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WO2004094345A8 - Protected monomers - Google Patents

Protected monomers Download PDF

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Publication number
WO2004094345A8
WO2004094345A8 PCT/US2004/011822 US2004011822W WO2004094345A8 WO 2004094345 A8 WO2004094345 A8 WO 2004094345A8 US 2004011822 W US2004011822 W US 2004011822W WO 2004094345 A8 WO2004094345 A8 WO 2004094345A8
Authority
WO
WIPO (PCT)
Prior art keywords
protected monomers
monomers
protected
synthesis
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/011822
Other languages
French (fr)
Other versions
WO2004094345A2 (en
WO2004094345A3 (en
Inventor
Muthiah Manoharan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alnylam Pharmaceuticals Inc
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2004/007070 external-priority patent/WO2004080406A2/en
Priority claimed from PCT/US2004/010586 external-priority patent/WO2004090108A2/en
Priority claimed from PCT/US2004/011255 external-priority patent/WO2004091515A2/en
Priority to JP2006513075A priority Critical patent/JP4991288B2/en
Priority to AU2004232964A priority patent/AU2004232964B2/en
Priority to CA002522349A priority patent/CA2522349A1/en
Priority to EP04759940A priority patent/EP1625138A4/en
Priority to US10/553,659 priority patent/US20070179100A1/en
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Priority to US10/916,185 priority patent/US7745608B2/en
Priority to US10/936,115 priority patent/US20050119214A1/en
Priority to US10/946,873 priority patent/US20050164235A1/en
Publication of WO2004094345A2 publication Critical patent/WO2004094345A2/en
Priority to US10/985,426 priority patent/US7723509B2/en
Anticipated expiration legal-status Critical
Publication of WO2004094345A3 publication Critical patent/WO2004094345A3/en
Priority to US11/833,934 priority patent/US7851615B2/en
Priority to US12/510,050 priority patent/US8017762B2/en
Priority to US12/619,382 priority patent/US8344125B2/en
Priority to US12/714,298 priority patent/US8507661B2/en
Priority to US12/724,267 priority patent/US8426377B2/en
Publication of WO2004094345A8 publication Critical patent/WO2004094345A8/en
Priority to US15/260,803 priority patent/US10119138B2/en
Priority to US15/906,908 priority patent/US10676740B2/en
Priority to US16/042,633 priority patent/US11015194B2/en
Priority to US17/243,503 priority patent/US20210254065A1/en
Priority to US17/697,685 priority patent/US20220403377A1/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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Abstract

This invention relates to protected monomers for the synthesis of iRNA agents.
PCT/US2004/011822 2003-04-09 2004-04-16 Protected monomers Ceased WO2004094345A2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP2006513075A JP4991288B2 (en) 2003-04-17 2004-04-16 A double-stranded iRNA agent and a method of modulating the stability of a pair of double-stranded iRNA agents.
AU2004232964A AU2004232964B2 (en) 2003-04-17 2004-04-16 Protected monomers
CA002522349A CA2522349A1 (en) 2003-04-17 2004-04-16 Protected monomers
EP04759940A EP1625138A4 (en) 2003-04-17 2004-04-16 Protected monomers
US10/553,659 US20070179100A1 (en) 2003-04-09 2004-04-16 Protected monomers
US10/916,185 US7745608B2 (en) 2003-04-17 2004-08-10 Modified iRNA agents
US10/936,115 US20050119214A1 (en) 2003-04-17 2004-09-07 Nuclease resistant double-stranded ribonucleic acid
US10/946,873 US20050164235A1 (en) 2003-04-17 2004-09-21 Modified iRNA agents
US10/985,426 US7723509B2 (en) 2003-04-17 2004-11-09 IRNA agents with biocleavable tethers
US11/833,934 US7851615B2 (en) 2003-04-17 2007-08-03 Lipophilic conjugated iRNA agents
US12/510,050 US8017762B2 (en) 2003-04-17 2009-07-27 Modified iRNA agents
US12/619,382 US8344125B2 (en) 2003-04-17 2009-11-16 Modified iRNA agents
US12/714,298 US8507661B2 (en) 2003-04-17 2010-02-26 Modified iRNA agents
US12/724,267 US8426377B2 (en) 2003-04-17 2010-03-15 iRNA agents with biocleavable tethers
US15/260,803 US10119138B2 (en) 2003-04-17 2016-09-09 iRNA agents with biocleavable tethers
US15/906,908 US10676740B2 (en) 2003-04-17 2018-02-27 Modified iRNA agents
US16/042,633 US11015194B2 (en) 2003-04-17 2018-07-23 iRNA agents with biocleavable tethers
US17/243,503 US20210254065A1 (en) 2003-04-17 2021-04-28 iRNA AGENTS WITH BIOCLEAVABLE TETHERS
US17/697,685 US20220403377A1 (en) 2003-04-17 2022-03-17 MODIFIED iRNA AGENTS

Applications Claiming Priority (26)

Application Number Priority Date Filing Date Title
US46377203P 2003-04-17 2003-04-17
US60/463,772 2003-04-17
US46566503P 2003-04-25 2003-04-25
US46580203P 2003-04-25 2003-04-25
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