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WO2004082737A3 - Extracorporeal blood treatment device for removing blood toxins, and methods thereof - Google Patents

Extracorporeal blood treatment device for removing blood toxins, and methods thereof Download PDF

Info

Publication number
WO2004082737A3
WO2004082737A3 PCT/US2004/007590 US2004007590W WO2004082737A3 WO 2004082737 A3 WO2004082737 A3 WO 2004082737A3 US 2004007590 W US2004007590 W US 2004007590W WO 2004082737 A3 WO2004082737 A3 WO 2004082737A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
methods
target molecules
toxins
treatment device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/007590
Other languages
French (fr)
Other versions
WO2004082737A2 (en
Inventor
Scott R Mallett
Alan A Davidner
Kimberly A Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemavation LLC
Original Assignee
Hemavation LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/391,445 external-priority patent/US20040182783A1/en
Priority claimed from US10/391,453 external-priority patent/US20040186412A1/en
Priority claimed from US10/390,558 external-priority patent/US7207964B2/en
Priority claimed from US10/391,443 external-priority patent/US7201730B2/en
Priority claimed from US10/390,565 external-priority patent/US20040185426A1/en
Priority claimed from US10/391,455 external-priority patent/US20040182784A1/en
Priority claimed from US10/391,454 external-priority patent/US20040186407A1/en
Priority claimed from US10/391,444 external-priority patent/US20040185041A1/en
Priority claimed from US10/390,572 external-priority patent/US7229427B2/en
Application filed by Hemavation LLC filed Critical Hemavation LLC
Publication of WO2004082737A2 publication Critical patent/WO2004082737A2/en
Publication of WO2004082737A3 publication Critical patent/WO2004082737A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

The present invention relates generally to devices and methods for removing cell mediators from blood, including bloodborne toxins and microorganisms. Aspects of the invention relate to devices and methods for removing target molecules from the blood using a diluent system (114), a hemoconcentrator/filter system (106, 110) and for subsequently removing target molecules from the ultrafiltrate using additional filtration (112) for endotoxins and cell mediators before returning the treated blood to a source. Ultraviolet irradiation (104) is used in some embodiments of the invention. In one aspect, an antimicrobial device is used to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit is used to remove approximately 50-75% of target molecules from the blood and a filter unit is used to remove target molecules from blood from the sieved plasma filtrate.
PCT/US2004/007590 2003-03-17 2004-03-12 Extracorporeal blood treatment device for removing blood toxins, and methods thereof Ceased WO2004082737A2 (en)

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US10/390,565 2003-03-17
US10/391,443 US7201730B2 (en) 2003-03-17 2003-03-17 Device and method for reducing inflammatory mediators in blood
US10/391,454 2003-03-17
US10/390,572 2003-03-17
US10/390,565 US20040185426A1 (en) 2003-03-17 2003-03-17 Ultraviolet light and filter apparatus for treatment of blood
US10/391,444 2003-03-17
US10/391,455 US20040182784A1 (en) 2003-03-17 2003-03-17 Concentrator and filter based blood treatment system
US10/391,445 US20040182783A1 (en) 2003-03-17 2003-03-17 Filter and concentrator device for treatment of blood
US10/390,558 2003-03-17
US10/391,443 2003-03-17
US10/390,558 US7207964B2 (en) 2003-03-17 2003-03-17 Apparatus and method for down-regulating immune system mediators in blood
US10/391,454 US20040186407A1 (en) 2003-03-17 2003-03-17 Concentrator and filter apparatus for treatment of blood
US10/391,453 2003-03-17
US10/390,572 US7229427B2 (en) 2003-03-17 2003-03-17 Irradiation and filter device for treatment of blood
US10/391,453 US20040186412A1 (en) 2003-03-17 2003-03-17 Extracorporeal blood treatment system using ultraviolet light and filters
US10/391,445 2003-03-17
US10/391,455 2003-03-17
US10/391,444 US20040185041A1 (en) 2003-03-17 2003-03-17 Method for extracorporeal treatment of blood

Publications (2)

Publication Number Publication Date
WO2004082737A2 WO2004082737A2 (en) 2004-09-30
WO2004082737A3 true WO2004082737A3 (en) 2005-05-12

Family

ID=33033395

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/007590 Ceased WO2004082737A2 (en) 2003-03-17 2004-03-12 Extracorporeal blood treatment device for removing blood toxins, and methods thereof

Country Status (1)

Country Link
WO (1) WO2004082737A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0621452D0 (en) * 2006-10-27 2006-12-06 Ucl Business Plc Therapy for liver disease
ES2403598T5 (en) † 2009-12-22 2016-12-13 Gambro Lundia Ab Method and apparatus for controlling a fluid flow rate in a fluid transport conduit of a medical device
WO2012135746A2 (en) * 2011-04-01 2012-10-04 Aethlon Medical, Inc. Methods and devices comprising extracorporeal blood flow

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464166A (en) * 1981-06-12 1984-08-07 Frederic A. Bourke, Jr. Method for externally treating the blood
US5951509A (en) * 1996-11-22 1999-09-14 Therakos, Inc. Blood product irradiation device incorporating agitation
US6193681B1 (en) * 1998-09-14 2001-02-27 American Immuno Tech, Llc. Septicemia prevention and treatment system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464166A (en) * 1981-06-12 1984-08-07 Frederic A. Bourke, Jr. Method for externally treating the blood
US5951509A (en) * 1996-11-22 1999-09-14 Therakos, Inc. Blood product irradiation device incorporating agitation
US6193681B1 (en) * 1998-09-14 2001-02-27 American Immuno Tech, Llc. Septicemia prevention and treatment system

Also Published As

Publication number Publication date
WO2004082737A2 (en) 2004-09-30

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