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WO2004084863A8 - Method of producing small microspheres of sugar, microspheres thus obtained and applications thereof - Google Patents

Method of producing small microspheres of sugar, microspheres thus obtained and applications thereof

Info

Publication number
WO2004084863A8
WO2004084863A8 PCT/FR2004/000662 FR2004000662W WO2004084863A8 WO 2004084863 A8 WO2004084863 A8 WO 2004084863A8 FR 2004000662 W FR2004000662 W FR 2004000662W WO 2004084863 A8 WO2004084863 A8 WO 2004084863A8
Authority
WO
WIPO (PCT)
Prior art keywords
microspheres
sugar
applications
producing small
phases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2004/000662
Other languages
French (fr)
Other versions
WO2004084863A1 (en
Inventor
Michel Duval
Patrick Sanial
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NOUVEAUX PRODUITS PHARMACEUTIQUES
NOUVEAUX PRODUITS PHARMA
Original Assignee
NOUVEAUX PRODUITS PHARMACEUTIQUES
NOUVEAUX PRODUITS PHARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NOUVEAUX PRODUITS PHARMACEUTIQUES, NOUVEAUX PRODUITS PHARMA filed Critical NOUVEAUX PRODUITS PHARMACEUTIQUES
Priority to EP04742280A priority Critical patent/EP1603539A1/en
Publication of WO2004084863A1 publication Critical patent/WO2004084863A1/en
Publication of WO2004084863A8 publication Critical patent/WO2004084863A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to a novel method of producing microspheres of sugar having a particle size of less than 500 µm. The invention is characterised in that it consists in alternating (i) phases in which a sugar syrup is finely sprayed onto a solid support comprising one or more sugars and (ii) drying phases, until the microspheres are produced.
PCT/FR2004/000662 2003-03-20 2004-03-18 Method of producing small microspheres of sugar, microspheres thus obtained and applications thereof Ceased WO2004084863A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04742280A EP1603539A1 (en) 2003-03-20 2004-03-18 Method of producing small microspheres of sugar, microspheres thus obtained and applications thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0303408A FR2852607B1 (en) 2003-03-20 2003-03-20 PROCESS FOR PRODUCING SMALL SIZE SUGAR MICROSPHERES, MICROSPHERES THAT MAY BE OBTAINED BY THIS PROCESS AND THEIR APPLICATIONS
FR03/03408 2003-03-20

Publications (2)

Publication Number Publication Date
WO2004084863A1 WO2004084863A1 (en) 2004-10-07
WO2004084863A8 true WO2004084863A8 (en) 2004-12-09

Family

ID=32922308

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2004/000662 Ceased WO2004084863A1 (en) 2003-03-20 2004-03-18 Method of producing small microspheres of sugar, microspheres thus obtained and applications thereof

Country Status (3)

Country Link
EP (1) EP1603539A1 (en)
FR (1) FR2852607B1 (en)
WO (1) WO2004084863A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201130428A (en) * 2010-01-25 2011-09-16 Japan Tobacco Inc Method for making flavoring pellets
US9918942B2 (en) * 2011-09-20 2018-03-20 Grain Processing Corporation Microspheres
CN105592710B (en) * 2013-10-01 2022-04-22 布勒股份公司 Spherical particles with a non-crystallising coagulated biopolymer matrix, method for the production thereof and use thereof
GB201418422D0 (en) 2014-10-17 2014-12-03 Mars Inc Confectionary production
WO2017093309A1 (en) 2015-11-30 2017-06-08 Nestec S.A. Amorphous porous particles for reducing sugar in food
AU2017318572C1 (en) * 2016-08-30 2021-01-07 Allergan, Inc. Method of manufacturing coated beads

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69111287T2 (en) * 1990-04-18 1995-12-21 Asahi Chemical Ind Spherical nuclei, spherical granules and processes for their production.
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
WO1997016078A1 (en) * 1995-10-27 1997-05-09 Givaudan-Roure (International) S.A. Aromatic granulated material
JP3447042B2 (en) * 1997-07-23 2003-09-16 フロイント産業株式会社 Method for producing single substance spherical particles
ES2157731B1 (en) * 1998-07-21 2002-05-01 Liconsa Liberacion Controlada ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION.
FR2796840B1 (en) * 1999-07-26 2003-06-20 Ethypharm Lab Prod Ethiques LOW-DOSE TABLETS AND METHOD OF PREPARATION

Also Published As

Publication number Publication date
EP1603539A1 (en) 2005-12-14
WO2004084863A1 (en) 2004-10-07
FR2852607B1 (en) 2006-07-14
FR2852607A1 (en) 2004-09-24

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