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WO2004084964A1 - Composite sous forme d'hydrogel a poids moleculaire eleve au phosphate de calcium poreux comportant un trou traversant, procede de preparation de ce dernier, os artificiel ou matiere a liberation prolongee destinee a un medicament contenant le composite - Google Patents

Composite sous forme d'hydrogel a poids moleculaire eleve au phosphate de calcium poreux comportant un trou traversant, procede de preparation de ce dernier, os artificiel ou matiere a liberation prolongee destinee a un medicament contenant le composite Download PDF

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Publication number
WO2004084964A1
WO2004084964A1 PCT/JP2004/002599 JP2004002599W WO2004084964A1 WO 2004084964 A1 WO2004084964 A1 WO 2004084964A1 JP 2004002599 W JP2004002599 W JP 2004002599W WO 2004084964 A1 WO2004084964 A1 WO 2004084964A1
Authority
WO
WIPO (PCT)
Prior art keywords
same
drug
molecular weight
high molecular
calcium phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2004/002599
Other languages
English (en)
Japanese (ja)
Inventor
Atsuo Ito
Noriko Asaka
Tokoha Sakurai
Masaki Uchida
Yu Sogo
Tetsuya Tateishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Advanced Industrial Science and Technology AIST
Original Assignee
National Institute of Advanced Industrial Science and Technology AIST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute of Advanced Industrial Science and Technology AIST filed Critical National Institute of Advanced Industrial Science and Technology AIST
Publication of WO2004084964A1 publication Critical patent/WO2004084964A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un composite sous forme d'hydrogel à poids moléculaire élevé au phosphate de calcium poreux qui comporte des trous traversants et des trous traversants artificiels à trois dimensions d'un diamètre compris entre 70 νm et 4 mm, qui présente une porosité comprise entre 20 et 80 % et qui contient du phosphate de calcium ayant un rapport molaire Ca/P compris entre 0,75 et 2,1 en tant que constituant primaire, ledit trou traversant étant revêtu de l'hydrogel à poids moléculaire élevé. Cette invention se rapporte également à un procédé de préparation du composite et à un os artificiel ou à une matière à libération prolongée destinée à un médicament renfermant le composite. Le composite selon la présente invention peut porter un ingrédient efficace tel qu'un médicament simplement par immersion dudit composite dans une solution contenant l'ingrédient.
PCT/JP2004/002599 2003-03-03 2004-03-03 Composite sous forme d'hydrogel a poids moleculaire eleve au phosphate de calcium poreux comportant un trou traversant, procede de preparation de ce dernier, os artificiel ou matiere a liberation prolongee destinee a un medicament contenant le composite Ceased WO2004084964A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003-056095 2003-03-03
JP2003056095A JP4228070B2 (ja) 2003-03-03 2003-03-03 貫通を有する多孔質リン酸カルシウム高分子ハイドロゲル複合体、その製造方法及びそれを用いた人工骨または薬剤徐放体

Publications (1)

Publication Number Publication Date
WO2004084964A1 true WO2004084964A1 (fr) 2004-10-07

Family

ID=33094799

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/002599 Ceased WO2004084964A1 (fr) 2003-03-03 2004-03-03 Composite sous forme d'hydrogel a poids moleculaire eleve au phosphate de calcium poreux comportant un trou traversant, procede de preparation de ce dernier, os artificiel ou matiere a liberation prolongee destinee a un medicament contenant le composite

Country Status (2)

Country Link
JP (1) JP4228070B2 (fr)
WO (1) WO2004084964A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006090777A1 (fr) * 2005-02-23 2006-08-31 Hi-Lex Corporation Matériau médical, racine de dent artificielle et procédé de fabrication de matériau pour utilisation clinique
CN101066469B (zh) * 2007-05-09 2010-05-19 上海理工大学 多孔胶原海绵的制备方法
CN102580167A (zh) * 2012-03-31 2012-07-18 上海理工大学 一种三维壳聚糖多孔支架的制备方法
JP5166864B2 (ja) * 2005-02-23 2013-03-21 株式会社ハイレックスコーポレーション 人工歯根
CN113398333A (zh) * 2021-06-01 2021-09-17 南京方拓新材料科技有限责任公司 一种水凝胶基磷酸钙镁材料及其作为骨修复材料的应用
CN114569223A (zh) * 2022-01-25 2022-06-03 苏州卓恰医疗科技有限公司 具有填充物的身体植入物及其制备方法

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007222611A (ja) * 2006-01-26 2007-09-06 National Institute Of Advanced Industrial & Technology 薬剤徐放性人工骨及びその製造方法
WO2008041774A1 (fr) * 2006-10-02 2008-04-10 National Institute For Materials Science Préparation à libération prolongée capable de conduction osseuse
WO2008041704A1 (fr) * 2006-10-02 2008-04-10 National Institute For Materials Science Préparation à libération contrôlée
JP4934773B2 (ja) * 2007-05-31 2012-05-16 Ｈｏｙａ株式会社 アパタイト／コラーゲン複合体からなる多孔体及びその製造方法
JP5008135B2 (ja) * 2007-05-31 2012-08-22 Ｈｏｙａ株式会社 アパタイト／コラーゲン複合体からなる多孔体及びその製造方法
JP5232484B2 (ja) * 2008-01-31 2013-07-10 日本特殊陶業株式会社 生体インプラント
KR20110039548A (ko) 2008-07-02 2011-04-19 넥스트21 케이 케이 칼슘 이온 용출을 제어한 인공 골재료
AU2010261389B2 (en) * 2009-06-15 2016-03-03 Cartiheal (2009) Ltd. Solid forms for tissue repair
CN107412864A (zh) * 2009-12-13 2017-12-01 阿米特·普拉卡什·戈维 生物活性移植物和复合物
JP5741988B2 (ja) * 2010-05-10 2015-07-01 国立研究開発法人理化学研究所 ハイドロゲル、その乾燥物およびハイドロゲルの製造方法
JP6961504B2 (ja) * 2018-01-26 2021-11-05 国立大学法人 岡山大学 徐放性デバイス
CN110982125B (zh) * 2019-12-19 2022-01-21 武汉纺织大学 一种形状自恢复多孔复合凝胶及其制备方法与应用
CN118056500A (zh) * 2022-11-18 2024-05-21 思摩尔国际控股有限公司 一种多孔有序基体材料及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5858041A (ja) * 1981-10-05 1983-04-06 三菱鉱業セメント株式会社 骨欠損部及び空隙部充てん材
JPS62295666A (ja) * 1986-06-16 1987-12-23 呉羽化学工業株式会社 連続二次元多孔型インプラント材及びその製造法
JPH078547A (ja) * 1993-06-29 1995-01-13 Asahi Optical Co Ltd 生体吸収性高分子含有焼結型骨補填材
JP2001198208A (ja) * 2000-01-19 2001-07-24 Natl Inst For Res In Inorg Mater リン酸カルシウム系生体用セラミック焼結体およびその製造方法
WO2003035576A1 (fr) * 2001-10-21 2003-05-01 National Institute Of Advanced Industrial Science And Technology Article poreux de phosphate de calcium fritte, procede de production de celui-ci, ainsi qu'os artificiel et echafaudae histomorphologique faisant appel a cet article

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5858041A (ja) * 1981-10-05 1983-04-06 三菱鉱業セメント株式会社 骨欠損部及び空隙部充てん材
JPS62295666A (ja) * 1986-06-16 1987-12-23 呉羽化学工業株式会社 連続二次元多孔型インプラント材及びその製造法
JPH078547A (ja) * 1993-06-29 1995-01-13 Asahi Optical Co Ltd 生体吸収性高分子含有焼結型骨補填材
JP2001198208A (ja) * 2000-01-19 2001-07-24 Natl Inst For Res In Inorg Mater リン酸カルシウム系生体用セラミック焼結体およびその製造方法
WO2003035576A1 (fr) * 2001-10-21 2003-05-01 National Institute Of Advanced Industrial Science And Technology Article poreux de phosphate de calcium fritte, procede de production de celui-ci, ainsi qu'os artificiel et echafaudae histomorphologique faisant appel a cet article

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006090777A1 (fr) * 2005-02-23 2006-08-31 Hi-Lex Corporation Matériau médical, racine de dent artificielle et procédé de fabrication de matériau pour utilisation clinique
JP5166864B2 (ja) * 2005-02-23 2013-03-21 株式会社ハイレックスコーポレーション 人工歯根
CN101066469B (zh) * 2007-05-09 2010-05-19 上海理工大学 多孔胶原海绵的制备方法
CN102580167A (zh) * 2012-03-31 2012-07-18 上海理工大学 一种三维壳聚糖多孔支架的制备方法
CN113398333A (zh) * 2021-06-01 2021-09-17 南京方拓新材料科技有限责任公司 一种水凝胶基磷酸钙镁材料及其作为骨修复材料的应用
CN113398333B (zh) * 2021-06-01 2022-10-11 东南大学苏州医疗器械研究院 一种水凝胶基磷酸钙镁材料及其作为骨修复材料的应用
CN114569223A (zh) * 2022-01-25 2022-06-03 苏州卓恰医疗科技有限公司 具有填充物的身体植入物及其制备方法
CN114569223B (zh) * 2022-01-25 2023-12-08 苏州卓恰医疗科技有限公司 具有填充物的身体植入物及其制备方法

Also Published As

Publication number Publication date
JP4228070B2 (ja) 2009-02-25
JP2004261456A (ja) 2004-09-24

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