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WO2004096061A1 - Sonde a ultrasons utilisee en association avec un agent pharmacologique - Google Patents

Sonde a ultrasons utilisee en association avec un agent pharmacologique Download PDF

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Publication number
WO2004096061A1
WO2004096061A1 PCT/US2003/009099 US0309099W WO2004096061A1 WO 2004096061 A1 WO2004096061 A1 WO 2004096061A1 US 0309099 W US0309099 W US 0309099W WO 2004096061 A1 WO2004096061 A1 WO 2004096061A1
Authority
WO
WIPO (PCT)
Prior art keywords
occlusion
probe
catheter
pharmacological agent
ultrasonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/009099
Other languages
English (en)
Inventor
Robert A. Rabiner
Bradley A. Hare
Rebecca I. Marciante
Elaine S. Buffen
Mark R. Gosnell
Heather L. Senseney-Mellor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnisonics Medical Technologies Inc
Original Assignee
Omnisonics Medical Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnisonics Medical Technologies Inc filed Critical Omnisonics Medical Technologies Inc
Priority to PCT/US2003/009099 priority Critical patent/WO2004096061A1/fr
Priority to AU2003223347A priority patent/AU2003223347A1/en
Publication of WO2004096061A1 publication Critical patent/WO2004096061A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22084—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving

Definitions

  • the present invention relates to an ultrasonic medical device, and more particularly to an apparatus and method of using an ultrasonic probe with a pharmacological agent to treat an occlusion and effectively remove the occlusion and prevent subsequent occlusion formation and other health risks .
  • U.S. Patent No. 6,508,782 to Evans et al. discloses a catheter for dissolving blockages in tissues.
  • the Evans et al. device uses a catheter with an inflatable member either alone or in conjunction with a medicament for dissolving the blockages.
  • the Evans et al. device discloses a catheter with an inflatable member near the distal tip of the catheter to prevent the blockage from passing downstream of the blockage and a perfusion channel for removal of the broken up blockage.
  • the present invention is an ultrasonic medical device comprising an elongated, flexible probe and a catheter surrounding a length of a longitudinal axis of the elongated, flexible probe.
  • a pharmacological agent moves through the catheter and enhances an effect of a transverse ultrasonic vibration of the elongated, flexible probe to treat the occlusion.
  • the transverse ultrasonic vibration of the elongated, flexible probe produces a plurality of transverse nodes and transverse anti-nodes along a portion of the longitudinal axis of the elongated, flexible probe.
  • Anti-node refers to a region of a maximum energy emitted by an ' ultrasonic probe at or proximal to a specific location along a longitudinal axis of the ultrasonic probe.
  • the probe tip 9 can be any shape including, but not limited to, bent, a ball or larger shapes, h one embodiment of the present invention, the ultrasonic energy source 99 is a physical part of the ultrasonic medical device 11. In another embodiment of the present invention, the ultrasonic energy source 99 is not a physical part of the ultrasonic medical device 11.
  • the combination of the pharmacological agent and the transverse vibrations of the ultrasonic probe 15 breaks up the occlusion 16 into a particulate downstream of the site of the occlusion 16 and continues to treat the particulate and breaks up the particulate into an aggregate to a size that is easily removed from the body in conventional ways.
  • the present invention provides an apparatus and a method for more completely removing an occlusion that is safe, simple, efficient, effective, user-friendly, reliable and cost effective.

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne un dispositif et un procédé d'utilisation d'une sonde à ultrasons (15) en association avec un agent pharmacologique pour potentialiser l'effet de traitement d'une occlusion par la sonde à ultrasons (15) et supprimer efficacement l'occlusion (16). L'agent pharmacologique est libéré par un cathéter (36) pour traiter l'occlusion et augmenter l'effet des vibrations ultrasonores transversales de la sonde à ultrasons (15), éliminant ainsi efficacement l'occlusion (16). L'agent pharmacologique poursuit sa progression avale vers le site de l'occlusion (16) et agit en association avec la sonde à ultrasons (15) pour ramener l'occlusion (16) à une taille qui permet de l'éliminer facilement du corps par voie naturelle. On empêche ainsi l'occlusion (16) de se reformer et on prévient d'autres risques éventuels pour la santé.
PCT/US2003/009099 2003-03-25 2003-03-25 Sonde a ultrasons utilisee en association avec un agent pharmacologique Ceased WO2004096061A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/US2003/009099 WO2004096061A1 (fr) 2003-03-25 2003-03-25 Sonde a ultrasons utilisee en association avec un agent pharmacologique
AU2003223347A AU2003223347A1 (en) 2003-03-25 2003-03-25 Ultrasonic probe used with a pharmacological agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/009099 WO2004096061A1 (fr) 2003-03-25 2003-03-25 Sonde a ultrasons utilisee en association avec un agent pharmacologique

Publications (1)

Publication Number Publication Date
WO2004096061A1 true WO2004096061A1 (fr) 2004-11-11

Family

ID=33415163

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/009099 Ceased WO2004096061A1 (fr) 2003-03-25 2003-03-25 Sonde a ultrasons utilisee en association avec un agent pharmacologique

Country Status (2)

Country Link
AU (1) AU2003223347A1 (fr)
WO (1) WO2004096061A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013036732A1 (fr) * 2011-09-10 2013-03-14 Cook Medical Technologies Llc Appareil de lithotritie par aspiration, procédé et kit associés
WO2016081026A1 (fr) * 2014-11-19 2016-05-26 C.R. Bard, Inc. Cathéter à ultrasons et système pourvu de modes de fonctions multiples
US9360124B2 (en) 2013-03-15 2016-06-07 Cook Medical Technologies Llc Bi-directional valve device for selective control of fluid flow through multiple converging paths
WO2023066200A1 (fr) * 2021-10-22 2023-04-27 北京荷清和创医疗科技有限公司 Module favorisant la thrombolyse et dispositif de thrombectomie interventionnelle
JP2023524762A (ja) * 2020-05-05 2023-06-13 ヴァーソノ・メディカル・リミテッド 虚血の治療

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5997497A (en) * 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
US6228046B1 (en) * 1997-06-02 2001-05-08 Pharmasonics, Inc. Catheters comprising a plurality of oscillators and methods for their use
US6652547B2 (en) * 1999-10-05 2003-11-25 Omnisonics Medical Technologies, Inc. Apparatus and method of removing occlusions using ultrasonic medical device operating in a transverse mode

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5997497A (en) * 1991-01-11 1999-12-07 Advanced Cardiovascular Systems Ultrasound catheter having integrated drug delivery system and methods of using same
US6228046B1 (en) * 1997-06-02 2001-05-08 Pharmasonics, Inc. Catheters comprising a plurality of oscillators and methods for their use
US6652547B2 (en) * 1999-10-05 2003-11-25 Omnisonics Medical Technologies, Inc. Apparatus and method of removing occlusions using ultrasonic medical device operating in a transverse mode

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013036732A1 (fr) * 2011-09-10 2013-03-14 Cook Medical Technologies Llc Appareil de lithotritie par aspiration, procédé et kit associés
US9775674B2 (en) 2011-09-10 2017-10-03 Cook Medical Technologies Llc Suction lithotripsy apparatus, method and kit
US10492865B2 (en) 2011-09-10 2019-12-03 Cook Medical Technologies Llc Suction lithotripsy apparatus, method and kit
US9360124B2 (en) 2013-03-15 2016-06-07 Cook Medical Technologies Llc Bi-directional valve device for selective control of fluid flow through multiple converging paths
US9982791B2 (en) 2013-03-15 2018-05-29 Cook Medical Technologies Llc Bi-directional valve device for selective control of fluid flow through multiple converging paths
US11035481B2 (en) 2013-03-15 2021-06-15 Cook Medical Technologies Llc Bi-directional valve device for selective control of fluid flow through multiple converging paths
WO2016081026A1 (fr) * 2014-11-19 2016-05-26 C.R. Bard, Inc. Cathéter à ultrasons et système pourvu de modes de fonctions multiples
JP2023524762A (ja) * 2020-05-05 2023-06-13 ヴァーソノ・メディカル・リミテッド 虚血の治療
WO2023066200A1 (fr) * 2021-10-22 2023-04-27 北京荷清和创医疗科技有限公司 Module favorisant la thrombolyse et dispositif de thrombectomie interventionnelle

Also Published As

Publication number Publication date
AU2003223347A1 (en) 2004-11-23

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