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WO2004092121A3 - Methods for preparing 2,3,5,6-substituted 3h-pyrimidin-4-ones - Google Patents

Methods for preparing 2,3,5,6-substituted 3h-pyrimidin-4-ones Download PDF

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Publication number
WO2004092121A3
WO2004092121A3 PCT/US2004/010639 US2004010639W WO2004092121A3 WO 2004092121 A3 WO2004092121 A3 WO 2004092121A3 US 2004010639 W US2004010639 W US 2004010639W WO 2004092121 A3 WO2004092121 A3 WO 2004092121A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing
methods
pyrimidin
ones
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/010639
Other languages
French (fr)
Other versions
WO2004092121A2 (en
Inventor
Irina Shcherbakova
Manuel Balandrin
Guangfei Huang
Otto Geoffroy
John Fox
Satheesh K Nair
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire NPS Pharmaceuticals Inc
Original Assignee
NPS Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Pharmaceuticals Inc filed Critical NPS Pharmaceuticals Inc
Priority to US10/551,920 priority Critical patent/US20070161792A1/en
Priority to JP2006509759A priority patent/JP2006522160A/en
Priority to EP04749815A priority patent/EP1613606A4/en
Publication of WO2004092121A2 publication Critical patent/WO2004092121A2/en
Publication of WO2004092121A3 publication Critical patent/WO2004092121A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Pyrimidinone compounds are disclosed. Methods of preparing the pyrimidinone compounds are also disclosed.
PCT/US2004/010639 2003-04-07 2004-04-07 Methods for preparing 2,3,5,6-substituted 3h-pyrimidin-4-ones Ceased WO2004092121A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/551,920 US20070161792A1 (en) 2003-04-07 2004-04-07 Methods for preparing 2,3,5,6-substituted 3h-pyrimidin-4-ones
JP2006509759A JP2006522160A (en) 2003-04-07 2004-04-07 Process for the preparation of 2,3,5,6-substituted 3H-pyrimidin-4-one
EP04749815A EP1613606A4 (en) 2003-04-07 2004-04-07 Methods for preparing 2,3,5,6-substituted 3h-pyrimidin-4-ones

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46085903P 2003-04-07 2003-04-07
US60/460,859 2003-04-07
US47932303P 2003-06-18 2003-06-18
US60/479,323 2003-06-18

Publications (2)

Publication Number Publication Date
WO2004092121A2 WO2004092121A2 (en) 2004-10-28
WO2004092121A3 true WO2004092121A3 (en) 2005-04-14

Family

ID=33303030

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/010638 Ceased WO2004092120A2 (en) 2003-04-07 2004-04-07 Pyrimidinone compounds as calcilytics
PCT/US2004/010639 Ceased WO2004092121A2 (en) 2003-04-07 2004-04-07 Methods for preparing 2,3,5,6-substituted 3h-pyrimidin-4-ones

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2004/010638 Ceased WO2004092120A2 (en) 2003-04-07 2004-04-07 Pyrimidinone compounds as calcilytics

Country Status (8)

Country Link
US (1) US7491728B2 (en)
EP (2) EP1613606A4 (en)
JP (2) JP2006522159A (en)
AT (1) ATE489368T1 (en)
AU (1) AU2004230903A1 (en)
CA (1) CA2521129A1 (en)
DE (1) DE602004030231D1 (en)
WO (2) WO2004092120A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI316511B (en) * 2002-11-26 2009-11-01 Smithkline Beecham Corp Calcilytic compounds
WO2004092120A2 (en) 2003-04-07 2004-10-28 Nps Pharmaceuticals, Inc. Pyrimidinone compounds as calcilytics
WO2005108376A1 (en) * 2004-05-06 2005-11-17 Smithkline Beecham Corporation Calcilytic compounds
TW200738649A (en) * 2005-11-22 2007-10-16 Smithkline Beecham Corp Calcilytic compounds
WO2008041118A2 (en) * 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
WO2015091267A1 (en) * 2013-12-16 2015-06-25 Bayer Cropscience Ag Six-membered c-n-linked aryl sulfide derivatives and aryl sulfoxide derivatives as pest control agents
AU2023406476A1 (en) 2022-12-02 2025-06-05 Neumora Therapeutics, Inc. Methods of treating neurological disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378678A (en) * 1992-07-17 1995-01-03 Rohm And Haas Company 2-aryl-5,6-ring-fused pyrimidines and herbicidal use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3185689A (en) * 1965-05-25 Tolyl-x-(jh)-pyrimidones
JPS4826020B1 (en) * 1970-06-09 1973-08-03
RU2026295C1 (en) * 1991-06-18 1995-01-09 Новосибирский институт органической химии СО РАН Method of synthesis chloroazines containing o-hydroxyphenyl group
US5300477A (en) * 1992-07-17 1994-04-05 Rohm And Haas Company 2-arylpyrimidines and herbicidal use thereof
ES2093929T3 (en) * 1992-07-17 1997-01-01 Rohm & Haas 2-SUBSTITUTED PYRIMIDINES AND HERBICIDAL USE THEREOF.
US5726124A (en) * 1992-07-17 1998-03-10 Rohm And Haas Company 2-arylpyrimidines and herbicidal use thereof
US5948775A (en) * 1997-03-19 1999-09-07 American Home Products Corporation 2- or 3-(substitutedaminoalkoxyphenyl)quinazolin-4-ones
WO2004092120A2 (en) 2003-04-07 2004-10-28 Nps Pharmaceuticals, Inc. Pyrimidinone compounds as calcilytics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378678A (en) * 1992-07-17 1995-01-03 Rohm And Haas Company 2-aryl-5,6-ring-fused pyrimidines and herbicidal use

Also Published As

Publication number Publication date
WO2004092121A2 (en) 2004-10-28
JP2006522160A (en) 2006-09-28
US7491728B2 (en) 2009-02-17
CA2521129A1 (en) 2004-10-28
US20070197555A1 (en) 2007-08-23
EP1613606A4 (en) 2008-12-03
EP1615897A2 (en) 2006-01-18
DE602004030231D1 (en) 2011-01-05
WO2004092120A3 (en) 2005-04-14
JP2006522159A (en) 2006-09-28
ATE489368T1 (en) 2010-12-15
AU2004230903A1 (en) 2004-10-28
WO2004092120A2 (en) 2004-10-28
EP1615897B1 (en) 2010-11-24
EP1613606A2 (en) 2006-01-11
EP1615897A4 (en) 2008-07-23

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