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WO2004005328A3 - Peptidomimetic compound useful as inhibitor of integrins - Google Patents

Peptidomimetic compound useful as inhibitor of integrins Download PDF

Info

Publication number
WO2004005328A3
WO2004005328A3 PCT/IT2003/000422 IT0300422W WO2004005328A3 WO 2004005328 A3 WO2004005328 A3 WO 2004005328A3 IT 0300422 W IT0300422 W IT 0300422W WO 2004005328 A3 WO2004005328 A3 WO 2004005328A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitor
integrins
compound useful
peptidomimetic compound
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IT2003/000422
Other languages
French (fr)
Other versions
WO2004005328A2 (en
Inventor
Mauro Marzi
Domenico Alloatti
Giuseppe Giannini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority to AU2003281226A priority Critical patent/AU2003281226A1/en
Publication of WO2004005328A2 publication Critical patent/WO2004005328A2/en
Publication of WO2004005328A3 publication Critical patent/WO2004005328A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The compound 3-carbonyl-[Arg-Gly-Asp]-1methyleneamine-tetrahydro-beta-carboline, a process for its preparation and its activity as an inhibitor of αvβ3 integrins are described. This compound is useful for the preparation of medicaments for the treatment of diseases due to abnormal angiogenesis.
PCT/IT2003/000422 2002-07-09 2003-07-03 Peptidomimetic compound useful as inhibitor of integrins Ceased WO2004005328A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003281226A AU2003281226A1 (en) 2002-07-09 2003-07-03 Peptidomimetic compound useful as inhibitor of integrins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002RM000370A ITRM20020370A1 (en) 2002-07-09 2002-07-09 PEPTID-CAMOID COMPOUND CONTAINING THE RGD SEQUENCE USEFUL AS AN INTEGRINE INHIBITOR.
ITRM2002A000370 2002-07-09

Publications (2)

Publication Number Publication Date
WO2004005328A2 WO2004005328A2 (en) 2004-01-15
WO2004005328A3 true WO2004005328A3 (en) 2004-02-26

Family

ID=11456401

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2003/000422 Ceased WO2004005328A2 (en) 2002-07-09 2003-07-03 Peptidomimetic compound useful as inhibitor of integrins

Country Status (3)

Country Link
AU (1) AU2003281226A1 (en)
IT (1) ITRM20020370A1 (en)
WO (1) WO2004005328A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103374056B (en) * 2012-04-20 2017-02-08 首都医科大学 1-Acetyl-beta-carboline-3-formyl amino-acid benzyl ester, and synthesis and application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004030494D1 (en) * 2004-10-30 2011-01-20 Univ Pais Vasco B-LACTAM RGD CYCLOPEPTIDES WITH GAMMA (G) INSERTS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849865A (en) * 1994-04-13 1998-12-15 La Jolla Cancer Research Foundation Peptides for altering bone resorption, angiogenesis and restenosis
EP1077218A2 (en) * 1999-08-04 2001-02-21 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors
US20010011087A1 (en) * 1996-12-20 2001-08-02 Volkmar Wehner Vitronectin receptor antagonists, their preparation and their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849865A (en) * 1994-04-13 1998-12-15 La Jolla Cancer Research Foundation Peptides for altering bone resorption, angiogenesis and restenosis
US20010011087A1 (en) * 1996-12-20 2001-08-02 Volkmar Wehner Vitronectin receptor antagonists, their preparation and their use
EP1077218A2 (en) * 1999-08-04 2001-02-21 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MOHAN R ET AL: "Pictet-Spengler Reaction on Solid Support: Synthesis of 1,2,3,4-Tetrahydro-beta-Carboline Libraries", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 37, no. 23, 3 June 1996 (1996-06-03), pages 3963 - 3966, XP004029271, ISSN: 0040-4039 *
XIONG JIAN-PING ET AL: "Crystal structure of the extracellular segment of integrin alphaVbeta3 in complex with an Arg-Gly-Asp ligand", SCIENCE (WASHINGTON D C), vol. 296, no. 5565, 5 April 2002 (2002-04-05), pages 151 - 155, XP002262471, ISSN: 0036-8075 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103374056B (en) * 2012-04-20 2017-02-08 首都医科大学 1-Acetyl-beta-carboline-3-formyl amino-acid benzyl ester, and synthesis and application thereof

Also Published As

Publication number Publication date
AU2003281226A8 (en) 2004-01-23
ITRM20020370A1 (en) 2004-01-09
AU2003281226A1 (en) 2004-01-23
ITRM20020370A0 (en) 2002-07-09
WO2004005328A2 (en) 2004-01-15

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