WO2004080369A1 - A vacuum soft packaging bag for injection powder and a connector used by the same - Google Patents

Abstract

The present invention discloses a soft packaging bag for injection powder. The packaging bag has a sealed soft bag body (10), which contains the injection powder and can be vacuumized. At least one sealed conduit (20) is provided on the edge of the bag body, from which the solvent can be inlet and the solution can be outlet. The conduit (20) is made of elastical material, which is hermetically connected to the bag body (10), and at least one end of which is sealed. A suction tube (40) can be installed to the inner of the packaging bag or a connector (30) which connects the packaging bag with a transfusion bottle, can be provided to the packaging bag. The connector (30) comprises of a connection tube (31) and connection heads (32), (33) located in both ends of the tube (3 1), wherein the connection head (32) can be an acupuncturing, embeding or helical type one. The connection head (33) is a syringe needle. A hanging hook (11) is provided in the same side of the packaging bag (10) and the conduit (20). The invention can improve the stability of the injection powder dramatically, and the solvent can be inlet conveniently, which dissolves the solutes. After dissolved, the solutes or the solution can be extracted out conveniently or transfused directly.

Description

 Vacuum soft packaging bag for powder injection for injection and connector used

Technical field

 The present invention relates to a packaging bag for packaging medicine, and more particularly, the present invention relates to a vacuum soft packaging bag for powder injection for injection. Background technique

 Powder injection is a commonly used pharmaceutical preparation. At present, hard glass bottles are generally used for packaging. The method is to put powder injection into glass bottles, and then stopper the rubber stopper and roll it with aluminum lid. This packaging is suitable for powder injections with relatively stable properties, and because of its simple structure and strong operability, it is widely used. However, for powder injections that are not very stable, such as those that are easy to absorb moisture or oxidize, because moisture or oxygen can accelerate the deterioration of the powder injection, the above packaging has obvious disadvantages because it cannot be completely sealed and / Or it is evacuated, which makes oxygen remain in the glass bottle, which causes some of the testing indicators of some powder injection types to easily exceed the specified range and become unqualified products. For example, sodium cefoperazone in the above package is likely to absorb moisture and cause moisture to exceed the standard; sodium cefoxitin in the above package is easily oxidized to cause the color to exceed the standard.

 The existence of the above problem directly affects the quality of the medicine, shortens the validity period of the medicine, and increases the difficulty of storage.

 PCT / EP99 / 02745 discloses a bag in which powdered sterile products can be stored and transported, and a solution, dispersion or suspension of the above products can be formed in the bag. The bag body disclosed in PCT / EP99 / 02745 is made of polyolefin, its periphery is hermetically sealed and

 1

Confirm this It includes at least one channel opening made of polyolefin, and the channel of the channel opening leads to the inside and the outside of the bag body respectively, and a fragile membrane is arranged in the channel to isolate the sterile product inside the bag from the outside. The advantage of the bag body in PCT / EP99 / 02745 is that it has good airtightness, but the disadvantage is that its storage method cannot guarantee that the sterile products in the bag body do not contact the air. Summary of the invention

 The invention aims to solve the problem of instability of powder injections stored in glass bottles, and provides a vacuum soft packaging bag for injections of injections with good sealing performance, which can be evacuated and can significantly improve the stability of injections. The flexible packaging bag can be conveniently introduced with a solvent to dissolve the powder injection, and the powder injection can be easily exported after being dissolved or can be directly infused.

 In order to achieve the above object, the present invention provides a vacuum soft packaging bag for powder injection for injection. The vacuum soft packaging bag includes a vacuum-tight sealed soft bag body containing powder injection, and at least one edge of the bag body is provided with one. The catheter for introducing the solvent and / or the solution, the outer sleeve of the catheter is covered with a hard outer sleeve, and the catheter and the bag body are hermetically sealed.

 In the above-mentioned soft powder injection powder packaging bag, the catheter may be made of an elastic material, and at least one end of the catheter is sealed. If one end of the catheter is sealed with an elastic material, a sealing plug may be used at the other end. The sealing plug can be installed at the outlet of the catheter. The use of a stopper can further ensure that the solvent and / or solution is withdrawn under sterile conditions.

The above-mentioned vacuum flexible packaging bag can be provided with two or more ducts on the same side edge of the bag body, or two or more ducts on the opposite side edge of the bag body, or even on the non-opposite side of the bag body. Two or more guides on different side edges of the Tube.

 In addition, the vacuum flexible packaging bag of the present invention can also be provided with a hanging hook for hanging on a certain side edge of the catheter; the hook can be one, two or more.

 To facilitate the addition of the solvent and / or the extraction of the solution in the vacuum flexible packaging bag, a suction tube may be provided inside the vacuum flexible packaging bag body. The suction tube is sealedly connected with the catheter and may extend inward from the catheter to the bottom of the bag body.

 On the other hand, in order to cooperate with the use of the vacuum soft packaging bag for powder injection for injection according to the present invention, the present invention also provides a connector for connecting the vacuum soft packaging bag for powder injection for injection with an infusion bottle, and the connector includes a connecting tube And two connectors at its two ends, one of which can be needled, flush or screwed, and the other can be a needle.

 The positive effect of the present invention is that, because it is a hermetically sealed vacuum package, by completely isolating the packaged material from contact with oxygen and moisture, it has a good sealing performance, so the stability of the powder injection can be significantly improved. At the same time, the catheter structure can easily dissolve the solute by entering the solvent. After dissolution, the liquid can be easily exported or directly infused, which reduces the contact opportunity between the injection solution and the air and ensures the safety of use. In addition, if a built-in suction tube connected to the sealed tube is provided in the bag, and the suction tube is directly at the bottom of the packaging bag, the solution can be easily extracted after the solvent is added to the bag. The invention also has the advantages of simple structure, easy implementation and flexible use.

FIG. 1 is a sectional view showing a structure of an embodiment (with a built-in straw) of the present invention. FIG. 2 is a structural cross-sectional view of another embodiment of the present invention.

 FIG. 3 is a schematic structural diagram of a connector of the present invention.

 In the figure, 1 0 ----- bag body

 1 1 --- hook

 20 --- catheter

 21 —-Outerwear

 22---sealing plug

 2 3 --- Sealing film or plug

 30 --- Connector

 31 --- Connecting tube

 32, 33 --- connector

 40 --- straw

Referring to FIG. 1, it is an embodiment of a vacuum soft packaging bag for powder injection for injection with a built-in straw. The vacuum soft packaging bag has a vacuum-tight sealed soft bag body 10 containing powder injection. The bag body is made of a suitable medical inner packaging soft material, such as polyethylene plastic, and its lower end is first open. After the powder injection is quantitatively filled by the machine, a vacuum is drawn, and the lower end seal is completely sealed. At the edge of the bag body 10, a sealed conduit 20 for introducing a solvent and a solution is provided. The conduit can be made of an elastic material such as rubber, silicone, and is heat-pressed or bonded to the bag body 10, and at least one end is It is sealed, and its connecting end with the bag body can be sealed by an elastic sealing film or plug 23 such as rubber or silicone. To make the seal more reliable, A sealing plug 22 is installed at its exit. Because the catheter needs to perform some connection operations, it is easier to operate if it has a certain hardness, so a hard outer jacket 21 made of plastic material can be bonded and fixed outside the catheter to facilitate practical operation. The catheter of the above structure can be inserted by a needle, and a solvent is fed into the bag, and the needle is automatically sealed after being pulled out. In order to completely dissolve the dissolved solution, a suction tube 40 is provided in the bag body. The upper end of the suction tube is sealedly connected to the lower end of the catheter by means of bonding, etc., and the lower end thereof extends inward to the near bottom of the bag body so that The solution can be completely aspirated.

 The use of the above vacuum flexible packaging bag is similar to the glass bottle powder injection. First remove the outer packaging bag, then unplug the catheter, pierce the catheter with a syringe (with the solvent extracted and stored), and insert it into the bag. The solvent is pushed into the bag along the catheter and the suction tube. After the solute is dissolved, the solution is drawn back with the syringe. After the solution enters the syringe along the suction tube and the catheter, the syringe is pulled out. It can then be injected directly intramuscularly or added to an infusion bottle for intravenous injection. If the solute dissolves very slowly, you can pull out the syringe first, wait for the solute to dissolve, and then re-insert as above.

Referring to FIG. 2, it is a vacuum soft packaging bag for powder injection for injection without a built-in straw. The vacuum soft packaging bag has a vacuum-tight and flexible soft bag body 10 containing powder injections, and the bag body is made of a suitable medical inner packaging soft material such as polyethylene plastic. At least one sealed duct 20 for introducing and extracting a solvent is provided on the edge of the bag body. In this embodiment, two catheters 20 are provided on the upper and lower sides of the bag body, which can be used for direct infusion. The catheter may be made of an elastic material such as rubber silicone, and is heat-sealed or adhesively connected to the bag body 10, and at least one end thereof is sealed, and the connection end with the bag body may be sealed by an elastic sealing film such as rubber, silica gel, or a plug 23 . A sealing plug 12 is installed at the exit of the duct 20. A hard outer sleeve 21 made of plastic material is fixed on the outside of the catheter 20 to facilitate practical operation. The catheter of the above structure can be inserted by a needle, and is automatically sealed after the needle is pulled out.

To meet the direct ^infusion: a case, the bag further having a connector connected to the infusion bag bottle 30, the connector configuration shown in FIG. 3, which is connected by a pipe 31 and both ends of the joint 32, 33 The connection tube 31 is made of hard plastic, the connector 32 may be a needle-punched, embedded or spiral type, and the connector 33 is a medical standard steel needle for puncture into an infusion bottle or other solvent bottle. The solvent is extracted and the solute in the packaging bag is dissolved to form a solution for injection. The joint 32 is matched with the catheter 20. If the connector joint 32 is a needle-type, the catheter 20 is prepared and sealed by using an elastic material such as rubber or silicone. A sealing plug 22 may be configured at the outer end of the catheter for further protection, and of course, the sealing plug 22 may not be added. If the joint 32 is of the embedded or spiral type, the catheter 20 is in the form of a sealing film made of an elastic material such as rubber, silicone, and the like, or of an embedded or spiral protective cover or plug.

 The packaging bag can also be covered with an outer packaging bag. It is made of transparent or opaque plastic or aluminum foil for packaging and protection. At the same time, it can print the necessary descriptions such as the product name and instructions for use.

 In order to facilitate hanging during the infusion, a hook 11 for hanging the guinea pig is provided on the same side edge of the bag body 10 and the catheter 20.

The use process of the packaging bag shown in FIG. 2 is as follows: tear the outer packaging bag, take out the inner vacuum packaging bag 10, and also remove the outer packaging of the connector 30; insert the steel needle of the connector joint 33 through the stopper and insert the infusion Bottle solution; insert the connector joint 32 into the catheter 20 and communicate with the inside of the packaging bag. Due to the pressure difference between the two sides, the solvent in the infusion bottle will automatically flow into the bag In bagging, dissolve the powder injection in the packaging bag. If the amount of solvent flowing into the bag is too little or the flow rate is too slow, take another clean syringe and insert it into another tube. Extract air to create a pressure difference, and then pull out the syringe until the amount of solvent flows in is suitable. Remove the syringe and repeat until appropriate. After the powder injection is completely dissolved in the packaging bag, you can squeeze the packaging bag by hand to return all the dissolved powder injection solution to the infusion bottle and mix it for intravenous injection by the patient; or pull out the connector and pass one of the catheters with The infusion tube is directly connected, and the packaging bag is used as an infusion bag, and the solution in the bag is used for direct infusion of the patient.

 The aforementioned bags are also available for intramuscular injection, but do not require a connector. When using, tear off the outer packaging bag, take out the inner vacuum packaging bag, and directly add the solution through one of the catheters with a syringe (already filled with an appropriate amount of solvent). After the solute is dissolved, use the syringe to draw the solution back into the syringe (you Invert the package to help draw the solution clean) and then give the patient an intramuscular injection. Of course, it is also possible to inject the solution of the syringe into another infusion bottle for infusion.

 The vacuum packaging bag of the present invention can be prepared according to the following process: quantitatively dispense powder injection for injection into the packaging bag (with a conduit 20), vacuuming and sealing (this packaging process is similar to vacuum packaging other powders such as milk powder) The same, except that the powder injections are packed in a sterile environment, and the packaging bag is a sterile packaging bag); then the outer packaging bag is put on, and the finished packaging bag is obtained after sealing.

 The packaging bag of the present invention can be adjusted according to the packaged material or the purpose of use, and the capacity of the packaging bag can range from 20 ml to 500 ml. The positions of the two upper and lower catheters are generally one above and one below, and can also be adjusted as required, such as both at the lower end.

Claims

Rights request  1. A vacuum soft packaging bag for powder injection for injection, characterized in that the vacuum soft packaging bag comprises a closed soft bag body (10) which can be evacuated and contains powder injection, and the bag body (10) At least one catheter (20) for introducing a solvent and / or a solution is provided at the edge of the catheter, the outer sleeve of the catheter (20) is sheathed with a hard outer sleeve (21), and the catheter (20) and the The bag body (10) is hermetically connected. 2. The vacuum flexible packaging bag according to claim 1, wherein the guide tube (20) is made of an elastic material, and at least one end of the guide tube (20) is sealed. 3. The vacuum flexible packaging bag according to claim 2, characterized in that one end of the guide tube (20) is sealed with an elastic material, and the other end uses a sealing plug (22). 4. The vacuum flexible packaging bag according to claim 1, wherein the vacuum flexible packaging bag comprises two ducts (20) provided on the same side edge of the bag body (10). 5. The vacuum flexible packaging bag according to claim 1, characterized in that the vacuum flexible packaging bag comprises two ducts (20) provided on opposite side edges of the bag body (10). 6. The vacuum flexible packaging bag according to claim 1, characterized in that the vacuum flexible packaging bag further comprises a hook provided on the same side edge as a duct (20) for hanging. 7. The vacuum soft packaging bag for powder injection for injection according to claim 1, further comprising a vacuum soft packaging bag provided inside the bag body (10) and sealingly connected with the duct (20). Straw (40). 8. The vacuum soft packaging bag for powder injection for injection according to claim 7, wherein the straw (40) extends inwardly from the catheter (20) to the bottom of the bag body (10) . 9. A connector for connecting the vacuum soft packaging bag for powder injection for injection with an infusion bottle according to any one of claims 1 to 8, characterized in that the connector (30) comprises a connecting tube (31) And joints (32), (33) at its two ends, where the joint (32) is a needle-punched, recessed or screw type, and the joint (33) is a needle.