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WO2004089073A3 - Inducible breast cancer model - Google Patents

Inducible breast cancer model

Info

Publication number
WO2004089073A3
WO2004089073A3 PCT/US2004/010292 US2004010292W WO2004089073A3 WO 2004089073 A3 WO2004089073 A3 WO 2004089073A3 US 2004010292 W US2004010292 W US 2004010292W WO 2004089073 A3 WO2004089073 A3 WO 2004089073A3
Authority
WO
WIPO (PCT)
Prior art keywords
breast cancer
cancer model
inducible
inducible breast
mammals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/010292
Other languages
French (fr)
Other versions
WO2004089073A2 (en
Inventor
Joerg Heyer
Lynda Chin
Ronald A Depinho
Yinghui Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aveo Pharmaceuticals Inc
Original Assignee
Genpath Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genpath Pharmaceuticals Inc filed Critical Genpath Pharmaceuticals Inc
Publication of WO2004089073A2 publication Critical patent/WO2004089073A2/en
Publication of WO2004089073A3 publication Critical patent/WO2004089073A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to mammals and cells comprising an expression construct for a nucleic acid encoding a breast cancer related oncogene and wherein the mammal and cell further comprise a cancer-prone genetic predisposition.
PCT/US2004/010292 2003-04-03 2004-04-01 Inducible breast cancer model Ceased WO2004089073A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46083503P 2003-04-03 2003-04-03
US60/460,835 2003-04-03

Publications (2)

Publication Number Publication Date
WO2004089073A2 WO2004089073A2 (en) 2004-10-21
WO2004089073A3 true WO2004089073A3 (en) 2005-03-17

Family

ID=33159808

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/010292 Ceased WO2004089073A2 (en) 2003-04-03 2004-04-01 Inducible breast cancer model

Country Status (1)

Country Link
WO (1) WO2004089073A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060222590A1 (en) 2005-04-05 2006-10-05 Murray Robinson Directed complementation
US12366585B2 (en) 2006-05-18 2025-07-22 Caris Mpi, Inc. Molecular profiling of tumors
EP2347009A4 (en) * 2008-10-14 2012-05-30 Caris Mpi Inc GENETIC AND PROTEIN TARGETS EXPRESSED BY GENES REPRESENTING BIOMARKER PROFILES AND SIGNATURE SETS BY TYPE OF TUMORS

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044889A2 (en) * 1999-01-28 2000-08-03 Mice & More Gmbh & Co. Kg Mammal with inducible ductal carcinoma in situ
WO2001009308A1 (en) * 1999-07-29 2001-02-08 Dana-Farber Cancer Institute, Inc. Inducible cancer model to study the molecular basis of host tumor cell interactions in vivo
WO2001069260A2 (en) * 2000-03-13 2001-09-20 Research Foundation For Mental Hygiene, Inc. A lysosomal pepstatin-insensitive proteinase as a novel biomarker for detecting and diagnosing breast cancer
WO2002079419A2 (en) * 2001-03-28 2002-10-10 Dana-Farber Cancer Institute, Inc. Identifying and characterizing genes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044889A2 (en) * 1999-01-28 2000-08-03 Mice & More Gmbh & Co. Kg Mammal with inducible ductal carcinoma in situ
WO2001009308A1 (en) * 1999-07-29 2001-02-08 Dana-Farber Cancer Institute, Inc. Inducible cancer model to study the molecular basis of host tumor cell interactions in vivo
WO2001069260A2 (en) * 2000-03-13 2001-09-20 Research Foundation For Mental Hygiene, Inc. A lysosomal pepstatin-insensitive proteinase as a novel biomarker for detecting and diagnosing breast cancer
WO2002079419A2 (en) * 2001-03-28 2002-10-10 Dana-Farber Cancer Institute, Inc. Identifying and characterizing genes

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AUSTRUP F ET AL: "Prognostic value of genomic alterations in minimal residual cancer cells purified from the blood of breast cancer patients.", BRITISH JOURNAL OF CANCER. DEC 2000, vol. 83, no. 12, December 2000 (2000-12-01), pages 1664 - 1673, XP002289596, ISSN: 0007-0920 *
CHIN L ET AL: "Essential role for oncogenic ras in tumour maintenance", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 400, 1999, pages 468 - 472, XP002284952, ISSN: 0028-0836 *
D'AMICO MARK ET AL: "The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.", CANCER RESEARCH, vol. 63, no. 12, 15 June 2003 (2003-06-15), pages 3395 - 3402, XP002289597, ISSN: 0008-5472 *
D'CRUZ CELINA M ET AL: "c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations", NATURE MEDICINE, vol. 7, no. 2, February 2001 (2001-02-01), pages 235 - 239, XP002289592, ISSN: 1078-8956 *
GUNTHER EDWARD J ET AL: "Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis.", GENES AND DEVELOPMENT, vol. 17, no. 4, 15 February 2003 (2003-02-15), pages 488 - 501, XP002289590, ISSN: 0890-9369 *
HAKEM R ET AL: "Animal models of tumor-suppressor genes.", ANNUAL REVIEW OF GENETICS. 2001, vol. 35, 2001, pages 209 - 241, XP002289594, ISSN: 0066-4197 *
HULIT JAMES ET AL: "ErbB-2-induced mammary tumor growth: The role of cyclin D1 and p27Kip1", BIOCHEMICAL PHARMACOLOGY, vol. 64, no. 5-6, September 2002 (2002-09-01), pages 827 - 836, XP002289595, ISSN: 0006-2952 *
MOODY SUSAN E ET AL: "Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis.", CANCER CELL, vol. 2, no. 6, December 2002 (2002-12-01), pages 451 - 461, XP002289591, ISSN: 1535-6108 *
ZELAZNY EDWARD ET AL: "Cooperating oncogenic events in murine mammary tumorigenesis: Assessment of ErbB2, mutant p53, and mouse mammary tumor virus", EXPERIMENTAL AND MOLECULAR PATHOLOGY, vol. 70, no. 3, June 2001 (2001-06-01), pages 183 - 193, XP002289593, ISSN: 0014-4800 *

Also Published As

Publication number Publication date
WO2004089073A2 (en) 2004-10-21

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