[go: up one dir, main page]

WO2004079007A3 - Time-lapse cell analysis method - Google Patents

Time-lapse cell analysis method Download PDF

Info

Publication number
WO2004079007A3
WO2004079007A3 PCT/JP2004/002694 JP2004002694W WO2004079007A3 WO 2004079007 A3 WO2004079007 A3 WO 2004079007A3 JP 2004002694 W JP2004002694 W JP 2004002694W WO 2004079007 A3 WO2004079007 A3 WO 2004079007A3
Authority
WO
WIPO (PCT)
Prior art keywords
time
cell
lapse
present
presenting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2004/002694
Other languages
French (fr)
Other versions
WO2004079007A2 (en
Inventor
Masato Miyake
Tomohiro Yoshikawa
Eiichiro Uchimura
Jun Miyake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Advanced Industrial Science and Technology AIST
Original Assignee
National Institute of Advanced Industrial Science and Technology AIST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute of Advanced Industrial Science and Technology AIST filed Critical National Institute of Advanced Industrial Science and Technology AIST
Priority to JP2006507660A priority Critical patent/JP2006522605A/en
Publication of WO2004079007A2 publication Critical patent/WO2004079007A2/en
Publication of WO2004079007A3 publication Critical patent/WO2004079007A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Computer Hardware Design (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The present invention provides a method and system for accurately presenting an actual state of a cell. The present invention also provides a system and method for presenting information within a cell over time and/or in real time without modification or directly where the cell is considered as a complex system. A method of the present invention for determining a state of a cell comprises a) obtaining a time-lapse profile of the cell by time-lapse monitoring of a transcription level associated with at least one transcription contorl sequence selected from the group consisting of transcription control sequences derived form the cell; and b) presenting the time-lapse profile.
PCT/JP2004/002694 2003-03-04 2004-03-03 Time-lapse cell analysis method Ceased WO2004079007A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006507660A JP2006522605A (en) 2003-03-04 2004-03-03 Time-lapse cell analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003057870 2003-03-04
JP2003-057870 2003-03-04

Publications (2)

Publication Number Publication Date
WO2004079007A2 WO2004079007A2 (en) 2004-09-16
WO2004079007A3 true WO2004079007A3 (en) 2004-12-02

Family

ID=32958778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/002694 Ceased WO2004079007A2 (en) 2003-03-04 2004-03-03 Time-lapse cell analysis method

Country Status (2)

Country Link
JP (1) JP2006522605A (en)
WO (1) WO2004079007A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5670020B2 (en) * 2008-10-21 2015-02-18 株式会社ビーエムティーハイブリッド Three-dimensional cell culture chip and method of using the same
JPWO2019021472A1 (en) * 2017-07-28 2020-07-30 オリンパス株式会社 Cell identification method, cell population production method and cell identification system
EP3859006B1 (en) 2018-09-28 2024-07-03 FUJIFILM Corporation Determination method
WO2020066344A1 (en) 2018-09-28 2020-04-02 富士フイルム株式会社 Determination method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088165A1 (en) * 2001-04-30 2002-11-07 Doranz Benjamin J Elucidation of gene function

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020006664A1 (en) * 1999-09-17 2002-01-17 Sabatini David M. Arrayed transfection method and uses related thereto

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088165A1 (en) * 2001-04-30 2002-11-07 Doranz Benjamin J Elucidation of gene function

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BAILEY S N ET AL: "APPLICATIONS OF TRANSFECTED CELL MICROARRAYS IN HIGH-THROUGHPUT DRUG DISCOVERY", DRUG DISCOVERY TODAY, ELSEVIER SCIENCE LTD, GB, vol. 7, no. 18, SUPPL, 2002, pages S113 - S118, XP008026706, ISSN: 1359-6446 *
CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING, vol. 28, no. 1-2, 2000, 18TH SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE AND THE 2ND INTERNATIONAL CONFERENCE ON ETHICAL ISSU; CLEMSON, SOUTH CAROLINA, USA; MAY 21-23, 1999, pages 203 - 208, ISSN: 0278-940X *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2000, WEBB KEN ET AL: "Fibronectin immobilized by a novel surface treatment regulates fibroblast attachment and spreading", XP009034748, Database accession no. PREV200000504258 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 28 April 2004 (2004-04-28), YOSHIKAWA TOMOHIRO ET AL: "Transfection microarray of human mesenchymal stem cells and on-chip siRNA gene knockdown", XP002291278, Database accession no. PREV200400300235 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 7 March 2001 (2001-03-07), PRECKEL TOBIAS ET AL: "The use of Lab-on-a-Chip technology for monitoring transfection efficiency in cells", XP009034806, Database accession no. PREV200100290293 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 2000 (2000-09-01), GORE M A ET AL: "Gene expression changes associated with cytotoxicity identified using cDNA arrays.", XP002291277, Database accession no. NLM11793227 *
FASEB JOURNAL, vol. 15, no. 4, 7 March 2001 (2001-03-07), ANNUAL MEETING OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY ON EXPERIMENTAL BIOL; ORLANDO, FLORIDA, USA; MARCH 31-APRIL 04, 2001, pages A531, ISSN: 0892-6638 *
FUNCTIONAL & INTEGRATIVE GENOMICS. SEP 2000, vol. 1, no. 2, September 2000 (2000-09-01), pages 114 - 126, ISSN: 1438-793X *
JOURNAL OF CONTROLLED RELEASE, vol. 96, no. 2, 28 April 2004 (2004-04-28), pages 227 - 232, ISSN: 0168-3659 *
WU R Z ET AL: "Cell-biological applications of transfected-cell microarrays", TRENDS IN CELL BIOLOGY 01 OCT 2002 UNITED KINGDOM, vol. 12, no. 10, 1 October 2002 (2002-10-01), pages 485 - 488, XP002291276, ISSN: 0962-8924 *
ZIAUDDIN JUNAID ET AL: "Microarrays of cells expressing defined cDNAs", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 411, no. 6833, 2001, pages 107 - 110, XP002246363, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
JP2006522605A (en) 2006-10-05
WO2004079007A2 (en) 2004-09-16

Similar Documents

Publication Publication Date Title
CA2465800A1 (en) Instrument
WO2003012440A8 (en) Method and system for predicting initial analyte values in stored samples
WO2002097414A3 (en) Analytical instruments and biosensors, and methods for increasing their accuracy and effective life
WO2006020579A3 (en) Method for rapid identification of microorganisms
WO2004046098A3 (en) Method for predicting autoimmune diseases
EP1253404A3 (en) Pedestrian navigation method and apparatus operative in a dead reckoning mode
WO2004011904A3 (en) Quality assurance for high-throughput bioassay methods
WO2007098427A3 (en) Massively multiplexed sequencing
WO2005001667A3 (en) Methods and apparatus for data analysis
WO2005015332A3 (en) Virtual load monitoring system and method
WO2002015458A3 (en) Discovering hidden damage in machinery and predicting remaining life
DE60115653D1 (en) Method for detecting emotions using subgroup specialists
ATE413633T1 (en) METHOD FOR DETERMINING CONTROL PARAMETERS FOR A CONTROL SYSTEM
WO2000066777A3 (en) Assay based on the analysis of dna melting curves
DE602004026111D1 (en) METHOD FOR TESTING NUCLEIC ACIDS USING THEM AND THE NUCLEIC ACID END USED THEREFOR
WO2004055491A8 (en) Novel method for sequence determination using nmr
WO2005079261A3 (en) System and method for tracking and quatitating chemical entites
WO2004015420A8 (en) Method for diagnosing multiple sclerosis
WO2004079007A3 (en) Time-lapse cell analysis method
WO2009085852A3 (en) Method and apparatus for improving performance of erasure sequence detection
WO2004061419A3 (en) Systems and methods for estimating properties of a sample
WO2004038412A3 (en) Method for detecting halitosis
WO2009125936A3 (en) Analysis method and kit for diagnosis of polycystic ovary syndrome
DE502005003978D1 (en) Method and device for functional control of a sensor
WO2005119209A3 (en) System and method for analyzing microbial growth

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2006507660

Country of ref document: JP

122 Ep: pct application non-entry in european phase