cellular analysis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BANKS R E, ET AL.: "The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis - Preliminary findings", ELECTROPHORESIS, vol. 20, 1999, pages 689 - 700, XP000925546, DOI: doi:10.1002/(SICI)1522-2683(19990101)20:4/5<689::AID-ELPS689>3.0.CO;2-J *
JAIN K K: "[14] Application of alser capture microdissection to proteomics", METHODS AND ENZYMOLOGY, vol. 356, 2002, pages 157 - 167 *
ORNSTEIN D K, ET AL.: "Proteomic analysis of laser capture microdissected human prostate cancer and in vitro prostate cell lines", ELECTROPHORESIS, vol. 21, 2000, pages 2235 - 2242 *

Also Published As

Publication number Publication date
AU2003251261A1 (en) 2004-02-16
WO2004011664A2 (en) 2004-02-05
SE0202346D0 (en) 2002-07-30
AU2003251261A8 (en) 2004-02-16

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