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WO2004085392A8 - Melatonin derivatives and their use for treating neurological dysfunctions - Google Patents

Melatonin derivatives and their use for treating neurological dysfunctions

Info

Publication number
WO2004085392A8
WO2004085392A8 PCT/EP2004/003119 EP2004003119W WO2004085392A8 WO 2004085392 A8 WO2004085392 A8 WO 2004085392A8 EP 2004003119 W EP2004003119 W EP 2004003119W WO 2004085392 A8 WO2004085392 A8 WO 2004085392A8
Authority
WO
WIPO (PCT)
Prior art keywords
treating neurological
cycloalkyl
neurological dysfunctions
melatonin derivatives
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/003119
Other languages
French (fr)
Other versions
WO2004085392A1 (en
Inventor
Stephan Schann
Pascal Neuville
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Domain Therapeutics SA
Original Assignee
Faust Pharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faust Pharmaceuticals SA filed Critical Faust Pharmaceuticals SA
Publication of WO2004085392A1 publication Critical patent/WO2004085392A1/en
Publication of WO2004085392A8 publication Critical patent/WO2004085392A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention relates to compounds of the general formula (1): wherein R1, R2, R3, R4 and R5 are H or a moiety of the formula : -(R6)n-R7; with R6 is a is an alkyl chain and R7 is, a moiety selected in the group consisting of -Cn,H2n2,+I, a cycloalkyl moiety, -N(Cn,H2n,+I)(Cn,H2n,+1), -NH-cycloalkyl, -O(Cn,H2n'+I), -0-cycloalkyl, =O, =S, -NO2, -I, -Br, -Cl, -F, -CF3, -OCF3, -COOH, -S03H, -P03H2, -CN, A3 and A4 are, C, N,O or S;m is from 0 to 2; and to their use for the treatment and/or prevention of diseases and conditions mediated by the imbalance of acetylcholine, and for treating and/or preventing glutamate excitotoxicity.
PCT/EP2004/003119 2003-03-25 2004-03-24 Melatonin derivatives and their use for treating neurological dysfunctions Ceased WO2004085392A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03360041 2003-03-25
EP03360041.2 2003-03-25

Publications (2)

Publication Number Publication Date
WO2004085392A1 WO2004085392A1 (en) 2004-10-07
WO2004085392A8 true WO2004085392A8 (en) 2004-12-23

Family

ID=33041125

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/003119 Ceased WO2004085392A1 (en) 2003-03-25 2004-03-24 Melatonin derivatives and their use for treating neurological dysfunctions

Country Status (1)

Country Link
WO (1) WO2004085392A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012173701A1 (en) * 2011-06-16 2012-12-20 President And Fellows Of Harvard College Novel rodent control agents and uses thereof
KR20130084047A (en) * 2012-01-16 2013-07-24 전북대학교산학협력단 Novel use of melatonin
CN109563089B (en) * 2016-05-12 2023-06-16 巴克老年研究所 Compounds that promote normal processing of APP
GB201907871D0 (en) 2019-06-03 2019-07-17 Small Pharma Ltd Therapeutic compositions
PT3873883T (en) 2019-11-07 2023-03-24 Small Pharma Ltd SYNTHESIS METHOD
US11773062B2 (en) 2021-03-22 2023-10-03 Small Pharma Ltd Deuterated compounds
US12042564B2 (en) 2020-06-02 2024-07-23 Cybin Uk Ltd Therapeutic solid dosage forms
US11406619B2 (en) 2020-08-28 2022-08-09 Small Pharma Ltd Injectable formulations
AU2021337466A1 (en) * 2020-09-01 2023-03-30 Enveric Biosciences Canada Inc. Halogenated psilocybin derivatives and methods of using
US11660289B2 (en) 2020-12-01 2023-05-30 Small Pharma Ltd. Deuterated or partially deuterated N,N-dimethyltryptamine compounds
US11697638B2 (en) 2021-09-08 2023-07-11 Small Pharma Ltd 5-methoxy-N,N-dimethyltryptamine crystalline forms
CN113968810B (en) * 2021-11-11 2023-06-16 河北维达康生物科技有限公司 Preparation method of N, N-dimethyl-5-hydroxytryptamine
US12318477B2 (en) 2021-11-18 2025-06-03 Cybin Uk Ltd Injectable and inhalable formulations
CN115124449B (en) * 2022-05-24 2024-02-02 上海英诺富成生物科技有限公司 Indole compound and preparation method and application thereof
CN116392480A (en) * 2023-03-15 2023-07-07 武汉科技大学 Application of melatonin in preparation of medicine for treating arrhythmia
WO2025099444A1 (en) * 2023-11-09 2025-05-15 Beckley Psytech Limited N-Acetylserotonin (NAS) Analogues

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2737725B1 (en) * 1995-08-08 1997-10-31 Valentonine NOVEL ACYLATED DERIVATIVES OF MELATONIN AND MELATONINERGIC ANALOGS, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
FR2787447B1 (en) * 1998-12-18 2001-03-23 Centre Nat Rech Scient NOVEL MELATONIN DERIVATIVES AND MEDICINAL PRODUCT COMPRISING SUCH DERIVATIVES

Also Published As

Publication number Publication date
WO2004085392A1 (en) 2004-10-07

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