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WO2004080407A3 - New serotonin modulating compounds and uses therefor - Google Patents

New serotonin modulating compounds and uses therefor Download PDF

Info

Publication number
WO2004080407A3
WO2004080407A3 PCT/US2004/007091 US2004007091W WO2004080407A3 WO 2004080407 A3 WO2004080407 A3 WO 2004080407A3 US 2004007091 W US2004007091 W US 2004007091W WO 2004080407 A3 WO2004080407 A3 WO 2004080407A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulating compounds
uses therefor
serotonin modulating
new serotonin
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/007091
Other languages
French (fr)
Other versions
WO2004080407A2 (en
Inventor
Dale S Dhanoa
Silvia Noiman
Oren Becker
Yael Marantz
Dongli Chen
Shacham Sharon
Boaz Inbal
Shay Bar-Haim
Alexander Heifetz
Srinivasa Rao Cheruku
Pradyumna Mohanty
Anurag Sharadendu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Predix Pharmaceuticals Holdings Inc
Original Assignee
Predix Pharmaceuticals Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Predix Pharmaceuticals Holdings Inc filed Critical Predix Pharmaceuticals Holdings Inc
Publication of WO2004080407A2 publication Critical patent/WO2004080407A2/en
Anticipated expiration legal-status Critical
Publication of WO2004080407A3 publication Critical patent/WO2004080407A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to 5-HT receptor antagonists. Novel compounds represented by Formula I, II or III, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as anxiety, depression, schizophrenia, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.
PCT/US2004/007091 2003-03-07 2004-03-08 New serotonin modulating compounds and uses therefor Ceased WO2004080407A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US45299303P 2003-03-07 2003-03-07
US45276603P 2003-03-07 2003-03-07
US45276203P 2003-03-07 2003-03-07
US60/452,993 2003-03-07
US60/452,766 2003-03-07
US60/452,762 2003-03-07

Publications (2)

Publication Number Publication Date
WO2004080407A2 WO2004080407A2 (en) 2004-09-23
WO2004080407A3 true WO2004080407A3 (en) 2006-06-01

Family

ID=32995975

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/007091 Ceased WO2004080407A2 (en) 2003-03-07 2004-03-08 New serotonin modulating compounds and uses therefor

Country Status (1)

Country Link
WO (1) WO2004080407A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2660474A1 (en) * 2006-08-17 2008-02-21 F. Hoffmann-La Roche Ag Arylpiperazine derivatives and uses thereof
BRPI0908807A2 (en) 2008-02-15 2015-07-28 Hoffmann La Roche 3-Alkyl piperazine derivatives and uses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262087B1 (en) * 1996-12-20 2001-07-17 H. Lundbeck A/S Indane or dihydroindole derivatives
US6790848B2 (en) * 2001-06-15 2004-09-14 Syntex (U.S.A.) Llc 4-piperazinylindole derivatives with 5-HT6 receptor affinity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262087B1 (en) * 1996-12-20 2001-07-17 H. Lundbeck A/S Indane or dihydroindole derivatives
US6790848B2 (en) * 2001-06-15 2004-09-14 Syntex (U.S.A.) Llc 4-piperazinylindole derivatives with 5-HT6 receptor affinity

Also Published As

Publication number Publication date
WO2004080407A2 (en) 2004-09-23

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